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Biochemical association between the prevalence of genetic polymorphism and myocardial infarction

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BIOCELL 2023年第3期47卷 473-484页

作者： MOMINA SHAHID kanwal rehman MUHAMMAD SAJID HAMID AKASH SHALEEM SUHAIL SUMBAL RASHEED MUHAMMAD IMRAN MOHAMMED AASSIRI Department of Pharmaceutical Chemistry Government College UniversityFaisalabad38000Pakistan Department of Pharmacy The Women UniversityMultan60000Pakistan Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityAbha62413Saudi Arabia Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha62413Saudi Arabia

Genetic polymorphism has a vital role in the pathogenesis and development of myocardial infarction(MI).Single nucleotide polymorphism at any one of the amino acid sequences can result in a diseased state.A single gene can exhibit genetic polymorphism at more than one position giving rise to different *** polymorphism of angiotensinogen(AGT)M235T,AGT T174M,and angiotensin-1-converting enzyme(ACE)I/D,endothelial nitric oxide synthase(eNOS),and methylenetetrahydrofolate reductase(MTHFR)can be a risk factor for ***,it is important to study the prevalence of genetic polymorphisms of these genes among different *** is influenced by genetic polymorphism of various genes,including AGT,ACE,eNOS,MTHFR,***,the association of genetic polymorphism of these genes varies among different populations,but different ethnic groups could show contradictory *** genes have shown a positive association with risks of MI in some populations,whereas the results have not been consistent with every ethnic *** this article,we have summarized the genetic variations in the aforementioned genes and their association with MI.

关键词： Endothelial nitric oxide synthase Methylenetetrahydrofolate reductase AGT M235T AGT T174M

Morin attenuates L-arginine induced acute pancreatitis in rats by downregulating myeloperoxidase and lipid peroxidation

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 148-154页

作者： kanwal rehman Ummara Rashid Komal Jabeen Muhammad Sajid Hamid Akash Department of Pharmacy University of AgricultureFaisalabadPakistan Institute of Physiology and Pharmacology University of AgricultureFaisalabadPakistan Department of Pharmaceutical Chemistry Government College University FaisalabadPakistan

Objective:To explore the therapeutic role of morin against L-arginine-induced acute pancreatitis in ***:The group 1 received two intraperitoneal injections of normal saline,and groups 2-4 were given two intraperitoneal injections of L-arginine(250 mg/100 g body weight)at 1 h interval to induce acute ***,group 2 received no further treatment while groups 3 and 4 were treated with morin(30 mg/kg)and diclofenac sodium(30 mg/kg),*** glucose and serum levels of insulin,α-amylase,malondialdehyde,myeloperoxidase,alanine aminotransferase,aspartate aminotransferase and cholesterol were ***,histopathological study was carried out to investigate the effect of morin treatment on physiology of the ***:L-arginine significantly altered the level of blood glucose and serum levels of insulin,α-amylase,malondialdehyde,myeloperoxidase,alanine aminotransferase,aspartate aminotransferase and *** with morin or diclofenac sodium significantly improved the levels of these ***,morin showed more significant effect than diclofenac *** analysis verified that morin protected the pancreas from deleterious effects of ***:Morin plays a protective role against L-arginineinduced acute pancreatitis via reducing lipid peroxidation and tissue inflammation,and attenuating acute pancreatitis-associated alteration in insulin secretion and glucose metabolism.

关键词： Morin Acute pancreatitis Diclofenac sodium L-arginine

Assessment of urinary concentration of cotinine in Chinese pregnant women exposed to environmental tobacco smoke

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Chinese Science Bulletin 2014年第13期59卷 1386-1391页

作者： Yajing Lei Wenhui Liu Lizheng Fang Muhammad Sajid Hamid Akash kanwal rehman Hua Narenmandura Weixing Shi Weixian Lu Yingchun Xu Shuqing Chen Institute of Pharmacology Toxicology and Biochemical Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Sir Run Run Shaw Hospital School of Medicine Zhejiang University College of Pharmacy Government College University Faisalabad Institute of Public Health College of Medical Science Zhejiang University Hangzhou EPIE Bio-detection Technology Limited

Environmental tobacco smoke(ETS)is a wellknown reason of many adverse health consequences in pregnant *** of ETS during pregnancy may increase the risk of some fetal diseases in pregnant women and/or birth defects in *** countries have implemented laws to control smoking and free of second hand smoke in all enclosed *** China,antismoking law was enforced in March *** aimed to assess the exposure of pregnant women to cotinine after anti-smoking law was implemented in *** urine samples were collected from 2,100 volunteers from Zhejiang Province,China and urinary concentration of cotinine was measured using gas chromatography and mass *** was detected in 87%of the pregnant *** GM and 95th percentile concentration inpregnant women were 4.28 and 44.00 lg/L,***,the GM and 95th concentration of cotinine were significantly higher in smoking group than in non-smoking group(P\0.0001).Our results indicate that pregnant women in China are at the high risk of exposure *** attempts are required to make strategies to find out the sources of ETS exposure and prevent smoking at public places especially during pregnancy.

关键词：烟雾浓度烟草烟雾孕妇中国尿液评估环境怀孕期间

Designing and Evaluating a Collaborative Knowledge Management Framework for Leaf Disease Detection

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Computer Systems Science & Engineering 2022年第8期42卷 751-777页

作者： Komal Bashir Mariam rehman Afnan Bashir Faria kanwal Department of Computer Science Lahore College for Women UniversityLahore54000Pakistan Department of Information Technology Government CollegeFaisalabad54000Pakistan Engage Research Lab School of Law and SocietyUniversity of the Sunshine CoastSippy DownsQLD 4556Australia

Knowledge Management(KM)has become a dynamic concept for inquiry in *** management of knowledge from multiple sources requires a systematic approach that can facilitate capturing all important aspects related to a particular discipline,several KM frameworks have been designed to serve this *** research aims to propose a Collaborative Knowledge Management(CKM)Framework that bridges gaps and overcomes weaknesses in existing *** paper also validates the framework by evaluating its effectiveness for the agriculture sector of Pakistan.A software LCWU aKMS was developed which serves as a practical implementation of the concepts behind the proposed CKMF *** aKMS served as an effective system for rice leaf disease detection and *** aimed to enhance CKM through knowledge sharing,lessons learned,feedback on problem resolutions,help from co-workers,collaboration,and helping *** were collected from 300 rice crop farmers by questionnaires based on *** Olfman model was used to estimate the effectiveness of *** tests were performed including frequency measures of variables,Cronbach’s alpha reliability,and Pearson’s *** research provided a KMS depicting KM and collaborative *** disease detection module was evaluated using the precision and recall method and found to be 94.16%*** system could replace the work of extension agents,making it a cost and time-effective initiative for farmer betterment.

关键词： Collaborative knowledge management framework jennex olfman km success model knowledge management rice disease detection

A Robust Data Hiding Reversible Technique for Improving the Security in e-Health Care System

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Computer Modeling in Engineering & Sciences 2023年第1期134卷 201-219页

作者： Saima kanwal Feng Tao Ahmad Almogren Ateeq Ur rehman Rizwan Taj Ayman Radwan School of Computer and Communication Lanzhou University of TechnologyLanzhou730050China Department of Computer Science College of Computer and Information SciencesKing Saud UniversityRiyadh11633Saudi Arabia Department of Electrical Engineering Government College UniversityLahore54000Pakistan Instituto de Telecomunicaoes and Universidade de Aveiro Aveiro3810-193Portugal

The authenticity and integrity of healthcare is the primary *** reversible watermarking schemes have been developed to improve the primary objective but increasing the quantity of embedding data leads to covering image distortion and visual quality resulting in data security detection.A trade-off between robustness,imperceptibility,and embedded capacity is difficult to achieve with current algorithms due to limitations in their *** this purpose insight,an improved reversibility watermarking methodology is proposed to maximize data embedding capacity and imperceptibility while maintaining data security as a primary concern.A key is generated by a random path with minimum bit flipping is selected in the 4 × 4 block to gain access to the data embedding *** random path's complex structure ensures data *** of various sizes(8 KB,16 KB,32 KB)are used to analyze image imperceptibility and evaluate quality *** proposed reversible watermarking methodology performance is tested under standard structures PSNR,SSIM,and *** results revealed that the MRI watermarked images are imperceptible,like the cover image when LSB is 3 bits *** proposed reversible watermarking methodology outperforms other related techniques in terms of average PSNR(49.29).Experiment results show that the suggested reversible watermarking method improves data embedding capacity and imperceptibility compared to existing state-of-the-art approaches.

关键词： Medical images security data hiding LSB matching hiding capacity imperceptibility

Reversible Watermarking Method with Low Distortion for the Secure Transmission of Medical Images

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Computer Modeling in Engineering & Sciences 2022年第3期130卷 1309-1324页

作者： Rizwan Taj Feng Tao Shahzada Khurram Ateeq Ur rehman Syed Kamran Haider Akber Abid Gardezi Saima kanwal School of Computer and Communication Lanzhou University of TechnologyLanzhouChina Faculty of Computing The Islamia University of BahawalpurBahawalpurPakistan Department of Electrical Engineering Government College UniversityLahorePakistan College of Internet of Things Engineering Hohai UniversityChangzhouChina Department of Computer Science COMSATS University IslamabadIslamabadPakistan

In telemedicine,the realization of reversible watermarking through information security is an emerging research ***,adding watermarks hinders the distribution of pixels in the cover image because it creates distortions(which lead to an increase in the detection probability).In this article,we introduce a reversible watermarking method that can transmit medical images with minimal distortion and high *** proposed method selects two adjacent gray pixels whose least significant bit(LSB)is different from the relevant message bit and then calculates the distortion *** use the LSB pairing method to embed the secret matrix of patient record into the cover image and exchange pixel *** results show that the designed method is robust to different attacks and has a high PSNR(peak signal-to-noise ratio)*** MRI image quality and imperceptibility are verified by embedding a secret matrix of up to 262,688 bits to achieve an average PSNR of 51.657 *** addition,the proposed algorithm is tested against the latest technology on standard images,and it is found that the average PSNR of our proposed reversible watermarking technology is higher(i.e.,51.71 dB).Numerical results show that the algorithm can be extended to normal images and medical images.

关键词： LSB reversible watermarking medical images security data distortion

Impact of climate change on sediment yield for Naran watershed,Pakistan

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International Journal of Sediment Research 2016年第3期31卷 212-219页

作者： Farooq Azim Abdul Sattar Shakir Habib-ur-rehman Afshan kanwal Centre of Excellence in Water Resource Engineering(CEWRE) University of Engineering & Technology(UET) Government College University CEWRE UET Department of Civil Engineering UET

In this paper,the site-specific impact of climate change on sediment yield has been assessed for the Naran watershed,*** data has been gathered for period 1961-2010 and HaDCM3 GCM predictors of SRES scenarios A2 and B2 have been *** precipitation and temperature time series have been statistically downscaled for time horizon 2011-2040 and *** data show both increasing and decreasing changes with respect to the *** sediment yield for future related to climate change has been *** results show that the both snowy and monsoon seasonal stream discharges are expected to *** will lead to increase in annual suspended sediment ***-wise,a less discharge and more sediment yield are expected during the early *** study concluded that the climate change and variability are influencing the watershed,and suspended sediment yield is likely to increase in the future.

关键词： Climate change Downscaling Hydrologic modeling Suspended sediment yield SHETRAN