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纤维蛋白胶预防青光眼引流阀植入术后早期低眼压

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 54-54页

作者： Vlimki J. 杨秀梅 Department of Ophthalmology Central Hospital of LahtiKeskussairaalankatu 7FIN-15850 LahtiFinland Dr.

Purpose:To prevent a leak of aqueous around the tube in the immediate postoperative period after glaucoma drainage implant(GDI)***:A total of 42 eyes of 34 consecutive patients with refractory glaucoma requiring single-plate Molteno implantation were retrospectively *** filtration was checked intraoperatively in all filtered *** glue was used over the scleral flap intraoperatively in every eye with peritubular *** Molteno tubes were completely closed with an absorbable ***:Peritubular filtration was detected in 11 eyes of 11 *** 11 eyes maintained intraocular pressure(IOP)≥ 16 mmHg in the immediate postoperative *** mean IOP on the first postoperative day was 30.5± 10 *** an average follow-up of 6 months,the mean IOP in these 11 eyes was 19.1± 6 *** complications or Seidel-positive aqueous leak were observed during the follow-up ***:Results suggest that intraoperative use of fibrin glue is a viable option for reducing peritubular filtration and preventing immediate postoperative hypotony after GDI surgery.

关键词：顽固性青光眼纤维蛋白胶术后早期引流阀植入低眼压预防 Molteno植入 Molteno管

Assessment of Liver Fibrosis in HBsAg-Negative and Anti HBc Positive Patients

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Open Journal of Gastroenterology 2024年第10期14卷 331-339页

作者： Kounpiélimé Sosthène Somda Aboubacar Coulibaly Oyétoundé Taofick Amanda Sandrine Marie Odile Soudre Lawagoulé Joseph Emile Ky Christiane Bere Arsène Roger Sombie Department of Hepato-Gastroenterology Yalgado Ouedraogo University Hospital (CHU-YO) Ouagadougou Burkina Faso Department of Medicine University Joseph KI-ZERBO Ouagadougou Burkina Faso

Background: Surface antigen (HBsAg) is the mean marker of hepatitis B virus infection. During the course of the infection, some patients lose the HBsAg and only the presence of anti-HBc antibody indicates previous contact with the virus. Among these patients, some have detectable viral load (occult infection) but most without viral replication. There is no guideline regarding these patients. The aim of this study was to assess hepatic fibrosis in patients with only the hepatitis B virus contact marker “total anti-HBc”. Patients and methods: it was a descriptive and analytical cross-sectional study, conducted in three private hospitals from January to August 2022. Were included HBsAg-negative and HBc-positive patients, consulting in Gastroenterology departments. Noninvasive methods (APRI, FIB-4 and FIBROSCAN) were used to evaluate liver stiffness because of their easy accessibility and low-cost. The hepatic fibrosis was considered significant when the score determined by APRI, FIB-4 and FIBROSCAN® tests was respectively greater than 1.5;2.67 and 8 kPa corresponding to fibrosis level 2 (F2). Results: A total of 63 HBsAg-negative/total HBcAg-positive patients were included. The mean age was 49.9 ± 13.4 years. The male/female sex ratio was 1.78. Of the 63 patients, 19 had significant liver fibrosis (30.1%) among which 9 patients had HCC. The FIB-4 score outperformed the APRI score in assessing liver fibrosis, with a sensitivity of 84.2%, a specificity of 100% and a negative predictive value of 93.6%. In univariate analysis, there was a significant association between the occurrence of significant liver fibrosis and age over 40 years, dyslipidaemia, obesity, alcohol consumption, smoking, herbal medicine, negative anti-HBs immunological status and detectable viral load. Conclusion: Our study revealed a high prevalence of significant to severe hepatic fibrosis in anti-HBc positive patients. In most of the cases, the fibrosis was severe. Progression to HCC has also been pos

关键词： Anti HBc Positives Liver Fibrosis Sub-Saharan Hepatitis B Virus

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弓形虫韩国ki-1分离株的生物学特性鉴定

中国寄生虫学与寄生虫病杂志 2006年第3期24卷 183-186页

作者：林爱芬申银希朴在焕韩银泽蔡钟一温州医学院附属台州医院中心实验室临海317000 韩国国立首尔大学寄生虫学和热带医学教研室

目的研究弓形虫韩国ki-1分离株的生物学特性。方法分别将弓形虫韩国ki-1株与国际标准RH株进行下列实验:透射电镜观察虫体的形态,不同浓度的速殖子接种BALB/c小鼠观察其毒力,蛋白质印迹(Westernblotting)分析弓形虫抗原与抗弓形虫单抗Tg... 详细信息

目的研究弓形虫韩国ki-1分离株的生物学特性。方法分别将弓形虫韩国ki-1株与国际标准RH株进行下列实验:透射电镜观察虫体的形态,不同浓度的速殖子接种BALB/c小鼠观察其毒力,蛋白质印迹(Westernblotting)分析弓形虫抗原与抗弓形虫单抗Tg563和抗新孢子虫单抗12B4反应,PCR-限制性片段长度多态(PCR-RFLP)技术分析其基因型,检测SAG1和ROP1基因编码区的序列。结果弓形虫韩国ki-1株的形态、毒力与RH株相似。ki-1和RH抗原仅与抗弓形虫单抗Tg563反应,而不与抗新孢子虫单抗12B4反应。PCR-RFLP技术分析表明,ki-1株属基因型I型弓形虫虫株。ki-1株与RH株相比,SAG1和ROP1基因均各有7个核苷酸及6个氨基酸差异。结论ki-1株为基因型I型弓形虫强毒株,与RH株间存在一定的基因差异。

关键词：弓形虫蛋白质印迹法 PCR 限制性片段长度多态(RFLP) 基因测序

Prognostic importance of lymph node yield after curative resection of gastroenteropancreatic neuroendocrine tumours

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World Journal of Clinical Oncology 2020年第4期11卷 205-216页

作者： Jaseela Chiramel Rose Almond Astrid Slagter Adeel Khan Xin Wang Kok Haw Jonathan lim Melissa Frizziero Bipasha Chakrabarty Annamaria Minicozzi Angela Lamarca Wasat Mansoor Richard A Hubner Juan William Valle Mairéad Geraldine McNamara Department of Medical Oncology The Christie NHS Foundation TrustManchester M204BXUnited Kingdom Royal Free London NHS Foundation Trust London NW32QGUnited Kingdom Statistics Group Digital ServicesThe Christie NHS Foundation TrustManchesterM204BXUnited Kingdom Antoni van Leeuwenhoek/Netherlands Cancer Institute Amsterdam 1066 CxNetherlands Department of Pathology The Christie NHS Foundation TrustManchester M204BXUnited Kingdom Department of Surgery Barts Health NHS TrustLondon EC1A 7BEUnited Kingdom Division of Cancer Sciences University of ManchesterManchester M139PLUnited Kingdom

BACKGROUND The prognostic significance of lymph nodes(LNs)metastases and the optimum number of LN yield in gastroenteropancreatic neuroendocrine tumours(GEP NETs)undergoing curative resection is still *** studies have demonstrated that cure rate for patients with GEP NETs can be improved by the resection of the primary tumour and regional lymphadenectomy AIM To evaluate the effect of lymph node(LN)status and yield on relapse-free survival(RFS)and overall survival(OS)in patients with resected GEP *** Data on patients who underwent curative resection for GEP NETs between January 2002 and March 2017 were analysed *** 3 tumours(ki67>20%)were *** Cox proportional hazard models were computed for RFS and OS and assessed alongside cut-point analysis to distinguish a suitable binary categorisation of total LNs retrieved associated with *** A total of 217 patients were included in the *** median age was 59 years(21-97 years)and 51%(n=111)were *** tumour sites were small bowel(42%),pancreas(25%),appendix(18%),rectum(7%),colon(3%),gastric(2%),others(2%).Median follow up times for all patients were 41 mo(95%CI:36-51)and 71 mo(95%CI:63–76)for RFS and OS respectively;50 relapses and 35 deaths were *** were retrieved in 151 *** or more LNs were harvested in 106 patients and LN positivity reported in 114 *** or more positive LNs were detected in 62 *** result of univariate analysis suggested perineural invasion(P=0.0023),LN positivity(P=0.033),LN retrieval of≥8(P=0.047)and localisation(P=0.0049)have a statistically significant association with shorter RFS,but there was no effect of LN ratio on RFS:P=0.1 or OS:P=*** necrosis(P=0.021)and perineural invasion(P=0.016)were the only two variables significantly associated with worse *** the final multivariable analysis,localisation(pancreas HR=27.33,P=0.006,small bowel HR=32.44,P=0.005),and retrieval of≥8 LNs(HR=2.7,P

关键词： Well differentiated neuroendocrine tumours Pancreatic neuroendocrine tumours Small intestinal neuroendocrine tumours ki67 Lymph node ratio Lymph node retrieval Lymph node positivity Relapse-free survival Overall survival

Corrigendum to‘Dual ultra-wideband(UWB)radar-based sleep posture recognition system:Towards ubiquitous sleep monitoring’[Engineered Regeneration 4(2023)36-43]

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Engineered Regeneration 2023年第2期4卷 223-223页

作者： Derek Ka-Hei Lai Li-Wen Zha Tommy Yau-Nam Leung Andy Yiu-Chau Tam Bryan Pak-Hei So Hyo Jung lim Daphne Sze ki Cheung Duo Wai-Chi Wong James Chung-Wai Cheung Department of Biomedical Engineering Faculty of EngineeringThe Hong Kong Polytechnic UniversityHong Kong 999077China Department of Bioengineering Imperial CollegeLondon SW72AZUnited Kingdom Research Institute of Smart Ageing The Hong Kong Polytechnic UniversityHong KongChina School of Nursing The Hong Kong Polytechnic UniversityHong KongChina

The authors regret that the name of the ethic committee that approved the study and the reference number was omitted from the published *** this research,all participants signed an informed consent after receiving an oral and written description of the experiment before the start of the *** study was approved by the Human Subjects Ethics HSEARS20210127007.

关键词： Engine wideband UWB

一项在HBeAg阳性、慢性乙型肝炎(CHB)患者中比较磷丙替诺福韦(TAF)与富马酸替诺福韦二吡呋酯(TDF)的3期研究:96周时疗效和安全性结果

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一项在HBeAg阳性、慢性乙型肝炎(CHB)患者中比较磷丙替诺福韦(TAF...

第九届全国疑难及重症肝病大会

作者： Kosh Agarwal Scott Fung Wai Kay Seto Young Suk lim Ed Gane Harry L.Janssen Manoj Sharma Wan Long Chuang Ho Bae ki Tae Yoon John F.Flaherty Audrey Lau Anuj Gaggar Vithika Suri Andrea Cathcart Lanjia Lin G Mani Subramanian Shalimar Norihiro Furusyo Maria Buti Henry L.Chan kings College Hospital Department of Medicine University of Toronto Queen Mary Hospital Hong Kong Asan Medical Center Kaohsiung Medical University Hospital Pusan National University Yangsan Hospital All India Institute of Medical Sciences Kyushu Medical Center The Chinese University of Hong Kong

背景和目的:TAF是替诺福韦(TFV)的一种新型前体药,在血浆中比TDF更稳定,增强了TFV进入肝细胞的给药,且循环TFV水平降低。这项针对HBeAg阳性患者的随机双盲研究显示,之前在48周时,在HBV DNA小于29IU/mL的患者比例方面,TAF的疗效并不劣于T...

背景和目的:TAF是替诺福韦(TFV)的一种新型前体药,在血浆中比TDF更稳定,增强了TFV进入肝细胞的给药,且循环TFV水平降低。这项针对HBeAg阳性患者的随机双盲研究显示,之前在48周时,在HBV DNA小于29IU/mL的患者比例方面,TAF的疗效并不劣于TDF,且骨骼和肾脏影响改善。本文摘展示了96周治疗后的结果。

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基于辣椒基因组测序探究辣味在种群中的进化

辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill kim Minkyu Park Seon-In Yeom Yong-Min kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong ki-Tae kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul kim Hye-Young Lee Shin-Young kim Myung-Shin kim Byoung-Cheorl Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin Jeong Won-Hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun lim June Hyun Park Jin Hoe Huh June-Sik kim Byung-Dong kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-ki kim Younhee Shin Seung-Jae Noh Junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A kim Jeong Mee Park Hyun-Jin kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze Hamid Ashrafi Theresa Hill Woo taek kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W kim Ik-Young Choi Beom-Soon Choi Jong-Sung lim Yong-Hwan Lee Doil Choi 刘峰张西露 Department of Plant Science Seoul National University Plant Genomics and Breeding Institute Seoul National University Department of Agricultural Biotechnology Seoul National University Department of Bioinformatics and Life Science Soongsil University Vegetable Breeding Research Center Seoul National University Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng Resources Research Laboratory Korea Ginseng Corporation Korea Research Institute of Bioscience and Biotechnology Division of Bioscience and Bioinformatics Myongji University Department of Plant and Environmental Sciences New Mexico State University Chile Pepper Institute New Mexico State University Seeders Inc. Department of Biological Sciences Seoul National University Arizona Genomics Institute University of Arizona Agricultural Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of Horticulture and Breeding Andong National University US Department of Agriculture-Agricultural Research Service Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for Plant Research Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instrumentation Center for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

Ultrasound Pulse Elastometry: Assessment of One Year’s Practice in the Hepato-Gastroenterology Department of the Saint Camille Hospital in Ouagadougou

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Open Journal of Gastroenterology 2024年第11期14卷 379-385页

作者： Kounpiélimé Sosthène Somda Lawagoulé Joseph Emile Ky Constant Lawrence Coudjo Johnson Stella Line Emmanuella Paré Ben Moctar Abdou Djibo Toussaint Vébamba Abraham Ouédraogo Fanta Ousseini Mamadou Sarifou Diallo Sandrine M. O. B. Héma/Soudré Aboubacar Coulibaly Arsène Roger Sombié Department of Gastroenterology Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso Department of Medicine Joseph KI-ZERBO University Ouagadougou Burkina Faso Department of Gastroenterology Fada NGourma Regional Hospital Fada NGourma Burkina Faso Department of Gastroenterology Donka National Hospital Conakry Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Guinea Department of Gastroenterology Tengandogo University Hospital Ouagadougou Burkina Faso

Aims: To review one year of ultrasound impulse elastometry in a hospital in Ouagadougou. Patients and Method: This is a retrospective descriptive study of data from one year’s use of impulse ultrasound elastometry. Ultrasound impulse elastometry was performed using the FibroScan® COMPACT 530. Fibrosis was considered significant when E (hepatic elasticity) ≥ 7.2 kPa (F2 fibrosis). The test was considered valid when the IQR/Median ratio ≤ 30% and there were at least 10 valid measurements. Results: A total of 1911 patients underwent FibroScan®. There were 1079 men, giving a sex ratio of 1.3. The mean age of the patients was 37.9 ± 12.2 years. The indication for FibroScan® was hepatitis B virus infection in 89% of cases. The validation criteria for FibroScan® were met in all patients. The mean value for elasticity was 7.9 kPa and for steatosis 212 dB/m. Fibrosis was non-significant in 75.5% of cases. More than half of our patients (56.7%) didn’t have steatosis, 24.8% had mild steatosis, 12.4% had moderate steatosis and 6.1% had severe steatosis. Conclusion: Ultrasound pulse elastometry plays an important role in monitoring chronic liver disease. It allows non-invasive diagnosis of hepatic fibrosis and steatosis. In our context, however, access to the test is limited by its availability only in large urban centers, and by its cost.

关键词： Pulse Elastometry Hepatic Fibrosis Steatosis Non-Invasive Evaluation of Fibrosis Africa