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Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping

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World Journal of Gastroenterology 2005年第33期11卷 5129-5135页

作者： Yasuhide Yamashita Kazuhiro Nishida Takashi Okuda Kenichi Nomura Yosuke Matsumoto Shoji Mitsufuji shigeo Horiike Hiroyuki Hata Chohei Sakakura Akio Hagiwara Hisakazu Yamagishi Masafumi Taniwaki Department of Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Department of Hematology and Oncology Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Second Department of Internal Medicine Kumamoto University School of Medicine Kumamoto 860-8555 Japan Department of Digestive Surgery Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Department of Clinical Molecular Genetics and Laboratory Medicine Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan

AIM: To identify chromosomal translocations specific to gastric cancer (GC), spectral karyotyping (SKY) analysis was performed on established cell lines and cancerous ascitic ***: SKY analysis of 10 established cell lines and seven cancerous ascitic fluid samples identified recurrent chromosomal breakpoints and translocations in GC,several of which involved chromosomal loci of oncogenes or tumor suppressor ***: A total of 630 chromosomal breaks were identified. Chromosome no.8 was the most frequently involved in rearrangements (65 breaks), followed by chromosomes no. 11 (53), no. 1 (49), no. 7 (46), no. 13 (37), no. 3 (36), no. 17 (33), and no. 20 (29). Frequent breakpoints were detected in 8q24.1 (30 breaks), 11q13 (29), 13q14 (16), 20q11.2 (14), 7q32 (13), 17q11.2 (13),18q21 (12), 17q23 (9), 18q11.2 (9). SKY analysis identified a total of 242 chromosomal rearrangements including 190 reciprocal and non-reciprocal translocations. The recurrent combinations of chromosomal bands involved in translocations were 8q24.1 and 13q14 (3 cases), 8q24.1 and 11q13 (3), 11q13 and 17q11.2 (2), and 18q11.2 and 20q11.2 (2). Our study validated the ability of SKY to characterize in detail the chromosomal rearrangements in solid tumors and derived cell lines. Moreover,fluorescence in situ hybridization helped to identify the insertions, translocations, and homogeneously staining regions of MYCand CCND1 gene ***: The non-random co-localization of certain cytogenetic bands suggests the importance of chromosomal translocations in gastric carcinogenesis, by serving as landmarks for the cloning of GC causing genes.

关键词： Gastric cancer SKY FISH Chromosomaltranslocation

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Fractionation of gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease

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World Journal of Hepatology 2016年第36期8卷 1610-1616页

作者： shigeo Sueyoshi Setsu Sawai Mamoru Satoh Masanori Seimiya Kazuyuki Sogawa Atsushi Fukumura Mikihiro Tsutsumi Fumio Nomura Department of Molecular Diagnosis Graduate School of Medicine Chiba University Clinical Proteomics Research Center Chiba University Hospital Department of Hepatology Kanazawa Medical University

AIM To assess how serum gamma-glutamyltransferase(GGT) fractions vary in patients with alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD). METHODS Serum samples were obtained from 14 patients with biopsy-proven alcoholic liver diseases and 9 patients with biopsy proven non-alcoholic fatty liver disease. In addition to these biopsy-proven cases, 16 obese(body mass index > 25) patients without any history of alcohol consumption but with a fatty liver on ultrasound examination and with elevated GGT were included for an additional analysis. Serum GGT fractionation was conducted by high-performance gel filtration liquid chromatography and was separated into the four fractions, big-GGT, medium-GGT, small-GGT(s-GGT), and free-GGT(f-GGT).RESULTS The results were expressed as a ratio of each fraction including the total GGT(t-GGT). The s-GGT/t-GGT ratioswere lowest for the control group and highest for the ALD group. The differences between the control and NAFLD groups and also between the NAFLD and ALD groups were statistically significant. In contrast, the f-GGT/t-GGT ratios were highest in the control group and lowest in the ALD group, with the differences being statistically significant. As a result, the s-GGT/f-GGT ratios were markedly increased in the NAFLD group as compared with the control group. The increase of the s-GGT/t-GGT ratios, the decrease of the f-GGT/t-GGT ratios, and the increase of s-GGT/F-GGT ratios as compared with the control group subjects were also found in obese patients with clinically diagnosed fatty change of the *** Serum GGT fractionation by high-performance gel filtration liquid chromatography is potentially useful for the differential diagnosis of ALD and NAFLD.

关键词： Gamma-glutamyltransferase f-GGT/t-GGT ratios Alcoholic liver disease Non-alcoholic fatty liver disease Gel filtration liquid chromatography

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Japanese Community Pharmacists’ Practice Research Literacy

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Pharmacology & Pharmacy 2015年第9期6卷 436-441页

作者： Yasuhiro Sawada Rieko Takehira shigeo Yamamura Faculty of Pharmaceutical Sciences Josai International University Chiba Japan Welcia Yakkyoku Co. Ltd. Tokyo Japan

Objectives: Lack of basic practice research literacy could be considered a barrier to conducting or participating in practice research. Therefore, we examined pharmacy practice research literacy in Japanese community pharmacists. Methods: Community pharmacists (n = 478) who delivered presentations at three major pharmacy-related conferences in 2012 and 2013 completed the survey. We selected 10 key terms related to practice research and asked participants whether they knew the meaning of. Questionnaires were sent to and returned by pharmacists via mail. Results: Of the 478 pharmacists who received questionnaires, 230 (47.9%) completed the survey. The response rates indicating that participants were familiar with the 10 key terms were approximately 50% or lower. The highest response rate was 67.0% for “bias”, and the lowest was 17.0% for “PICO/PECO: Patient-Intervention-Comparison-Outcome/Patient-Exposure-Comparison-Outcome”. Younger pharmacists tended to know several key terms, such as “p values”, “bias”, and “outcome”. Conclusion: Japanese community pharmacists were not knowledgeable with respect to conducting and participating in pharmacy practice research. Practice research knowledge was superior in younger pharmacists. Education in pharmacy schools and continuing professional development programs is important for community pharmacists’ practice research development.

关键词： Pharmacy Practice Research Research Literacy Japanese Community Pharmacists

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Prevalence of Anxiety and Associated Factors among University Students: A Cross-Sectional Study in Japan

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International Journal of Mental Health Promotion 2023年第7期25卷 855-861页

作者： Yoshikiyo Kanada Shota Suzumura Soichiro Koyama Kazuya Takeda Kenta Fujimura Takuma Ii shigeo Tanabe Hiroaki Sakurai Faculty of Rehabilitation School of Health SciencesFujita Health UniversityToyoake4701192Japan Department of Rehabilitation Medicine National Center for Geriatrics and GerontologyObu4748511Japan

Mental health difficulties can impact students’motivation,focus,and ability to communicate with *** attending medical universities are more likely to experience anxiety,depression,and other mood changes for thefirst ***,no study has examined their prevalence among Japanese rehabilitation *** study investigated the prevalence of anxiety among Japanese rehabilitation students and aimed to identify its predictors.A cross-sectional study was conducted among 148first-year physical and occupational therapy students at a private medical university in Japan in June *** on sociodemographic and personal characteristics,such as gender,age,subject major,regular exercise,place of residence,and sleeping hours,were recorded using an original *** included the State-Trait Anxiety Inventory,COVID-19 questionnaire,and Beck Depression Inventory–Second Edition(BDI-II).The results indicated that 83(56%)and 77(52%)students exhibited state anxiety and trait anxiety symptoms,***-four(23%)students experienced mild depressive *** were further determined between gender,subject major,handling of stress,loneliness,satisfaction with life,satisfaction with social connections,anxiety about the future,satisfaction with school life,fulfillment of friendships,and *** variables demonstrated a statistically significant association:handling stress(p<0.05;95%CI 0.409–2.472),satisfaction with life(p<0.01;95%CI 0.500–0.897),anxiety about the future(p<0.01;95%CI 1.397–4.087),and depression(total score of BDI-II,p<0.01;95%CI 1.555–100.742).Our results emphasize that universities must establish a system for early identification and support of anxiety and depression in students.

关键词： Anxiety university students COVID-19 mental health Japan rehabilitation students

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Endocytotic sorting and trafficking control epithelial tube geometry in Drosophila

Endocytotic sorting and trafficking control epithelial tube ...

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细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉

作者：董波 shigeo Hayashi Laboratory for Morphogenetic Signaling Riken Center for Developmental Biology

Apical extracellular matrix filling the lumen controls the morphology and geometry of epithelial tubes, yet the regulation of luminal protein composition and its role in tube morphogenesis are not well ***,we show that an endosomal-retrieval machinery consisting of Rab9,retromer,and actin nucleator WASH regulates selective recycling of the luminal protein Serpentine in the

关键词： retrograde trafficking retromer Rab9 epithelial tube ESCRT

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Successful endoscopic hemostasis for gastric arterial bleeding due to invasion of malignant lymphoma

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World Journal of Gastroenterology 2005年第27期11卷 4285-4286页

作者： Kenichi Nomura Shinya Yamada Daisuke Shimizu Takashi Okuda Yuri Kamitsuji Naohisa Yoshida Yosuke Matsumoto Naoki Wakabayashi Kazuya Mikami shigeo Horiike Takeshi Okanoue Masafumi Taniwaki Masafumi Taniwaki Molecular Gastroenterology and Hepatology Department of Urology Clinical Molecular Genetics and Laboratory Medicine

A 75-year-old male with malignant lymphoma (ML) accompanied with gastric lesion was treated with combination chemotherapy. The patient produced tarry stool on the 4th d, and emergency gastroscopy showed arterial bleeding from the lesion. Hemostasis was achieved by injecting pure ethanol and using hemostatic clips. There is only one previous report on endoscopic hemostasis being effective for bleeding due to lymphoma. Since gastric bleeding causes significant mortality, endoscopic hemostasis should be considered as first-line treatment for ML patients who were treated with chemotherapy.

关键词： Malignant lymphoma Endoscopic hemostasis Pure ethanol injection Hemostatic clips

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Pseudomembranous colitis presenting as acute colonic obstruction without diarrhea in a patient with gastric Burkitt lymphoma

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World Journal of Gastroenterology 2005年第17期11卷 2681-2683页

作者： Kenichi Nomura Kohei Fukumoto Daisuke Shimizu Takashi Okuda Naohisa Yoshida Yuri Kamitsuji Yosuke Matsumoto Hideyuki Konishi Yuji Ueda shigeo Horiike Takeshi Okanoue Masafumi Taniwaki Department of Molecular Hematology and Oncology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Department of Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Department of Inflammation and Immunology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Division of Digestive Surgery Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Department of Molecular Hematology and Oncology Kyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan Department of Clinical Molecular Genetics and Laboratory MedicineKyoto Prefectural University of MedicineGraduate School of Medical ScienceKyotoJapan

Pseudomembranous colitis (PMC) usually manifests asfever and diarrhea in hospitalized patients treated withsystemic antibiotics. We described a case of PMC withintestinal obstruction but without diarrhea. A 60-yearold man was hospitalized for chemotherapy for the treatment of Burkitt lymphoma of the stomach. The patient became febrile and complained of crampy abdominal pain during the post-chemotherapy nadir. Plain abdominal radiography showed some intestinal gas and niveau. Because stool cytotoxin assay for clostridium difficile was positive and colon fiberscopic examination showed a pseudomembrane at the left side of the colon,and a diagnosis of PMC was made. Treatment with intracolonic vancomycin administration by colonoscopy and nasoileus tube was successful. Physicians should take into account the possibility of bowel obstruction due to PMC occurring in patients undergoing chemotherapy and perform emergency colonoscopy examination of suspected cases.

关键词： Pseudomembranous colitis Ileus Vancomycin Chemotherapy Lymphoma

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Effect of a Natural Inulin-Containing Product, “Kikuimo Extract” on Intestinal Microbes and Gene Expression in the Liver and Adipose Tissue of Menopausal Monkeys

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Food and Nutrition Sciences 2016年第9期7卷 752-762页

作者： shigeo Nakayama Fusako Mitsunaga Akira Maeda Shin Nakamura Nihontounyoushoken Co. Ltd. Iida Japan Primate Research Institute Kyoto University Inuyama Japan NPO Primate Agora Inuyama Japan Intelligence and Technology Lab Inc. Kaizu Japan Oasis Co. Ltd. Takarazuka Japan

Inulin is a soluble and indigestible fiber derived from natural plants such as Jerusalem artichoke (Helianthus tuberosus), “Kikuimo”. In the current study, a nutrigenomics approach was utilized to evaluate the in vivo function of “Kikuimo Extract” (KE) in ovariectomized cynomolgus macaque, a post-menopausal non-human primate model. KE was administered orally before feeding, for 3 months for the following examinations: 1) the effect of KE on intestinal microbes was examined by quantitative analyses of the intestinal bacteria using real-time PCR with DNA extracted from monkey feces;2) the effect of KE on gene expression was investigated by real-time RT-PCR using RNA extracted from both the liver and adipose tissue of the monkeys. KE administration modulated menopause-mediated altered microbes to increase Lactobacilli, Veillonella, and Bacteroides in all monkeys. KE administration regulated the altered expression of functional genes, SCAP, LDLR, and LXRA (lipid metabolism);GLUT-4 (glucose transport);CYP1A1 and CYP1A2 (drug metabolism);and CYP-17-2 and CYP-19-2 (E2 synthesis) in the menopausal monkeys. In menopausal monkeys, KE showed potent prebiotic effect on beneficial microflora and regulating effect on altered expression of functional genes associated with metabolism and E2 production. Thus, KE appears to be a practical functional food that alleviates the altered conditions of intestinal microbes and gene expression in the liver and adipose tissue in a menopausal state.

关键词： Functional Food Prebiotics Bacterial DNA Gene Expression

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Factors associated with incomplete colonoscopy at a Japanese academic hospital

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World Journal of Gastroenterology 2014年第22期20卷 6961-6967页

作者： shigeo Koido Toshifumi Ohkusa Kosaburo Nakae Tetsuji Yokoyama Tomoyoshi Shibuya Naoto Sakamoto Kan Uchiyama Hiroshi Arakawa Taro Osada Akihito Nagahara Sumio Watanabe Hisao Tajiri Division of Gastroenterology and Hepatology Department of Internal MedicineThe Jikei University School of MedicineChiba 277-8567Japan Department of Gastroenterology Juntendo University School of MedicineTokyo 113-8421Japan Department of Technology Assessment and Biostatistics National Institute of Public HealthSaitama 351-0197Japan

AIM: To evaluate significant risk factors for incomplete colonoscopy at a Japanese academic hospital.

关键词： Colonoscopy Incomplete Intubation rates Japanese academic hospital Risk factors Inflammatory bowel disease

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铝阳极氧化的极限厚度

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轻金属 1989年第6期 59-64页

作者： shigeo Hoshino shigeomi Matsumoto 周建生

一、绪言作为装饰或防腐底层的铝阳极氧化膜的厚度一般为3～10微米。另一方面,硬质阳极氧化的膜厚从20～100微米。过去不应用厚度超过100微米的氧化膜,因而对这种膜的研究很少。但是近来的发展指出,有时需要应用比以往更厚的氧化膜。

关键词：铝阳极氧化氧化膜极限厚度

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