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Novel applications of statins for bone regeneration

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National Science Review 2015年第1期2卷 85-99页

作者： Sarita R.Shah Caroline A.Werlang f.kurtis kasper Antonios G.Mikos Department of Bioengineering Rice University Department of Chemical and Biomolecular Engineering Rice University

The use of statins for bone regeneration is a promising and growing area of research. Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl, the rate-limiting enzyme of the mevalonate pathway. Because the mevalonate pathway is responsible for the synthesis of a wide variety of important biochemical molecules, including cholesterol and other isoprenoids,the efects of statins are pleiotropic. In particular, statins can greatly afect the process of bone turnover and regeneration via efects on important cell types, including mesenchymal stem cells, osteoblasts, endothelial cells, and osteoclasts. Statins have also been shown to have anti-inlammatory and antimicrobial properties that may be useful since infection can derail normal bone healing. his review will explore the pleiotropic efects of statins, discuss the current use of statins for bone regeneration, particularly with regard to biomaterials-based controlled delivery, and ofer perspectives on the challenges and future directions of this emerging area of bone tissue engineering.

关键词： tissue engineering osteogenesis statin HMG-Co A reductase local delivery

The song remains the same： Juvenile Richardson＇s ground squirrels do not respond differentially to mother＇s or colony member＇s alarm calls

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Current Zoology 2012年第5期58卷 773-780页

作者： James f. HARE kurtis J. WARKENTIN Department of Biological Sciences University of Manitoba Winnipeg MB Canada R3T 2N2 Department of Zoology Brandon University Brandon MB R7A 6A9

Alarm calls are emitted by Richardson＇s ground squirrels Urocitellus richardsonii in response to avian and terrestrial predators. Conspecifics detecting these calls respond with increased vigilance, promoting predator detection and evasion, but in doing so, lose time from foraging. That loss can be minimized if alarm call recipients discriminate among signalers, and weight their response accordingly. for juvenile ground squirrels, we predicted that the trade-off between foraging and vigilance could be optimized via selective response to alarm calls emitted by their own dam, and/or neighboring colony members over calls broad- cast by less familiar conspecifics. Alarm calls of adult female Richardson＇s ground squirrels were elicited in the field using a predator model and recorded on digital audio tape. free-living focal juveniles were subjected to playbacks of a call of their mother, and on a separate occasion a call from either another adult female from their own colony, or an adult female from another colony. Neither immediate postural responses and escape behavior, nor the duration of vigilance manifested by juveniles differed with exposure to alarm calls of the three adult female signaler types. Thus, juveniles did not respond preferentially to alarm calls emitted by their mothers or colony members, likely reflecting the high cost of ignoring alarm signals where receivers have had limited opportunity to establish past signaler reliability [Current Zoology 58 （5）： 773-780, 2012].

关键词： Alarm Signal Communication Maternal Call Recognition Signal Reliability Ground Squirrel Social Discrimination

Liver tumor infiltrating lymphocytes: Comparison of hepatocellular and cholangiolar carcinoma

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World Journal of Gastroenterology 2009年第40期15卷 5053-5057页

作者： Hans-Udo kasper Uta Drebber Dirk Ludger Stippel Hans Peter Dienes Anton Gillessen Department of Pathology Medical CenterClemenshospital Münster Department of Pathology University of Cologne Department of Visceral and Vascular Surgery University of Cologne Department of Gastroenterology Herz-Jesu-Hospital Hiltrup

AIM: To investigate the role of tumor inf iltrating lym-phocytes (TIL) in primary hepatocellular and cholangio-lar carcinomas of the ***: Immunohistochemical analysis was per-formed including antibodies to CD3, CD4, CD8, CD20, CD56 and TIA-1 in formalin-f ixed and paraff in-embed-ded tissue of 35 liver resection specimens of hepatocel-lular or cholangiocellular carcinomas. Semiquantitative evaluation was performed with emphasis on the area of the tumor itself and of the tumor/liver ***: All hepatocellular carcinomas showed in-filtration of lymphocytes predominantly around the tumor in the tumor/liver interface consisting mainly of CD3+ CD4+ T lymphocytes [164.3/10 high power f ields (HPf)] and in the tumor itself of CD8+ cells (54.9/10 HPf). Cholangiocarcinomas contained a heterogeneous amount of TIL, composed mainly of CD3+ T cells with a predominance of CD8+ cells in the tumor tissue (52.6/10 HPf) and of CD4+ cells in the interface region (223.1/10 HPf). CD56+ cells of the innate immune system were scarce. There was no significant difference between hepatocellular or cholangiolar carcinoma. No correlation with the clinicopathological data was seen. CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells indepen-dent of histogenetic origin. Different functions of lym-phocytes in these regions seem possible.

关键词： Liver neoplasms Hepatocellular carcinoma Lymphocytes Immunologic factors Cholangiocarcinoma

Hydrogeochemistry of the Bicaz storage lake, East Carpathians, Romania

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Chinese Journal Of Geochemistry 2006年第B8期25卷 157-158页

作者： Nathalie Gassama Constantin Cocirta Haino Uwe kasper Neculai Al. Apetroaei GéEAC EA 2100 Université Francois Rabelais F-37200 Tours France Institut fuer Geologie und Mineralogie Universitaet Koeln D-50674 Koeln Germany Laboratorul de Acvacultura si Ecologie acvatica Piatra Neamt Universitatea ALI. Cuza RO-700134 lasi Romania

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Harrison's Principles of Internal Medicine (2 Vol Set) 17th ed.

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弓形虫温度敏感变异株疫苗和眼弓形虫病(英文)

2008年

作者： Anthony S. fauci Eugene Braunwald Dennis L. kasper Stephen L. Hauser Dan L. Longo J. Larry Jameson Joseph Loscalzo

ISBN: (纸本)9780071476911

Introducing the most dramatically revised edition of Harrison's ever!Now with NEW bonus DVD with 37 chapters and more than 500 brand new images and video clips! MORE THAN TRUSTED, BEYOND ESSENTIAL . . . !The #1 selling medical textbook worldwide, Harrison's has defined internal medicine for millions of clinicians and students. The new Seventeenth Edition retains Harrison's acclaimed balance of pathobiology, cardinal signs and manifestations of disease, and best approaches to patient management, yet has been massively updated to give you an innovative array of bold new features and content. If ever there was one must-have resource for clinicians and students - this is it!UNMATCHED EXPERTISE AT YOUR fINGERTIPS!As an unprecedented amount of medical information bombards you and your patients, where do you go to sort it out and make sense of it all? When your patients request clarification on something they've “printed off” where do you turn for expert explanations? The same trusted resource physicians and students have turned to for over fifty years: Harrison's Principles of Internal Medicine. Now more than ever, trust Harrison's to filter and clarify the exploding knowledge base, to highlight the breakthroughs, and to deliver a clear, balanced distillation of the best and most current information on which to base clinical *** MOST EXCITING AND EXTENSIVELY REVISED EDITION EVER!Here are just a few of the reasons why the new 17th Edition of Harrison's is the best edition yet:A) Bonus companion DVD featuring:- 37 new “e-chapters"- over 500 brand-new radiological, laboratory- clinical images, including complete atlases- state-of-the-art video clips- an Image Bank of nearly all the illustrations contained in the parent textB) Expanded, modernized illustration program with more than 800 brand-new, additional illustrations-a 60% increase over the previous editionC) Dozens of brand new chapters on vital topics in medical education and clinical practice: Global Issues

关键词： Internal medicine. Internal Medicine.

来源：畅想之星图书光盘版（南... 评论

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弓形虫温度敏感变异株疫苗和眼弓形虫病(英文)

2007年ACC／AHA非心脏手术围手术期心血管评估与管理指南：实施概要

全国寄生虫学与热带医学学术研讨会

作者：吕芳丽黄世光 Lloyd H.kasper 中山大学中山医学院寄生虫学教研室暨南大学医学院达特茅斯医学院医学和微生物学教研室

Ocular toxoplasmosis(OT),a potentially blinding disorder,is the most common cause of human retinochoroiditis *** this study,the role of CD8+,CD4,B cell,and IL-10 gene in the protective immunity of ocular vaccination with the temperature-sensitive mutant of RH Toxoplasma gondii strain(ts-4) and challenge with RH strain was investigated in murine models utilizing inbred C57BL/6 mice-deficient in CD4,CD8,B cells (μMT),or IL-10 ***-normal histology with few tachyzoites was observed in the eyes of wild-type(WT) mice immunized intraperitoneally with the avirulent ts-4 strain followed by intraocular challenge with the RH strain of *** contrast,all mutant mice had partially decreased vaccine-induced resistance associated with increased ocular parasite burdens after RH strain *** inflammation without evidence of necrosis associated with increased parasite burdens were observed in the eyes of CD4 knockout(KO) mice after ***8 KO andμMT mice,as well as IL-10 KO mice,demonstrated increased ocular necrosis in response to ocular *** parasite burden was significantly increased in the eyes of both CD8 KO andμMT mice.A significant increase of the percentages of B cells and CD8 T cells in the draining lymph nodes were observed in WT and IL-10 KO mice after *** expected,there were no increases in the levels of immunoglobulin G in serum or aqueous humor inμMT mice,and there was no increase in the levels of gamma interferon and tumor necrosis factor alpha in the sera of CD4 KO mice after *** results suggest that the attenuated ts-4 of *** inoculated intracamerally can induce ocular protective immunity;mice deficient in CD8,CD4 T cells or B cells exhibit increased ocular parasite burden after challenge;CD4,CD8,B cell, and IL-10 gene are all necessary to the vaccine-induced resistance to ocular challenge by virulent RH strain.

关键词： Toxoplasma gondii Mice Eye Vaccine

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麻醉与镇痛 2010年第6期6卷 1-28页

作者： Lee A fleisher Joshua A Beckman Kenneth A Brown Hugh Calkins Elliott Chaikof Kirsten E fleischmann William K freeman James B froehlich Edward K kasper Judy R Kersten Barbara Riegel John f Robb Sidney C Smith Alice K Jacobs Cynthia D Adams Jeffrey L Anderson Elliott M Antman Christopher E Buller Mark A Creager Steven M Ettinger David P faxon Valentin fuster Jonathan L Halperin Loren f Hiratzka Sharon A Hunt Bruce W Lytle Rick Nishimura Joseph P Ornato Richard L Page Lynn G Tarkington Clyde W Yancy

美国心脏病学院镁国心脏协会工作组有关实践指南的一份报告（编写委员会对2002年非心脏手术围手术期心血管评估指南的修改）

关键词：非心脏手术管理指南血管评估围手术期 ACC/AHA 美国心脏病学院实践指南心脏协会

Chemical characterization of aquifers with the same geological origin

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Chinese Journal Of Geochemistry 2006年第B8期25卷 158-158页

作者： Nathalie Gassama Haino Uwe kasper Aline Dia Nathalie Jendrzejewski Constantin Cocirta Sophie Violette GéEAC EA 2100 Université Francois Rabelais F-37200 Tours France Institut für Geologie und Mineralogie Universitaet Koln D-50674 Koeln Germany UMR 6118 Géosciences Rennes F-35042 Rennes France UMR 704 7 Lab Géochimie des lsotopes Stables IPGP Paris F- 75252 Paris France UMR 7619 Sisyphe Université Pierre et Marie Curie Paris F-75252 Paris France

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ACC／AHA2006年非心脏手术围手术期心血管评估指南更新：关于围手术期β-受体阻滞剂使用的专题更新--美国心脏病学会／美国心脏协会医疗指南工作组报告（非心脏手术围手术期心血管评估2002指南更新编写委员会）

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麻醉与镇痛 2008年第1期4卷 2-10页

作者： Lee A. fleisher, MD, fACC Joshua A. Beckman, MD, fACC Kenneth A. Brown, MD, fACC, fAHA Hugh Calkins, MD, fACC, fAHA EUiott L. Chaikof, MD, PhD Kirsten E. fleischmann, MD, MPH, fACC William K. freeman, MD, fAC James B. froehlich, MD, MPH, fACC Edward K. kasper, MD, fACC Judy K Kersten, MD, fACC Barbara Riegel, DNSc, RN, fAHA John f. Robb, MD, fACC 李恒(译) 阎哲(译) 杨承祥(校) Society for Vascular Medicine and Biology Official Representative American Society of Nuclear Cardiology Official Representative Heart Rhythm Society Official Representative Society for Vascular Surgery Official Representative American Society of Echocardiography Official Representative Society of Cardiovascular Anesthesiologists Official Representative Society for Cardiovascular Angiography and Interventions Official Representative 不详

美国心脏病学会／美国心脏协会（ACC／AHA）医疗指南工作组尽力避免因编写委员会成员与企业的关系或个人利益而导致的任何实际的、可能的，或者是已发现的利益冲突。编写委员会的所有成员以及本文件的同行评议人必须对可能被视为是实际... 详细信息

美国心脏病学会／美国心脏协会（ACC／AHA）医疗指南工作组尽力避免因编写委员会成员与企业的关系或个人利益而导致的任何实际的、可能的，或者是已发现的利益冲突。编写委员会的所有成员以及本文件的同行评议人必须对可能被视为是实际上或是潜在的利益冲突进行声明。工作组对以上声明进行审查。在每次会议上，这些声明必须口头汇报给编写委员会的每位成员；当发生变动时，编写委员会对声明进行更新并再次核查。编写委员会成员和企业的关系见附表1，同行评议人与企业的关系见附表2。本指南旨在确定在大多数情形下满足大部分患者需求的方案。指南反映了对当前可获得的科学文献进行系统分析后专家们达成的共识，其目的在于提高医疗质量。如果将指南用于管理／投资决策，其终极目标应是医疗质量得到提高并服务于患者。关于具体患者的医疗问题，必须由医疗人员和患者根据具体情况共同做出最终决定。Sidney C Smith，Jr．，MD，fACC，fAHA ACC／AHA医疗指南工作组主席Elliot ***，MD，fACC，fAHA

关键词： ACC/AHA 美国心脏病学会美国心脏协会医疗指南 β-受体阻滞剂委员会工作组非心脏手术