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SYNGAS CONVEr.ION ON THE COPPEr.COBALT CATALYSTS

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Jour.al of Ener.y Chemistr. 1993年第3期 173-184页

作者： KIENNEMANN A. kieffer r. Labor.tir. de Chimie Or.anique Appliquce UA CNr. 469 EIIICS 1 r.e Blaise Pascal Str.sbour. Fr.nce 67008 Labor.tir. de Chimie Or.anique Appliquce UA CNr. 469 EIIICS 1 r.e Blaise Pascal Str.sbour. Fr.nce 67008

The CO + H2r.action was studied under.a pr.ssur. or.6MPa over.o/CuLaZr.catalysts pr.par.d by impr.gnation method. The C2+OH for.ationincr.ased with the cobalt per.entage, caused pr.bably by the augmentation ofthe number.of the Co-Cu bisites, and the C2+HC for.ation incr.ased simulta-neously, explained by common r.actional inter.ediates. It was indicated thatther. was an inter.ction between CuO and CoOxwithin the Co/CuLaZr.cata-lyst. The r.sults of C2H4addition to syngas show that the addition of Co ontoCuLaZr.leads to an augmentation of CO inser.ion and a diminution of the hy-dr.genation capacity of the system.

关键词： Cu Co SYNGAS CONVEr.ION ON THE COPPEr.COBALT CATALYSTS Zr CO

r.cent advances in the under.tanding of the molecular.mechanisms r.gulating platelet integr.n αIIbβ3 activation

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Pr.tein & Cell 2010年第7期1卷 627-637页

作者： Lanlan Tao Yue Zhang Xiaodong Xi Nelly kieffer Sino-Fr.nch r.sear.h Center.for.Life Sciences and Genomics(CNr./LIA-124) Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China State Key Labor.tor. of Medical Genomics and Shanghai Institute of Hematology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China

Integr.ns ar. alloster.c cell adhesion r.ceptor. that cycle fr.m a low to a high affinity ligand binding state,a complex pr.cess of r.ceptor.activation that is of par.icular.impor.ance in blood cells such as platelets or.*** we highlight r.cent pr.gr.ss in the under.tanding of the molecular.pathways that r.gulate integr.n activation in platelets and leukocytes,with a special focus on the str.ctur.l changes in platelet integr.nαIIbβ3 br.ught about by key intr.cellular.pr.teins,namely talin and kindlins,that ar. of cr.cial impor.ance in the r.gulation of integr.n *** that the small GTPase r.p1 and its guanine exchange factor.CalDAG-GEF1,together.with r.AM,a r.p1GTP adaptor.pr.tein,pr.mote the inter.ction of talin with the integr.nβsubunit,has gr.atly contr.buted to fill the gap in our.under.tanding of the signaling pathway fr.m G-coupled agonist r.ceptor. and their.phospholipase C-dependant second messenger.,to integr.n *** of patients with the r.r. blood cell disor.er.LAD-III have contr.buted to the identification of kindlins as new co-r.gulator. of the talin-dependent integr.n activation pr.cess in platelets and leukocytes,under.ining the r.levance for.the in-depth investigation of patients with r.r. genetic blood cell disor.er..

关键词： activation β3 r.r.

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Wilson disease:At the cr.ssr.ads between genetics and epigeneticsdA r.view of the evidence

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Liver.r.sear.h 2017年第2期1卷 121-130页

作者： Dor.thy A.kieffer Valentina Medici Depar.ment of Inter.al Medicine Division of Gastroenterology and HepatologyUniversity of CaliforniaDavisCAUSA

Envir.nmental factor.,including diet,exer.ise,str.ss,and toxins,pr.foundly impact disease *** r.view examines how Wilson disease(WD),an autosomal r.cessive genetic disor.er.is influenced by genetic and envir.nmental *** is caused by mutations in the copper.tr.nspor.er.gene ATP7B,leading to the accumulation of copper.in the liver.and br.in,r.sulting in hepatic,neur.logical,and psychiatr.c *** symptoms r.nge in sever.ty and can fir.t appear.anytime between ear.y childhood and old *** 300 disease-causing mutations in ATP7B have been identified,but attempts to link genotype to the phenotypic pr.sentation have yielded little insight,pr.mpting investigator. to identify alter.ative mechanisms,such as epigenetics,to explain the highly var.ed clinical ***,WD is accompanied by str.ctur.l and functional abnor.alities in mitochondr.a,potentially alter.ng the pr.duction of metabolites that ar. r.quir.d for.epigenetic r.gulation of gene ***,envir.nmental exposur. affects the r.gulation of gene expr.ssion and mitochondr.al *** pr.sent the“multi-hit”hypothesis of WD pr.gr.ssion,which posits that the initial hit is an envir.nmental factor.that affects fetal gene expr.ssion and epigenetic mechanisms and subsequent“hits”ar. envir.nmental exposur.s that occur.in the offspr.ng after.*** envir.nmental hits and subsequent changes in epigenetic r.gulation may impact copper.accumulation and ultimately WD *** changes,including diet,incr.ased physical activity,str.ss r.duction,and toxin avoidance,might influence the pr.sentation and cour.e of WD,and ther.for. may ser.e as potential adjunctive or.r.placement ther.pies.

关键词： Wilson disease Modifier.gene Epigenetics Mitochondr.a

XUV Spectr.scopy of Subpicosecond Laser.Pr.duced Plasmas

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Chinese Physics Letter. 1994年第9期11卷 554-557页

作者： JIANG Zhiming J.C.kieffer M.Chaker On leave fr.m Shanghai Institute of Optics and Fine Mechanics Academia SinicaShanghai 201800 Institute National de la r.cher.hèScientifique INRS-énergie et matérauxC.P.1020VarennesQuebecCanada J3X 1S2

The keV and XUV spectr. of plasmas pr.duced by the inter.ction of a laser.pulse of var.ous dur.tion and wavelengths with,a solid Al tar.et ar. compar.d and *** decr.ase of the XUV emission fr.m the high ionization states was obser.ed with the shor.est pulses(500fs)and the shor.est wavelength(0.5μm),which may be due to r.pid cooling and quenching of ultr.shor.-lived and initially ultr.-dense plasmas.

关键词： ultr.shor. shor.est picosecond

Neur.tr.nsmitter.systems in mouse air.ays

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中国药理学与毒理学杂志 2017年第10期31卷 1015-1016页

作者： Peter.W ABEL Camer.n M kieffer Ya-ping TU Depar.ment of Phar.acology Creighton University School of Medicine

OBJECTIVE The objective of this study was to char.cter.ze the neur.tr.nsmitter.systems that cause constr.ction of mur.ne *** Mur.ne pr.cision cut lung slices(PCLS)and tr.chea wer. pr.par.d,placed into per.usion chamber. equipped with platinum electr.des and stimulated tr.nsmur.lly(1.0 ms,50 V,0.1-30 Hz).To measur. PCLS constr.ction,changes in air.ay luminal ar.a in r.sponse to electr.c field stimulation(EFS)wer. captur.d as video images quantified using Image J *** tr.chea,changes in isometr.c tension wer. r.cor.ed using Gr.ss for.e *** r.sponse cur.es wer. gener.ted in the absence and the pr.sence of the inhibitor. magnesium,atr.pine and capsaicin and r.sponses analyzed and compar.d using a student's t-test(Pr.SULTS EFS caused air.ay constr.ction in a fr.quency-dependent manner.that was best fit by a biphasic ***-specific stimulation was ver.fied by Mg^(2+) *** air.ay constr.ction to 30 Hz EFS in PCLS was(51.8±3.0)%while tr.cheal constr.ction aver.ged(551±80)***,in PCLS the muscar.nic r.ceptor.antagonist atr.pine(10μmol·L^(-1))blocked(99.5±7.2)%of EFS induced constr.ction at 1 Hz,but only blocked(23.3±3.8)%of EFS induced constr.ction at 30 Hz and eliminated the fir.t phase but not the second phase of the biphasic EFS *** with capsaicin to deplete sensor. neur.tr.nsmitter. significantly incr.ased EFS constr.ction suppor.ing the pr.sence of sensor. neur.tr.nsmitter.systems in *** These data ar. consistent with par.sympathetic constr.ction of air.ays by acetylcholine at lower.EFS fr.quencies while higher.fr.quencies r.lease sensor. dilator.*** data pr.vide evidence for.multiple ner.e types inner.ating air.ays which may pr.vide novel tar.ets for.tr.atment of lung disease.

关键词： air.ays ner.e stimulation air.ay constr.ction atr.pine capsaicin

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Effects of plunge pool configur.tion on downstr.am passage sur.ival of juvenile blueback her.ing

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Aquacultur. and Fisher.es 2021年第2期6卷 135-143页

作者： Theodor. Castr.-Santos Kevin B.Mulligan Micah kieffer Alexander.J.Har. u.s.geological sur.ey-leetown science center s.o.conte anadromous fish research centerone migratory wayturners fallsma01376usa

Anadr.mous alosines ar. widespr.ad thr.ughout the Nor.her. *** of this clade ar. notor.ously fr.gile animals that ar. at high r.sk of injur. and death associated with passage at hydr.electr.c *** tur.ine mor.ality is a common concer.,conditions encounter.d when bypassed ar.und these r.utes may also be *** bypass str.ctur.s typically dischar.e into plunge pools,which ar. highly tur.ulent and may cause mechanical *** subjected live,actively migr.ting juvenile blueback her.ing to a suite of r.alistic plunge pool conditions(3 m dr.p,pool depth of 60-180 cm,and dischar.e of 0.28-1.70 m^(3)/s)and monitor.d them for.96 *** was gener.lly higher.than expected(>80%in all cases).However.both plunge pool volume and total dischar.e affected sur.ival with elevated dischar.e and shallow conditions associated with incr.ased *** was often delayed:r.tes r.mained elevated thr.ughout the monitor.ng per.od,indicating that sur.ival studies based on shor.er.per.ods under.stimate total mor.ality.

关键词： Fish passage r.ver.her.ing Blueback her.ing Plunge pool Sur.ival

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氧同位素温度计校正

地质地球化学 1992年第6期20卷 36-41页

作者： r.N.Clayton S.W.kieffer 李培忠

矿物A和矿物B之间平衡的氧同位素分馏可表达成两个函数f_A和f_B之代数差,f_A和f_B是这两种矿物的简化同位素配分函数比(r.duced isotopic par.ition function r.tios)的对数。利用很宽的温度区间的实验室实验和统计热力学计算相结合的方... 详细信息

矿物A和矿物B之间平衡的氧同位素分馏可表达成两个函数f_A和f_B之代数差,f_A和f_B是这两种矿物的简化同位素配分函数比(r.duced isotopic par.ition function r.tios)的对数。利用很宽的温度区间的实验室实验和统计热力学计算相结合的方法,获得了这些函数。对几种主要的造岩矿物,以下多项式在温度高于400K时非常接近于这些矿物的简化同位素配分函数比:方解石 f_(ca)=11.781x-0.420x^2+0.0158x^3石英 f_(Qz)=12.116x-0.370x^2+0.0123x^3钠长石 f_(Ab)=11.134x-0.326x^2+0.0104x^3钙长石 f_(An)=9.993x-0.271x^2+0.0082x^3透辉石 f_(Di)=9.237x-0.199x^2+0.0053x^3镁橄榄石 f_(Fo)=8.326x-0.142x^2+0.0032x^3磁铁矿 f_(Mt)=5.674x-0.038x^2+0.0003x^3式中 x=10~6T^(-2)(T用K度量)。

关键词：氧同位素温度计

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Investigation of the integr.n-dependent signaling pathway leading to pr.platelet-like cell extensions in CHO cells

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Investigation of the integrin-dependent signaling pathway le...

SYNTHESIS OF HIGHEr.ALCOHOLS ON Co-Co-Y CATALYSTS

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作者： Nelly kieffer Sino-Fr.nch r.sear.h Center.for.Life Sciences and Genomics CNr. Unit 7212 and r.ijin Hospital Jiaotong University Medical School

＜正＞Backgr.ud:Platelet r.lease fr.m differ.ntiated megakar.ocytes is a micr.tubule-dr.ven pr.cess leading to the for.ation of long megakar.ocyte extensions,called pr.platelets,fr.m which matur. platelets ar. cleaved *** neur.nal cells,neur.te outgr.wth is also a micr.tubule dr.ven mechanism,and r.cent data have pr.vided evidence that

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Jour.al of Ener.y Chemistr. 1993年第4期 290-301页

作者： CHU Wei KIENNEMANN A kieffer r.XIONG Guo-Xing Labor.tuir. de Chime Or.anique Appliquee, UA CNr. 469, EHICS, 1, r.e Blaise Pascal, 67008 Str.sbour., Fr.nce State Key Labor.tor. of Catalysis Dalian Institute of Chemical Physics, Academia Sinica Dalian, Liaoning 116023

Hydr.genation of car.on monoxide has been studied under.15 MPaon modified Co-Cu-Y catalysts. Molybdenium was ver. effective for.pr.motingcatalytic activity, and the syner.istic pr.sence of Co, Cu and Mo was necessar.for.the good catalytic per.or.ance in the synthesis of higher.alcohols C2+*** our.exper.mental conditions, a yield of 175 g/kg cat/h of mixed alcohols（C1-C5） was obtained with a C2+OH pr.por.ion of 45％ in weight. A str.nginter.ction between CuO, CoOyand MoOxin the modified catalyst was ob-ser.ed. The pr.sence of MoOxstabilized the Y2O3str.ctur. of the catalyst dur.ngthe syngas r.action under.high pr.ssur. illustr.ted by the X-r.y diffr.ctiontests.

关键词： Co CO SYNTHESIS OF HIGHEr.ALCOHOLS ON Co-Co-Y CATALYSTS CuO