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Clinical use of nuclear cardiology in the assessment of heart failure

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World Journal of Cardiology 2010年第10期2卷 344-356页

作者： Shinro Matsuo kenichi nakajima Seigo Kinuya Department of Nuclear Medicine Kanazawa University Hospital

A nuclear cardiology test is the most commonly performed non-invasive cardiac imaging test in patients with heart failure, and it plays a pivotal role in their assessment and management. Quantitative gated single positron emission computed tomography (QGS) is used to assess quantitatively cardiac volume, left ventricular ejection fraction (LVEF), stroke volume, and cardiac diastolic function. Resting and stress myocardial perfusion imaging, with exercise or pharmacologic stress, plays a fundamental role in distinguishing ischemic from nonischemic etiology of heart failure, and in demonstrating myocardial viability. Diastolic heart failure also termed as heart failure with a preserved LVEF is readily identified by nuclear cardiology techniques and can accurately be estimated by peak filling rate (PFR) and time to PFR. Movement of the left ventricle can also be readily assessed by QGS, with newer techniques such as threedimensional, wall thickening evaluation aiding its assessment. Myocardial perfusion imaging is also commonly used to identify candidates for implantable cardiac defibrillator and cardiac resynchronization therapies. Neurotransmitter imaging using 123 I-metaiodobenzylguanidine offers prognostic information in patients with heart failure. Metabolism and function in the heart are closely related, and energy substrate metabolism is a potential target of medical therapies to improve cardiac function in patients with heart failure. Cardiac metabolic imaging using 123 I-15-(p-iodophenyl)3-R, S-methylpentadecacoic acid is a commonly used tracer in clinical studies to diagnose metabolic heart failure. Nuclear cardiology tests, including neurotransmitter imaging and metabolic imaging, are now easily preformed with new tracers to refine heart failure diagnosis. Nuclear cardiology studies contribute significantly to guiding management decisions for identifying cardiac risk in patients with heart failure.

关键词： Quantitative gated single computed tomogrphoton emission aphy Metaiodobenzylguanidine β-methyl-p-iodophenyl-pentadecanoic acid Diastolic function Prognosis

Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy

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World Journal of Gastroenterology 2005年第47期11卷 7520-7524页

作者： Izumi Shimbo Taketo Yamaguchi Takeo Odaka kenichi nakajima Akinori Koide Hidehiko Koyama Hiromitsu Saisho Department of Medicine and Clinical Oncology Graduate School of MedicineChiba University1-8-1 InohanaChuo-kuChiba-CityChiba260-0856Japan Tako Chuo Hospital Tako-machi Katori-CountryChiba289-2241Japan Kawasaki Chiba Hospital Minami-choChuo-kuChiba-CityChiba260-0842Japan International University of Health and Welfare Mita HospitalMita Minato-ku Tokyo108-8329Japan

AIM： To investigate the effect of probiotic bacterium, Clostridium butyricum MIYAIRI 588 strain （CBM） on the changes of the fecal flora in Helicobacter pylori （H pylon） treatment. METHODS： Thirty-five patients with gastric or duodenal ulcers positive for H pylori were randomized either to 1 wk amoxicillin, clarithromycin, lansoprazole （Group 1） or to the same regimen supplemented with CBM 7 d ahead of the triple therapy （Group 2）. Stool samples were collected before and 2, 4, 7, 15, and 22 d after the starting eradication therapy, and were examined intestinal flora. Patients were required to keep a diary record of their condition. RESULTS： Obligate anaerobes decreased significantly on d 2, 4, 8 and 15 in Group 1. On the other hand, they did not decrease significantly in Group 2. The Escherichia coli was dominant bacterium in Enterobacteriaceae, but that was replaced by other species such as Klebsiella and Enterobacter after eradication in Group 1. The change was suppressed in Group 2. Abdominal symptoms were less frequent in Group 2 than in Group 1. CONCLUSION： The combined use of CBM reduced the changes in the intestinal flora and decreased the incidence of gastrointestinal side effects.

关键词： Clostridium butyricum Intestinal flora Helicobacter pylori Eradication

IQ-SPECT201Tl心肌灌注显像:使用正常人数据进行定量分析的效果

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中华核医学与分子影像杂志 2018年第2期38卷 150-151页

作者：唐军 Takahiro Konishi kenichi nakajima Koichi Okuda Hiroto Yoneyama Shinro Matsuo Takayuki Shibutani Masahisa Onoguchi Seigo Kinuya 上海交通大学医学院附属苏州九龙医院核医学科 Department of Nuclear Medicine Kanazawa University Hospital

目的智能SPECT(IQ-SPECT)能进行图像的快速采集和衰减校正,经这种技术获得的图像与常规显像技术相比是不一样的。该研究就Tl心肌灌注显像(MPI),比较使用正常日本人数据(NDBs)的IQ-SPECT和常规SPECT的诊断效能。方法 36例患者进行了一日... 详细信息

目的智能SPECT(IQ-SPECT)能进行图像的快速采集和衰减校正,经这种技术获得的图像与常规显像技术相比是不一样的。该研究就Tl心肌灌注显像(MPI),比较使用正常日本人数据(NDBs)的IQ-SPECT和常规SPECT的诊断效能。方法 36例患者进行了一日法Tl腺苷负荷-静息MPI。IQ-SPECT图像的采集时长大约是常规SPECT图像采集时长的四分之一。IQ-SPECT的图像重建在做或不做散射和衰减校正(SCAC)的情况下采用有序子集共轭梯度最小化法进行。常规SPECT的图像重建在不做SCAC的情况下采用滤波反投影法进行。总负荷得分(SSS)使用日本核医学会相关工作组建立的NDBs计算获得,对IQ-SPECT和常规SPECT各自使用采集条件匹配的NDBs获得的SSS进行了比较,同时比较了2种方法诊断冠状动脉粥样硬化性心脏病的效能。结果常规SPECT的SSS是6.6±8.2,IQ-SPECT做和不做SCAC的SSS分别是6.5±9.7和6.6±9.4(各SSS间差异均无统计学意义)。常规SPECT和IQ-SPECT的SSS间有很强的正相关关系(r=0.921,P<0.000 1),IQ-SPECT做和不做SCAC的SSS也有很好的相关性(r=0.907,P<0.000 1)。常规SPECT的灵敏度、特异性和准确性分别是80.8%、78.9%和79.4%;做SCAC的IQ-SPECT的相应参数分别是88.5%、86.8%和87.3%;不做SCAC的IQ-SPECT的相应参数分别是80.8%、80.3%和82.0%。常规SPECT、做SCAC的IQ-SPECT和不做SCAC的IQ-SPECT的受试者操作特征分析曲线下面积分别是0.77、0.86和0.80(各面积间差异均无统计学意义)。结论在不做SCAC的情况下,只要使用了合适的NDBs,IQSPECTTl MPI与常规SPECT的诊断效能具有可比性。

关键词： IQ-SPECT 正常日本人数据库心肌灌注显像快速采集

Erratum to:Certification Criteria in Type I Ecolabelling Related to Metals for Sustainable Materials Management

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Journal of Shanghai Jiaotong University(Science) 2012年第4期17卷 512-512页

作者： DAIGO Ichiro nakajima kenichi FUJISAKI Takashi Graduate School of Engineering The University of Tokyo National Institute for Environmental Studies 3. Japan Environment Association

利用日本多中心数据库对人工神经网络进行再训练以探测心肌缺血

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中华核医学与分子影像杂志 2018年第10期38卷 710-710页

作者：刘颍桦(译) 唐军(审校) 苏州大学医学部放射医学与防护学院 215123 上海交通大学医学院附属苏州九龙医院核医学科 215021

目的人工神经网络（ANN）已被应用于探测心肌灌注缺损和缺血。该研究的目的是比较最新1.1版本的ANN与最初1.0版本的诊断准确性。方法研究了106例冠状动脉（简称冠脉）造影阳性的患者[平均年龄（77±10）岁]，其中多支冠脉病变（狭窄≥50... 详细信息

目的人工神经网络（ANN）已被应用于探测心肌灌注缺损和缺血。该研究的目的是比较最新1.1版本的ANN与最初1.0版本的诊断准确性。方法研究了106例冠状动脉（简称冠脉）造影阳性的患者[平均年龄（77±10）岁]，其中多支冠脉病变（狭窄≥50%）者占52%，陈旧性心肌梗死患者占27%，行冠脉重建术者占30%。1.0和1.1版本的ANN已分别在瑞典（1 051例）和日本（1 001例）用于99Tcm-甲氧基异丁基异腈（MIBI）心肌灌注显像的诊断训练，计算其诊断当地患者负荷态心肌灌注缺损和缺血的可能性（0.0～1.0）。以相关专家的阅片结果作为＂金标准＂，计算受试者工作特征（ROC）曲线下面积（AUC），比较2个版本ANN的诊断准确性。结果1.1和1.0版本的ANN诊断负荷态心肌灌注缺损的AUC分别为0.95和0.93（P＝0.27），但1.1版本诊断心肌缺血的能力显著提高（P＝0.005 5），其AUC为0.96（灵敏度87%，特异性96%），1.0版本的AUC为0.89（灵敏度78%，特异性97%）。在未行冠脉重建且无陈旧性心肌梗死的患者中，1.1版本的AUC也有显著提高（P＝0.009 3），其AUC为0.98（灵敏度88%，特异性100%），而1.0版本的AUC为0.88（灵敏度76%，特异性100%）。与1.0版本相比，1.1版本的中位ANN可能性常为0.1～0.7，这使得1.1版本的诊断准确性更高。以冠脉狭窄作为＂金标准＂时，1.1版本的诊断准确性在单支冠脉病变或无冠脉狭窄的患者中也有提高（47例；AUC：0.81与0.66，P＝0.006 0）。结论1.1版本的ANN在日本人数据库中训练后，其诊断能力得到提高，尤其在诊断心肌缺血方面。

关键词：核心脏病学人工智能心肌灌注显像冠状动脉粥样硬化性心脏病

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DESIGN EXAMPLE OF A HYBRID TENSION MEMBRANE STRUCTURE

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DESIGN EXAMPLE OF A HYBRID TENSION MEMBRANE STRUCTURE

Serum type Ⅳ collagen level is predictive for esophageal varices in patients with severe alcoholic disease

The International Colloquium on Space Structures for Sports Buildings

作者： kenichi SUGIZAKI HAJIME nakajima MASAO SAITOH Technology Development Division Shimizu Construction Co. Ltd. 2-16-1 Kyobashi Chuo-ku Tokyo 104 Japan Technology Development Division Shimizu Construction Co. Ltd. 2-16-1 Kyobashi Chuo-ku Tokyo 104 Japan Dept.of Architecture College of Science & Technology Nihon University 1-8 Surugadai Kanda Chiyoda-ku Tokyo 101 Japan

INTRODUCTION We had a chance to design and construct a hybrid tension membrane structure. Using this structure as an example,we introduce some design views and problems on the design and construction processes,such as...

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World Journal of Gastroenterology 2008年第13期14卷 2044-2048页

作者： Satoshi Mamori Yasuyuki Searashi Masato Matsushima kenichi Hashimoto Shinichiro Uetake Hiroshi Matsudaira Shuji Ito Hisato nakajima Hisao Tajiri Division of Gastroenterology and Hepatology Department ofInternal Medicine the Jikei University School of Medicine Tokyo105-8461 Japan Division of Clinical Research anddevelopment the Jikei University School of Medicine Tokyo105-8461 Japan Tokyo Medical Center of Alcohol RelatedDisabilities Tokyo 175-0091 Japan

AIM： To determine factors predictive for esophagea varices in severe alcoholic disease （SAD）. METHODS： Abdominal ultrasonography （US） was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/ or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal （UGI） endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables. RESULTS： Twenty-five patients （56.8%） had esophageal varices. A univariate analysis revealed a significant difference in age and type Ⅳ collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type Ⅳ collagen as the only independent variable predictive for esophageal varices （P = 0.017）. The area under the curve （AUC） for type Ⅳ collagen as determined by the receiver operating characteristic （ROC） for predicting esophageal varices was 0.78. CONCLUSION： This study suggests that the level of type Ⅳ collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD.

关键词： Type Ⅳ collagen Esophageal varice Alcoholic disease Abdominal ultrasonography Alcoholism

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World Journal of Gastroenterology 2006年第11期12卷 1805-1809页

作者： Yoshimi nakajima Hitoshi Takagi Naondo Sohara Ken Sato Satoru Kakizaki kenichi Nomoto Hideki Suzuki Taketoshi Suehiro Tatsuo Shimura Takayuki Asao Hiroyuki Kuwano Masatomo Mori Ken Nishikura Department of Medicine and Molecular Science Gunma University Graduate School of Medicine MaebashiGunma 371-8511Japan Department of Surgery Gunma University Graduate School of Medicine MaebashiGunma 371-8511Japan Division of Molecular and Functional Pathology Department of Cellular Function Niigata University Graduate School of Medicine and Dental SciencesNiigataNiigata 951-8510Japan

A 42-year-old woman was admitted to our hospital because of multiple liver tumors detected by ultrasonography. Colonoscopy revealed submucosal tumor in the rectum, which was considered the primary lesion. Endoscopic mucosal resection followed by histopathological examination revealed that the tumor was carcinoid. The resected margin of the tumor was positive for malignant cells. Two courses to transcatheter arterial chemotherapy for liver metastasis were ineffective. Accordingly, the rectal tumor and metastatic lymph nodes were surgically resected. One month after the operation, she received liver transplantation （left lateral segment and caudate lobe） from her son. No recurrent lesion has been observed at two years after the liver transplantation. Liver transplantation should be considered as a treatment option even in advanced case of carcinoid metastasis to the liver. We also discuss the literature on liver transplantation for metastatic carcinoid tumor.

关键词： Carcinoid Liver metastasis Living related liver transplantation