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Seeing is believing:Stem cells to treat blindness

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Genes & Diseases 2016年第2期3卷 103-104页

作者： Fei Li jim Hu The Editorial Office of Genes&Diseases Chongqing400046China Department of Pathology and Laboratory Medicine The Hospital for Sick ChildrenUniversity of TorontoTorontoONM5G 0A4Canada

The majority of clinical blindness is caused by a loss of transparency of the lens and cornea,largely due to cataracts and corneal *** most common treatment used to restore the transparency is surgical removal of the damaged tissues,followed by transplantation of donated corneal tissue or an artificial ***,these therapies are not without limitations or untoward *** the intricate regulatory signals required for cornea and lens development has made it possible to harness the lineage growth potential of stem cells for cornea repair and lens regeneration,as showcased in two recent studies published in the March 17th issue of Nature.

关键词： Clinical trial Congenital cataract Cornea repair Human iPSCs LEC Lens regeneration

Interfacial friction effects on sealing performances of elastomer packer

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Petroleum Science 2024年第3期21卷 2037-2047页

作者： Peng-Cheng wang Ming-Hui Chen jim Jenkinson Yong-Xin Song Li Sun Department of Mechanical Engineering University of HoustonHoustonTX77024USA Guren Nanomaterials Suzhou215127JiangsuChina Department of Marine Engineering Dalian Maritime UniversityDalian116026LiaoningChina

Elastomer sealing performance is of critical importance for downhole tools application including the use of fracturing(Frac)plugs during multi-stage hydraulic *** practice sealing performances of such plugs are normally evaluated through pressure tests,and in numerical simulation studies,maximum contact stress,average contact stress and contact length data are used to determine sealing quality between a packer and *** previous studies,the impact of friction forces on sealing performance is often *** work aims to fill this knowledge gap in determining the influence of friction forces on elastomer packer sealing *** first determined the most appropriate constitutive hyperelastic model for the elastomers used in frac *** we compared analytical calculation results with Finite Element Analysis simulation using a simplified tubular geometry and showed the significant influences on interfacial friction on elastomer packer stress distribution,deformation,and contact stress after *** the demonstration of validity of FEA method,we conducted systematic numerical simulation studies to show how the interfacial friction coefficients can affect the maximum contact stress,average contact stress,contact stress distribution,and maximum mises stress for an actual packer used in plug *** addition,we also demonstrated how the groove in a packer can affect packer deformation and evolvement during setting with the consideration of interfacial *** study underscores the critical role that friction forces play in Frac plug performance and provides a new dimension for optimizing packer design by controlling interfacial interactions at the packer contact surfaces.

关键词： Elastomer seal Friction Sealing performance Contact stress

A Theoretical Framework for Demystifying the Causes of Dysfunction and Disorder in the Chinese Market Economy:A weberian Perspective Huangnan

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Fudan Journal of the Humanities and Social Sciences 2020年第2期13卷 259-275页

作者： Huangnan Shen jim XiaoJie Liu Department of Management London School of Economics and Political ScienceLondonUK Department of Economics Sciences PoParisFrance

This paper explores a theoretical framework for demystifying the causes of the dysfunction and disorder of the present Chinese market *** is posited that Max weber’s classification of the two potentially conflicting ethics he associates with the behaviour of politicians,the ethic of conviction and the ethic of responsibility offers the basis for a more thorough and accurate account of the dysfunction and disorder within China’s current markets and political ***,this paper contends that cultural determinism and neo-institutional economics fail to capture the contextual factors influencing the transition from the Maoist era of state control to contemporary China’s market led economy(following the opening-up of the country since 1978)than a wider reaching weberian analysis of the contextual factors involved might *** paper proposes that the distinct ethical foundation for the Chinese market economy is based upon the ethic of conviction,which is the continuity of the philosophical underpinnings of the national ideology during the Maoist *** turn,this has led to the distortion of the incentives for firms in China to provide high-quality goods and *** paper also conducts a study of the ethical foundations of the present Chinese economy from the comparative perspectives of Smith’s concept of the market economy and from a Confucian *** this comparative examination,it will be demonstrated that the ethical feature of the modern market economy,stemming from Smith and Confucianism,is based on the ethic of responsibility,which is a mutually opposed concept to the ethic of conviction;therefore,firms whose business ethics are founded upon the ethic of“responsibility”are less prone to deceive consumers as they adhere to a contractual“responsibility”towards the consumer that many Chinese firms still see as of secondary importance as the ethic of“conviction”still dominating the policies,society and culture of the centralist econ

关键词： Moral Foundation Chinese Market Economy Morality of Conviction Morality of Responsibility weberian Analysis

The 12th International Symposium on Spermatology

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Asian Journal of Andrology 2015年第4期17卷 519-520页

作者： R John Aitken jim M Cummins Brett Nixon Priority Research Centre in Reproductive Science Discipline of Biological Sciences and HunterMedical Research Institute University of NewcastleNSW 2308 Australia Division of Veterinary andBiomedical Sciences Murdoch University MurdochWA. Australia.

The 12th International Symposium of Spermatology continued the excellent tradition of this meeting since its inception in 1969 when the first Symposium was held in Italy under the Chairmanship of Professor Baccio Baccetti. This unique Symposium is held every 4 years and serves as a beacon for sperm cell biologists from all over the world, regardless of which species, animal or plant, they are working on. This willingness to embrace the fundamental biology of this distinctive cell type without species limitations is one of the hallmarks of this Symposium. For sperm biologists - it is our Olympics. The meeting in Newcastle, NSw brought together around 300 biologists from more than 22 different countries covering North and South America, Africa, Europe, Asia and Australia. Given the considerable distances and high cost involved in travelling to the East Coast of NSw, this was an outstanding outcome. The Symposium featured a series of 31 plenary lectures culminating in the prestigious Thaddeus Mann Memorial Lecture, which was delivered with typical grace and brilliance by Professor Masaru Okabe.

关键词： International Symposium Spermatology

Small universal simple spiking neural P systems with weights

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Science China(Information Sciences) 2014年第9期57卷 19-29页

作者： ZENG XiangXiang PAN LinQiang PREZ-jimNEZ Mario J. key Laboratory of Image Processing and Intelligent Control School of AutomationHuazhong University of Science and Technology Department of Computer Science and Artificial Intelligence University of SevillaAvda. Reina Mercedes s/nSevilla 41012Spain

Spiking neural P systems with weights(wSN P systems,for short)are a new variant of spiking neural P systems,where the rules of a neuron are enabled when the potential of that neuron equals a given *** is known that wSN P systems are universal by simulating register ***,in these universal systems,no bound is considered on the number of neurons and *** this work,a restricted variant of wSN P systems is considered,called simple wSN P systems,where each neuron has only one *** complexity parameter,the number of neurons,to construct a universal simple wSN P system is *** is proved that there is a universal simple wSN P system with 48 neurons for computing functions;as generator of sets of numbers,there is an almost simple(that is,each neuron has only one rule except that one neuron has two rules)and universal wSN P system with 45 neurons.

关键词： bio-inspired computing membrane computing P system spiking neural P system universal computing device

world Society for Pediatric Infectious Diseases declaration on combating antimicrobial resistance in children

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world Journal of Pediatrics 2018年第6期14卷 523-524页

作者： jim Buttery Yonghong Yang Mike Sharland Department of Infection and Immunity Monash Children’s Hospital246 Clayton RoadClaytonMelbourneVIC 3168Australia Monash University MelbourneVICAustralia Beijing Children’s Hospital Affi liated to Capital Medical University BeijingPeople’s R epublic of China Shenzhen Children’s Hospital ShenzhenPeople’s R epublic of China Pediatric Infectious Diseases Research Group St George’sUniversity of LondonLondonUK

Preface The rise of antimicrobial resistance (AMR) is recognised as a major threat to global health. The United Nations' Sustain-able Development Goals (SDG) do not explicitly address AMR, but many of the targets within the goals depend on effective therapy for infectious diseases. Notably, these include targets 3.1, 3.2, 3.3, and 3.8, relating to the reduc-tion of early life mortality, eradicating ongoing epidemics including AIDS, tuberculosis and malaria, and achieving universal health coverage, as well as targets relating to pov-erty, malnourishment, and education (1)The world Health Organization (wHO) recognised the outstanding importance of AMR by passing a Global Action Plan in 2015 and declar-ing AMR a global priority (2)However, the wHO Global Action Plan on AMR mentions children only twice and to date includes no specific objectives or action points focusing on child health.

关键词： Diseases world Society children

Heat dissipating upper body compression garment:Thermoregulatory,cardiovascular, and perceptual responses

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Journal of Sport and Health Science 2019年第5期8卷 450-456页

作者： Iker Leoz-Abaurrea Nicholas Tam Roberto Aguado-jiménez Department of Health Sciences Public University of NavarreNavarre 31500Spain UCT/MRC Research Unit for Exercise Science and Sports Medicine Department of Human BiologyUniversity of Cape TownCape Town 7725South Africa

Purpose:The aim of the present study was to determine the effects of an upper body compression garment(UBCG)on thermoregulatory responses during cycling in a controlled laboratory thermoneutral environment(~23℃).A secondary aim was to determine the cardiovascular and perceptual responses when wearing the ***:Sixteen untrained participants(age:21.3±5.7 years;peak oxygen consumption(V02 peak):50.88±8.00 mL/min/kg;mean±SD)performed 2 cycling trials in a thermoneutral environment(~23℃)wearing either UBCG or control(Con)*** consisted of a 5-min rest on a cycle ergometer,followed by 4 bouts of cycling for 14-min at ~50%VO2 peak,with 1-min rest between each *** the end of these bouts there was 10-min of passive *** the entire protocol rectal temperature(Trec),skin temperature(Tskin),mean body temperature(Tbody),and heat storage(HS)were *** rate(HR),VO2,pH,hematocrit(Hct),plasma electrolytes,weight loss(wloss),and perceptual responses were also ***:There were no significant differences between garments for Tskin,HS,HR,VO2,pH,Hct,plasma electrolyte concentration,wloss,and perceptual responses during the *** did not differ between garment conditions during rest,exercise,or recovery although a greater reduction in Trec wearing UBCG(p=0.01)was observed during *** Tbody during recovery was found when wearing UBCG(36.82℃±0.30℃ vs.36.99℃±0.24℃).Conclusion:wearing a UBCG did not benefit thermoregulatory,cardiovascular,and perceptual responses during exercise although it was found to lower Tbody during recovery,which suggests that it could be used as a recovery tool after exercise.

关键词： Body temperature Compression garment Cycling Heat dissipation Thermoregulation

Non-ST elevation acute coronary syndrome in the elderly

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Journal of Geriatric Cardiology 2020年第1期17卷 9-15页

作者： Pablo Díez-Villanueva César jiménez Méndez Fernando Alfonso Cardiology Department Hospital Universitario La Princesa Universidad Autónoma de Madrid

1 Introduction Societies are ageing at an accelerated *** scenario is a well-known challenge for health care systems,as chronic diseases,multiple comorbidities and dependency are all entities that often converge in the ***,there is an issue regarding a reduction in the general incidence of acute coronary syndrome(ACS)together with a delayed in the age of presentation,which,in sum,lead to an increase in both incidence and prevalence of ACS with age,especially non-ST elevation myocardial infarction(NSTEMI).

关键词： Acute coronary syndrome Myocardial infarction The elderly

Lophozonia tree cavities used for nesting by Slender-billed Parakeets(Enicognathus leptorhynchus)in the central valley of southern Chile:a potentially vanishing keystone resource

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Chinese Birds 2017年第1期8卷 25-36页

作者： Thomas H.white Jr. Jaime E.jiménez Puerto Rican Parrot Recovery Program United States Fish and Wildlife ServiceBox 1600Rio GrandePR 00745USA Sub-Antarctic Biocultural Conservation Program Department of Biological SciencesUniversity of North TexasDentonTX 76201USA Sub-Antarctic Biocultural Conservation Program Department of Philosophy and ReligionUniversity of North TexasDentonTX 76201USA Omora Etnobotanical Park Universidad de MagallanesPuerto WilliamsChile

Background: The Slender-billed Parakeet(Enicognathus leptorhynchus) is a psittacine endemic to southern Chile and an obligate secondary cavity-nester. In the central valley of southern Chile, most(94%) of the known Slender-billed Parakeet nests have occurred in large, mature southern beech(Lophozonia obliqua) trees(locally known as "pellines"). As relicts of the original old-growth forests of southern Chile, most pellines have been lost due to extensive landclearing throughout the region, potentially threatening long-term persistence of the Slender-billed ***: we conducted our study in the central valley of southern Chile, near the city of Osorno during three consecutive nesting seasons(November–January, 2008–2011). Nest trees used by Slender-billed Parakeets were located by direct observation of parakeet activities and through interviews with local residents, some of whom were former parrot nest poachers. Nest cavities were accessed, inspected and measured using single-rope climbing techniques. we report means, standard errors, 95% confidence intervals and ranges for 11 cavity-related variables. we also report clutch sizes encountered in active nests, and age estimates of nest trees based on known growth rates of Lophozonia trees in southern Chile. Linear regressions were used to evaluate potential relationships between cavity-related variables and clutch ***: we located and measured 38 Lophozonia tree cavities used for nesting by Slender-billed Parakeets. Compared to those used by other psittacines, nest trees were relatively large, averaging 30.4 breast height of 134.5 ter ± 1.1 m in height with a mean diameter at ± 4.7 cm. Based on estimated annual diameincrement, ages of nest trees ranged from approximately 209–485 years. Nest cavities entrances averaged 12.5 ± 0.9 m in height above ground level. Cavity entrance widths averaged 51.0 ± 13.3 cm(vertical) by 11.5 ± 0.7 cm(horizontal). Cavity entrance orientations were apparently random, with

关键词： Conservation Deforestation Habitat loss Lophozonia obliqua Pellines Psittacidae Regeneration