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春秋季长江口及其邻近海域营养盐污染研究

生态环境 2006年第2期15卷 276-283页

作者：王芳康建成周尚哲郑琰明徐韧孙瑞文吴涛华南师范大学地理科学学院广东广州510631 上海师范大学城市生态与环境研究中心上海200234 国家海洋局东海环境监测中心上海200137

依据东海环境监测中心两个航次的资料和美国国家海洋大气管理局(NOAA)相关资料,开发Matlab计算机数值分析和图形显示技术,对长江口及其邻近海域的营养盐污染状况进行分析和探讨。结果表明:海域总体营养盐超标严重;氮、磷污染物的来源主... 详细信息

依据东海环境监测中心两个航次的资料和美国国家海洋大气管理局(NOAA)相关资料,开发Matlab计算机数值分析和图形显示技术,对长江口及其邻近海域的营养盐污染状况进行分析和探讨。结果表明:海域总体营养盐超标严重;氮、磷污染物的来源主要为径流携带入海,磷还受外海流系高质量浓度磷输入的影响;营养盐污染特征显示,表、底层营养盐均自入海口向外围、由近岸向远岸迅速递减,秋季冲淡水将污染物向外海携带,污染区也相应向外海推移;营养盐结构显示,该区w(N)/w(P)比值最高达到了405,无机氮异常丰富,海域浮游植物生长的限制因子存在时空变化。分析得到营养盐污染特征与长江河口锋位置及冲淡水流向的关系密切,可以考虑由长江河口锋位置及冲淡水流向来确定污染物的聚集位置和扩展方向。

关键词：长江口海洋环境营养盐污染

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan Meng kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

南极洲伊丽莎白公主地区主要离子沉积方式及nssSO_4^(2-)气候效应研究

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极地研究 1999年第3期11卷 161-168页

作者：张明军李忠勤秦大河效存德康建成李军中国科学院兰州冰川冻土研究所兰州730000 中国极地研究所上海200129 AntarcticCRCandAustraliaAntarcticDivision

通过对１９９６／１９９７年中国首次南极内陆冰盖考察获得的南极洲伊丽莎白公主地区５０ｍ雪芯样品主要阴、阳离子浓度、通量和积累率关系的研究，揭示以下规律：１）南极洲伊丽莎白公主地区大气中各主要离子浓度足够大，足以使本地... 详细信息

通过对１９９６／１９９７年中国首次南极内陆冰盖考察获得的南极洲伊丽莎白公主地区５０ｍ雪芯样品主要阴、阳离子浓度、通量和积累率关系的研究，揭示以下规律：１）南极洲伊丽莎白公主地区大气中各主要离子浓度足够大，足以使本地区冰雪中主要离子浓度不随积累率的变化而变化，即离子浓度不受积累率的影响。２）各主要离子干、湿沉积所占比重的计算结果表明，本地区离子沉积方式以湿沉积为主。另外，ｎｓｓＳＯ２－４的研究结果表明火山爆发的中、短期气候效应在伊丽莎白公主地区反应不明显。

关键词：离子干沉积湿沉积南极沉积古气候效应

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杆式射流侵彻运动厚壳装药目标的数值模拟

弹箭与制导学报 2019年第1期39卷 89-92页

作者：赵庚郭光全张钧陈智刚付建平康建成中北大学地下目标毁伤技术国防重点学科实验室太原030051 晋西工业集团有限责任公司太原030051 空军驻山西地区军事代表室太原030024

为提高杆式射流对运动厚壳装药目标冲击起爆的效能,利用仿真软件对不同弹目交汇条件下杆式射流侵彻运动厚壳装药目标的过程进行数值模拟,分析了弹轴偏移量和弹目运动方向夹角对杆式射流侵彻威力的影响。结果表明:杆式射流对运动厚壳装... 详细信息

为提高杆式射流对运动厚壳装药目标冲击起爆的效能,利用仿真软件对不同弹目交汇条件下杆式射流侵彻运动厚壳装药目标的过程进行数值模拟,分析了弹轴偏移量和弹目运动方向夹角对杆式射流侵彻威力的影响。结果表明:杆式射流对运动厚壳装药有一定的侵彻效能,弹目追赶交汇要比迎头交汇更容易引爆目标装药;当弹目交汇角一定时,随着弹轴偏移量的增加,引爆厚壳装药的难度加大。研究结果可为反厚壳装药战斗部的设计提供一定的参考依据。

关键词：杆式射流运动厚壳装药冲击起爆数值模拟

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

重金属废水污染农田土壤事件环境损害评估研究

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环保科技 2020年第2期26卷 46-51页

作者：毛金群康俭成黄婉玉高庚申贵州省环境科学研究设计院贵阳550081 贵州省煤田地质局一五九队贵阳550081

以贵州省某厂的废水污染农田土壤为例,通过现场访谈、专家咨询、监测分析和方案对比等方法,从消除危险、污染场地修复及期间生态功能损失对污染场地进行环境污染损害评估。经测算,污染农田面积约40000 m 2,评估区域土壤均受到不同程度... 详细信息

以贵州省某厂的废水污染农田土壤为例,通过现场访谈、专家咨询、监测分析和方案对比等方法,从消除危险、污染场地修复及期间生态功能损失对污染场地进行环境污染损害评估。经测算,污染农田面积约40000 m 2,评估区域土壤均受到不同程度的重金属污染:一号区域土壤全部为重度污染;二号区域91%面积的土壤呈重度污染,7%的土壤为中度污染,轻微和轻度污染仅占2%。污染农田的农作物特别是稻米的重金属含量超标情况较严重,长期食用潜在的人体健康风险超过可接受水平。最终确认污染损害费用估算约5360570元。

关键词：环境污染损害评估废水

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北极斯瓦尔巴群岛的旅游资源

旅游科学 2008年第6期22卷 55-60页

作者：康建成任惠茹闫国东徐明星上海师范大学城市生态与环境研究中心上海200234

北极斯瓦尔巴群岛地区是地球最北端的陆区,那里特有的景观,如午夜的太阳、极光、海湾、冰川、极地动物、苔原生态体系、人类探索北极的足迹等都是宝贵的极地旅游资源,有待于我们开发和利用。

关键词：北极斯瓦尔巴群岛环境旅游资源

Emission control strategies of hazardous trace elements from coal-fired power plants in China

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Journal of Environmental Sciences 2020年第7期32卷 66-90页

作者： Adwek George Boxiong Shen Dongrui kang jiancheng Yang Jiangze Luo School of Energy and Environmental Engineering Tianjin Key Laboratory of Clean Energy Utilization and Pollution ControlHebei University of TechnologyTianjinChina Department of Energy and Environmental Engineering Mount Kenya UniversityThika-Kenya

China’s energy dependents on coal due to the abundance and low cost of *** provides a secure and stable energy source in ***-dependence on coal results in the emission of Hazardous Trace Elements(HTEs)including selenium(Se),mercury(Hg),lead(Pb),arsenic(As),etc.,from Coal-Fired Power Plants(CFPPs),which are the major toxic air pollutants causing widespread *** this reason,it is essential to provide a succinct analysis of the main HTEs emission control techniques while concurrently identifying the research prospects framework and specifying future research *** study herein reviews various techniques applied in China for the selected HTEs emission control,including the technical,institutional,policy,and regulatory *** specific areas covered in this study include health effects,future coal production and consumption,the current situation of HTEs in Chinese coal,the chemistry of selected HTEs,control techniques,policies,and action plans safeguarding the emission *** review emphasizes the fact that China must establish and promote efficient and clean ways to utilize coal in order to realize sustainable *** principal conclusion is that cleaning coal technologies and fuel substitution should be great potential HTEs control technologies in *** research should focus on the simultaneous removal of HTEs,PM,SOx,and NOx in the complex flue gas.

关键词： Coal Coal-fired power plants Policies Heavy trace elements