检索结果-南通市图书馆

作者： Jennifer R Lamberth Sheila c Reddy Jen-Jung Pan kevin J Dasher Division of Gastroenterology Hepatology and NutritionDepartment of Internal Medicine the University of Texas Health Science Center at Houston

There are no standard guidelines to follow when a patient with chronic hepatitis B infection becomes pregnant or desires pregnancy. Topics to consider include which patients to treat, when to start treatment, what treatment to use and when to stop treatment. Without any prophylaxis or antiviral therapy, a hepatitis B surface antigen and E antigen positive mother has up to a 90% likelihood of vertical transmission of hepatitis B virus(HBV) to child. Standard of care in the United States to prevent perinatal transmission consists of administration of hepatitis B immune globulin and HBV vaccination to the infant. The two strongest risk factors of mother to child transmission(MTcT) of HBV infection despite immunoprophylaxis are high maternal HBV viral load and high activity of viral replication. The goal is to prevent transmission of HBV at birth by decreasing viral load and/or decreasing activity of the virus. Although it is still somewhat controversial, most evidence shows that starting antivirals in the third trimester is effective in decreasing MTcT without affecting fetal development. There is a growing body of literature supporting the safety and efficacy of antiviral therapies to reduce MTcT of hepatitis B. There are no formal recommendations regarding which agent to choose. Tenofovir, lamivudine and telbivudine have all been proven efficacious in decreasing viral load at birth without known birth defects, but final decision of which antiviral medication to use will have to be determined by physician and patient. The antivirals may be discontinued immediately if patient is breastfeeding, or within first four weeks if infant is being formula fed.

关键词： chronic hepatitis B infection Pregnancy Hepatitis B immune globulin Hepatitis B virus vaccine Antivirals

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-grade pancreatic intraepithelial lesions： prevalence and implications in pancreatic neoplasia

引用

Hepatobiliary & Pancreatic Diseases International 2017年第2期16卷 202-208页

作者： Jean R Park Feng Li Veeral M Oza Brett c Sklaw kevin M cronley Michael Wellner Benjamin Swanson Somashekar G Krishna Division of Hospital Medicine The Ohio State University Wexner Medical Center Columbus Ohio USA Division of Gastroenterology Hepatology and Nutrition The Ohio State University Wexner Medical Center Columbus Ohio USA Department of Pathology The Ohio State University Wexner Medical Center Columbus Ohio USA

BAcKGROUND： High-grade pancreatic intraepithelial neoplasia（Pan IN-3）, a precursor of pancreatic ductal adenocarcinoma（PDAc）, is not universally detected in resected pancreatic neoplasms. We sought to determine the prevalence and prognostic relevance of Pan IN-3 lesions in primary surgical resections of PDAcs and intraductal papillary mucinous neoplasms（IPMNs）.METHODS： A retrospective review of a tertiary care center pathology database（1/2000-6/2014） was performed. Demographics, imaging, pathology, disease-recurrence, and survival data were ***： A total of 458 patients who underwent primary pancreatic resection were included. “Pan IN-3” lesions were found in 74（16.2%） patients who either had PDAc（n=67） or main duct（MD）-IPMN（n=7）. Among IPMN-MDs, Pan IN-3 lesions were exclusively found in those with pathological evidence of chronic pancreatitis. For PDAcs, the median overall survival（OS） for pancreata with Pan IN-3 lesions was significantly better than those without（OS 1.12 years, interquartile range [IQR] 0.72, 2.05 years vs OS 0.86 years, IQR 0.64,1.60 years respectively; P=0.04）. Multivariate cox regression analysis demonstrated that the presence of Pan IN-3 lesions was associated with a reduced risk of death（HR=0.43; 95% cI： 0.23-0.82; P=0.01）.cONcLUSIONS： Following primary resection of pancreatic adenocarcinoma, the lower survival observed in patients without Pan IN-3 lesions might suggest a state of complete or accelerated transformation. Further investigations are necessary to validate these findings that might impact disease prognosis and management.

关键词： pancreatic intraepithelial neoplasia intraductal papillary mucinous neoplasms pancreatic neoplasia pancreatic ductal adenocarcinoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

critical review of the use and scientific basis of forensic gait analysis

引用

Forensic Sciences Research 2018年第3期3卷 183-193页

作者： Nina M.van Mastrigt kevin celie Arjan L.Mieremet Arnout c.c.Ruifrok Zeno Geradts Department of Digital Technology and Biometry Netherlands Forensic InstituteThe HagueThe Netherlands Intelligent Information Systems University of AmsterdamAmsterdamThe Netherlands

This review summarizes the scientific basis of forensic gait analysis and evaluates its use in the Netherlands,United Kingdom and Denmark,following recent critique on the admission of gait evidence in canada.A useful forensic feature is(1)measurable,(2)consistent within and(3)different between *** the academic literature,this article found that(1)forensic gait features can be quantified or observed from surveillance video,but research into accuracy,validity and reliability of these methods is needed;(2)gait is variable within individuals under differing and constant circumstances,with speed having major influence;(3)the discriminative strength of gait features needs more research,although clearly variation exists between ***,forensic gait analysis has contributed to several criminal trials in Europe in the past 15 *** admission of gait evidence differs between *** methods are mainly observer-based:multiple gait analysts(independently)assess gait features on video footage of a perpetrator and *** gait feature databases,likelihood ratios of the hypotheses that the observed individuals have the same or another identity can be *** gait recognition algorithms calculate a difference measure between video clips,which is compared with a threshold value derived from a video gait recognition database to indicate ***,only partly automated algorithms have been used in *** argue that the scientific basis of forensic gait analysis is ***,gait feature databases enable its use in court for supportive evidence with relatively low evidential *** recommendations made in this review are(1)to expand knowledge on inter-and intra-subject gait variabilities,discriminative strength and interdependency of gait features,method accuracies,gait feature databases and likelihood ratio estimations;(2)to compare automated and observer-based gait recognition methods;to design(3)an

关键词： Forensic science forensic gait analysis validation biometric characteristics image analysis video analysis survey gait recognition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Entropy generation in bypass transitional boundary layer flows

引用

Journal of Hydrodynamics 2014年第5期26卷 669-680页

作者： GEORGE Joseph OWEN Landon D. XING Tao McELIGOT Donald M. cREPEAU John c. BUDWIG Ralph S. NOLAN kevin P. Department of Mechanical Engineering College of EngineeringUniversity of IdahoMoscowIdaho 83843USA University of Idaho Idaho FallsIdaho 83402USA University of Idaho BoiseIdaho 83702USA Imperial college London London SW7-28ZUK

The primary objective of this study is to evaluate the accuracy of using computational fluid dynamics （cFD） turbulence models to predict entropy generation rates in bypass transitional boundary layers flows under zero and adverse pressure gradients. Entropy generation rates in such flows are evaluated employing the commercial cFD software, ANSYS FLUENT. Various turbulence and transitional models are assessed by comparing their results with the direct numerical simulation （DNS） data and two recent cFD studies. A solution verification study is conducted on three systematically refined meshes. The factor of safety method is used to estimate the numerical error and grid uncertainties. Monotonic convergence is achieved for all simulations. The Reynolds number based on momentum thickness, Reo, skin-friction coefficient, cf, approximate entropy generation rates, S, dissipation coefficient, cd , and the intermittency, y, are calculated for bypass transition simulations. All Reynolds averaged Navier-Stokes （RANS） turbulence and transitional models show improvement over previous cFD results in predicting onset of transition. The transition SST k - ω 4 equation model shows closest agreement with DNS data for all flow conditions in this study due to a much finer grid and more accurate inlet boundary conditions. The other RANS models predict an early onset of transition and higher boundary layer entropy generation rates than the DNS shows.

关键词： entropy generation bypass transition Reynolds averaged Navier-Stokes (RANS) transitional boundary layer turbulence models

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relationship Between Built Environment, Socio-economic Factors and carbon Emissions from Shopping Trip in Shenyang city, china

引用

chinese Geographical Science 2017年第5期27卷 722-734页

作者： LI Jing LO kevin ZHANG Pingyu GUO Meng Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Department of Geography Hong Kong Baptist University School of Geographical Science Northeast Normal University

Promoting active travel behavior and decreasing transport-related carbon dioxide （cO2） emissions have become a priority in many chinese cities experiencing rapid urban sprawl and greater automobile dependence. However, there are few studies that holistically examine the physical and social factors associated with travel cO2 emissions. Using a survey of 1525 shoppers conducted in Shenyang, china, this study estimated shopping-related travel cO2 emissions and examined how the built environment and individual socioeconomic characteristics contribute to shopping travel behavior and associated c02 emissions. We found that, firstly, private car trips generate nearly eight times more carbon emissions than shopping trips using public transport, on average. Second, there was sig- nificant spatial autocorrelation with cO2 emissions per trip, and the highest carbon emissions were clustered in the inner suburbs and between the first and second circumferential roads. Third, shopping travel cO2 emissions per trip were negatively correlated with sev- eral built environment features including population density, the quantity of public transport stations, road density, and shop density. They were also found to be significantly related to the individual socio-eeonomic characteristics of car ownership, employment status, and education level using a multinomial logistic regression model. These empirical findings have important policy implications, assisting in the development of measures that contribute to the sustainability of urban transportation and meet carbon mitigation targets.

关键词： transport carbon emission travel behavior built environment socio-economic factors shopping trips china

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A multi-locus phylogenetic evaluation of Diaporthe (Phomopsis)

引用

Fungal Diversity 2012年第5期56卷 157-171页

作者： Dhanushka Udayanga Xingzhong Liu Pedro W.crous Eric H.c.McKenzie Ekachai chukeatirote kevin D.Hyde Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China cBS-KNAW Fungal Biodiversity centre Uppsalalaan 83584 CTUtrechtThe Netherlands Landcare Research Private Bag 92170AucklandNew Zealand

The genus Diaporthe(Phomopsis)includes important plant pathogenic fungi with wide host ranges and geographic *** the present study,phylogenetic species recognition in Diaporthe is re-evaluated using a multi-locus phylogeny based on a combined data matrix of rDNA ITS,and partial sequences from the translation elongation factor 1-α(EF 1-α),βtubulin(TUB)and calmodulin(cAL)molecular *** sequences of available extype cultures have been included,providing a multi-locus backbone tree for future studies on *** utilizable loci were analyzed individually and in combination,and ITS,EF 1-αand multi-locus phylogenetic trees are *** phylogenetic tree inferred by combined analysis of four loci provided the best resolution for species as compared to single gene *** are provided for nine species previously known in Phomopsis that are transferred to Diaporthe in the present *** unraveling of cryptic species complexes of Diaporthe based on Genealogical concordance Phylogenetic Species Recognition(GcPSR)is emphasized.

关键词： Ex-type culture Host diversity Mating types Molecular systematics New combination Phytopathogen Species recognition Taxonomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：