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Development and Characterization of Novel FAP-Targeted Theranostic Pairs: A Bench-to-Bedside Study

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Research 2024年第3期2023卷 473-485页

作者： Wei Huang Yizhen Pang Qiufang Liu chenyi Liang Shuxian An Qianyun Wu You Zhang Gang Huang Haojun Chen Jianjun Liu Weijun Wei Department of Nuclear Medicine Institute of Clinical Nuclear MedicineRenj HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghai 200127China Department of Nuclear Medicine and Minnan PET Center Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361003China Department of Nuclear Medicine Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China

Fibroblast activation protein (FAP) is among the most popular targets in nuclear medicine imaging and cancer theranostics. Several small-molecule moieties (FAPI-04, FAPI-46, etc.) are used for developing FAP-targeted theranostic agents. Nonetheless, the circulation time of FAP inhibitors is relatively short, resulting in rapid clearance via kidneys, low tumor uptake, and associated unsatisfactory treatment efficacy. To address the existing drawbacks, we engineered 3 peptides named FD1, FD2, and FD3 with different circulation times through solid-phase peptide synthesis. All the 3 reported peptides bind to human and murine FAP with single-digit nanomolar affinity measured by surface plasmon resonance. The diagnostic and therapeutic potential of the agents labeled with 68Ga and 177Lu was assessed in several tumor models exhibiting different levels of FAP expression. While radiolabeled FD1 was rapidly excreted from kidneys, radiolabeled FD2/FD3 have significantly prolonged circulation, increased tumor uptake, and decreased kidney accumulation. Our findings indicated that [68Ga]Ga-DOTA-FD1 positron emission tomography (PET) effectively detected FAP dynamics, whereas [177Lu]Lu-DOTA-FD2 and [177Lu]Lu-DOTA-FD3 exhibited remarkable therapeutic efficacy in FAP-overexpressing tumor models, including pancreatic cancer cell models characterized by abundant stroma. Moreover, a pilot translational investigation demonstrated that [68Ga]Ga-DOTA-FD1 had the capability to identify both primary and metastatic tumors with precision and distinction. In summary, we developed [68Ga]Ga-DOTA-FD1 for same-day PET imaging of FAP dynamics and [177Lu]Lu-DOTA-FD2 and [177Lu]Lu-DOTA-FD3 for effective radioligand therapy of FAP-overexpressing tumors.

关键词： DOTA expressing labeled

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政府环境审计能够促进重污染企业创新吗?

环境经济研究 2021年第4期6卷 102-125页

作者：康辰怿张华南京审计大学商学院 211815

政府环境审计作为一项特殊的环境规制政策,能在发挥环境治理职能的同时,影响重污染企业的创新能力。基于2007—2019年中国A股工业上市公司的面板数据,本文利用2009年审计署颁布《审计署关于加强资源环境审计工作的意见》这一外生事件构... 详细信息

政府环境审计作为一项特殊的环境规制政策,能在发挥环境治理职能的同时,影响重污染企业的创新能力。基于2007—2019年中国A股工业上市公司的面板数据,本文利用2009年审计署颁布《审计署关于加强资源环境审计工作的意见》这一外生事件构建准自然实验,采用双重差分法检验政府环境审计对重污染企业创新能力的影响。研究发现:政府环境审计能够显著提升重污染企业的创新能力,具体表现为企业期末无形资产占总资产的比重显著增加。机制分析表明,政府环境审计通过提升重污染企业营运能力进而促进了重污染企业创新。同时,较高的政府补贴水平会削弱这一激励效应。进一步异质性分析表明,在注册地位于东部、西部及东北地区的企业、所有权属性为国有控股的企业和负债规模适中的企业中,政府环境审计能够有效激励重污染企业的创新能力。研究结论证明了政府环境审计能间接促进相关重污染企业的创新活动,展示了政府环境审计在不同情形下的政策效果。

关键词：政府环境审计企业创新重污染企业双重差分法

Facile solution-processed molybdenum oxide as hole transporting material for efficient organic solar cell

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Journal of Energy Chemistry 2022年第6期31卷 108-114,I0004页

作者： Qian kang chenyi Yang Bowei Xu Jianhui Hou State Key Laboratory of Polymer Physics and Chemistry Beijing National Laboratory for Molecular SciencesInstitute of Chemistry Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Chemical Resource Engineering College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

The large energy barrier in hole extraction still remains a great challenge in developing hole transporting layer (HTL) materials for organic solar cells (OSCs).Thus,solution-processed HTL materials with excellent hole collection ability and good compatibility with large-area processing technique are strongly desired for ***,we developed a cost-effective and solution-processed MoO_(3)HTL for efficient *** adding a small amount of glucose as reducing reagent into the ammonium molybdate precursor solution,a deeply n-doped MoO_(3),namely G:Mo,was prepared through the sol–gel *** to pristine MoO_(3),the conductivity of G:Mo was enhanced by two orders of magnitude,which greatly improved the hole collection ability of the *** with G:Mo can exhibit comparable PCE to the PEDOT:PSS *** PBDB-TF:BTP-eC9 as the active layer,a PCE of 17.1%is obtained for the device,which is the highest PCE value for OSC using a solution-processed MoO_(3)*** importantly,G:Mo is well compatible with the blade-coating *** OSC using a blade-coated G:Mo showed almost no PCE loss as compared to the device with spin-coated G:Mo *** results from this work indicate that G:Mo is a promising HTL material for the practical production of OSCs.

关键词： Printable n-doping Molybdenum oxide High conductivities Anode interlayers

Hydrogen-assisted scalable preparation of ultrathin Pt shells onto surfactant-free and uniform Pd nanoparticles for highly efficient oxygen reduction reaction in practical fuel cells

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Nano Research 2022年第3期15卷 1892-1900页

作者： Liuxuan Luo Cehuang Fu Aiming Wu Zechao Zhuang Fengjuan Zhu Fangling Jiang Shuiyun Shen Xiyang Cai Qi kang Zhifeng Zheng chenyi Hu Jiewei Yin Guofeng Xia Junliang Zhang Institute of Fuel Cells Key Laboratory for Power Machinery and Engineering of MOESchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Tsinghua UniversityBeijing 100084China The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Department of Polymer Science and Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong UniversityShanghai 200240China

Concentrating active Pt atoms in the outer layers of electrocatalysts is a very effective approach to greatly reduce the Pt loading without compromising the electrocatalytic performance and the total electrochemically active surface area(ECSA)for the oxygen reduction reaction(ORR)in hydrogen-based proton-exchange membrane fuel ***,a facile,low-cost,and hydrogen-assisted two-step method is developed in this work,to massively prepare carbon-supported uniform,small-sized,and surfactant-free Pd nanoparticles(NPs)with ultrathin~3-atomic-layer Pt shells(Pd@Pt_(3L) NPs/C).Comprehensive physicochemical characterizations,electrochemical analyses,fuel cell tests,and density functional theory calculations reveal that,benefiting from the ultrathin Pt-shell nanostructure as well as the resulting ligand and geometric effects,Pd@Pt_(3L) NPs/C exhibits not only significantly enhanced ECSA,electrocatalytic activity,and noble-metal(NM)utilization compared to commercial Pt/C,showing 81.24 m^(2)/gPt,0.710 mA/cm^(2),and 352/577 mA/mgNM/Pt in ECSA,area-,and NM-/Pt-mass-specific activity,respectively;but also a much better electrochemical stability during the 10,000-cycle accelerated degradation *** importantly,the corresponding 25-cm^(2) H2-air/O_(2) fuel cell with the low cathodic Pt loading of~0.152 mgPt/cm^(2)geo achieves the high power density of 0.962/1.261 W/cm^(2)geo at the current density of only 1,600 mA/cm^(2)geo,which is much higher than that for the commercial Pt/*** work not only develops a high-performance and practical Pt-based ORR electrocatalyst,but also provides a scalable preparation method for fabricating the ultrathin Pt-shell nanostructure,which can be further expanded to other metal shells for other energy-conversion applications.

关键词： palladium platinum oxygen reduction reaction core@shell nanostructure scalable preparation proton-exchange membrane fuel cell

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桩承式路堤土拱效应的试验和数值研究

岩土力学 2011年第7期32卷 1975-1983页

作者：费康王军军陈毅河海大学岩土力学与堤坝工程教育部重点实验室南京210098 扬州大学岩土工程研究所江苏扬州225009

对桩承式路堤中的土拱效应进行了三维模型试验研究。根据试验结果,分析了应力折减系数大小和填土中的竖向应力分布特点。对比分析了实测值与Terzaghi方法和Hewlett&Randolph方法计算值之间的差异,验证了各方法的适用性。采用三维有限元... 详细信息

对桩承式路堤中的土拱效应进行了三维模型试验研究。根据试验结果,分析了应力折减系数大小和填土中的竖向应力分布特点。对比分析了实测值与Terzaghi方法和Hewlett&Randolph方法计算值之间的差异,验证了各方法的适用性。采用三维有限元对模型试验进行了数值模拟,重点分析了路堤填土的大主应力方向、应力水平和沉降模式等几个关键问题。试验和数值结果表明,Terzaghi方法与Hewlett、Randolph方法给出的应力折减系数数值接近,但填土中竖向应力分布模式截然不同,且与实测值有所区别。若在Terzaghi方法中采用合适的滑动面形状,得到的计算结果与实测值较吻合,能够反映竖向应力沿深度分布的特点。

关键词：桩承式路堤土拱效应模型试验有限元

Application of microneedle-based vaccines in biosecurity

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Journal of Biosafety and Biosecurity 2022年第1期4卷 75-83页

作者： Zhiying Jin Baohua Zhao Wei Wan Yue Li Xuexin Bai chenyi Hu Jing Wang Yanwei Li Wenwen Xin Lin kang Hao Yang Jinglin Wang Shan Gao State Key Laboratory of Pathogens and Biosecurity Institute of Microbiology and EpidemiologyAMMSBeijing 100071China Hebei Key Laboratory of Animal Physiology Biochemistry and Molecular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China

Countries must have strong early warning,detection,and response capabilities in the face of the risks and challenges posed by major infectious diseases and bioterrorism *** is one of the most effective means for countries to maintain biosecurity and respond to bioterrorism *** are emerging as a potential vaccine delivery method with minimal pain,no bleeding,and the ability to be self-administered,doing away with the need for professional health care *** last advantage,particularly if combined with room temperature preservation,could have an important role in improving national biosecurity through large-scale,rapid deployment of a biological *** this review,we summarized the research status of microneedles,including the types,materials,and production technologies of *** progress regarding microneedles in the field of biosecurity is introduced and challenges in its future application are discussed.

关键词： Microneedle Vaccine Transdermal delivery Biosecurity

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可见红外双波段智能伪装织物

工程热物理学报 2023年第5期44卷 1304-1308页

作者：廖雨田王晨逸毛铭冉刘辉东刘抗武汉大学动力与机械学院武汉430072

随着红外侦测技术的快速发展,提高热物体的红外伪装能力在国防领域具有重要意义。本文提出一种可见红外双波段智能伪装织物,利用纳米多孔吸湿膜红外发射率的温度自适应性,实现织物红外动态伪装;并利用红外透明的表层设计织物颜色,实现... 详细信息

随着红外侦测技术的快速发展,提高热物体的红外伪装能力在国防领域具有重要意义。本文提出一种可见红外双波段智能伪装织物,利用纳米多孔吸湿膜红外发射率的温度自适应性,实现织物红外动态伪装;并利用红外透明的表层设计织物颜色,实现可见与红外兼容伪装。实验表明,当织物温度在22~64℃之间变化时,其红外发射率能在0.95~0.38范围内自适应调节。该织物将可见颜色与红外辐射的调控集于一片柔性布上,在可见红外兼容智能伪装技术领域具有一定的应用前景。

关键词：智能伪装织物红外波可见光

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中西文化交汇与新加坡儒教复兴运动的兴起

世界民族 2020年第2期 117-126页

作者：张晨怡中央民族大学历史文化学院北京100081

19世纪末20世纪初,在中西文化的交互作用下,在新加坡华人社会兴起了一场规模浩大的儒教复兴运动。新加坡儒教复兴运动虽明显受中国本土的孔教运动影响,但与康有为试图借助政治的力量将孔教定为国教不同,新加坡儒教复兴运动走的是民间化... 详细信息

19世纪末20世纪初,在中西文化的交互作用下,在新加坡华人社会兴起了一场规模浩大的儒教复兴运动。新加坡儒教复兴运动虽明显受中国本土的孔教运动影响,但与康有为试图借助政治的力量将孔教定为国教不同,新加坡儒教复兴运动走的是民间化的道路。基于新华社会多元的语言状况,儒教复兴运动中一个重要的特点,就是运用中英双语来推广儒学。受新加坡地区浓郁的宗教氛围影响,新加坡儒教复兴运动以构建儒教为要旨,力图整合佛教、道教以及民间宗教信仰,并通过与基督教的论争来完善理论体系的建构。新加坡儒教复兴运动的兴起,是儒家文化在新加坡的传播由自发走向自觉的集中体现,同时也是儒学在宋明理学之后第二次转向的重要组成部分。

关键词：新加坡华人儒学儒教再华化文化认同

Electronic structure of aqueous two-dimensional photocatalyst

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npj Computational Materials 2021年第1期7卷 431-439页

作者： Dawei kang Xianghua Kong Vincent Michaud-Rioux Ying-Chih Chen Zetian Mi Hong Guo School of Physics and Engineering Henan University of Science and TechnologyLuoyangChina College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhenChina Department of Physics McGill UniversityMontrealQCCanada Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMIUSA

The electronic structure,in particular the band edge position,of photocatalyst in presence of water is critical for photocatalytic water *** propose a direct and systematic density functional theory(DFT)scheme to quantitatively predict band edge shifts and their microscopic origins for aqueous 2D photocatalyst,where thousands of atoms or more are able to be *** scheme is indispensable to correctly calculate the electronic structure of 2D photocatalyst in the presence of water,which is demonstrated in aqueous MoS_(2),GaS,InSe,GaSe and *** is found that the band edge of 2D photocatalysts are not rigidly shifted due to water as reported in previous studies of aqueous ***,the CBM shift is quantitatively explained by geometric deformation,water dipole and charge redistribution effect while the fourth effect,i.e.,interfacial chemical contact,is revealed in the VBM ***,the revealed upshift of CBM in aqueous MoS2 should thermodynamically help carriers to participate in hydrogen evolution reaction(HER),which underpin the reported experimental findings that MoS2 is an efficient HER *** work paves the way to design 2D materials in general as low-cost and high-efficiency photocatalysts.

关键词： catalyst structure quantitatively