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基于网络化的国际合作培训对提高精神科护士核心能力的效果

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上海交通大学学报（医学版） 2015年第8期35卷 1213-1216页

作者：施忠英张曙映高麒孔庆芳 Maritta Valimaki 上海交通大学医学院附属精神卫生中心上海200030 同济大学护理学院上海200092 Department of Nursing Science University of TurkuTurun yliopisto 20014

目的探讨基于网络化的国际合作培训对提高精神科护士核心能力的效果。方法于2013年6月—10月对实验组67名护士和对照组56名护士开展以巩固和提高精神科护士核心能力为目标的培训课程。课程为上海交通大学医学院附属精神卫生中心护理部... 详细信息

目的探讨基于网络化的国际合作培训对提高精神科护士核心能力的效果。方法于2013年6月—10月对实验组67名护士和对照组56名护士开展以巩固和提高精神科护士核心能力为目标的培训课程。课程为上海交通大学医学院附属精神卫生中心护理部与芬兰图尔库大学护理学院合作,采用网络化学习的形式。在实施医院常规业务培训的基础上,对实验组进行为期5个月的网络课程培训。应用注册护士核心能力量表(CIRN)分别在干预前后进行评定。结果实验组CIRN总分和各因子值(除专业发展)培训前后自身比较差异有统计学意义(P<0.01);培训后实验组CIRN总分和各因子值(除临床护理和专业发展)与对照组比较差异有统计学意义(P<0.05)。结论基于网络化学习的国际合作培训对提高精神科护士核心能力具有良好的效果,有助于精神科护理继续教育领域国际间的合作与交流。

关键词：网络化学习核心能力精神科护士

Triple combination targeting PI3K,ER,and CDK4/6 inhibits growth of ER-positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor

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Cancer Communications 2023年第6期43卷 720-725页

作者： Mikkel G.Terp Martina Tuttolomondo Neil Portman Sidse Ehmsen Lene E.Johansen Martin Bak Elgene lim Henrik J.Ditzel Department of Cancer and Inflammation Research Institute of Molecular MedicineUniversity of Southern DenmarkOdenseDenmark Garvan Institute of Medical Research DarlinghurstSydneyNew SouthWalesAustralia St.Vincent’s Clinical School Faculty of MedicineUniversity of New SouthWales SydneySydneyNew South WalesAustralia Department of Oncology Institute of Clinical ResearchOdense University HospitalOdenseDenmark Department of Pathology Sydvestjysk SygehusEsbjergDenmark Academy of Geriatric Cancer Research(AgeCare) Odense University HospitalOdenseDenmark

Dear Editor,Despite the improved outcome of advanced estrogen receptor-positive(ER+)breast cancer patients treated with endocrine therapy in combination with either a cyclindependent kinase 4/6 inhibitor(CDK4/6i)or a phosphoinositide 3-kinase inhibitor(PI3ki),the disease will eventually progress,and the optimal treatment strategy upon progression remains undefined[1-4].To address this,we developed MCF-7-and T47D-derived PIK3CAmutated breast cancer cell lines[5]resistant to combined CDK4/6i palbociclib and fulvestrant(MPF-R and TPFR)or combined PI3ki alpelisib and fulvestrant(MAF-R and TAF-R),respectively(Supplementary Materials and Methods).Drug-sensitive isogenic cells(M-S and T-S)grown in parallel with MPF-R and TPF-R cells and the original MCF-7/S0.5 and T47D cells were analyzed for comparison.

关键词： PIK3CA breast cancer

Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey

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World Journal of Gastroenterology 2009年第1期15卷 86-94页

作者： Ho Gak kim Jimin Han Myung-Hwan kim Kyu Hyun Cho Im Hee Shin Gwang Ha kim Jae Seon kim Jin Bong kim Tae Nyeun kim Tae Hyeon kim Tae Hyo kim Jae Woo kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu taek Lee Dong ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon Department of Internal Medicine Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea Department of Medical Statistics Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Pusan National University School of Medicine Busan 602-739 South Korea Department of Internal Medicine Korea University College of Medicine Seoul 136-705 South Korea Department of Internal Medicine Hallym University College of Medicine Chuncheon 200-704 South Korea Department of Internal Medicine Yeungnam University College of Medicine Daegu 705-717 South Korea Department of Internal Medicine Wonkwang University College of Medicine Iksan Jeonbuk 570-711 South Korea Department of Internal Medicine Gyeongsang National University School of Medicine Jinju Gyeongnam 660-702 South Korea Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Gangwon 220-701 South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul 110-799 South Korea Department of Internal Medicine lnje University College of Medicine Seoul 139-713 South Korea Department of Internal Medicine Soonchunhyang University College of Medicine Bucheon Gyunggi 420-767 South Korea Department of Internal Medicine Inje University College of Medicine Busan 614-735 South Korea Department of Internal Medicine Chosun University College of Medicine Gwangju Jeonbuk 501-717 South Korea Department of Internal Medicine Ulsan University Hospital University of Ulsan College of Medicine Ulsan 681-714 South Korea Department of Internal Medicine Dongguk University College of Medicine Gyeongju Gyeongbuk 791-707 South Korea Department of Internal Medicine Hallym University College of Medicine Anyang Gyeonggi 431-070 South Korea Department of Internal Medicine Ajou University School of Medicine Suwon

AIM： To investigate prevalence of C/onorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. METHODS： Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. RESULTS： Of 3080 patients with gastrointestinal diseases, 396 （12.9%） had clonorchiasis and 1140 patients （37.2%） had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 （20.9%） patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than nonnfected patients [34/396 （8.6%） vs 145/2684 （5.4%）, P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation （P = 0.008）. Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. CONCLUSION： Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

关键词： Clonorchis sinensis Epidemiology Cholangiocarcinoma Korea Multicenter study Clonorchiasis

焚烧浆厂不凝气体生产硫酸——一种生物精炼理念

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焚烧浆厂不凝气体生产硫酸——一种生物精炼理念

中国造纸学会第十八届学术年会

作者： Naveen Chenna Eevi Smolander Asta Humalajoki Tero Juutilainen Erkki Vlimki Veli-Matti Pietarinen 维美德技术公司

在硫酸盐浆厂,硫是一种重要的化学元素,参与木片成浆的反应。硫出现在黑液、白液、排放的废水中,它以不凝气（NCG）的方式脱离浆厂工艺。硫的排放会对环境造成负面影响。NCG中还原性的硫会导致工厂周围有刺激性气味,一旦它们释放到大气... 详细信息

在硫酸盐浆厂,硫是一种重要的化学元素,参与木片成浆的反应。硫出现在黑液、白液、排放的废水中,它以不凝气（NCG）的方式脱离浆厂工艺。硫的排放会对环境造成负面影响。NCG中还原性的硫会导致工厂周围有刺激性气味,一旦它们释放到大气中,就转变为氧化硫,导致土壤大规模酸化,从而对植被和生物多样性造成负面影响。传统工艺中,NCG被仔细收集并在碱炉、动力炉、石灰窑或单独的NCG炉中焚烧。在很多情况下,烟气中的氧化硫不能回收,因此会增加工厂的排放水平。目前,维美德开发了焚烧NCG生产硫酸的技术,从NCG焚烧产生的二氧化硫在催化转化器中被氧化成三氧化硫,并与水蒸气一起冷凝生成硫酸。第一座这种类型的硫酸生产装置已于2017年开机,并一直在芬兰Aanekoski生物制品工厂运行。这种内部生产的硫酸可以替代工厂内多个需要外购的酸。本文描述了NCG焚烧生产硫酸工艺、环保优势以及安装生产硫酸装置使工厂化学平衡得以封闭,从而使工厂向实现生物精炼理念更迈进一步。

关键词：湿酸性气体硫酸产品浆厂不凝气体工厂化学品平衡

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中国入世与外商对华直接投资

决策借鉴 2001年第1期14卷 26-30页

作者：王国安杨小华林龙泽杭州电子工业学院浙江杭州310012 澳大利亚邦德大学商学院国立群山大学校

回顾了中国从 1 979年以来利用外商直接投资 (FDI)的总体发展情况 ,阐述了中国入世后对中国一些行业的影响 ,并对今后中国如何有效利用外商直接投资提出了建议。

关键词：外商直接投资中国入世外资利用

高胰岛素血症和稳态模型评估胰岛素抵抗对发生高血压的预测作用:一个韩国人口样本中的5年随访研究

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中华高血压杂志 2012年第2期20卷 198-198页

作者： ki Chul Sung Soo lim Robert S.Rosenson 罗冬梅叶鹏

该研究调查血浆胰岛素浓度和稳态模型评估的胰岛素抵抗指数（homeostasis model assessment of insulinresistance，HOMA—IR）是否在一个健康和相对消瘦的韩国成年人口样本中与高血压的发病率相关。方法：研究者从参与2003和2008年一... 详细信息

该研究调查血浆胰岛素浓度和稳态模型评估的胰岛素抵抗指数（homeostasis model assessment of insulinresistance，HOMA—IR）是否在一个健康和相对消瘦的韩国成年人口样本中与高血压的发病率相关。方法：研究者从参与2003和2008年一般健康状况评估，基础血压正常的个体15638人中选取受试者10894人。

关键词：健康状况评估胰岛素抵抗指数高胰岛素血症高血压随访研究预测作用样本人口

High‑Performance Thick Cathode Based on Polyhydroxyalkanoate Binder for Li Metal Batteries

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Advanced Fiber Materials 2024年第1期6卷 214-228页

作者： Dong Hyuk Kang Minhyuck Park Jeonghun Lee Chan Yeol kim Jimin Park Youn‑ki Lee Jong Chan Hyun Son Ha Jin Hwan Kwak Juhee Yoon Hyemin kim Hyun Soo kim Do Hyun kim Sangmin kim Ji Yong Park Robin Jang Seung Jae Yang Hee‑Dae lim Se Youn Cho Hyoung‑Joon Jin Seungjin Lee Yunil Hwang Young Soo Yun KU‑kiST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841South Korea Carbon Composite Materials Research Center Korea Institute of Science and Technology(KIST)92 Chundong‑roBongdong‑eupWanju‑gunJeollabuk‑do 55324South Korea Energy Storage Research Center Korea Institute of Science and Technology(KIST)514‑gil Hwaraong‑roSeoul 02792South Korea Program in Environmental and Polymer Engineering Inha University100 Inha‑ro Michuhol‑guIncheon 22212South Korea Advanced Analysis Data Center Korea Institute of Science and Technology(KIST)514‑gil Hwaraong‑roSeoul 02792South Korea Advanced Nanohybrids Laboratory Department of Chemistry and Chemical EngineeringInha University100 Inha‑roMichuhol‑guIncheon 22212South Korea CJ CheilJedang Corporation 55 Gwanggyo‑ro 42Beon‑gilYeongtong‑guSuwon 16495South Korea Department of Chemical Engineering Hanyang University222 Wangsimni‑roSeongdong‑guSeoul 04763South Korea Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841South Korea

Thick cathodes can overcome the low capacity issues,which mostly hamper the performance of the conventional active cathode materials,used in rechargeable Li ***,the typical slurry-based method induces cracking and flaking during the fabrication of thick *** addition,a significant increase in the charge-transfer resistance and local cur-rent overload results in poor rate capabilities and cycling stabilities,thereby limiting electrode *** this study,a synergistic dual-network combination strategy based on a conductive nanofibrillar network(CNN)and a nano-bridging amor-phous polyhydroxyalkanoate(aPHA)binder is used to demonstrate the feasibility of constructing a high-performance thick *** CNN and aPHA dual network facilitates the fabrication of a thick cathode(≥250μm thickness and≥90 wt%active cathode material)by a mass-producible slurry *** thick cathode exhibited a high rate capability and excel-lent cycling *** addition,the thick cathode and thin Li metal anode pair(Li//t-NCM)exhibited an optimal energy performance,affording high-performance Li metal batteries with a high areal energy of~25.3 mW h cm^(-2),a high volumetric power density of~1720 W L^(-1),and an outstanding specific energy of~470 W h kg^(-1)at only 6 mA h cm^(-2).

关键词： Thick cathode Polyhydroxyalkanoate binder Nano-bridging Conductive nano-fibrillar network Lithium metal battery

支气管哮喘患者的BAL液中的IL-6和TNF-α

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中华结核和呼吸杂志 1997年第Z1期20卷 67-67页

作者： Park CS lim GI ki SY Moon SH Jeong SW kim HT Uh ST kim YH 傅锦红(译) DivisionofAllergyandRespiratoryMedicain SoonChunHyangUniversitySeoulKorea

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减量FOLFIRINOX方案挽救性治疗吉西他滨抵抗的晚期胰腺癌:一项Ⅱ期研究

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癌症 2018年第8期37卷 327-335页

作者： Jung Hoon kim Sang-Cheol Lee Sung Yong Oh Seo-Young Song Namsu Lee Eun Mi Nam Soonil Lee In Gyu Hwang Hyo Rak Lee Kyu taek Lee Sang-Byung Bae Han Jo kim Joung Soon Jang Do Hyoung lim Hyun Woo Lee Seok Yun Kang Jung Hun Kang Department of Internal Medicine Institute of Health SciencesGyeongsang National University Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University HospitalCheonan Department of Internal Medicine Dong-A University Hospital Department of Internal Medicine Kangwon National University School of Medicine Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University HospitalSeoul Department of Internal Medicine Ewha Womans UniversityCollege of Medicine Department of Internal Medicine Dankook University Hospital Department of Internal Medicine Chung-Ang UniversityCollege of Medicine Division of Hematology and Medical Oncology Department of Internal MedicineKorea Cancer Hospital Department of Hematology-Oncology Ajou University Hospital

背景与目的奥沙利铂、伊立替康、氟尿嘧啶和亚叶酸的联合化疗方案(FOLFIRINOX)极大提高了晚期胰腺癌患者的生存期。然而,FOLFIRINOX方案作为吉西他滨失败后二线治疗的疗效尚未进行前瞻性的检测。我们研究了减量FOLFIRINOX方案治疗吉西... 详细信息

背景与目的奥沙利铂、伊立替康、氟尿嘧啶和亚叶酸的联合化疗方案(FOLFIRINOX)极大提高了晚期胰腺癌患者的生存期。然而,FOLFIRINOX方案作为吉西他滨失败后二线治疗的疗效尚未进行前瞻性的检测。我们研究了减量FOLFIRINOX方案治疗吉西他滨抵抗的晚期胰腺癌患者的可行性和安全性。方法在14家医院进行了这一多中心II期前瞻、开放标签的单臂研究。经组织学确诊为胰腺浸润性导管腺癌、有可测量或可评价的病灶、东部肿瘤协作组体能状况评分0或1分、器官功能良好、年龄19岁或以上的患者符合入组条件。减量FOLFIRINOX方案的组成:奥沙利铂65 mg/m2、伊立替康135 mg/m2和亚叶酸400 mg/m2,第1天静脉注射;5?氟尿嘧啶2000 mg/m2,第1–2天持续静脉输注46 h;每2周重复。主要终点为FOLIFLIOX治疗起始后的无进展生存期。次要终点为客观缓解率、疾病控制率、总生存期、安全性和耐受性。采用Kaplan?Meier法评估了总生存期和无进展生存期。结果我们招募了来自14个中心的39例患者。客观缓解率为10.3%,疾病控制率为64.1%。6个月和1年总生存率分别为59.0%和15.4%。中位无进展生存期和总生存期分别为3.8个月[95%置信区间(confidence interval,CI)=1.5–6.0个月]和8.5个月(95%CI=5.6–11.4个月)。3或4级不良事件为中性粒细胞减少(41%)、恶心(10.3%)、食欲减退(10.3%)、贫血(7.7%)、黏膜炎(7.7%)、肺炎/胸膜融合(5.1%)和乏力(5.1%)。发生1例由感染性休克引起的治疗相关死亡。结论减量FOLFIRINOX方案有望作为二线方案治疗吉西他滨抵抗的胰腺癌。

关键词：减量FOLFIRINOX方案二线治疗胰腺癌吉西他滨