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Chinese Journal of Structural Chemistry 2020年第1期39卷 66-78,3页

作者： YING Jia-Wen SUN Qun YANG Li-Fang ke mei-Rong HUANG Jian-Dong College of Chemistry State Key Laboratory of Photocatalysis on Energy and EnvironmentFujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and ChemotherapyFuzhou UniversityFuzhou 350116China

We design and synthesize a series of novel silicon(IV)phthalocyanines(SiPcs,1a,2a,1b,and 2b)axially conjugated with arginine or arginine-containing oligopeptides(Arg-Arg,Cys-Arg,Cys-Arg-Arg)through ester or ether linkers to demonstrate the effects of substituents and coupling ways on the spectral behaviors and photodynamic *** ester-linked SiPcs(1a and 2a)show slight red-shift,higher fluorescence emission and singlet oxygen generation compared to the ether-linked analogues(1b and 2b)due to the stronger electron-withdrawing ability of the ester group,suggesting that electronic effect of the linkers plays an important role in their spectral *** introduction of arginine could effectively reduce the aggregation of phthalocyanine in aqueous *** higher cellular uptake and plasma membrane localization ability,1b and 2b exhibit significantly higher photocytotoxicity against both HepG2 and Hela ***,the in vivo fluorescence imaging suggests that 2b is the most specific toward H22 tumor-bearing ICR mice,and it shows efficient tumor growth inhibition with the tumor inhibition rate up to 93%.Thus,this work would provide a new reference for the development of phthalocyanine-based photosensitizers.

关键词： photodynamic therapy phthalocyanine arginine spectral property anticancer activity

Laparoscopic resection of an obturator schwannoma： a case report

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Chinese Medical Journal 2010年第13期123卷 1804-1806页

作者： YI ke WANG Yu-mei CHEN Jie Department of Gynecology West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China

Schwannomas are usually benign tumors that arise from a nerve supporting the Schwann cells, those are mostly associated with the cranial or main peripheral nerves. The occurrence of retroperitoneal schwannoma is quite rare, and in such a case, surgical excision is the first option for treatment. In 1996, Melvin confirmed the feasibility of the complete resection of a retroperitoneal schwannoma using laparoscopy for the first time. Until recently, only few cases of laparoscopic resection of retroperitoneal schwannoma have been reported.

关键词： laparoscopy obturator schwannomas

Benchmark Dose Estimation for Cadmium-Induced Renal Effects Based on a Large Sample Population from Five Chinese Provinces

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Biomedical and Environmental Sciences 2015年第5期28卷 383-387页

作者： ke Shen ke Qin mei JIA Wen Jing CHENG Xi Yu LI Hao ZHANG Jie Ying LUO Hui Fang HE Jin Sheng CHEN Zhi Nan College of Life Sciences and Bioengineering School of ScienceBeijing Jiaotong University Tongji Medical College Huazhong University of Science and Technology

A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium （UCd） for renal dysfunction as benchmark dose low （BMDL）. The urinary N-acetyl-13-D-glucosaminidase （UNAG） was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18μg/g creatinine （cr） to 4.26μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses （BMR） of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males.

关键词： Benchmark Dose Estimation for Cadmium-Induced Renal Effects Based on a Large Sample Population from Five Chinese Provinces BMD Cd

废弃水厂用煤质颗粒活性炭吸附苯甲酸钠性能研究

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应用化工 2024年第4期53卷 787-790,796页

作者：李璐周克梅周卫东范佩刘振东周冰洁吴彬彬王郑南京林业大学土木工程学院江苏南京210037 南京水务集团有限公司江苏南京210002

直接再利用某水厂的废弃活性炭作为苯甲酸钠的吸附剂。通过对废弃活性炭进行灰分、SEM-BET表征分析得,废弃活性炭表面变得光滑,碘值仅有339.86 mg/g,介孔占比大,表明活性炭表面吸附位点被占据,其吸附性能下降。拟合结果显示,废弃活性炭... 详细信息

直接再利用某水厂的废弃活性炭作为苯甲酸钠的吸附剂。通过对废弃活性炭进行灰分、SEM-BET表征分析得,废弃活性炭表面变得光滑,碘值仅有339.86 mg/g,介孔占比大,表明活性炭表面吸附位点被占据,其吸附性能下降。拟合结果显示,废弃活性炭对苯甲酸钠的吸附更符合Freundlich等温模型和拟二级动力学模型。随着温度的升高,苯甲酸钠的去除率下降,与热力学参数焓变是负值一致,属于放热反应。拟合的废弃活性炭对苯甲酸钠的最大吸附容量为1.108 mg/g,证明了废弃活性炭可应用于工业废水中,为水厂最终处置废弃活性炭找到了新的出路。

关键词：废弃活性炭苯甲酸钠吸附资源化利用

Effect of Activated Carbon as a Support on Metal Dispersion and Activity ofRuthenium Catalyst for Ammonia Synthesis

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Chemical Research in Chinese Universities 2002年第4期18卷 448-452页

作者： ZHENG Xiao-ling ZHANG Shu-juan LIN Jian-xin XU Jiao-xing FU Wu-jun WEI ke-mei National Engineering Research Center of Chemical Fertilizer Catalyst Fuzhou UniversityFuzhou 350002P.R.China

Ten kinds of activated carbon from different raw materials were used as supports to prepare ruthenium catalysts. N_2 physisorption and CO chemisorption were carried out to investigate the pore size distribution and the ruthenium dispersion of the catalysts. It was found that the Ru dispersion of the catalyst was closely related to not only the texture of carbon support but also the purity of activated carbon. The activities of a series of the carbon-supported barium-promoted Ru catalysts for ammonia synthesis were measured at 425 ℃, 10 0 MPa and 10 000 h -1. The result shows that the same raw material activated carbon, with a high purity, high surface area, large pore volume and reasonable pore size distribution might disperse ruthenium and promoter sufficiently, which activated carbon as support, could be used to manufacture ruthenium catalyst with a high activity for ammonia synthesis. The different raw material activated carbon as the support would greatly influence the catalytic properties of the ruthenium catalyst for ammonia synthesis. For example, with coconut shell carbon(AC1) as the support, the ammonia concentration in the effluent was 13 17% over 4%Ru-BaO/AC1 catalyst, while with the desulfurized coal carbon(AC10) as the support, that in the effluent was only 1 37% over 4%Ru-BaO/AC10 catalyst.

关键词： Activated carbon Ruthenium Supported catalyst Ammonia synthesis

The Chemical Reactions of 11-Hydroxycephalotaxine

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Chinese Chemical Letters 2000年第6期11卷 489-492页

作者： Chuan Pin ZOU ke mei WU Liang HUANG (Institute of Materia Medica, Chinese Academy of Medical Sciences,Peking Union Medical College, Beijing 10050) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College

Some of the chemical reactions of 11-hydroxycephalotaxine 1, which were encountered during the derivation of 1 and the related compounds were reported.

关键词： 11-hydroxycephalotaxine structural modification

Construction of multifunctional lanthanum manganese mixed nanoparticles mediated by ionic liquids for selective aerobic oxidation of cyclohexane

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Rare Metals 2024年第5期43卷 2205-2221页

作者： Hao Li Rui-Rui Zhang ke-Xin Li Shuang Wei Yu-mei Liu Rui-Xia Liu Beijing key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Selective oxidation of alkanes to produce highvalue chemicals is an essential strategy and means to realize efficient utilization of *** this work,a strategy of lanthanum manganese mixed metal oxides(LMMO)regulated via a facile ionic liquid(IL)-assisted hydrothermal method was proposed to construct the multifunctional catalysts,which exhibited excellent catalytic performance in the selective aerobic oxidation of *** 8.9%cyclohexane conversion with 90%KA oi(cyclohexanol and cyclohexanone)selectivity was achieved over the optimal LMMO catalyst under mild *** effects of anion type,carbon chain length and concentration of ILs on the structure and properties of catalysts were investigated through various characterizations,indicating the structure-directing and template effect of ILs on the multifunctional *** formation of self-assembled spherical nanoparticles followed the"dissolution-nucleation-proliferation"mechanism with the introduction of 1-butyl-3-methylimidazolium hydrogen sulfate,ascribing the synergistic effect between the microenvironment of ILs and the hydrothermal ***,the high reactive oxygen concentration redox capacity,and suitable basic sites of LMMO catalysts mediated by ILs enhance the activation of C-H bonds and molecular oxygen,simultaneously influencing the adsorption and desorption of the substrate.A comprehensive understanding of the high KA oil selectivity and radical reaction mechanism was elucidated based on in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)and radical trapping *** recycling and regeneration experiments further illuminated that the removal of adsorbed cyclohexanone acting on the LMMO catalyst was the key to achieve high KA oil selectivity.

关键词： Ionic liquids Nanoparticle Multifunctional catalyst Cyclohexane oxidation

Study of Intramolecular Cyclization of N-styryl-oxo-cinnamides (Ⅱ)

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Chinese Chemical Letters 1998年第3期9卷 235-236页

作者： Nian Chun MA ke mei WU and Liang HUANG(Institute of Materia Medica Chinese Academy of Medical Sciences,Peking Union Medical College, Beijing 100050) Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

The preparations and intramolecular cyclizations of amides 5, (N-methyl-N-(2 - trans-2-phenylethenyl)-3-phenyl-2, 3-cis-oxiranecarboxamide) and 8, (N-methyl-N-(2-cis-2-phenylethenyl ) - 3 -pheny 1-2, 3 - cis -oxiranec... 详细信息

关键词： intramolecular cyclization cis-oxirane cis-ene trans-ene

INSERTION OF PTC-GENERATED DICHLOROCARBENE INTO C-B BO ND.A FACILE SYNTHESIS OF keTONES FROM ALkeNES VIA ORGANOBORATES

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Chinese Chemical Letters 1993年第6期4卷 471-474页

作者： De Jie ZHAO Tian Yi ke Chang mei ke Zi Xing SHAN Chemistry Department,Wuhan University,Wuhan 430072

The insertion of dichlorocarbene generated from chloroform by Phase Transfer Catalysis(PTC)into carbon-boron bond of dialkylborate anions 3,obtained by method A and B,resulted in the formation of the inter- mediates 5... 详细信息

关键词： CI INSERTION OF PTC-GENERATED DICHLOROCARBENE INTO C-B BO ND.A FACILE SYNTHESIS OF keTONES FROM ALkeNES VIA ORGANOBORATES PTC CHC TEBA OH BO ND VIA

Identification of functional genes regulating gastric cancer progression using integrated bioinformatics analysis

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World Journal of Clinical Cases 2023年第21期11卷 5023-5034页

作者： Kun Yu Dong Zhang Qiang Yao Xing Pan Gang Wang Hai-Yang Qian Yao Xiao Qiong Chen ke mei Department of Radiology Shanghai Xuhui Dahua HospitalShanghai 200090China Department of Spinal Surgery Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200090China Division of Chemistry and Ionizing Radiation Measurement Technology Shanghai Institute of Measurement and Testing TechnologyShanghai 200090China

BACKGROUND Gastric cancer(GC)is one of the most common cancers and has a poor *** of GC has remained unchanged over the past few *** To investigate the potential therapeutic targets and related regulatory biomarkers of *** We obtained the public GC transcriptome sequencing dataset from the Gene Expression Omnibus *** datasets contained 348 GC tissues and 141 healthy *** total,251 differentially expressed genes(DEGs)were identified,including 187 down-regulated genes and 64 up-regulated *** DEGs’enriched functions and pathways include Progesterone-mediated oocyte maturation,cell cycle,and oocyte meiosis,Hepatitis B,and the Hippo signaling *** analysis showed that BUB1,MAD2L1,CCNA2,CCNB1,and BIRC5 may be associated with regulation of the cell cycle phase mitotic spindle checkpoint *** selected 26 regulated genes with the aid of the protein-protein interaction network analyzed by Molecular Complex *** We focused on three critical genes,which were highly expressed in GC,but negatively related to patient ***,we found that knockdown of Yu K et *** analysis in GC WJCC https://*** 5024 July 26,2023 Volume 11 Issue 21 BIRC5,TRIP13 or UBE2C significantly inhibited cell proliferation and induced cell *** addition,knockdown of BIRC5,TRIP13 or UBE2C increased cellular sensitivity to *** Our study identified significantly upregulated genes in GC with a poor prognosis using integrated bioinformatics methods.

关键词： Gastric cancer Bioinformatics analysis Differentially expressed gene Protein-protein interaction network Cisplatin resistance