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Anti-Radical and Neuroprotective Potential of <i>Ficus infectoria</i>in Scopolamine Induced Memory Impairment in Mice

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Advances in Alzheimer's Disease 2018年第2期7卷 62-77页

作者： Kiran Zahid Syed Muhammad Faheem Ahmad Maqsood Ahmed farah khan Department of Botany Lahore College for Women University Lahore Pakistan UVAS—University of Veterinary and Animal Sciences Lahore Pakistan Riphah International University Lahore Pakistan

Ficus infectoria has a wide distribution in Bangladesh, Nepal, Pakistan, Sri Lanka, Southwest China and Indochina and is an enrich source of phytochemicals thereby possess antibacterial, antifungal and hyperglycaemic activities. In this study, we attempted to examine the cognitive ability of methanolic and ethanolic extract of F. infectoria fruit extract in scopolamine induced memory impairment in mice by using preliminary phytochemical and antioxidant tests, and the cognitive ability of the methanolic and ethanolic fruit extract of F. infectoria. Fruit extract was analyzed in scopolamine amnesia mice using passive avoidance approach. Piracetam was used as a reference drug (200 mg/Kg). Further confirmation was provided by means of mice brain homogenate biochemical tests. Maximum phytochemical, antioxidant activity and nootropic ability were observed in the ethanolic fruit extract of F. infectoria. Plant extract was used at three doses i.e. 75 mg/Kg, 150 mg/Kg and 300 mg/Kg and exhibited nootropic abilities in all tests used. Enhanced SDL value i.e. (291.2 ± 0.33+++###) was observed by the administration of plant extract at all dose range in comparison to reference drug i.e. piracetam (252.8 ± 1.60###) used in the study. The plant extract utilization has showed increase in total protein (25.08 ± 0.26+++### mg/g of tissue) and reduced glutathione content (33.0 ± 0.46+++### nmoles/mg of protein) and vice versa while low malondialehyde (MDA) (9.18 ± 0.17+++### nmoles/mg of protein) and AChE activity (0.067 ± 0.009+++### M/min/g protein). However, opposite situation was observed in the scopolamine amnesia mice. Hence it was concluded the plant extract possessed neuroprotective activity in the scopolamine induced cognitive decline in mice thereby used as cost effective natural medicines in near future.

关键词： Antioxidant Malondialdehyde Reduced Glutathione Acetylcholinestrase Scopolamine Hydrobromide Neuroprotective Ficus infectoria

Phytochemistry and potential therapeutic actions of Boswellic acids:A mini-review

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Asian Pacific Journal of Tropical Biomedicine 2017年第6期7卷 513-523页

作者： farah Iram Shah Alam khan Asif Husain Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesJamia Hamdard (Hamdard University) Department of Pharmacy Oman Medical College

The pentacyclic triterpenic acids isolated from the oleo gum resin of various Boswellia species are collectively called as Boswellic acids(BA).The oleo gum resin obtained from Indian variety *** serrata(Family – Burseraceae) is commonly known as Salai *** resin fraction of Salai guggal is rich in Boswellic acids and its essential oil is composed of a mixture of mono,di and sesquiterpenes while gum fraction chiefly contains pentose and hexose *** oleo-gum resin is quite popular among traditional practitioners of traditional Chinese and Indian Systems of medicine owing to their wide range of useful biological properties such as anti-inflammatory,anti-arthritic,antirheumatic,anti-diarrheal,anti-hyperlipidemic,anti-asthmatic,anti-cancer,anti-microbial anti-fungal,anti-complementary and analgesic activity,*** has been used as a herbal medicine since the prehistoric time to cure acute and chronic ailments including inflammatory *** investigation of this herbal medicine lead to identification of Boswellic acids which are found to be novel,potent,specific antiinflammatory agents due to non-redox inhibition of 5-lipoxygenase(5-LO) ***,the other important targets of Boswellic acids also include topoisomerases,angiogenesis,and cytochrome p450 *** review is a sincere attempt to discuss and present the current status of therapeutic potential,phytochemical as well as pharmacological profile of Boswellic acids primarily obtained from ***.

关键词： Boswellia serrata Boswellic acids Inflammation Leukotriene synthesis 5-Lipoxygenase

Pistacia chinensis:Strong antioxidant and potent testicular toxicity amelioration agent

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Asian Pacific Journal of Tropical Medicine 2017年第4期10卷 359-369页

作者： farah Noureen Muhammad Rashid khan Naseer Ali Shah Rahmat Ali khan Kiran Naz Saadia Sattar Department of Biochemistry Faculty of Biological SciencesQuaid-i-Azam University Department of Biosciences COMSATS Institute of Information Technology Department of Biotechnology UST Bannu KPK

Objective:To evaluate in ritro and in riro antioxidant potency of Pistacia chinensis(***) bark and leaves extracts along with its protective role against CCl_4 induced toxicity in testis of the *** Various in vitro models such as DPPH,ABTS,hydrogen peroxide,superoxide,hydroxyl and nitric oxide scavenging activities,anti-lipid peroxidation activity,phospho-molybdenum activity.β carotene bleaching assay was used for analysis of antioxidant *** groups for in riro study were:Group Ⅰ(control)*** Ⅱ(Vehicle control).Group Ⅲ(1 mL/kg b.w 30%CCl_4).Group Ⅳ(1 mL/kg b.w CCk_4+Silymarin).Group Ⅴ(200 mg/kg b.w PCBE+CCl_4),Group Ⅵ(400 mg/kg b.w PCBE+CCl_4) and Group Ⅶ(400 mg/kg b.w PCBE alone).Results:In ritro antioxidant assays displayed significant results and the highest activity was not specified to a specific ***,ethyl acetate extract of bark(PCBF) showed highest results in most of the antioxidant assays ***-carotene bleaching,hydroxyl radical *** peroxidation and superoxide radical scavenging *** this base,this fraction was selected for in riro antioxidant *** tissues were analyzed to observe the protective effects of PCBE on antioxidant enzymes:cataluse,superoxide *** reductase,glutathione peroxidase and quinone reductase activities and glutathione(GSH) as well as nitrite *** of plasma testosterone was also compared to various *** suggests a protective role of *** against CCl_4induced ***:It is concluded that some bioactive antioxidants of *** bark might be a good source to isolate the potent antioxidant components.

关键词： Pislacia chinensis Plasma testosterone Glutathione-S-transferase Antioxidant enzymes

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Ps-06013

Ps-06013

Enhancing Mild Cognitive Impairment Detection through Efficient Magnetic Resonance Image Analysis

第二届国际防痨和肺部疾病联合会亚太区学术大会暨2009...

作者： farah Zaman khan Bangladesh Dental College ＆ Institute Of Medical Technology

＜正＞Bangladesh has enacted a tobacco control law in 2005 in accordance with some of the provisions of WHO ***,tobacco consumption in Bangladesh is increasing,especially among the youth and *** to a report,59%

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Computers, Materials & Continua 2024年第8期80卷 2081-2098页

作者： Atif Mehmood Zhonglong Zheng Rizwan khan Ahmad Al Smadi farah Shahid Shahid Iqbal Mutasem K.Alsmadi Yazeed Yasin Ghadi Syed Aziz Shah Mostafa M.Ibrahim Department of Computer Science and Technology Zhejiang Normal UniversityJinhua321002China Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua321004China Department of Data Science and Artificial Intelligence Zarqa UniversityZarqa13100Jordan School of Chemical and Environmental Engineering College of ChemistryChemical Engineering andMaterials ScienceSoochow UniversitySuzhou215123China Department of Management Information Systems College of Applied Studies and Community ServiceImam Abdulrahman Bin Faisal UniversityDammam32244Saudi Arabia Department of Computer Science Al Ain UniversityAbu Dhabi999041United Arab Emirates Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61519Egypt Healthcare Technology and Innovation Theme Faculty Research Centre for Intelligent HealthcareCoventry UniversityCoventryCV48BWUK

Neuroimaging has emerged over the last few decades as a crucial tool in diagnosing Alzheimer’s disease(AD).Mild cognitive impairment(MCI)is a condition that falls between the spectrum of normal cognitive function and ***,previous studies have mainly used handcrafted features to classify MCI,AD,and normal control(NC)*** paper focuses on using gray matter(GM)scans obtained through magnetic resonance imaging(MRI)for the diagnosis of individuals with MCI,AD,and *** improve classification performance,we developed two transfer learning strategies with data augmentation(i.e.,shear range,rotation,zoom range,channel shift).The first approach is a deep Siamese network(DSN),and the second approach involves using a cross-domain strategy with customized *** performed experiments on the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset to evaluate the performance of our proposed *** experimental results demonstrate superior performance in classifying the three binary classification tasks:NC ***,NC ***,and MCI ***,we achieved a classification accuracy of 97.68%,94.25%,and 92.18%for the three cases,*** study proposes two transfer learning strategies with data augmentation to accurately diagnose MCI,AD,and normal control individuals using GM *** findings provide promising results for future research and clinical applications in the early detection and diagnosis of AD.

关键词： Alzheimer’s disease mild cognitive impairment normal control transfer learning classification augmentation

Eslicarbazepine acetate:A therapeutic agent of paramount importance in acute anticonvulsant therapy

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Journal of Acute Disease 2017年第6期6卷 245-254,253页

作者： farah Iram Shah Alam khan Aftab Ahmad Anees A.Siddiqui Asif Husain Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia Hamdard(Hamdard University)New Delhi-110062India Department of Pharmacy Oman Medical CollegeMuscatSultanate of Oman Health Information Technology Department Jeddah Community CollegeKing Abdulaziz UniversityP.O.Box-80283Jeddah-21589Kingdom of Saudi Arabia

Eslicarbazepine acetate (ESL) is a new, once daily, orally administered, third generation antiepileptic drug which is indicated in the treatment of partial-onset seizures. ESL is known to exert it's anticonvulsant effect by blocking the voltage-gated sodium channels. Several clinical trials and pharmacological studies have revealed that seizure control was better with ESL monotherapy (1 200 or 1 600 mg once daily) following a switch from other antiepileptic drugs in comparison with pseudo-placebo patients. The studies have indicated the ESL to be well tolerated and produced only mild to moderate emergent adverse events with the therapy. Being a dibenzazepine family member, structure and chemistry of ESL resembles more or less to carbamazepine and oxcarbazepine. ESL differs structurally from carbamazepine and oxcarbazepine at the 10, 11 position of dibenazepine nucleus. This molecular variation results in differences in metabolism and thus helps to prevent the formation of toxic epoxide metabolites. ESL following oral administration is rapidly metabolised to active metabolite namely S-licarbazepine which is responsible for its pharmacological activity. ESL exhibits acceptable pharmacokinetic profile and shows insignificant drug-drug interactions. In phase III clinical program, ESL was found to be efficacious and well tolerated in adult patients with partial onset seizures previously not controlled with treatment with one or two other antiepileptic drugs.

关键词： Eslicarbazepine acetate Partial-onset seizures Epilepsy Antiepileptic drugs Drug interactions

Sorption Kinetics, Isotherm and Thermodynamic Modeling of Defluoridation of Ground Water Using Natural Adsorbents

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American Journal of Analytical Chemistry 2013年第5期4卷 221-228页

作者： Aamna Balouch Mazhar Kolachi farah Naz Talpur Humaira khan Muhammad I. Bhanger Dr. M. A. Kazi Institute of Chemistry University of Sindh Jamshore Pakistan Environmental Engineering & Management Mehran University of Engineering & Technology Jamshoro Pakistan National Center of Excellence in Analytical Chemistry University of Sindh Jamshoro Pakistan

The aim of study is to investigate the removal ability of some natural adsorbents for fluoride ion from aqueous solution. The batch dynamic adsorption method was carried out at neutral pH as the functions of contact time, adsorbent dose, adsorbate concentration, temperature and effect of co-anions, which are commonly present in water. The sorption kinetics and equilibrium adsorption isotherms of fluoride on natural adsorbing materials had been investigated at afore-mentioned optimized. Equilibrium adsorption isotherms, viz., Freundlich and Langmuir isotherms were investigated. Lagergren and Morris-Weber kinetic equations were employed to find the rate constants. The negative enthalpy ΔH = -46.54 KJ·mol-1 and Gibbs free energy calculated was ΔG288-333—(2.07785, 3.08966, 4.1064, 4.90716 and 5.38036 KJ·mol-1) respectively, envisage exothermic and spontaneous nature of sorption.

关键词： Isotherm Kinetics and Thermodynamic Modeling Ground Water Natural Adsorbent Defluoridation

Extraction of Fat and Fatty Acid Composition from Slaughterhouse Waste by Evaluating Conventional Analytical Methods

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American Journal of Analytical Chemistry 2021年第5期12卷 202-225页

作者： Ariba khan farah Naz Talpur Muhammad Iqbal Bhanger Syed Ghulam Musharraf Hassan Imran Afridi National Centre of Excellence in Analytical Chemistry University of Sindh Jamshoro Pakistan Hussain Ebrahim Jamal Research Institute of Chemistry International Centre for Chemical and Biological Sciences University of Karachi Karachi Pakistan

To attain maximum recovery of useful compounds from slaughterhouse waste (Suet, Tongue, Pancreas) of selected ruminant (cow, goat, lamb, and bull), the fat extraction efficiency of popular methods was compared along with fatty acid (FAs) composition. Four selected methods including Soxhlet (SOX), acid hydrolysis, Bligh & dyer (B&D), and Folch (FOL) were assessed. After methylation, extracted lipids were analyzed by Gas chromatography for FA composition. Data indicated that all selected methods were significantly (p < 0.05) different from each other, particularly higher differences were noticed for low lipid-containing products (Tongue, Pancreas) as well as their respective FA Composition. Based on Analysis of Variance and Principal component analysis, the effective method for lipid and FA Composition analysis was the FOL method. The Soxhlet method was only effective for samples with high-fat content i.e., suet, while the B&D method gave comparatively low lipid content in analyzed samples. Hence based on the results, excellent fat and fatty acid extraction was achieved with the FOL method.

关键词： Fatty Acid Slaughterhouse Waste Animal by-Products Extraction Methods Lipid Analysis Gas Chromatography

Seimatoric acid and colletonoic acid:Two new compounds from the endophytic fungi,Seimatosporium *** Colletotrichum sp.

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Chinese Chemical Letters 2014年第12期25卷 1577-1579页

作者： Hidayat Hussain Natalia Root farah Jabeen Ahmed Al-Harrasi Ahmed Al-Rawahi Manzoor Ahmad Zahid Hassan Ghulam Abbas Fazal Mabood Afzal Shah Amin Badshah Amjad khan Riaz Ahmad Ivan R.Green Siegfried Draeger Barbara Schulz Karsten Krohn Department of Chemistry University of PaderbornWarburger Strasse 100Paderborn 33098Germany UoN Chair of Oman's Medicinal Plants and Marine Natural Products University of NizwaP.O.Box 33Postal Code 616Birkat Al MauzNizwaOman Department of Chemistry University of MalakandChakdaraDir(L)Pakistan Department of Chemistry CIITAbbottabad CampusAbbottabad 22060Pakistan Department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Chemistry and Polymer Science University of StellenboschP/Bag X1Matieland 7602South Africa Institute of Microbiology University of BraunschweigSpielmannstraβe 7Braunschweig 38106Germany

A new metabolite,named seimatoric acid（1）,representing a new oxobutanoic acid derivative has been isolated from Seimatosporium sp., in addition to four known compounds viz.,2-hydroxymethyl-4β,5α,6β-trihydroxycyclohex-2-enone（2）,（-）-phyllostine（3）,（＋）-epiepoxydon（4） and（＋）-epoxydon monoacetate（5）.Similarly one new benzoic acid derivative,named colletonoic acid（6） was isolated from the ethyl acetate fraction of Colletotrichum *** structures of the new compounds were elucidated by detailed ^1 H NMR,^13C NMR,COSY,*** spectroscopic analysis,and *** acid（1）was also isolated from another taxonomical unidentified fungal strain 4295 in *** structures of the known compounds were elucidated by their spectral data comparison to literature *** studies showed that colletonoic acid（6） showed good antibacterial,antifungal,and antialgal activities.

关键词： Seimatosporium sp. Colletotrichum sp. Activity Natural product