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Antidiabetic Drugs in Combination with Hydroxychloroquine Improve Glycemic Control in Alloxan Induced Diabetic Rats

Pharmacology & Pharmacy 2014年第7期5卷 725-735页

作者： Shaheda Zannah Md. Saiful Islam A. F. M. Towheedur Rahman Md. Asaduzzaman Abdul Alim Al Bari Yusuf Ali Gazi Jahirul Islam A. H. M. khurshid Alam Hazrat Ali Mamunur Rashid Department of Chemistry Khulna University of Engineering and Technology Khulna Bangladesh Department of Pharmacy University of Rajshahi Rajshahi Bangladesh

Worldwide prevalence of diabetes mellitus has become an issue of great concern in current decades. This life threatening disease is associated with worsening of glycemic control and progressive metabolic dysfunctions. Objective: Current study aimed to investigate the effect of hydroxychloroquine (HCQ) as an adjunct to glibenclamide or metformin on glycemic control in alloxan induced diabetic rats. Methods: HCQ was combined separately with two conventional anti-diabetic drugs;glibenclamide and metformin. At first, alloxan (120 mg/kg) induced diabetic rats were treated with single dose of metformin (850 mg/70 kg BW), glibenclamide (10 mg/70 kg BW) and HCQ (300 mg/70 kg BW) intraperitoneally once daily for two weeks. Then non fixed dose combinations of glibenclamide (5 mg/70 kg BW) with HCQ (150 mg/70 kg BW) and metformin (425 mg/70 kg BW) with HCQ (150 mg/70 kg BW) were injected along with those of the three drugs alone once daily for four weeks. Results: In alloxan induced diabetic rats, glibenclamide, metformin and their combination therapies reduced blood glucose level significantly but combination therapies are the most effective. Glibenclamide or metformin in combination with HCQ also significantly (P < 0.05) reduced the elevated levels of total cholesterol, triglycerides, and low density lipoprotein cholesterol (LDL-C) level and increased high density lipoprotein cholesterol (HDL-C) level. Moreover, HCQ potentiates the liver glycogen synthesis of metformin or glibenclamide. Conclusion: Outcomes of this investigation indicate that combination of glibenclamide or metformin with HCQ improves glycemic control and provides additional metabolic benefits, not achieved with either glibenclamide or metformin alone.

关键词： Diabetes Mellitus Glycemic Control HCQ Glibenclamide Metformin

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早期应用Ilizarov环形外固定器在治疗Gustilo Ⅱ、ⅢA和ⅢB型开放性胫骨干骨折中的作用

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中国矫形外科杂志 2012年第4期20卷 302-302页

作者：康庆林宁桦 Naveed Wani Asif Baba khurshid Kangoo 上海市第六人民医院骨科 200233 本刊编辑部

胫骨是最容易骨折的长骨。主要因为其所在位置及较少的组织覆盖,故开放性骨折在胫骨发生较多。尽管这种骨折发生率高,但对处理胫骨开放性骨折的理想方法仍然颇具争议。在发达国家,彻底清创术和髓内固定当前逐渐成为这类骨折首选的治疗... 详细信息

胫骨是最容易骨折的长骨。主要因为其所在位置及较少的组织覆盖,故开放性骨折在胫骨发生较多。尽管这种骨折发生率高,但对处理胫骨开放性骨折的理想方法仍然颇具争议。在发达国家,彻底清创术和髓内固定当前逐渐成为这类骨折首选的治疗方法。然而,在发展中国家却有所不同,很多病人因为缺乏足够医疗设施而得不到及时的救治。

关键词：开放性胫骨干骨折 Ilizarov 治疗方法环形外固定器早期应用胫骨开放性骨折 ⅢB型骨折发生率

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Cardiac markers: Role in the pathogenesis of arterial hypertension

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World Journal of Hypertension 2022年第1期10卷 1-14页

作者： Saira Rafaqat Shaheed Afzal Sana Rafaqat Huma khurshid Simon Rafaqat Department of Zoology Lahore College for Women UniversityLahore 5400Pakistan Emergency Department of Cardiology Punjab Institute of CardiologyLahore 5400Pakistan Department of Biotechnology Lahore College for Women UniversityLahore 5400Pakistan Department of Business Forman Christian CollegeLahore 5400Pakistan

Cardiac biomarkers may play unique roles in the prognostic evaluation of patients with hypertension,as many cardiac biomarker levels become abnormal long before the onset of obvious cardiovascular disease(CVD).There are numerous cardiac ***,this review article only reported the roles of creatinine kinase-MB,cardiac troponins,lipoprotein a,osteopontin,cardiac extracellular matrix,C-reactive protein,cardiac matrix metalloproteinases,cardiac natriuretic peptides,myoglobin,renin,and dynorphin in the pathogenesis of *** article explained recent major advances,as well as discoveries,significant gaps,and current debates and outlined possible directions for future *** studies are required to determine the association between myoglobin and other cardiac markers in ***,therapeutic approaches are required to determine the early control of these cardiac markers,which ultimately reduce the prevalence of CVDs.

关键词： Cardiac markers Hypertension Pathogenesis Prevalence Cardiovascular diseases

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Extraperitoneal robot-assisted radical prostatectomy: Comparison with transperitoneal technique

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World Journal of Clinical Urology 2013年第2期2卷 3-9页

作者： Chris Anderson Ben Ayres Rami Issa Matthew Perry Evangelos Liatsikos Jens-Uwe Stolzenburg khurshid R Ghani Department of Urology St George’s HospitalSt George’s Healthcare NHS TrustLondon SW17 0JTUnited Kingdom Department of Urology University of Patras School of Medicine26500 RIO PatrasGreece Department of Urology University of Leipzig04103 LeipzigGermany Vattikuti Urology Institute Henry Ford HospitalDetroitMI 48202United States

AIM: To determine peri-operative, oncological, functional and safety profiles of extraperitoneal robot-assisted radical prostatectomy(e RARP) vs transperitoneal robot-assisted radical prostatectomy(t RARP) in a single ***: A total of 120 consecutive patients underwent 50 e RARP and 70 e RARP operations respectively by the same surgical team. Peri-operative and post-operative outcomes including blood loss, hospitalization, complications(Clavien grade), positive surgical margin(PSM) rates, continence and erectile function were compared. The performance of e RARP required several technical modifications. These included developmentof Retzius' space by balloon insufflation, laparoscopic dissection of lateral extensions of this area; caudal port positioning; cranial digital stripping of peritoneum for sucker port and lodging the bagged prostate specimen adjacent to the lateral assistant port to permit space for urethro-vesical ***: Robotic console times were shorter with e RARP vs t RARP(145.1 min vs 198.3 min, P < 0.0001). There were no significant differences in blood loss, PSM rates(e RARP 17.7% vs t RARP 22%) or complications(e RARP 8.5% vs t RARP 8%). A drain was used in all patients after t RARP and in 25/70 e RARP cases. Length of hospital stay was shorter after e RARP(mean 1.94 d vs 3.6 d, P < 0.0002). There were no differences between techniques in continence or potency at 6 mo. e RARP required several technical modifications: development of Retzius' space by balloon insufflation, laparoscopic dissection of lateral extensions of this area; caudal port positioning; and lodging the bagged prostate specimen adjacent to the lateral assistant port to permit space for urethro-vesical ***: e RARP demonstrated advantages in surgical times, hospital stay and equivalence in PSM rates, complications and functional outcomes. e RARP is a useful alternative to t RARP especially in patients with adhesions, pre-existing inguinal hern

关键词： Prostatic neoplasms Robotics Laparoscopy Prostatectomy Complications

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