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Impact of the origin of sinus node artery on recurrence after pulmonary vein isolation in patients with paroxysmal atrial fibrillation

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Chinese Medical Journal 2013年第9期126卷 1624-1629页

作者： ZHANG Zhi-jun CHEN ke TANG Ri-bo SANG Cai-hua Edmundo Patricio Lopes Lao YAN Qian HE Xiao-nan DU Xin LONG De-yong YU Rong-hui DONG Jian-zeng MA Chang-sheng Department of Cardiology Center for Atrial Fibrillation BeijingAnzhen Hospital Capital Medical University Beijing Instituteof Heart Lung and Blood Vessel Diseases Beijing 100029 China

Background Major atrial coronary arteries, including the sinus node artery （SNA）, were commonly found in the areas involved in atrial fibrillation （AF） ablation and could cause difficulties in achieving linear block at the left atrial （LA） roof. The SNA is a major atrial coronary artery of the atrial coronary circulation. This study aimed to determine impact of the origin of SNA on recurrence of AF after pulmonary vein isolation （PVI） in patients with paroxysmal AF. Methods Seventy-eight patients underwent coronary angiography for suspected coronary heart disease, followed by catheter ablation for paroxysmal AF. According to the origin of SNA from angiographic findings, they were divided into right SNA group （SNA originating from the right coronary artery） and left SNA group （SNA originating from the left circumflex artery）. Guided by an electroanatomic mapping system, circumferential pulmonary vein ablation （CPVA） was performed in both groups and PVI was the procedural endpoint. All patients were followed up at 1, 3, 6, 9 and 12 months post-ablation. Recurrence was defined as any episode of atrial tachyarrhythmias （ATAs）, including AF, atrial flutter or atrial tachycardia, that lasted longer than 30 seconds after a blanking period of 3 months. Results The SNA originated from the right coronary artery in 34 patients （43.6%） and the left circumflex artery in 44 patients （56.4%）. Freedom from AF and antiarrhythmic drugs （AADs） at 1 year was 67.9 % （53/78） for all patients. After 1 year follow-up, 79.4% （27/34） in right SNA group and 59.1% （26/44） in left SNA group （P=0.042） were in sinus rhythm. On multivariate analysis, left atrium size （HR=1.451, 95%Cl： 1.240-1.697, P 〈0.001） and a left SNA （HR=6.22, 95%Cl： 2.01-19.25, P=0.002） were the independent predictors of AF recurrence. Conclusions The left SNA is more frequent in the patients with paroxysmal AF. After one year follow-up, the presence of a left SNA was identified as an independent predictor of AF recurrence a

关键词： atrial fibrillation catheter ablation coronary angiography recurrence sinus node artery

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OsNAC5 orchestrates OsABI5 to fine-tune cold tolerance in rice

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Journal of Integrative Plant Biology 2024年第4期66卷 660-682页

作者： Ruiqing Li Yue Song Xueqiang Wang Chenfan Zheng bo Liu Huali Zhang Jian ke Xuejing Wu Liquan Wu Ruifang Yang Meng Jiang College of Agronomy Anhui Agricultural UniversityHefei 230036China Hainan Institute Yazhou Bay Sci-Tech CityZhejiang UniversitySanya 572025China National key Laboratory of Rice Biology Advanced Seed InstituteZhejiang UniversityHangzhou 311225China State key Laboratory of Rice Biology and Chinese National Center for Rice Improvement China National Rice Research InstituteHangzhou 311401China key Laboratory of Germplasm Innovation and Genetic Improvement of Grain and Oil Crops(Co-Construction by Ministry and Province) Ministry of Agriculture and Rural AffairsCrop Breeding and Cultivation Research InstituteShanghai Academy of Agricultural SciencesShanghai 201106China

Due to its tropical origins,rice(Oryza sativa)is susceptible to cold stress,which poses severe threats to ***5,a NAC-type transcription factor,participates in the cold stress response of rice,but the detailed mechanisms remain poorly ***,we demonstrate that OsNAC5 positively regulates cold tolerance at germination and in seedlings by directly activating the expression of ABSCISIC ACID INSENSITIVE 5(OsABI5).Haplotype analysis indicated that single nucleotide polymorphisms in a NAC-binding site in the OsABI5 promoter are strongly associated with cold ***5 also enhanced OsABI5 stability,thus regulating the expression of cold-responsive(COR)genes,enabling fine-tuned control of OsABI5 action for rapid,precise plant responses to cold *** affinity purification sequencing coupled with transcriptome deep sequencing identified several OsABI5 target genes involved in COR expression,including DEHYDRATION-RESPONSIVE ELEMENT BINDING FACTOR 1A(OsDREB1A),OsMYB20,and PEROXIDASE 70(OsPRX70).In vivo and in vitro analyses suggested that OsABI5 positively regulates COR gene transcription,with marked COR upregulation in OsNAC5-overexpressing lines and downregulation in osnac5 and/or osabi5 knockout *** study extends our understanding of cold tolerance regulation via OsNAC5 through the OsABI5-CORs transcription module,which may be used to ameliorate cold tolerance in rice via advanced breeding.

关键词： ABA signaling ABI5 cold tolerance DREB NAC5 rice

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Triple three-dimensional MS/MS spectrum facilitates quantitative ginsenosides-targeted sub-metabolome characterization in notoginseng

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 4045-4058页

作者： Zhang, ke Jia, Jinru Li, Ting Liu, Wenjing Tu, Pengfei Wan, Jian-bo Li, Jun Song, Yuelin Beijing Univ Chinese Med Beijing Res Inst Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China SCIEX China Beijing 100015 Peoples R China Henan Univ Chinese Med Sch Pharm Zhengzhou 450046 Peoples R China Univ Macau Inst Chinese Med Sci State Key Lab Qual Res Chinese Med Taipa 999078 Macao Peoples R China

Although serving as the workhorse, MS/MS cannot fully satisfy the analytical requirements of quantitative sub-metabolome characterization. Because more information intrinsically correlates to more structural and concentration clues, here, efforts were devoted to comprehensively tracing and deciphering MS/MS behaviors through constructing triple three-dimensional (3x3D)-MS/MS spectrum. Ginsenosides-targeted metabolomics of notoginseng, one of the most famous edible medicinal plants, was employed as a proof-of-concept. Serial authentic ginsenosides were deployed to build the correlations between 3x3D-MS/MS spectra and structure/concentration features. Through assaying ginsenosides with progressive concentrations using QTOF-MS to configure 1(st) 3D spectrum, the generations of MS1 spectral signals, particularly multi-charged multimer anions, e.g., [2M-2H](2-) and [2M+2HCOO](2-) ions, relied on both concentration and the amount of sugar chains. By programming progressive collision energies to the front collision cell of Qtrap-MS device to gain 2(nd) 3D spectrum, optimal collision energy (OCE) corresponding to the glycosidic bond fission was primarily correlated with the masses of precursor and fragment ions and partially governed by the glycosidation site. The quantitative relationships between OCEs and masses of precursor and fragment ions were utilized to build large-scale quantitative program for ginsenosides. After applying progressive exciting energies to the back collision chamber to build 3(rd) 3D spectrum, the fragment ion and the decomposition product anion exhibited identical dissociation trajectories when they shared the same molecular geometry. After ginsenosides-focused quantitative metabolomics, significant differences occurred for sub-metabolome amongst different parts of notoginseng. The differential ginsenosides were confirmatively identified by applying the correlations between 3x3D-MS/MS spectra and structures. Together, 3x3D-MS/MS spectrum covers all

关键词： Quantitative sub- metabolome characterization Ginsenosides Structural identification Notoginseng Full exciting energy ramp- MS3 spectrum MASS-SPECTROMETRY PANAX-NOTOGINSENG NATURAL COMPOUNDS IDENTIFICATION CHROMATOGRAPHY STRATEGY GINSENG TECHNOLOGY DISCOVERY SAPONINS

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扩大经鼻-经鞍结节入路神经内镜手术治疗鞍上Rathke's囊肿的疗效分析

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中国临床神经外科杂志 2024年第1期29卷 4-7页

作者：李倩武丹洋宋东昊杨绍成续岭柯代波谢明祥肖顺武遵义医科大学附属医院神经外科贵州遵义563000

目的探讨鞍上Rathke’s囊肿(RCCs)的临床特点及扩大经鼻-经鞍结节入路神经内镜手术的疗效。方法回顾性分析2018年10月至2021年8月收治的11例鞍上RCCs的临床资料,均行扩大经鼻-鞍结节入路神经内镜手术治疗。结果根据影像学特征及神经内... 详细信息

目的探讨鞍上Rathke’s囊肿(RCCs)的临床特点及扩大经鼻-经鞍结节入路神经内镜手术的疗效。方法回顾性分析2018年10月至2021年8月收治的11例鞍上RCCs的临床资料,均行扩大经鼻-鞍结节入路神经内镜手术治疗。结果根据影像学特征及神经内镜下探查分型:鞍上型7例,脚间池型2例,垂体柄型1例,混合型1例。入院血清泌乳素增高5例、头痛10例、视力受损5例、月经紊乱2例,术后均改善。术后随访0.5~30个月,出现迟发性脑脊液鼻漏1例、蝶窦脓肿1例,无囊肿复发。结论鞍上RCCs易出现症状,根据术前头颅MRI和术中神经内镜表现进行分型,有利于术中对囊周结构的保护,并制定有效手术方案。在掌握颅底重建技术基础上,经鼻-鞍结节扩大入路神经内镜手术治疗鞍上RCCs是安全的、有效的,而且创伤较小。

关键词：鞍上Rathke’s囊肿神经内镜手术扩大经鼻-鞍结节入路疗效

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Stromal lenticule addition keratoplasty with corneal crosslinking for corneal ectasia secondary to FS-LASIK:a case series

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 596-602页

作者： Li-Xiang Wang Ying-Ping Deng Meng-Zhen Xie ke Ma Hong-bo Yin Qiong Wang Rui Gong Jing Tang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina

●AIM:To explore the clinical efficacy and safety of stromal lenticule addition keratoplasty(SLAK)with corneal crosslinking(CXL)on patients with corneal ectasia secondary to femtosecond laser-assisted in situ keratomileusis(FS-LASIK).●METHODS:A series of 5 patients undertaking SLAK with CXL for the treatment of corneal ectasia secondary to FS-LASIK were followed for *** lenticules were collected from patients undertaking small incision lenticule extraction(SMILE)for the correction of *** a stromal lenticule was aimed at improving the corneal thickness for the safe application of crosslinking and compensating for the thin cornea to improve its mechanical strength.●RESULTS:All surgeries were conducted successfully with no significant *** best corrected visual acuity(BCVA)ranged from 0.05 to 0.8-2 before *** pre-operational total corneal thickness ranged from 345-404μm and maximum keratometry(Kmax)ranged from 50.8 to *** the combination surgery,both the corneal keratometry(range 55.9 to 92.8)and total corneal thickness(range 413-482μm)significantly *** out of 5 patients had improvement of corneal biomechanical parameters(reflected by stiffness parameter A1 in Corvis ST).However,3 patients showed decreased BCVA after surgery due to the development of irregular astigmatism and transient *** the onset of corneal edema right after SLAK,the corneal topography and thickness generally stabilized after 3mo.●CONCLUSION:SLAK with CXL is a potentially beneficial and safe therapy for advanced corneal *** work needs to address the poor predictability of corneal refractometry and compare the outcomes of different surgical modes.

关键词： corneal ectasia femtosecond laserassisted in situ keratomileusis stromal lenticule addition keratoplasty corneal crosslinking corneal thickness corneal biomechanics

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一类笛卡尔乘积图的等周数

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大连理工大学学报 2005年第5期45卷 762-765页

作者：吕可波杨家亮王军大连理工大学应用数学系

等周数是互联网络的一个重要参数,它与图的连通性和二部带宽等参数密切相关.A z izog lu和Egec iog lu运用嵌入的方法得到了形如Pk×Pk×…×Pk的笛卡尔乘积图的等周数.通过将S嵌入以V(S)为顶点的完全有向图Kd(d=V(S))的方法给出i(S)的... 详细信息

等周数是互联网络的一个重要参数,它与图的连通性和二部带宽等参数密切相关.A z izog lu和Egec iog lu运用嵌入的方法得到了形如Pk×Pk×…×Pk的笛卡尔乘积图的等周数.通过将S嵌入以V(S)为顶点的完全有向图Kd(d=V(S))的方法给出i(S)的下界,将上述嵌入方法推广,从而得到了形如Pl1×Pl2×…×Pla×Cm1×Cm2×…×Cmb×Kn1×Kn2×…×Knc的笛卡尔乘积图的等周数.讨论了笛卡尔乘积图的等周数与二部带宽和Cheeger常数之间的关系,并给出了循环图Ck的d重直积图的等周数.

关键词：等周数笛卡尔乘积图二部带宽

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Gut microbiota induced abnormal amino acids and their correlation with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 883-895页

作者： Sheng-Qun Jiang Su-Na Ye Yin-Hua Huang Yi-Wen Ou ke-Yang Chen Jian-Su Chen Shi-bo Tang Aier Eye Hospital Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Aier Eye Institute and Changsha Aier Hospital Changsha 410000Hunan ProvinceChina The First Affiliated Hospital of Bengbu Medical University Bengbu 233000Anhui ProvinceChina School of Public Health Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To explore the correlation of gut microbiota and the metabolites with the progression of diabetic retinopathy(DR)and provide a novel strategy to elucidate the pathological mechanism of ***:The fecal samples from 32 type 2 diabetes patients with proliferative retinopathy(PDR),23 with nonproliferative retinopathy(NPDR),27 without retinopathy(DM),and 29 from the sex-,age-and BMI-matched healthy controls(29 HC)were analyzed by 16S rDNA gene *** fecal samples from PDR,DM,and HC groups were assayed by untargeted *** metabolites were measured using liquid chromatographymass spectrometry(LC-MS)*** between gut microbiota and fecal metabolites were ***:A cluster of 2 microbiome and 12 metabolites accompanied with the severity of DR,and the close correlation of the disease progression with PDR-related microbiome and metabolites were *** be specific,the structure of gut microbiota differed in four *** and richness of gut microbiota were significantly lower in PDR and NPDR groups,than those in DM and HC groups.A cluster of microbiome enriched in PDR group,including Pseudomonas,Ruminococcaceae-UCG-002,Ruminococcaceae-UCG-005,Christensenellaceae-R-7,was *** analysis showed that the glucose and nicotinate degradations were significantly higher in PDR group than those in HC ***,serine,ornithine,and arachidonic acid were significantly enriched in PDR group,while proline was enriched in HC *** analysis illustrated that arginine biosynthesis,lysine degradation,histidine catabolism,central carbon catabolism in cancer,D-arginine and D-ornithine catabolism were elevated in PDR *** analysis revealed that Ruminococcaceae-UCG-002 and Christensenellaceae-R-7 were positively associated with L-arginine,ornithine levels in fecal ***:This study elaborates the different microbiota structure in the gut from four *** relative abundance of

关键词： proliferative retinopathy gut microbiota Ruminococcaceae amino acid metabolism arginine

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Phase transformation and damping behavior of lightweight porous TiNiCu alloys fabricated by powder metallurgy process

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Transactions of Nonferrous Metals Society of China 2013年第7期23卷 2029-2036页

作者：江鸿杰柯常波曹姗姗马骁张新平华南理工大学材料科学与工程学院广州510640

Porous TiNiCu ternary shape memory alloys （SMAs） were successfully fabricated by powder metallurgy method. The microstructure, martensitic transformation behavior, damping performance and mechanical properties of the fabricated alloys were intensively studied. It is found that the apparent density of alloys decreases with increasing the Cu content, the porous Ti50Ni40Cu10 alloy exhibits wide endothermic and exothermic peaks arisen from the hysteresis of martensitic transformations, while the porous Ti50Ni30Cu20 alloy shows much stronger and narrower endothermic and exothermic peaks owing to the B2-B19 transformation taking place easily. Moreover, the porous Ti50Ni40Cu10 alloy shows a lower shape recovery rate than the porous Ti50Ni50 alloy, while the porous Ti50Ni30Cu20 alloy behaves reversely. In addition, the damping capacity （or internal friction, IF） of the porous TiNiCu alloys increases with increasing the Cu content. The porous Ti50Ni30Cu20 alloy has very high equivalent internal friction, with the maximum equivalent internal friction value five times higher than that of the porous Ti50Ni50 alloy.

关键词： porous TiNiCu alloys powder metallurgy martensitic transformation damping behavior

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