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基于环境复杂度的移动机器人变步长RRT路径规划算法与仿真研究

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北京化工大学学报（自然科学版） 2023年第4期50卷 87-93页

作者：康博涵黄静雯北京化工大学信息科学与技术学院北京100029 北京物资学院物流学院北京101149

针对移动机器人路径规划算法不能根据环境自适应调整步长的问题,提出一种基于环境复杂度的变步长路径规划算法。以快速搜索随机树(RRT)算法为例,引入衡量路径规划性能的参数,通过遗传算法寻找最优步长与环境复杂度之间的关系,建立最优... 详细信息

针对移动机器人路径规划算法不能根据环境自适应调整步长的问题,提出一种基于环境复杂度的变步长路径规划算法。以快速搜索随机树(RRT)算法为例,引入衡量路径规划性能的参数,通过遗传算法寻找最优步长与环境复杂度之间的关系,建立最优步长与环境复杂度的函数表达式。针对局部环境的特殊性,提出基于滑动窗的变步长RRT路径规划算法。基于该算法,移动机器人能够根据实时局部环境动态改变路径规划的搜索步长,提高了算法的整体性能。最后通过Matlab仿真实验验证了所提出的RRT算法较传统RRT算法具有高效、平稳、代价小的优点。

关键词：移动机器人路径规划快速搜索随机树算法遗传算法滑动窗环境复杂度

基于区块链的智能服务交易跨链服务框架与通信机制

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网络与信息安全学报 2021年第3期7卷 105-114页

作者：康博涵章宁朱建明中央财经大学信息学院北京100081

由于不同区块链上的区块链服务间缺乏有效通信机制,链与链之间难以形成有效互联互通。在智能服务交易过程中,交易主客体之间不仅仅是数据资产的单项转移,而且其服务范围扩展涵盖到更为广阔的数字资产转移场景。设计一种智能服务交易的... 详细信息

由于不同区块链上的区块链服务间缺乏有效通信机制,链与链之间难以形成有效互联互通。在智能服务交易过程中,交易主客体之间不仅仅是数据资产的单项转移,而且其服务范围扩展涵盖到更为广阔的数字资产转移场景。设计一种智能服务交易的跨链通信服务框架,并采用基于组件式、模块化设计,使智能服务交易主客体较为容易地接入服务框架,实现跨链可扩展性;提出适用于智能服务交易的三阶段跨链通信机制,保证智能服务交易跨链生态下的原子性和一致性。

关键词：区块链智能服务交易跨链通信通信机制

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电商营销新模式提升饲料企业经营效益分析

中国饲料 2022年第12期 94-97页

作者：韩璐璐康博涵秦媛石家庄信息工程职业学院河北石家庄050000

近年来,随着互联网技术的不断发展,新型电商营销模式成为饲料经济发展的重要引擎。但饲料企业的新型电商营销模式还有待完善,饲料企业经济模式与新型电商营销新模式结合不深,饲料企业经济发展缺乏完善的规划和管理机制,同时人力资源力... 详细信息

近年来,随着互联网技术的不断发展,新型电商营销模式成为饲料经济发展的重要引擎。但饲料企业的新型电商营销模式还有待完善,饲料企业经济模式与新型电商营销新模式结合不深,饲料企业经济发展缺乏完善的规划和管理机制,同时人力资源力量不足。基于此,饲料企业应首先将新型电商新模式与饲料企业经济进行有效化深度融合;其次,新型电商新模式发展规划要深度完善,饲料企业经营机制建设要不断优化,同时还需要发展新型电商营销新模式和饲料企业经济复合人才。

关键词：新型电商营销新模式饲料经济

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo Li Fu Tang Jingkai Zhang Yuetong kang Hean Zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

Bioinspired nanocomposites with self-adaptive mechanical properties

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Nano Research 2024年第2期17卷 633-648页

作者： Grant Kitchen bohan Sun Sung Hoon kang 13400 N Charles St Department of Materials Science and EngineeringJohns Hopkins UniversityBaltimore 21218USA 23400 N Charles St Department of Mechanical EngineeringJohns Hopkins UniversityBaltimore 21218USA 33400 N Charles St Hopkins Extreme Materials InstituteJohns Hopkins UniversityBaltimore 21218USA

Conventional synthetic materials have fixed mechanical properties and suffer defects,damage,and degradation over *** makes them unable to adapt to changing environments and leads to limited ***,self-adaptive materials inspired by natural materials have emerged as a solution to address these *** the ability to change their mechanical properties based on changing mechanical environments,repairing defects,and maintaining their mechanical properties,these materials can lead to improved performance while decreasing *** this review,we explore self-adaptive phenomena found in nature that have inspired the development of synthetic self-adaptive materials,and the mechanisms that have been employed to create the next generation of *** potential applications of these materials,the challenges that existing approaches face,and future research opportunities are also discussed.

关键词： nanocomposites self-adaptive materials bioinspired materials force-activated resilience

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan Meng kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

Location and allocation problem for spare parts depots on integrated logistics support

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Journal of Systems Engineering and Electronics 2019年第6期30卷 1252-1259页

作者： WEN Meilin LU bohan LI Shuyu kang Rui School of Reliability and Systems Engineering Beihang UniversityBeijing 100191China Science and Technology on Reliability and Environmental Engineering Laboratory Beijing 100191China

In equipment integrated logistics support(ILS), the supply capability of spare parts is a significant factor. There are lots of depots in the traditional support system, which makes too many redundant spare parts and causes high cost of support. Meanwhile,the inconsistency among depots makes it difficult to manage spare parts. With the development of information technology and transportation, the supply network has become more efficient. In order to further improve the efficiency of supply-support work and the availability of the equipment system, building a system of one centralized depot with multiple depots becomes an appropriate *** this case, location selection of the depots including centralized depots and multiple depots becomes a top priority in the support system. This paper will focus on the location selection problem of centralized depots considering ILS factors. Unlike the common location selection problem, depots in ILS require a higher service level. Therefore, it becomes desperately necessary to take the high requirement of the mission into account while determining location of depots. Based on this, we raise an optimal depot location model. First, the expected transportation cost is ***, factors in ILS such as response time, availability and fill rate are analyzed for evaluating positions of open depots. Then, an optimization model of depot location is developed with the minimum expected cost of transportation as objective and ILS factors as constraints. Finally, a numerical case is studied to prove the validity of the model by using the genetic algorithm. Results show that depot location obtained by this model can guarantee the effectiveness and capability of ILS well.

关键词： location problem spare parts depot integrated logis tics support genetic algorithm.

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte