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Longitudinal gut fungal alterations and potential fungal biomarkers for the progression of primary liver disease

Science China(Life Sciences) 2024年第6期67卷 1183-1198页

作者： Shiman Jiang Lvwan Xu Yanfei Chen Zheyue Shu Longxian Lv Yuxi Zhao kefan bi Sisi Yang Qiangqiang Wang Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Liver disease,a major health concern worldwide,is a serious and progressive ***,we not only established a mouse model of DEN+CCl4-induced primary liver disease but also collected clinical human samples to investigate longitudinal alterations in the gut *** liver disease advanced,gut integrity was disrupted,and the mycobiota was disturbed in the mouse *** metabolites associated with hepatocellular carcinoma(HCC)differed from those associated with the cirrhotic phase as follows:levels of stercobilin and aflatoxin B1 dialcohol were reduced,while levels of triterpenoids,bafilomycin A1,and DHEA were increased in the HCC *** abundance of the phylum Chytridiomycota increased as the chronic liver disease progressed and was then replaced by the phylum Ascomycota in *** on the results from clinical human samples,the genus Candida(Ascomycota)(in humans)and the genus Kazachstania(Ascomycota)(in mice)occupied a dominant position in the HCC group,while other fungi were *** increased abundance of *** and depletion of *** may be hallmarks of the progression of liver cirrhosis to early ***,the administration of *** and *** in the LC-HCC progression could accelerate or retard the progression of ***,gut fungi have the potential to serve as a noninvasive clinical biomarker and even a treatment method.

关键词： gut mycobiome liver disease longitudinal studies hepatocarcinogenesis fungal biomarker

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电动汽车聚合商参与需求响应定价策略及收益分配研究

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电工电能新技术 2024年第7期43卷 41-50页

作者：庞松岭赵雨楠毕克凡岳焕展张谦智能电网与海岛微网联合实验室(海南电网有限责任公司电力科学研究院) 海南海口570125 输变电装备技术全国重点实验室(重庆大学) 重庆400044

针对需求响应市场中电动汽车充电电价的制定未充分考虑区域电网与电动汽车聚合商的利益均衡问题及电动汽车集群参与需求响应后如何合理分配收益的问题,论文提出计及电动汽车集群需求响应的电价谈判策略,及基于改进Shapley值的电动汽车... 详细信息

针对需求响应市场中电动汽车充电电价的制定未充分考虑区域电网与电动汽车聚合商的利益均衡问题及电动汽车集群参与需求响应后如何合理分配收益的问题,论文提出计及电动汽车集群需求响应的电价谈判策略,及基于改进Shapley值的电动汽车集群收益分配策略。首先,建立了电动汽车聚合商需求响应成本电价模型,结合电动汽车可参与需求响应时段,提出了基于需求响应容量的电价谈判策略,获得可平衡双方利益的需求响应电价;然后基于上述电价测算电动汽车集群参与需求响应的收益,并采用改进的Shapley值进行收益分配。最后通过算例证明所提策略可均衡电动汽车集群与电力公司的收益,并有效确保收益的合理分配,提高电动汽车用户参与需求响应的积极性。

关键词：电动汽车 V2G 需求侧响应优化调度收益分配

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Integrated analysis of human influenza A(H1N1)virus infectionrelated genes to construct a suitable diagnostic model

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biOCELL 2021年第4期45卷 885-899页

作者： WENbiAO CHEN kefan bi JINGJING JIANG XUJUN ZHANG HONGYAN DIAO State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou310003China

The genome characteristics and structural functions of coding proteins correlate with the genetic diversity of the H1N1 virus,which aids in the understanding of its underlying pathogenic *** this study,analyses of the characteristic of the H1N1 virus infection-related genes,their biological functions,and infection-related reversal drugs were ***,we used multi-dimensional bioinformatics analysis to identify the key genes and then used these to construct a diagnostic model for the H1N1 virus *** was a total of 169 differently expressed genes in the samples between 21 h before infection and 77 h after *** were used during the protein-protein interaction(PPI)analysis,and we obtained a total of 1725 interacting ***,we performed a weighted gene co-expression network analysis(WGCNA)on these genes,and we identified three modules that showed significant potential for the diagnosis of the H1N1 virus *** modules contained 60 genes,and they were used to construct this diagnostic model,which showed an effective prediction ***,these 60 genes were involved in the biological functions of this infectious virus,like the cellular response to type I interferon and in the negative regulation of the viral life ***,20 genes showed an upregulated expression as the infection *** 36 upregulated genes were used to examine the relationship between genes,human influenza A virus,and infection-related reversal *** study revealed numerous important reversal drug molecules on the H1N1 *** included rimantadine,interferons,and shikimic *** study provided a novel method to analyze the characteristic of different genes and explore their corresponding biological function during the infection caused by the H1N1 *** diagnostic model,which comprises 60 genes,shows that a significant predictive value can be the potential biomarker for the diagnosis of the H1N1 virus infection.

关键词： Human influenza A H1N1 virus Gene Diagnosis model

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Absorption-dominant EMI shielding performance of multiple folded bi_(2)Se_(3)/PVDF nanocomposite films

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Journal of Materiomics 2024年第1期10卷 27-36页

作者： Xinyi Pu Zunpeng Feng Siyuan Sun Ke bi Yanan Hao State Key Laboratory of Information Photonics and Optical Communications School of ScienceBeijing University of Posts and TelecommunicationsBeijing100876China Chinese Academy of Engineering Innovation Strategy Beijing100088China

Absorption-dominant electromagnetic interference(EMI)shielding materials are promising in reducing electromagnetic radiation pollution,but their preparation processes are usually difficult and unsuitable for large-scale *** this work,multiple folded bi_(2)Se_(3)/PVDF nanocomposite films were fabri-cated by using a convenient tape-casting method and multiple folding,which can be easily extended in industrial *** EMI shielding effectiveness(SE)of the composite materials was investigated,which shows typical absorption-dominant behavior and can substantially reduce secondary ***,for the 35%(in volume)bi_(2)Se_(3)/PVDF nanocomposite film,the SE_(A)of single-layered film with a thickness of 60 mm reaches 20 dB while SE_(R)is lower than 5 *** folding the film into eight layers,the SE_(A)increased to 50 dB while SE_(R)remains below 5 *** method provides an effective way to the fabrication of absorption-dominant electromagnetic absorption(EMA)and EMI shielding material.

关键词： Electromagnetic interference shielding(EMI) Electromagnetic wave absorption bismuth selenide Composite

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On the Proper Holomorphic Mappings between Equidimensional Hartogs Domains over Hermitian Symmetric Manifolds

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1215-1228页

作者： En Chao bi School of Mathematics and Statistics Qingdao UniversityQingdao 266071P.R.China

In this paper,we study a family of Hartogs domains fibred over Hermitian symmetric manifolds being a unit ball in C^(m).The aim of the present study is to establish the rigidity results about proper holomorphic mappings between two equidimensional Hartogs domains over Hermitian symmetric *** particular,we can fully determine its biholomorphic equivalence and automorphism group.

关键词： Proper holomorphic mapping Hartogs domains Hermitian symmetric manifolds

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Optical Modeling of Sea Salt Aerosols Using in situ Measured Size Distributions and the Impact of Larger Size Particles

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Advances in Atmospheric Sciences 2024年第10期41卷 1917-1935页

作者： Wushao LIN Lei bi Key Laboratory of Geoscience big Data and Deep Resource of Zhejiang Province School of Earth SciencesZhejiang UniversityHangzhou 310058China

Sea salt aerosols play a critical role in regulating the global climate through their interactions with solar *** size distribution of these particles is crucial in determining their bulk optical *** this study,we analyzed in situ measured size distributions of sea salt aerosols from four field campaigns and used multi-mode lognormal size distributions to fit the *** employed super-spheroids and coated super-spheroids to account for the particles’non-sphericity,inhomogeneity,and hysteresis effect during the deliquescence and crystallization *** compute the singlescattering properties of sea salt aerosols,we used the state-of-the-art invariant imbedding T-matrix method,which allows us to obtain accurate optical properties for sea salt aerosols with a maximum volume-equivalent diameter of 12μm at a wavelength of 532 *** results demonstrated that the particle models developed in this study were successful in replicating both the measured depolarization and lidar ratios at various relative humidity(RH)***,we observed that large-size particles with diameters larger than 4μm had a substantial impact on the optical properties of sea salt aerosols,which has not been accounted for in previous ***,excluding particles with diameters larger than 4μm led to underestimating the scattering and backscattering coefficients by 27%−38%and 43%−60%,respectively,for the ACE-Asia field ***,the depolarization ratios were underestimated by 0.15 within the 50%−70%RH *** findings emphasize the necessity of considering large particle sizes for optical modeling of sea salt aerosols.

关键词： sea salt aerosol particle size distribution lidar optical property

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Advances in regional nodal management of early-stage breast cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 215-225页

作者： Zhao bi Yongsheng Wang Breast Cancer Center Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250017China

With the continuous improvement of systemic treatment, reasonable local regional control of early-stage breast cancer can be translated into survival benefits. The optimization of regional nodal management in patients with limited sentinel lymph node(SLN) metastasis needs to be weighed by surgical complications, regional recurrence risk, and lymph node status, as well as other escalating treatment(systemic/radiotherapy) that may result from deescalating surgery. With the effective support and supplementation of systemic therapy and radiotherapy, the management of axillary surgery is developing in a de-escalating trend. The widespread application of neoadjuvant therapy has contributed to optimizing the management of patients with clinically node-negative/imaging nodepositive disease. In clinical practice, it is necessary to consider the residual tumor burden of regional lymph nodes when formulating the optimal irradiation fields in patients with limited positive SLN without axillary lymph node dissection. The combined application of genomic tests and American College of Surgeons Oncology Group Z0011/AMAROS criteria could provide patients with a better strategy of dual de-escalation treatment, which includes the de-escalation of both axillary surgery and systemic treatment. In the era of sentinel lymph node biopsy(SLNB), the regional nodal management of breast cancer should adhere to the concept of “updating ideas, making bold assumptions, and carefully seeking proof”, make full use of the benefits of systemic therapy and radiotherapy to reduce the scope of surgery and complications, and expand the “net benefit” of efficacy and quality of life. This review discusses the optimization of regional nodal management in the era of SLNB, in order to provide reference information for clinicians.

关键词： Breast cancer sentinel lymph node biopsy internal mammary lymph node radiotherapy surgery

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On-the-fly precision spectroscopy with a dual-modulated tunable diode laser and Hz-level referencing to a cavity

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Advanced Photonics 2024年第4期6卷 36-44页

作者： Shuangyou Zhang Toby bi Pascal Del’Haye Max Planck Institute for the Science of Light ErlangenGermany Friedrich-Alexander Universität Erlangen-Nürnberg Department of PhysicsErlangenGermany

Advances in laser spectroscopy have enabled many scientific breakthroughs in physics,chemistry,biology,and *** frequency combs pushed measurement limits with ultrahigh-frequency accuracy and fast-measurement speed,while tunable-diode-laser spectroscopy is used in scenarios that require high power and continuous spectral *** these advantages of tunable-diode-laser spectroscopy,it is challenging to precisely determine the instantaneous laser frequency because of fluctuations in the scan ***,we demonstrate a simple spectroscopy scheme with a frequencymodulated diode laser that references the laser on-the-fly to a fiber *** fiber cavity's free spectral range is on-the-fly calibrated with sub-10-Hz frequency *** achieve a relative precision of the laser frequency of 2×10^(-8)for an 11-THz frequency range at a measurement speed of 1 THz∕*** is an improvement of more than 2 orders of magnitude compared to existing diode-laser-spectroscopy *** scheme provides precise frequency calibration markers,while simultaneously tracking the instantaneous scan speed of the *** demonstrate the versatility of our method through various applications,including dispersion measurement of a fiber,ultrahigh-Q microresonators,and spectroscopy of a hydrogen fluoride gas *** simplicity,robustness,and low cost of this spectroscopy scheme are valuable for out-of-the-lab applications like lidar and environmental monitoring.

关键词： tunable laser spectroscopy radio-frequency modulation integrated photonics gas spectroscopy frequency comb

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ORPA:a fast and efficient phylogenetic analysis method for constructing genome-wide alignments of organelle genomes

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Journal of Genetics and Genomics 2024年第3期51卷 352-358页

作者： Guiqi bi Xinxin Luan Jianbin Yan Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518124China Zhengzhou Research Base State Key Laboratory of Cotton BiologySchool of Agricultural SciencesZhengzhou UniversityZhengzhouHenan 450001China

Creating a multi-gene alignment matrix for phylogenetic analysis using organelle genomes involves aligning single-gene datasets manually,a process that can be time-consuming and prone to *** HomBlocks pipeline has been created to eliminate the inaccuracies arising from manual *** processing of a large number of sequences,however,remains a time-consuming *** conquer this challenge,we develop a speedy and efficient method called Organelle Genomes for Phylogenetic Analysis(ORPA).ORPA can quickly generate multiple sequence alignments for whole-genome comparisons by parsing the result files of NCbi BLAST,completing the task just in 1 *** increasing data volume,the efficiency of ORPA is even more pronounced,over 300 times faster than HomBlocks in aligning 60 high-plant chloroplast *** phylogenetic tree outputs from ORPA are equivalent to HomBlocks,indicating its outstanding *** to its speed and accuracy,ORPA can identify species-level evolutionary conflicts,providing valuable insights into evolutionary cognition.

关键词： Ultrafast alignment Organelle phylogenomics Phylogenomic conflict Efficient pipeline Multiple sequence alignment pipeline

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bimetallic In_(2)O_(3)/bi_(2)O_(3) Catalysts Enable Highly Selective CO_(2) Electroreduction to Formate within Ultra-Broad Potential Windows

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Energy & Environmental Materials 2024年第1期7卷 257-264页

作者： Zhongxue Yang Hongzhi Wang Xinze bi Xiaojie Tan Yuezhu Zhao Wenhang Wang Yecheng Zou Huai ping Wang Hui Ning Mingbo Wu State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringCollege of New EnergyChina University of Petroleum(East China)Qingdao 266580China Shandong Dongyue Future Hydrogen Energy Material Co. Ltd.Zibo 255000China

CO_(2)electrochemical reduction reaction(CO_(2)RR)to formate is a hopeful pathway for reducing CO_(2)and producing high-value chemicals,which needs highly selective catalysts with ultra-broad potential windows to meet the industrial ***,the nanorod-like bimetallic ln_(2)O_(3)/bi_(2)O_(3)catalysts were successfully synthesized by pyrolysis of bimetallic Inbi-MOF *** abundant oxygen vacancies generated from the lattice mismatch of bi_(2)O_(3)and ln_(2)O_(3)reduced the activation energy of CO_(2)to*CO_(2)·^(-)and improved the selectivity of*CO_(2)·^(-)to formate ***,the carbon skeleton derived from the pyrolysis of organic framework of Inbi-MOF provided a conductive network to accelerate the electrons *** catalyst exhibited an ultra-broad applied potential window of 1200 mV(from-0.4 to-1.6 V vs RHE),relativistic high Faradaic efficiency of formate(99.92%)and satisfactory stability after 30 *** in situ FT-IR experiment and DFT calculation verified that the abundant oxygen vacancies on the surface of catalysts can easily absorb CO_(2)molecules,and oxygen vacancy path is dominant *** work provides a convenient method to construct high-performance bimetallic catalysts for the industrial application of CO_(2)RR.

关键词： bimetallic catalyst CO_(2)electrochemical reduction reaction formate oxygen vacancy wide potential window

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