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Effect of acacetin on inhibition of apoptosis in Helicobacter pyloriinfected gastric epithelial cell line

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3624-3634页

作者： Qi-Xi Yao Zi-Yu Li Hou-Le kang Xin He min kang Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Orthopaedics The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Emergency Luzhou People’s HospitalLuzhou 646000Sichuan ProvinceChina

BACKGROUND Helicobacter pylori(***)infection can cause extensive apoptosis of gastric epithelial cells,serving as a critical catalyst in the progression from chronic gastritis,gastrointestinal metaplasia,and atypical gastric hyperplasia to gastric *** eradication of *** is paramount for ameliorating the pathophysiological conditions associated with chronic inflammation of the gastric mucosa and the primary prevention of gastric ***,which has multifaceted pharmacological activities such as anti-cancer,anti-inflammatory,and antioxidative properties,has been extensively investigated across various ***,the impact and underlying mechanisms of action of acacetin on ***-infected gastric mucosal epithelial cells remain *** To explore the defensive effects of acacetin on apoptosis in ***-infected GES-1 cells and to investigate the underlying *** GES-1 cells were treated with *** and acacetin in *** viability was assessed using the CCK-8 assay,cell mortality rate via lactate dehydrogenase assay,alterations in cell migration and healing capacities through the wound healing assay,rates of apoptosis via flow cytometry and TUNEL staining,and expression levels of apoptosis-associated proteins through western blot *** *** infection led to decreased GES-1 cell viability,increased cell mortality,suppressed cell migration,increased rate of apoptosis,increased expressions of Bax and cle-caspase3,and decreased Bcl-2 ***,acacetin treatment enhanced cell viability,mitigated apoptosis induced by *** infection,and modulated the expression of apoptosis-regulatory proteins by upregulating Bcl-2 and downregulating Bax and cleaved *** Acacetin significantly improved GES-1 cell viability and inhibited apoptosis in ***-infected GES-1 cells,thereby exerting a protective effect on gastric mucosal epithelial cells.

关键词： Gastric epithelial GES-1 cells Helicobacter pylori Infection Acacetin Antibiotic resistance Apoptosis

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Subclinical paraganglioma of the retroperitoneum:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2672-2677页

作者： Li-min kang Fa-Kun Yu Fu-Wei Zhang Lei Xu Department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina

BACKGROUND Paraganglioma(PGL)located in the retroperitoneum presents challenges in diagnosis and treatment due to its hidden location,lack of specific symptoms in the early stages,and absence of distinctive manifestations on *** SUMMARY A 56-year-old woman presented with a left upper abdominal mass discovered 1 wk ago during a physical *** did not have a history of smoking,alcohol consumption,or other harmful habits,no surgical procedures or infectious diseases,and had a 4-year history of *** admission,she did not exhibit fever,vomiting,or abdominal *** examination indicated mild percussion pain in the left upper abdomen,with no palpable enlargement of the liver or *** tests and tumor markers showed no significant *** computed tomography and magnetic resonance imaging of the upper abdomen revealed a cystic solid mass in the left epigastrium measuring approximately 6.5 cm×4.5 cm,with inhomogeneous enhancement in the arterial phase,closely associated with the lesser curvature of the stomach and the *** patient underwent laparoscopic resection of the retroperitoneal mass,which was successfully removed without tumor rupture.A 12-month postoperative follow-up period showed good *** This case report details the successful laparoscopic resection of a retroperitoneal subclinical PGL,resulting in a good recovery observed at the 12-month ***,the patient also experienced unexpected cure of hypertensive disease.

关键词： Paraganglioma Retroperitoneal anatomy Subclinical Pheochromocytoma Laparoscopy Case report

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Multiple Uplift and Exhumation of the Southeastern Tibetan Plateau:Evidence from Low-Temperature Thermochronology

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 569-584页

作者： WU Limin PENG Touping FAN Weiming ZHAO Guochun GAO Jianfeng DONG Xiaohan PENG Shili min kang Tin Aung MYINT State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Chinese Academy of Sciences Center for Excellence in Deep Earth Science Guangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China Department of Earth Sciences The University of Hong KongHong Kong 999077China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiGuangdong 519085China Department of Geology University of MandalayMandalay 05011Myanmar

Since the Cenozoic,the Tibetan Plateau has experienced large-scale uplift and outgrowth due to the India-Asia ***,the mechanism and timing of these tectonic processes still remain ***,using apatite fission track dating and inverse thermal modeling,we explore the mechanism of different phases of rapid cooling for different batholiths and intrusions in the southeastern Tibetan *** contrast to previous views,we find that the coeval granitic batholith exposed in the same tectonic zone experienced differential fast uplift in different sites,indicating that the present Tibetan Plateau was the result of differential uplift rather than the entire lithosphere uplift related to lithospheric collapse during Cenozoic *** addition,we also suggest that the 5-2 Ma mantle-related magmatism should be regarded as the critical trigger for the widely coeval cooling event in the southeastern Tibetan Plateau,because it led to the increase in atmospheric CO_(2)level and a hotter upper crust than before,which are efficient for suddenly fast rock weathering and ***,we propose that the current landform of the southeastern Tibetan Plateau was the combined influences of tectonic and climate.

关键词： apatite fission track rapid cooling differential uplift magmatism southeastern Tibetan Plateau

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Research on the Coupled and Coordinated Development of Tourism and Transport in Chengdu City

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Proceedings of Business and Economic Studies 2024年第3期7卷 6-15页

作者： min kang Qiguang Lv Chongqing University of Science and Technology Chongqing 401331China

Based on a total of 16 indicators selected from the tourism and transport industries,an evaluation index system of the coupling and coordination development level of tourism and transport is *** entropy value method and the coupling coordination degree model are used to conduct an empirical study on the development level and coupling coordination level of the transport and tourism industries in Chengdu City from 2011 to *** results show that,on the whole,the coupling coordination degree of transport and tourism in Chengdu is poor and has been in a state of mild to moderate *** development level of tourism lagged behind the development of transport from 2011 to 2012,and the two were in a state of mild ***,from 2013 onwards,the development level of tourism was prioritized over the development level of *** shift caused the coupling coordination degree of the two industries to decline sharply to 0.23305 in *** development level of the tourism industry increased again,reaching 0.34206 in 2019,which marked an ***,the coordination degree of the transport and tourism industries evolved from moderate dislocation to mild ***,the results of the empirical research are analyzed,and corresponding suggestions are put forward to promote the sustainable growth of the transport and tourism industries in Chengdu *** suggestions aim to improve the coupled and coordinated development level of the two industries.

关键词： Coupling coordination Chengdu city Transport industry Tourism industry Entropy value method Coupling coordination degree model

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甘草柑橘皮果醋发酵工艺研究

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粮食与油脂 2024年第7期37卷 63-69,87页

作者：亢敏山西工商学院山西太原030006

以柑橘皮为主料,甘草为辅料,采用液态发酵法制备甘草柑橘皮果醋。先以总黄酮含量为指标,在单因素试验的基础上通过响应面法优化酒精液制备工艺;再在最佳酒精液制备条件下,以总酸含量和感官评分为指标,通过响应面法优化果醋制备工艺,并... 详细信息

以柑橘皮为主料,甘草为辅料,采用液态发酵法制备甘草柑橘皮果醋。先以总黄酮含量为指标,在单因素试验的基础上通过响应面法优化酒精液制备工艺;再在最佳酒精液制备条件下,以总酸含量和感官评分为指标,通过响应面法优化果醋制备工艺,并对其理化及微生物指标进行分析。结果表明:酒精液最佳工艺参数为酵母菌接种量0.5%(以原料液体积为基准)、原料液糖度16%、发酵时间9 d,在此条件下果醋总黄酮含量为5.37%。最佳果醋制备参数为醋酸菌接种量2.0%(以酒精液体积为基准)、发酵温度35℃、初始乙醇体积分数8.5%、发酵时间9 d,在此条件下果醋总酸含量为5.61 g/100 mL,感官评分为8.74,微生物指标符合相关标准要求。

关键词：甘草柑橘皮果醋发酵工艺感官评分

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Pay attention to the application of indocyanine green fluorescence imaging technology in laparoscopic liver cancer resection

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World Journal of Clinical Cases 2024年第23期12卷 5288-5293页

作者： Li-min kang Fu-Wei Zhang Fa-Kun Yu Lei Xu Department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina

Traditional laparoscopic liver cancer resection faces challenges,such as difficultiesin tumor localization and accurate marking of liver segments,as well as theinability to provide real-time intraoperative *** approach falls shortof meeting the demands for precise and anatomical liver *** introductionof fluorescence imaging technology,particularly indocyanine green,hasdemonstrated significant advantages in visualizing bile ducts,tumor localization,segment staining,microscopic lesion display,margin examination,and lymphnode *** technology addresses the inherent limitations oftraditional laparoscopy,which lacks direct tactile feedback,and is increasinglybecoming the standard in laparoscopic *** by fluorescenceimaging technology,laparoscopic liver cancer resection is poised to become thepredominant technique for liver tumor removal,enhancing the accuracy,safetyand efficiency of the procedure.

关键词： Indocyanine green Fluorescence imaging technology Laparoscopy Hepatectomy Liver tumor

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区域国别音乐文化标志性符号及其形态、时空、语境要素——以中国南方与周边跨界族群音乐的比较为例

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中国音乐 2024年第3期 76-86页

作者：杨民康中国音乐学院云南艺术学院哈尔滨音乐学院中央音乐学院

中国与周边跨界族群音乐在音乐艺术形态、社会文化形态及文化意义等方面的发展和变迁,始终伴随着不同层级音乐文化标志性符号的形成、塑造和发展。中国音乐文化标志性符号可分为地域性音乐符号、区域性音乐符号和国族性音乐符号等不同... 详细信息

中国与周边跨界族群音乐在音乐艺术形态、社会文化形态及文化意义等方面的发展和变迁,始终伴随着不同层级音乐文化标志性符号的形成、塑造和发展。中国音乐文化标志性符号可分为地域性音乐符号、区域性音乐符号和国族性音乐符号等不同层级类型,这种区分以符号形态学和语义学分析为基础,并且在符号语义学的涵义层面,作为象征性和隐喻性音乐符号呈现出来。在研究思路上,区域国别学理论为这些讨论提供了一个重要的参考维度,文化圈和文化(特质)丛理论则给予了一个具有可操作性的方法论依据。本文以云南与周边跨界族群音乐为例,聚焦音乐符号学涵义层,结合形态标准、时空条件和语境要素几方面标准,对不同层级、类型的音乐文化标志性符号展开讨论和分析。

关键词：区域国别音乐文化音乐文化标志性符号南方与周边跨界族群音乐

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一种改进的残余力向量法在结构损伤识别中的应用

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计算力学学报 2024年第2期41卷 263-269页

作者：康哲民雷能忠祖庆芝漳州职业技术学院建筑工程学院漳州363000 武夷学院土木工程与建筑学院武夷山354300 丘陵山地智慧城镇建设技术福建省高校(武夷学院)重点实验室武夷山354300

残余力向量法是结构损伤识别中常用的方法,复杂结构中单元数量较多而损伤位置较少,容易造成无关变量增多,进而导致计算量过大的问题。鉴于此,本文提出一种改进的残余力向量法用于结构的损伤识别。该方法利用刚度联系向量与残余力向量之... 详细信息

残余力向量法是结构损伤识别中常用的方法,复杂结构中单元数量较多而损伤位置较少,容易造成无关变量增多,进而导致计算量过大的问题。鉴于此,本文提出一种改进的残余力向量法用于结构的损伤识别。该方法利用刚度联系向量与残余力向量之间线性相关的特性,以向量投影值作为损伤定位的影响系数,初步筛选出结构可能出现损伤的单元范围。在此基础上,构建出残余力向量对应的线性方程组,根据顺序主子式不为零的条件,对线性方程组进行行初等变换,再根据单元的数量保留前n维线性方程,通过求解该方程组的代数解可得到该结构单元的刚度损伤参数。以简支梁为例的数值模拟表明,本文方法可减少无关单元变量的计算,降低残余力向量的维度并且具有较好的抗噪能力。

关键词：残余力向量法损伤识别线性相关刚度联系矩阵抗噪分析

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不同脱苦处理对砂仁风味品质的影响研究

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粮食与油脂 2024年第5期37卷 91-97页

作者：何梦影张康逸康志敏河南省农业科学院农副产品加工研究中心河南郑州450002

以感官评分及电子舌技术为考察手段,比较水处理、乙醇处理、酸处理以及超声辅助复合处理方式对砂仁脱苦效果的影响,进一步通过气相色谱-质谱(GC-MS)初步确定砂仁中的苦味物质,并最终筛选出适宜砂仁脱苦的工艺。结果表明:乙醇及超声复合... 详细信息

以感官评分及电子舌技术为考察手段,比较水处理、乙醇处理、酸处理以及超声辅助复合处理方式对砂仁脱苦效果的影响,进一步通过气相色谱-质谱(GC-MS)初步确定砂仁中的苦味物质,并最终筛选出适宜砂仁脱苦的工艺。结果表明:乙醇及超声复合脱苦处理对砂仁苦涩味脱除效果及感官品质较好,其中,超声复合脱苦处理对砂仁本身的风味化合物种类影响较小,砂仁中呈苦味的主要挥发性物质可能为可巴烯、β-愈创木烯、α-香附酮、4-萜烯醇、2-茨醇。

关键词：砂仁脱苦处理风味电子舌

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双螺杆挤压温度对玉米淀粉结构和理化性质的影响

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粮油食品科技 2024年第2期32卷 30-36页

作者：许鑫高伟康雪敏崔波齐鲁工业大学(山东省科学院)生物基材料及绿色造纸国家重点实验室山东济南250353 齐鲁工业大学(山东省科学院)食品科学与工程学院山东济南250353

淀粉在挤压机内的熔融行为变化影响着挤出物的物理性质,探究淀粉挤压过程中熔融行为对于生产理想的热塑性淀粉基材料具有重要意义。本文探究不同挤压温度(60、70、80、90和100℃)对玉米淀粉结构和理化性质的影响。结果表明,在高温和机... 详细信息

淀粉在挤压机内的熔融行为变化影响着挤出物的物理性质,探究淀粉挤压过程中熔融行为对于生产理想的热塑性淀粉基材料具有重要意义。本文探究不同挤压温度(60、70、80、90和100℃)对玉米淀粉结构和理化性质的影响。结果表明,在高温和机械剪切作用下,淀粉颗粒发生破碎,颗粒尺寸减小。淀粉分子内氢键被破坏,使淀粉更易与水分子结合,从而提高了热塑性淀粉(TPS)的水合特性。随着温度升高,直链淀粉含量增加,相对结晶度(RC)和双螺旋有序度(DO)减小,表明玉米淀粉在受热过程中长程和短程有序结构被破坏。挤压机的高温处理降低了TPS的焓值,破坏了淀粉糊形成凝胶网络的能力,样品存在弱凝胶行为,但刚性和弹性减弱。综上所述,双螺杆挤压温度使淀粉颗粒结构、晶体结构、水合特性和流变特性发生了不同程度的变化,为挤压优质热塑性淀粉材料提供新思路。

关键词：双螺杆挤压热塑性淀粉结构理化性质

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