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安徽农业科学 2014年第25期42卷 8486-8487,8491页

作者：姚然柯建宏昆明理工大学机电工程学院云南昆明650093

分析了模糊控制应用在小型花卉温室中的优越性。利用Matlab对整个模糊控制系统进行了仿真试验。研究表明,模糊控制不仅能将温度恒定在一个确定范围,而且能体现温度控制平稳,控制超调量小的特点。

关键词：模糊控制 Matlab 温度控制

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui Ye Xue-Zhi Zhang jian-Xiang Liu hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

基于Flash ActionScript机械加工误差统计分析实验的设计与开发

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制造业自动化 2012年第13期34卷 125-129页

作者：郭德伟江洁闵洁柯建宏昆明理工大学机电工程学院昆明650093 红河学院工学院蒙自661100

采用Flash ActionScript技术并结合Pro/E软件设计开发了一套机械加工误差统计分析虚拟实验系统软件,实现对实验样本数据的外部输入处理,或自动生成具有一定规律的随机样本数据,并能根据误差统计分析实验要求,自动绘制出相应的分布图或... 详细信息

采用Flash ActionScript技术并结合Pro/E软件设计开发了一套机械加工误差统计分析虚拟实验系统软件,实现对实验样本数据的外部输入处理,或自动生成具有一定规律的随机样本数据,并能根据误差统计分析实验要求,自动绘制出相应的分布图或点图图形,达到实验教学目的。

关键词： ActionScript 加工误差 6σ理论虚拟实验机械教学

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单组元聚集体的聚集——迁移的模型

温州师范学院学报 2005年第2期26卷 43-46页

作者：许道岳柯见洪温州师范学院物理与电子信息学院浙江温州325027

提出了可逆迁移过程和不可逆聚集过程共存的聚集体生长模型.假定聚集反应速率核为I(i;j)=2I,迁移反应速率核为K(i;j)=Jij或K(i;j)=Jj.建立Smoluchowski速率方程,由此求出了系统的集团浓度分布的精确解.结果表明,集团浓度分布符合标度特性.

关键词：动力学行为聚集过程迁移标度规律

基于Flash ActionScript技术的齿轮范成虚拟实验

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制造业自动化 2012年第18期34卷 56-58页

作者：郭德伟柯建宏江洁苏艳萍红河学院工学院蒙自661100 昆明理工大学机电工程学院昆明650093

高校网络虚拟实验室的建设已成为学校信息化的一个重要指标,其中的关键便是虚拟实验的设计。采用ActionScript技术开发了一套齿轮范成实验系统软件,能直观、动态地模拟齿轮范成加工情况,并能充分展示齿轮设计参数对于渐开线齿廓曲线的... 详细信息

高校网络虚拟实验室的建设已成为学校信息化的一个重要指标,其中的关键便是虚拟实验的设计。采用ActionScript技术开发了一套齿轮范成实验系统软件,能直观、动态地模拟齿轮范成加工情况,并能充分展示齿轮设计参数对于渐开线齿廓曲线的影响规律。该软件能较好地克服传统机械范成仪的不足,更好地达到实验教学目的。

关键词： ActionScript 齿轮范成渐开线齿轮虚拟实验机械教学

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基于华中数控的椭球宏程序编程研究

价值工程 2014年第31期33卷 66-67页

作者：位建伟柯建宏张小岚昆明理工大学昆明650500 昆明市农业局昆明650500

在实际生产中,参数化数控程序只需要修改相应的参数即可完成一类零件的加工。椭球是一类典型的零件,根据椭球的数学方程很容易定义椭球的变量参数,因此极适合参数化生产。本文以椭球为例,利用椭球的参数方程讲述椭球的参数化编程方法。

关键词：椭球参数方程宏程序参数化

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小型花卉玻璃温室温度模糊控制系统建模研究

安徽农业科学 2015年第26期43卷 373-375页

作者：黄茂启柯建宏吴肖龙昆明理工大学机电工程学院云南昆明650500

运用模糊控制原理,针对一种小型花卉玻璃温室设计了一个温度模糊控制模型,用Matlab进行了模糊控制过程仿真,通过对仿真所得结果进行分析和程序的修改,修订模糊控制规则,最终设计出一个模糊控制器。研究表明,该方法可为温室温度模糊控制... 详细信息

运用模糊控制原理,针对一种小型花卉玻璃温室设计了一个温度模糊控制模型,用Matlab进行了模糊控制过程仿真,通过对仿真所得结果进行分析和程序的修改,修订模糊控制规则,最终设计出一个模糊控制器。研究表明,该方法可为温室温度模糊控制系统设计提供参考。

关键词：温室控制模糊控制器 Matlab

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang jian Wu Hui hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin hong-Lian Wang Yun-Feng Wang Fan Yang jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

不同类型玉米自交系数量性状配合力及聚类分析

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西南农业学报 2012年第2期25卷 379-384页

作者：邱正高祁志云雷开荣袁亮张亚勤柯剑鸿吴红杨华重庆市农业科学院玉米研究所重庆401329 重庆市农业科学院生物技术研究中心重庆401329 重庆市玉米工程技术中心重庆401329

以13个不同类型的玉米自交系为材料,按格林芬方法Ⅱ遗传交配设计,分析了数量性状的遗传效应;采用SSR标记对这13个自交系及5个对照自交系进行了聚类分析。结果表明:自交系CML162、S181、HN06-10、S147、掖478综合性状配合力表现优良;控... 详细信息

以13个不同类型的玉米自交系为材料,按格林芬方法Ⅱ遗传交配设计,分析了数量性状的遗传效应;采用SSR标记对这13个自交系及5个对照自交系进行了聚类分析。结果表明:自交系CML162、S181、HN06-10、S147、掖478综合性状配合力表现优良;控制轴粗、穗行数、单粒厚度、百粒重、出籽率和秃尖6个性状的遗传以基因加性效应为主;控制株高、穗位高、穗长、穗粗、行粒数、粒长、单穗粒重7个性状的遗传以基因非加性效应为主。根据品种间的分子遗传多态性,将18个自交系划分成7个类群:丹340、渝5、HN06-10为一类;B73、掖478、京甜、CML162为一类;MO17、太191o2、青贮、S147为一类;HZ4(黄早四)单独为一类;齐319、S181、郑爆裂为一类;GY302、GY923为一类;泰甜独立成一类。

关键词：玉米自交系数量性状配合力聚类分析