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Disrupted Maturation of Prefrontal Layer 5 Neuronal Circuits in an Alzheimer’s Mouse Model of Amyloid Deposition

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Neuroscience Bulletin 2023年第6期39卷 881-892页

作者： Chang Chen Jing Wei Xiaokuang Ma Baomei Xia Neha Shakir Jessica k.zhang Le zhang Yuehua Cui Deveroux Ferguson Shenfeng Qiu Feng Bai Department of Neurology Affiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing210008China Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZ85004USA

Mutations in genes encoding amyloid precursor protein(APP)and presenilins(PSs)cause familial forms of Alzheimer’s disease(AD),a neurodegenerative disorder strongly associated with *** is currently unknown whether and how AD risks affect early brain development,and to what extent subtle synaptic pathology may occur prior to overt hallmark AD *** mutant APP/PS1 over-expression mouse lines are key tools for studying the molecular mechanisms of AD *** these lines,the 5XFAD mice rapidly develop key features of AD pathology and have proven utility in studying amyloid plaque formation and amyloidβ(Aβ)-induced *** reasoned that transgenic mutant APP/PS1 over-expression in 5XFAD mice may lead to neurodevelopmental defects in early cortical neurons,and performed detailed synaptic physiological characterization of layer 5(L5)neurons from the prefrontal cortex(PFC)of 5XFAD and wild-type littermate controls.L5 PFC neurons from 5XFAD mice show early APP/Aβ***-cell patch-clamp recording at an early post-weaning age(P22–30)revealed functional impairments;although 5XFAD PFC-L5 neurons exhibited similar membrane properties,they were intrinsically less *** addition,these neurons received smaller amplitude and frequency of miniature excitatory synaptic *** functional disturbances were further corroborated by decreased dendritic spine density and spine head volumes that indicated impaired synapse *** biotinylation followed by Western blot analysis of PFC-L5 tissue revealed that 5XFAD mice showed reduced synaptic AMPA receptor subunit GluA1 and decreased synaptic NMDA receptor subunit *** with this,patch-clamp recording of the evoked L23>L5 synaptic responses revealed a reduced AMPA/NMDA receptor current ratio,and an increased level of AMPAR-lacking silent *** results suggest that transgenic mutant forms of APP/PS1 overexpression in 5XFAD mice leads to early deve

关键词： Alzheimer’s disease Mouse model Synaptic plasticity Long-term potentiation Cortical circuit Electrophysiology Learning and memory

An explicit integration scheme for hypo-elastic viscoplastic crystal plasticity

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Transactions of Nonferrous Metals Society of China 2014年第7期24卷 2401-2407页

作者： k.zhang B.HOLMEDAL S.DUMOULIN O.S.HOPPERSTAD Department of Materials Science and Engineering Norwegian University of Science and Technology SINTEF Materials and Chemistry Department of Structural Engineering Norwegian University of Science and Technology Structural Impact Laboratory (SIMLab) Center for Research-based InnovationNorwegian University of Science and Technology

An explicit integration scheme for rate-dependent crystal plasticity （CP） was developed. Additive decomposition of the velocity gradient tensor into lattice and plastic parts is adopted for describing the kinematics; the Cauchy stress is calculated by using a hypo-elastic formulation, applying the Jaumann stress rate. This CP scheme has been implemented into a commercial finite element code （CPFEM）. Uniaxial compression and roiling processes were simulated. The results show good accuracy and reliability of the integration scheme. The results were compared with simulations using one hyper-elastic CPFEM implementation which involves multiplicative decomposition of the deformation gradient tensor. It is found that the hypo-elastic implementation is only slightly faster and has a similar accuracy as the hyper-elastic formulation.

关键词： crystal plasticity hypo-elasticity hyper-elasticity forward Euler integration

Regulation of voltage-gated Ca2+ channels by RGk proteins

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Regulation of voltage-gated Ca2+ channels by RGK proteins

Synthesis, characterization and biocompatibility studies of zinc oxide(ZnO) nanorods for biomedical application

第九届全国钙信号和细胞功能研讨会

作者： Zafir Buraei Wei k.zhang Department of Biological Sciences Columbia University New YorkNY 10027U.S.A.

The Rem,Rem2,Rad and Gem/kir(RGk)family of monomeric GTP-binding proteins potently inhibits high-voltage activated(HVA)Ca channels The molecular mechanisms of this inhibition are largely *** proteins associate directly with Ca charmelβsubunits(Caβ)and this interaction is widely thought to be essential for RGks’inhibitory action We find that Gem suppresses the activity of surface P/Q-type Ca channels in Xenopus oocytes and that this inhibition requires Caβbut not the Gem/Caβ*** constructing chimeras between P/Q channels and RGk-insensitive low-voltage activated T-type channels,we identify a region of Caα

关键词： Cell=neuron Method=electrophysiology Topic=modulation

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Nano-Micro Letters 2010年第1期2卷 31-36页

作者： R.Gopikrishnan k.zhang P.Ravichandran S.Baluchamy V.Ramesh S.Biradar P.Ramesh J.Pradhan J.C.Hall A.k.Pradhan G.T.Ramesh Molecular Toxicology Laboratory Center for Biotechnology and Biomedical Sciences Norfolk State University Center for Materials Research Norfolk State University Health Science Academy Bayside High School Virginia Beach

Nanoparticles are increasingly being recognized for their potential utility in biological applications including ***,we have synthesized zinc oxide(ZnO)nanorods using zinc acetate and hexamethylenetetramine as precursors followed by characterizing using X-ray diffraction,fourier transform infrared spectroscopy,scanning electron microscopy and transmission electron *** growth of synthesized zinc oxide nanorods was found to be very close to its hexagonal nature,which is confirmed by X-ray *** nanorod was grown perpendicular to the long-axis and grew along the[001]direction,which is the nature of ZnO *** morphology of synthesized ZnO nanorods from the individual crystalline nucleus was confirmed by scanning and transmission electron *** length of the nanorod was estimated to be around 21 nm in diameter and 50 nm in *** toxicology studies showed that synthesized ZnO nanorods exposure on hela cells has no significant induction of oxidative stress or cell death even in higher concentration(10μg/ml).The results suggest that ZnO nanorods might be a safer nanomaterial for biological applications.

关键词： Zinc oxide [ZnO] Nanorods XRD SEM & TEM Cytotoxicity

Stepping from Two-to Three-Body Molecular Self-Assembled Nanophases and the Concept of Syntaxy

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Stepping from Two-to Three-Body Molecular Self-Assembled Nan...

An Analytical Model of the Comet's Collision with Jupiter

第19届全国分子筛学术大会

作者： L.Bonneviot P.Wu k.zhang Ecole Normal Superieure de Lyon Université de Lyon Shanghai key Laboratory of Green Chemistry and Chemical Processes East China Normal University

＜正＞Mesoporous nanospheres are highly regarded for their applications in nanomedicine,optical devices,batteries,nanofiltration and heterogeneous catalysis.A fine structural control on monophasic or biphasic nanoporous nanoparticles using an easy-to-perform process remains a challenge addressed here in terms of mechanism and structural tools of *** is shown that moving from the classical two-body{S+,I-}type of phase association often described

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紫金山天文台台刊 1996年第2期15卷 16-19页

作者： Chen Dao-han Purple Mountaion Observatory,Academia Sinica,Chinaand Department of mathematics,University of Exeter,U.k.and k.zhang (Department of mathematics,University of Exeter,U.k.)

We employ an simplified analytical model to investigate the wave motion produced by the impact of Comt SL9 on the Jovian atmosphere and,under the assumption that all the kinetic energy of a comet fragment is completely converted in-to the energy of wave motions in the Jovian atmosphere,derive an analytical fromula describing the relation between the resulting wave motion in the atmosphere and the parameters of a comet fragment (the radius,density and speed).

关键词：心石

Revealing microstructural evolution and mechanical properties of resistance spot welded NiTi-stainless steel with Ni or Nb interlayer

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Journal of Materials Science & Technology 2024年第13期180卷 160-173页

作者： k.zhang A.Shamsolhodaei A.Ghatei-kalashami J.P.Oliveira C.Zang N.Schell J.Li A.R.H.Midawi J.G.Lopes J.Yan P.E.J.Rivera-Díaz-del-Castillo P.Peng Y.N.Zhou Department of Mechanical and Mechatronics Engineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada CENIMAT/I3N Department of Materials ScienceNOVA School of Science and TechnologyUniversidade NOVA de Lisboa2829-516CaparicaPortugal Materials Research Group Department of Mechanical EngineeringUniversity of SouthamptonSouthamptonSO171BJUK Helmholtz-Zentrum Hereon Institute of Materials PhysicsMax-Planck-Str.1Geesthacht21502Germany UNIDEMI Department of Mechanical and Industrial EngineeringNOVA School of Science and TechnologyUniversidade NOVA de Lisboa2829-516CaparicaPortugal

Dissimilar welding of NiTi and stainless steel(SS)for multifunctional device fabrication is challenging due to the brittle nature of intermetallic compounds(IMCs)that are formed in the weld *** this work,Ni and Nb interlayers were applied for the resistance spot welding(RSW)of NiTi and SS to replace the harmful Fe_(2)Ti phase and to restrict the mixing of dissimilar molten metals,*** evolution and mechanical properties of the joints were *** was shown that a conventional weld nugget was created in the absence of any interlayer in the welded joint suffering from traversed cracks due to the formation of brittle IMCs network in the fusion zone(FZ).By the addition of Ni from the interlayer,Fe_(2)Ti dominated weld nugget was efficaciously replaced by Ni_(3)Ti phase;however,the presence of the large pore and cracks reduced the effective joining *** use of a Nb interlayer resulted in a fundamentally different joint,in which FZs at NiTi and SS sides separated by the unmolten Nb would suppress the mixing of dissimilar molten ***-containing eutectic structures with low brittleness formed at the interfaces,contributing to the enhancement of joint strength(increased by 38%on fracture load and 460%on energy absorption).A high-melting-point interlayer showed great potential to realize a reliable and high-performing RSWed NiTi-SS joint.

关键词： NiTi Stainless steel Resistance spot welding Intermetallic compounds Mechanical properties

Tailoring the surface chemical bond states of the NbN coatings by doping Ag:impact the tribological behavior and wettability

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Tailoring the surface chemical bond states of the NbN coatin...

中国晶体学会第六届学术年会暨会员代表大会——多晶（粉晶）衍射分会

作者： P.Ren M.Wen S.X.Du k.zhang W.T.Zheng Department of Materials Science Jilin University

There has been much emphasis in the high hardness,robust hydrophobic and excellent tribological behavior for transition metal nitrides when which as protective coating materials exposed to *** this work,the Nb(Ag)N coatings were deposited on Si(100)substrates by reactive co-sputtering,in which the Nb atoms were substituted by the Ag atoms as Ag/Nb ratio(R) increases from 0.01 to *** coatings exhibit the high hardness(8GPa),low coefficient of friction(CoF,0.18) and wear rates(0.41×10 mm Nm),also with the high hydrophobic property(Water contact angle(WCA),-119°).Significantly,a detailed investigation both in experiment and theoretical calculation were employed to reveal the relationship between the micro structure and the excellent trobological behavior and high *** the R increased from 0 to 0.15,the coatings transformed from NbN to NbN/Ag solute nanostructure ***,the CoF deceased from 0.67 to 0.18 and the wear-rate reduced,which can be ascribed to the AgNbO tribo-film rapidly formed during friction due to the reducing of the N desorption activation energy as R *** increasing R to 0.26,the lubricating effects became weaker because the Ag nanoinclusions segregation at NbN grain boundaries cause the restraint of information for AgNbO,finally result in the increased in the *** the NbN/Ag solute nanostructure coatings(0.01 < R < 0.15) with high WCAs(10319°) can be ascribed to the surface silver ions(Ag) in the AgO have a special closed shells structure of the electron(4d5s),leading a less number of the polar sites for the hydrogen bonding with interfacial water molecules on the surface of ***,WCA of the NbN/Ag coating decreased to 96° as R up to 0.26,these also can be attributed to the Ag separated from the supersaturated NbN lattice accompanied by the decreasing of AgO contents on the surface of the *** all,as increased of Ag content,the fomation of solute nanostructures in the coatings

关键词： NbN/Ag coating Solute nanostructures Microhardness Hydrophobic Friction and wear

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P-Q^2图及其在锌合金压铸中的应用

模具制造 2005年第5期5卷 51-54页

作者： k.zhang D.k.Gross Teck Cominco Metals Ltd.

介绍了P-Q2图(P为金属压力,Q为金属流量)的概念,并讨论了PQ2规则在锌合金压铸中的应用,尤其是其在合理设置浇注系统尺寸方面的指导作用。

关键词：锌合金应用压铸指导作用浇注系统合理设置金属