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Structural and immunogenomic insights into B-cell receptor activation

Journal of Genetics and Genomics 2020年第1期47卷 27-35页

作者： Yangyang Feng Yu Wang Shaocun Zhang kabeer haneef Wanli Liu MOE Key Laboratory of Protein Sciences Center for Life SciencesCollaborative Innovation Center for Diagnosis and Treatment o f Infectious DiseasesSchool of Life SciencesBeijing Key Lab for Immunological Research on Chronic DiseasesInstitute for ImmunologyTsinghua UniversityBeijingJ00084China

B cells express B-cell receptors(BCRs) which recognize antigen to trigger signaling cascades for B-cell activation and subsequent antibody production. BCR activation has a crucial influence on B-cell fate. How BCR is activated upon encountering antigen remains to be solved, although tremendous progresses have been achieved in the past few years. Here, we summarize the models that have been proposed to explain BCR activation, including the cross-linking model, the conformation-induced oligomerization model, the dissociation activation model, and the conformational change model. Especially, we elucidate the partially resolved structures of antibodies and/or BCRs by far and discusse how these current structural and further immunogenomic messages and more importantly the future studies may shed light on the explanation of BCR activation and the relevant diseases in the case of dysregulation.

关键词： B-cell receptor B-cell activation BCR structure Immunogenomics

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Mini-organs with big impact:Organoids in liver cancer studies

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Oncology Research 2023年第5期31卷 677-688页

作者： MUHAMMAD BABAR KHAWAR YAJUN WANG ANEEQA MAJEED ALI AFZAL kabeer haneef HAIBO SUN Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhouChina Jiangsu Key Laboratory of Experimental and Translational Non-Coding RNA Research YangzhouChina Applied Molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowalPakistan Department of Oncology Haian Hospital of Traditional Chinese MedicineHaianChina Molecular Medicine and Cancer Therapeutics Lab Department of ZoologyFaculty of Sciences TechnologyUniversity of Central PunjabLahorePakistan Chinese Institute for Brain Research(CIBR) BeijingChina

Hepatocellular carcinoma,the most common primary liver cancer and a leading cause of death,is a difficult disease to treat due to its heterogeneous *** models,such as 2D culture and patient-derived xenografts,have not proven ***,the development of 3D culture techniques,such as organoids,which can mimic the tumor microenvironment(TME)and preserve heterogeneity and pathophysiological properties of tumor cells,offers new opportunities for treatment and *** also have the potential for biomarker detection and personalized medication,as well as genome editing using CRISPR/Cas9 to study the behavior of certain genes and therapeutic *** review explores to-the-date development of organoids with a focus on TME modeling in 3D organoid ***,it discusses gene editing using CRISPR/Cas9 in organoids,the challenges faced,and the prospects in the field of organoids.

关键词： Heterogeneity Tumor Organoid Liver Treatment Therapy

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Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases

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Rheumatology & Autoimmunity 2022年第4期2卷 185-197页

作者： Na Kang Xiaohang Liu kabeer haneef Wanli Liu School of Life Sciences Institute for ImmunologyMOE Key Laboratory of Protein SciencesBeijing Advanced Innovation Center for Structural BiologyCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijing Key Laboratory for Immunological Research on Chronic DiseasesTsinghua UniversityBeijingChina Tsinghua‐Peking Center for Life Sciences BeijingChina

All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular *** immune system activates when damaged or injured cells release damage‐associated molecular patterns(DAMPs).In addition to well‐characterized DAMPs such as high‐mobility group box 1 and adenosine triphosphate,studies on new classes of DAMPs have ***,we review recent reports of a new class of isoprenoid‐derived DAMPs,including farnesyl pyrophosphate and geranylgeranyl pyrophosphate,both of which are pivotal metabolic inter-mediates of the mevalonate *** also explore the roles of old and new DAMPs in autoimmune diseases that result from dysregulated *** findings highlight that understanding the functional mechanisms of DAMPs is important to enrich the DAMP family and decipher their immunoregulatory mechanisms to provide new therapeutics for the prevention and treatment of autoimmune diseases.

关键词： autoimmune diseases damage‐associated molecular patterns farnesyl pyrophosphate geranylgeranyl diphosphate mevalonate pathway

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