检索结果-南通市图书馆

Discovery and application of 6π-azaelectrocyclization to natural product synthesis and synthetic biology

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2012年第1期55卷 19-30页

作者： TANAKA Katsunori katsumura shigeo FUKASE Koichi Department of Chemistry Graduate School of ScienceOsaka University1-1 Machikaneyama Department of Chemistry and Open Research Center on Organic Tool Molecules School of Science and TechnologyKwansei Gakuin University

While elucidating the inhibitory mechanism of a hydrolytic enzyme by aldehyde-containing natural product,we discovered a reaction involving a rapid 6π-azaelectrocyclization of azatrienes generated from aldehyde with lysine *** electrocyclic reaction of the 1-azatriene system,a cyclization precursor,exhibited a significant substituent *** chiral piperidine synthesis and a one-pot library synthesis of pyridines on solid-supports were applied to synthesize pyridine/indole alkaloid-type natural ***,we developed lysine-based labeling and engineering of biomolecules and living cells based on the rapid 6π-*** labels and oligosaccharide structures were introduced efficiently and selectively into surface lysines under the mild conditions;notable effects of N-glycans on proteins and living cells were visualized for the first time by PET and noninvasive fluorescence imaging.

关键词： 6π-azaelectrocyclization enzyme inhibition lysine natural product synthesis synthetic biology labeling chemical engineering living cells N-glycan in vivo imaging tumor targeting

Discovery and application of 6π-azaelectrocyclization to natural product synthesis and synthetic biology

在线全文

学校读者我要写书评

暂无评论

中国科学：化学 2012年第2期42卷 197-197页

作者： TANAKA Katsunori katsumura shigeo FUKASE Koichi Department of Chemistry Graduate School of ScienceOsaka University1-1 MachikaneyamaToyonakaOsaka560-0043Japan Department of Chemistry and Open Research Center on Organic Tool Molecules School of Science and TechnologyKwansei Gakuin UniversityGakuen 2-1SandaHyogo 669-1337Japan

关键词：合成生物学天然产物应用生物分子工程取代基效应不对称合成吲哚生物碱赖氨酸

Social acceptance and associated risks of geothermal energy development in East Africa: perspectives from geothermal energy developers

在线全文

学校读者我要写书评

暂无评论

Clean Energy 2024年第5期8卷 20-33页

作者： Abdek Mahamoud Abdi Takehiko Murayama shigeo Nishikizawa Kultip Suwanteep School of Environment and Society Tokyo Institute of Technology226-8502G5-94259 NagatsutaMidori-kuYokohama CityKanagawaJapan Djibouti Office of Geothermal Energy Development PK20 Arta RoadDjibouti cityDjibouti

Social acceptance is a challenging aspect that affects the development of geothermal energy and such issues have been reported in many countries,such as Germany,Japan,Greece,and *** this study,we discuss the barriers to social acceptance and associated risks faced by geothermal energy developers in East *** have conducted semi-structured interviews with international organ-izations(38.5%),public companies(38.5%),and private companies(23.1%).The interviews were qualitatively analysed using inductive content *** key barriers identified by respondents were the lack of political,market,and community awareness;lack of local political support;lack of public funding;human resource shortages;involuntary resettlement;local cultural aspects;employ-ment issues;and demographic *** lack of awareness of geothermal energy affects public and private funding,and leads to negative risk perception by ***,such as air,soil,and water pollution,land acquisition,social exclusion,resource risks,and drilling and project costs,were considered important by our *** this study,we emphasize the need for the following:raising awareness regarding geothermal energy;training professionals;implementing strong surface studies to reduce the risks asso-ciated with the exploration stage;and conducting environmental and social impact assessment reports to mitigate negative risks to local communities,while also ensuring their engagement and raising their awareness about the negative risks of geothermal energy.

关键词： risks social acceptance barriers geothermal energy East African Region

Marangoni-flow-assisted assembly of single-walled carbon nanotube films for human motion sensing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fundamental Research 2024年第3期4卷 570-574页

作者： Yuguang Chen Yitan Li Lu Han Hao Sun Min Lyu Zeyao Zhang shigeo Maruyama Yan Li Key Laboratory for the Physics and Chemistry of Nanodevices Beijing National Laboratory of Molecular SciencesState Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Bruker(Beijing)Scientific Technology Co.Ltd. Beijing 100192China Department of Mechanical Engineering The University of TokyoTokyo 113-8656Japan Peking University Shenzhen Institute Shenzhen 518057China PKU-HKUST ShenZhen-HongKong Institution Shenzhen 518057China

Single-walled carbon nanotubes(SWCNTs)present excellent electronic and mechanical properties desired in wearable and flexible *** preparation of SWCNT films is the first step for fabricating various *** work developed a scalable and feasible method to assemble SWCNT thin films on water surfaces based on Marangoni flow induced by surface tension *** films possess a large area of 40 cm×30 cm(extensible),a tunable thickness of 15∼150 nm,a high transparency of up to 96%,and a decent *** are ready to be directly transferred to various substrates,including flexible *** strain sensors were fabricated with the films on flexible *** sensors worked with high sensitivity and *** realizing multi-functional human motion sensing,including responding to voices,monitoring artery pulses,and detecting knuckle and muscle actions,the assembled SWCNT films demonstrated the potential for application in smart devices.

关键词： Single-walled carbon nanotubes Marangoni flow Assembly Interfaces Sensors

Lithium Ion Transport Environment by Molecular Vibrations in Ion-Conducting Glasses

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第3期7卷 133-142页

作者： Hiroki Yamada Koji Ohara Satoshi Hiroi Atsushi Sakuda Kazutaka lkeda Takahiro Ohkubo Kengo Nakada Hirofumi Tsukasaki Hiroshi Nakajimai Laszlo Temleitner Laszlo Pusztai Shunsuke Ariga Aoto Matsuo Jiong Ding Takumi Nakano Takuya Kimura Ryo Kobayashi Takeshi Usuki Shuta Tahara Koji Amezawa Yoshitaka Tateyama shigeo Mori Akitoshi Hayashi Diffraction and Scattering Division Japan Synchrotron Radiation Research Institute(JASRI)1-1-1 KoutoSayo-choSayo-gun Hyogo 679-5198Japan Faculty of Materials for Energy Shimane University1060Nishi-Kawatsu-ChoMatsue Shimane 690-8504Japan Department of Applied Chemistry Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Institute of Materials Structure Science High Energy Accelerator Research Organization(KEK)203-1 ShirakataTokai-muraNaka-gunlbaraki 319-1106Japan Graduate School of Engineering Chiba University 1-33 Yayoi-cho Inage-kuChiba 263-8522Japan Department of Materials Science Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Wigner Research Centre for Physics Konkoly Thegeút 29-33 H-1121Budapest Hungary International Research Organisation of Advanced Science and Technology(IROAST) Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Department of Applied Physics Nagoya Institute of TechnologyGokisoShowaNagoya 466-8555Japan Faculty of Science Yamagata University1-4-12 KojirakawaYamagata-shiYamagata 990-5860Japan Faculty of Science University of the Ryukyus1 SenbaruNishihara-choOkinawa 903-0213Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Center for Green Research on Energy and Environmental Materials(GREEN)and International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan

Controlling Li ion transport in glasses at atomic and molecular levels is key to realizing all-solid-state batteries,a promising technology for electric *** this context,Li_(3)PS_(4)glass,a promising solid electrolyte candidate,exhibits dynamic coupling between the Li^(+)cation mobility and the PS_(4)^(3-)anion libration,which is commonly referred to as the paddlewheel *** addition,it exhibits a concerted cation diffusion effect(i.e.,a cation-cation interaction),which is regarded as the essence of high Li ion ***,the correlation between the Li^(+)ions within the glass structure can only be vaguely determined,due to the limited experimental information that can be ***,this study reports that the Li ions present in glasses can be classified by evaluating their valence oscillations via Bader analysis to topologically analyze the chemical *** is found that three types of Li ions are present in Li_(3)PS_(4)glass,and that the more mobile Li ions(i.e.,the Li3-type ions)exhibit a characteristic correlation at relatively long distances of ***,reverse Monte Carlo simulations combined with deep learning potentials that reproduce X-ray,neutron,and electron diffraction pair distribution functions showed an increase in the number of Li3-type ions for partially crystallized glass structures with improved Li ion transport *** results show order within the disorder of the Li ion distribution in the glass by a topological analysis of their ***,considering the molecular vibrations in the glass during the evaluation of the Li ion valences is expected to lead to the development of new solid electrolytes.

关键词： electrolytes ionic conductors modeling molecular dynamics

Mixed convection around a heated vertical cylinder embedded in porous medium

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2005年第7期15卷 661-664页

作者： shigeo KIMURA Institute of Nature and Environmental Technology Kanazawa University Japan Kanazawa 920-8667

Numerical simulation has been performed to investigate the combined effects of wake flow pattern and buoyancy on the characteristics of the flow and heat transfer for the mixed convective flow around a vertical cylinder embedded in porous medium. Three-dimensional Darcy’s equations are solved. The discretization procedure for the governing equations is based on the finite-volume method. Peclect number and Rayleigh number are two major independent parameters representing the effects of the flow and heat transfer, respectively. The flow pattern, temperature distribution, and Nusselt number distribution are investigated in wide ranges of these independent parameters. Correlation results for the onset of the secondary flow and enhancement of the heat transfer are presented and discussed.

关键词： mixed convection porous medium numerical simulation vertical heated cylinder lateral flow.

Suicide attempt using potassium tablets for congenital chloride diarrhea:A case report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第8期8卷 1463-1470页

作者： shigeo Iijima Department of Pediatrics Hamamatsu University School of MedicineHamamatsu 4313192Japan

BACKGROUND Congenital chloride diarrhea(CCD)is a rare inherited disorder of intestinal electrolyte transport that results in a large wastage of electrolytes and *** in substitution therapy using sodium chloride(NaCl)and potassium chloride(KCl)have dramatically improved survival for patients with *** KCl is widely prescribed as a potassium supplement;however,it has also occasionally been used in suicide attempts,as potassium poisoning can generate life-threatening *** SUMMARY A 26-year-old female presented to the emergency department(ED)with selfpoisoning,having taken 30 tablets of slow-release KCl(total:240 mmol potassium)following an auditory *** patient had been undergoing substitution therapy with NaCl and KCl for CCD and been followed up in the pediatric *** month prior,she developed insomnia and anxiety and had consulted a *** the ED,although her general condition was good,she appeared *** serum potassium level was 7.0 mmol/L,indicating hyperkalemia,and electrocardiographic changes showed tenting of the *** responded to the administration of calcium gluconate,sodium bicarbonate,and insulin with glucose,and the serum potassium level ***,she was diagnosed with *** In CCD management,physicians should pay careful attention to patients’extraintestinal issues,including psychological disorders that may emerge in adulthood.

关键词： Congenital chloride diarrhea Substitution therapy Suicide Potassium overdose Schizophrenia Case report

Efficient Task Decomposition for Sequential Crowdsourced Task Solving

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2020年第3期29卷 468-475页

作者： JIANG Huan ZUO Min MATSUBARA shigeo National Engineering Laboratory for Agri-product Quality Traceability School of Computer and Information EngineeringBeijing Technology and Business University

In order to facilitate crowdsourcing-based task solving, complex tasks are decomposed into smaller subtasks that can be executed by individual *** task into sequential subtasks attracts a plenty of empirical explorations. The absence of formal studies makes it difficult to provide task requesters with explicit guidelines on task decomposition *** formally present the vertical task decomposition model by specifying the positive quality dependencies among sequential subtasks. Our focus is on addressing solutions of low quality intentionally provided by selfinterested workers who are paid equally or based on their contributions. By combining the theoretical analysis on workers’ strategic behaviors and experimental exploration on the efficiency of task decomposition, our study demonstrates the relationship between the incentive and the worker’s performance, and gives the explicit instructions on vertical task decomposition, which show promise on improving the quality of the final outcome.

关键词： Crowdsourcing Task decomposition Subtask dependence Solution quality Revenue sharing

MDP-Based Budget Allocation for Efficient Cooperative Task Solving

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2017年第5期26卷 966-972页

作者： JIANG Huan ZUO Min MATSUBARA shigeo School of Computer and Information Engineering Beijing Technology and Business University

In order to facilitate crowdsourcing-based task solving,complex tasks are decomposed into interdependent subtasks that can be executed cooperatively by individual *** to maximize the quality of the final solution subject to the self-interested worker’s utility maximization,a key challenge is to allocate the limited budget among the subtasks as the rewards for workers having various levels of *** study is the first attempt to show the value of Markov decision processes(MDPs)for the problem of optimizing the quality of the final solution by dynamically determining the budget allocation on sequentially dependent subtasks under the budget constraints and the uncertainty of the workers’ *** simulation-based approach verifies that compared to some offline methods where workers’ abilities are fully known,our proposed MDP-based payment planning is more efficient at optimizing the final quality under the same limited budget.

关键词： Budget allocation Markov decision processes(MDPs) Cooperative task solving Task quality optimization Crowdsourcing