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Novel mutations in PDE6A and CDHR1 cause retinitis pigmentosa in Pakistani families

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1843-1851页

作者： Muhammad Dawood Siying Lin Taj ud din Irfan Ullah Shah Niamat Khan Abid Jan Muhammad Marwan Komal Sultan Maha Nowshid Raheel Tahir Asif Naveed Ahmed Muhammad Yasin Emma LBaple Andrew HCrosby Shamim Saleha Department of Biotechnology and Genetic Engineering Kohat University of Science and Technology(KUST)Kohat 26000Khyber PakhtunkhwaPakistan Medical Research RILD Wellcome Wolfson Centre(Level 4)Royal Devon and Exeter NHS Foundation TrustExeterDevon EX25DWUK Department of Ophthalmology KMU Institute of Medical Sciences(KIMS)Kohat 26000Khyber PakhtunkhwaPakistan

AIM:To investigate the genetic basis of autosomal recessive retinitis pigmentosa(arRP)in two consanguineous/endogamous Pakistani ***:Whole exome sequencing(WES)was performed on genomic DNA samples of patients with arRP to identify disease causing *** sequencing was performed to confirm familial segregation of identified mutations,and potential pathogenicity was determined by predictions of the mutations’***:A novel homozygous frameshift mutation[NM_000440.2:c.1054delG,p.(Gln352Argfs*4);Chr5:g.149286886del(GRCh37)]in the PDE6A gene in an endogamous family and a novel homozygous splice site mutation[NM_033100.3:c.1168-1G>A,Chr10:g.85968484G>A(GRCh37)]in the CDHR1 gene in a consanguineous family were *** PDE6A variant p.(Gln352Argfs*4)was predicted to be deleterious or pathogenic,whilst the CDHR1 variant c.1168-1G>A was predicted to result in potential alteration of ***:This study expands the spectrum of genetic variants for arRP in Pakistani families.

关键词： autosomal recessive retinitis pigmentosa PDE6A CDHR1 variants Pakistani families

气提式三重循环生物膜反应器处理制药废水中的甾体雌激素

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环境科学研究 2006年第4期19卷 56-60页

作者：崔成武纪树兰任海燕 NAEEM ud din Ahmad 韩磊北京工业大学环境与能源工程学院北京100022 中国科学院微生物研究所北京100080

为验证气提式三重循环生物膜反应器处理甾体雌激素的效能，建立了一套SPE／HPLC／MS／MS分析方法，对反应器进、出水中的甾体雌激素——甾酮（E1），17β-雌二醇（E2），雌三醇（E3）以及17α-乙炔基雌二醇（EE2）进行检测．该方法的加... 详细信息

为验证气提式三重循环生物膜反应器处理甾体雌激素的效能，建立了一套SPE／HPLC／MS／MS分析方法，对反应器进、出水中的甾体雌激素——甾酮（E1），17β-雌二醇（E2），雌三醇（E3）以及17α-乙炔基雌二醇（EE2）进行检测．该方法的加标回收率为88％～103％，精密度为4％～9％．该方法对E1，E2，E3和EE2的进水定量限（LOQ）分别为0．7，0．8，0．9和0．5ng／L；对出水的定量限分别为2．0，1．0，2．0和1．0ng／***和氨氮容积负荷最高为7．5和1．6kg／（m^3·d），出水依然能够保持稳定．进水pH稳定在9．0～10．5，而反应器的pH一直稳定在9．0以下，体系对pH变化造成的冲击比较适应．同时，反应器内形成了稳定的NO2^- -N积累，CODCr和氨氮的去除率分别达到了70％和73％．

关键词：气提式三重循环生物膜反应器 SPE/HPLC/MS/MSW分析方法甾体雌激素短程硝化

Role of Information & Communication Technology (ICT) and E-governance in Health Sector of Pakistan: a Case Study of Peshawar

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Role of Information & Communication Technology (ICT) and E-g...

作者：尤迪（IZHAR ud din）华中农业大学

学位级别：硕士

随着信息通信技术(ICT)和互联网服务的飞速发展,政府逐步将其应用于为人民提供的各种服务之中。基于电子政务在服务交付、效率和可达性方面发挥的重要作用,世界上大多数公共组织都热衷于从传统管理方式向电子形式过渡和转化,电子政务取... 详细信息

随着信息通信技术(ICT)和互联网服务的飞速发展,政府逐步将其应用于为人民提供的各种服务之中。基于电子政务在服务交付、效率和可达性方面发挥的重要作用,世界上大多数公共组织都热衷于从传统管理方式向电子形式过渡和转化,电子政务取得了飞速发展。本研究针对巴基斯坦医疗卫生部门中的ICT和电子政务展开研究,尚属首次,因此本研究是一种积极的探索,非常有价值。本文以巴基斯坦白沙瓦地区公共以及私立医院的170例患者的访谈及问卷调查数据为基础数据,对该区域内电子政务的发展现状进行了探索分析。首先分类别对白沙瓦地区医疗卫生的电子政务现状进行了分析,指出其目前仍处于初级阶段,有待进一步推广;之后又对这170例患者对ICT的认知进行了访谈,结果显示该地区民众对ICT的认知严重不足;最后针对上述研究提出了建议:(1)电子政务应用于医疗卫生部门的条件包括基础设施、电力、合适的用户界面、数据隐私保护等方面;(2)政府应该在医疗卫生部门逐步推广实施电子政务。这能够提高系统的效率、透明度、并能够强化监督作用,同时也能够大大提高服务交付的速度。

关键词：电子政务卫生部门信息通信技术白沙瓦

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巴基斯坦蚕业简况

中国蚕业 1983年第1期 58-59页

作者： Zafar ud din

养蚕在巴基斯坦有悠久的历史,是一项家庭妇女的副业活动。在50—60年代,我们对养蚕工作进行了重新组织。巴基斯坦对蚕丝的需求量越来越大,但由于条件限制,一般只在春季养蚕,每年的饲养量极少,一年养2.2—2.5万盒种。一盒种单产25公斤鲜... 详细信息

养蚕在巴基斯坦有悠久的历史,是一项家庭妇女的副业活动。在50—60年代,我们对养蚕工作进行了重新组织。巴基斯坦对蚕丝的需求量越来越大,但由于条件限制,一般只在春季养蚕,每年的饲养量极少,一年养2.2—2.5万盒种。一盒种单产25公斤鲜茧,10公斤干茧,3.5公斤生丝。每年可生产鲜茧55—57.5万公斤。干茧22—23万公斤,生

关键词：巴基斯坦南亚蚕业蚕桑业养蚕桑树园艺作物栽桑蚕品种蚕种

Development of Correlation Between Surface Crack Size and Corrosion Pit Size for Service Life Prediction

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气提式三重循环生物膜反应器用于制药废水的处理

2007国际机械工程与力学会议

作者： Keliang REN Guozhi LV Majd-ud-din MUHAMMAD Youhong ZHANG Department of Aeronautical Structural Engineering Northwestern Polytechnical University Department of Physics & Electrical Information Engineering Ningxia University

In order to set up the relation between corrosion pits and equivalent initial surface crack （EISC）, for quantitative assessment of the residual strength of the aging structure in corrosive environment, a series of pre-corroded samples are prepared at different time and temperature, and subsequent fatigue experiments under uniaxial cyclic load have been performed with LY12-CZ Aluminium alloy. After pre-corrosion and fatigue test, the equivalent initial surface crack size is calculated through reverse integration of the Paris fatigue crack growth law and has solved the non-linear equation using Monte Carlo method from the experiment fatigue life. Finally life predictions are made using the pit sizes measured in experiment and EISC size calculated by reverse integration of the Paris fatigue crack growth law as the initial size of surface crack in computer package AFGROW, and compared with the experimented fatigue life. The results show that the size of equivalent initial surface crack is less than 19.7 to 22.5 percent of surface corrosion pit size which has the same life.

关键词： Corrosion pit Surface crack Equivalent initial crack Monte Carlo method Aging structure Residual strength AFGROW

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中国给水排水 2006年第5期22卷 80-83页

作者：任海燕纪树兰崔成武韩磊 Naeem ud din Ahmad 王道北京工业大学环境与能源工程学院北京100022 中国科学院微生物研究所北京100080

采用气提式三重循环生物膜反应器（TLABR）处理制药废水，稳定阶段对COD和NH4^＋-N的去除率分别为73％和70％。当温度为27～30℃、pH=8．5时，反应器内形成了稳定的NO2^--N积累。同时，考察了不同HRT下高效反应器的处理效果，探讨了pH... 详细信息

采用气提式三重循环生物膜反应器（TLABR）处理制药废水，稳定阶段对COD和NH4^＋-N的去除率分别为73％和70％。当温度为27～30℃、pH=8．5时，反应器内形成了稳定的NO2^--N积累。同时，考察了不同HRT下高效反应器的处理效果，探讨了pH对反应器内发生的短程硝化效果的影响以及亚硝化菌对游离氨浓度的适应性。结果表明：在HRT为3、6、9h下，对COD和氨氮的去除率分别为65．3％、73．9％、75．1％和48．9％、68．4％、72．8％；NO2^--N积累率分别为92．7％、76．2％、69．7％；反应器出水水质稳定，体现了高效性和抗冲击负荷能力。

关键词：制药废水气提式三重循环生物膜反应器甾体雌激素短程硝化

Varied presentations, magnitude, and outcome of traumatic neck injuries at a level I trauma center

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Emergency and Critical Care Medicine 2022年第2期2卷 45-49页

作者： Parvez Mohi ud din Dar Jogendra Boddeda Supreet Kaur Pratyusha Priyadarshini Abhinav Kumar dinesh Bagaria Narendra Choudhary Junaid Alam Sushma Sagar Subodh Kumar Amit Gupta Biplab Mishra Division of Trauma Surgery and Critical Care Jai Prakash Narayan Apex Trauma CentreAll India Institute of Medical Sciences(AIIMS)New DelhiIndia Department of General Surgery All India Institute of Medical Sciences(AIIMS)JodhpurRajasthanIndia

Introduction:Traumatic neck injuries(TNIs)constitute 5%–10%of all trauma *** injuries can be caused by either penetrating or blunt *** can have a varied presentation like cut injury over the neck,bleeding,neck swelling,breathing difficulty,dysphagia,***:This was a retrospective observational study conducted at a level I trauma center in India from January 2016 to March *** hundred thirty patients who required admission and intervention due to TNIs were included in this ***:One hundred thirty patients with neck injuries were included in this *** were predominant(91.5%)with the age ranging from 10 to *** most common mechanism of injury was physical assault(40.7%),followed by road traffic injury(23.8%)and self-inflicted injuries(18.4%).Penetrating trauma was *** neck wound with bleeding was the most common presenting *** II injuries were more common(83.8%)followed by zone I(12.3%)and zone III(3.8%).Soft tissue injury including skin,platysma breach,and strap muscle injury was present in 46.9% of *** injury was present in 13.8%,tracheal injury in 28.5%,vascular injury in 13.8%,and esophageal injury in 4.6% of ***:Penetrating neck trauma is more common than blunt in developing countries like *** Trauma Life Support(ATLS)protocol guides the initial *** definitive management depends on the type and mechanism of injury,anatomical level,severity,and the organ injured.

关键词： Bleeding Neck trauma Resuscitation Trachea Vascular injury

Growth and characterization of ZnO multipods on functional surfaces with different sizes and shapes of Ag particles

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Chinese Physics B 2013年第8期22卷 683-689页

作者： A Kamalianfar S A Halim Mahmoud Godarz Naseri M Navasery Fasih ud din J A M Zahedi Kasra Behzad K P Lim A Lavari Monghadam S K Chen Department of Physics Faculty of Science University Putra Malaysia43400 UPM Serdang Selangor Malaysia Department of Physics Farhangian UniversityIran Institute for Mathematical Research University Putra Malaysia43400 UPM Serdang Selangor Malaysia Department of Physics Faculty of Science Malayer UniversityMalayer Iran Department of Physics Karaj Branch Islamic Azad UniversityKaraj Iran Department of Physics Science Faculty Shahr-e-Ghods Branch Islamic Azad UniversityTehran Iran

Three-dimensional ZnO multipods are successfully synthesized on functional substrates using the vapor transport method in a quartz tube. The functional surfaces, which include two different distributions of Ag nanoparticles and a layer of commercial Ag nanowires, are coated onto silicon substrates before the growth of ZnO nanostructures. The structures and morphologies of the ZnO/Ag heterostructures are investigated using X-ray diffraction and field emission scanning electron microscopy. The sizes and shapes of the Ag particles affect the growth rates and initial nucleations of the ZnO structures, resulting in different numbers and shapes of multipods. They also influence the orientation and growth quality of the rods. The optical properties are studied by photoluminescence, UV-vis, and Raman spectroscopy. The results indicate that the surface plasmon resonance strongly depends on the sizes and shapes of the Ag particles.

关键词： ZnO ZnO-Ag surface plasmon resonance

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好氧颗粒污泥的形成机理

水处理技术 2006年第2期32卷 13-15,19页

作者：崔成武纪树兰高景峰任海燕 Naeem ud din Ahmad 北京工业大学环境与能源工程学院北京100022 中国科学院微生物研究所北京100080

本文综述了几种比较流行的好氧颗粒污泥的形成机理,并进行了分析讨论。同时,总结了各种条件下形成好氧颗粒污泥的理化特性、培养条件及其形态。

关键词：好氧颗粒污泥污泥形态形成机理理化特性培养条件形态