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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.reddy Erika Orlov PHemachandra reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of Pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of Public Health Texas Tech University Health Sciences CenterLubbockTXUSA

the process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in Ht22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated Ht22cells expressing mutant tau(mtau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mtau-Ht22 cells(Ht22 cells transfected with cDNA mutant tau)were seen to display increased levels of synaptophysin,MAP-2,andβ-***,we confirmed and noted reduced levels of both total and p-tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mta u-expressed Ht22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mta u-Ht22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mta u-Ht22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mta u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells Ht22 neurite outgrowth neuronal development small molecule

LoRa Sense:Sensing and Optimization of LoRa Link Behavior Using Path-Loss Models in Open-Cast Mines

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 425-466页

作者： Bhanu Pratap reddy Bhavanam Prashanth Ragam School of Computer Science and Engineering VIT-AP UniversityAmaravati52237India

the Internet of things(Iot)has orchestrated various domains in numerous applications,contributing significantly to the growth of the smart world,even in regions with low literacy rates,boosting socio-economic *** study provides valuable insights into optimizing wireless communication,paving the way for a more connected and productive future in the mining *** Iot revolution is advancing across industries,but harsh geometric environments,including open-pit mines,pose unique challenges for reliable *** advent of Iot in the mining industry has significantly improved communication for critical operations through the use of Radio Frequency(RF)protocols such as Bluetooth,Wi-Fi,GSM/GPRS,Narrow Band(NB)-Iot,SigFox,ZigBee,and Long Range Wireless Area Network(LoRaWAN).this study addresses the optimization of network implementations by comparing two leading free-spreading Iot-based RF protocols such as ZigBee and *** field tests are conducted in various opencast mines to investigate coverage potential and signal *** is tested in the tadicherla open-cast coal mine in ***,LoRaWAN field tests are conducted at one of the associated cement companies(ACC)in the limestone mine in Bargarh,India,covering both Indoor-toOutdoor(I2O)and Outdoor-to-Outdoor(O2O)environments.A robust framework of path-loss models,referred to as Free space,Egli,Okumura-Hata,Cost231-Hata and Ericsson models,combined with key performance metrics,is employed to evaluate the patterns of signal *** field testing and careful data analysis revealed that the Egli model is the most consistent path-loss model for the ZigBee protocol in an I2O environment,with a coefficient of determination(R^(2))of 0.907,balanced error metrics such as Normalized Root Mean Square Error(NRMSE)of 0.030,Mean Square Error(MSE)of 4.950,Mean Absolute Percentage Error(MAPE)of 0.249 and Scatter Index(SI)of *** the O2O scenario,the Ericsson model

关键词： Internet of things long range wireless area network ZigBee mining environments path-loss models coefficient of determination mean square error

Facile one-step hydrothermal route to MSe/Mo_(3)Se_(4)(M:Zn,Mn,and Ni)-based electrode materials for ultralong-life hybrid supercapacitors

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Journal of Materials Science & technology 2023年第25期156卷 230-240页

作者： B.N.Vamsi krishna Obula reddy Ankinapalli Ayyaluri ramakrishna reddy Jae Su Yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea

transition metal selenides have attracted great interest in electrochemical energy storage applications because of their good electrochemical activity and conductivity ***,we reported the metal molybdenum selenide(M Se/Mo_(3)Se_(4)(M:Zn,Mn,and Ni))electrode materials on their morphological and electrochemical properties by varying the metal ions via a facile hydrothermal *** effects of the structural,morphological,and surface area properties of the prepared powder materials on their electrochemical performance were *** to the hierarchical porous and unique interconnected structure,the nickel molybdenum selenide nanosheet spheres(NMS NSSs)-based electrode material delivered an excellent specific capacity value of 252 mAh g^(-1) at a current density of 1 Ag^(-1).Moreover,the optimized NMS NSSs electrode exhibited outstanding cycling stability with a capacity retention of 80%and a corresponding coulombic efficiency of 99%after 80,000 ***,a pouch-type hybrid supercapacitor(HSC)device was assembled using NMS NSSs material as a positive electrode and activated carbon as a negative electrode in 1 M aqueous kOH ***,the assembled HSC device exhibited superior energy and power density values as well as magnificent cycling *** real-time practical applications,light-emitting diodes and a digital display were powered using two series-connected HSC ***,the obtained tremendous results strongly suggest that the NiSe/Mo_(3)Se_(4) NSSs-based materials could be a promising electrode for ultralong-life energy storage applications.

关键词： Nickel selenides Molybdenum selenides Nanosheet spheres Ultralong-life cycling stability

Spectral change and far-red emission of Mn^(2+)ions co-doped NaSrB_(5)O_(9):Dy^(3+)luminescence material for plant growth LEDs

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Journal of Rare Earths 2022年第2期40卷 218-225,I0002页

作者： k.Munirathnam koduru Mallikarjuna R.Vijaya P.C.Nagajyothi k.ramakrishna reddy M.Srinivas Department of Physics School of Applied SciencesREVA UniversityBengaluru560064India Department for Management of Science and technology Development Ton Due Thang UniversityHo Chi Minh CityVietnam Faculty of Applied Sciences Ton Due Thang UniversityHo Chi Minh CityVietnam Department of Physics Visvodaya Government Degree CollegeVenkatagiri524132India School of Mechanical Engineering Yeungnam UniversityGyeongsan33541South Korea Department of Chemistry School of Applied SciencesREVA UniversityBengaluru560064India

Due to the characteristic emission of phosphors,phosphor-converted LEDs have been employed to provide the requisite light sources for indoor plant growth in the optical agricultural ***,we prepared a series of Mn^(2+)co-doped NaSrB5 O9:Dy^(3+)phosphors via a solid-state reaction *** phosphors have significant three-band emissions at 467 nm(blue region),606 nm(orange region),and765 nm(far-red region),ascribed to the^(4)F_(9/2)-^(6)H_(15/2)and 4 F9/2-6 H13/2 transitions of the Dy^(3+)ions and the^(4)t_(1g)(G)-^(6)A_(1g)(S)spin-forbidden transition of the Mn^(2+)ions,respectively,when excited by light of 376 nm(near-UV region).the co-dopant in the host material facilitates tunable photoluminescence(PL)due to energy transfer from the Dy^(3+)ions to the Mn^(2+)*** three emission peaks from the prepared phosphors well match with the absorption spectra of the photosynthesis pigments of plants,chlorophyll and phytochrome,which can absorb blue(400-500 nm),orange-red(550-700 nm),and infrared(IR)radiation,indicating that these phosphors have potential applications in the fabrication of plant-growth *** to the PL studies,the structure of the phosphors was determined by X-ray diffraction,refined by Rietveld method and chemically quantified by X-ray photoelectron spectroscopy.

关键词： Phosphors Refinement X-ray photoelectron spectroscopy Energy transfer Plant growth LEDs Rare earths

Synthesis and Characterization of C-tiO_2/FetiO_3 and CQD/C-tiO_2/FetiO_3 Photocatalysts with Enhanced Photocatalytic Activities Under Sunlight Irradiation

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Acta Metallurgica Sinica(English Letters) 2016年第1期29卷 17-27页

作者： ramakrishna Dadigala Bhagavanth reddy Gangapuram Rajkumar Bandi Ayodhya Dasari Veerabhadram Guttena Department of Chemistry Osmania University

Sunlight-driven C-tiO2/FetiO3 composites were synthesized with different weight fractions of FetiO3. the as-prepared samples were characterized by UV-Visible diffuse reflectance spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction analysis, transmission electron microscopy, scanning electron microscopy, energy-dis- persive X-ray spectroscopy, and photoluminescence. Under sunlight irradiation, the C-tiO2/FetiO3 photocatalysts degraded methyl orange （MO） efficiently and displayed much higher photocatalytic activity than that of pure FetiO3 or carbon-doped titanium dioxide （C-tiO2）, and the C-tiOE/FetiO3 photocatalyst with 10 wt% of FetiO3 exhibited the highest photocatalytic activity. the enhancement of photocatalytic activity was mainly ascribed to the formation of a heterojunction between C-tiO2 and FetiO3, which facilitated the transfer and separation of photogenerated electron-hole pairs. the quenching effects of different scavengers demonstrated that the reactive superoxide radicals （02-） and hydroxyl radicals （OH） played a major role in the MO degradation. the possible photocatalytic mechanism is discussed on the basis of the band structures of C-tiO2 and FetiO3. to further enhance the photocatalytic efficiency, double-heterojunctioned CQD/C-tiO2/FetiO3 composite was prepared by loading carbon quantum dots onto the C-tiO2/FetiO3 surface.

关键词： C-tiO2 FetiO3 CQD Composites Sunlight photocatalytic activity

Metal Organic Framework Derived Zirconia-Carbon Nanoporous Mat for Integrated Strain Sensor Powered by Solid‑State Supercapacitor

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Advanced Fiber Materials 2023年第4期5卷 1404-1416页

作者： Brindha Ramasubramanian Vundrala Sumedha reddy Ye Zhen Seeram ramakrishna Vijila Chellappan Department of Mechanical Engineering Center for Nanofibers and NanotechnologyNational University of SingaporeSingapore 117574Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)#08‑032 Fusionopolis WayInnovisSingapore 138634Singapore

Flexible electronics are essential for the rapid development of human-machine interface technology,encompassing sensors and energy storage ***-state supercapacitors with 1D nanofiber electrodes are critical for enhancing ion *** this study,a flexible supercapacitor integrated with a strain sensor was designed using a polyvinyl alcohol/polymethyl methacrylate(PVA/PMMA)-based electrolyte and a metal-organic framework(MOF)-derived Zr-nanoporous carbon mat(Zr-NPC).the sensor showed remarkable sensitivity over a broad strain range,enabling reliable and precise detection of mechanical *** supercapacitor with Zr-NPC@PVDF electrode also demonstrated a specific capacitance of 286 mF cm^(-2) at 0.5 mA cm^(-2),maintaining high flexibility and mechanical *** fabricated supercapacitor maintained around 81%charge retention after 10,000 ***,the self-powered integrated model was directly connected to the human body to detect physical motion,accentuating its potential for widespread applications in wearable technology.

关键词： Supercapacitor Piezoresistive sensor Porosity Nanocarbon

CompactChain:an efficient stateless chain for UtXO-model blockchain

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Frontiers of Computer Science 2024年第2期18卷 167-179页

作者： B Swaroopa reddy t Uday kiran reddy Department of Electrical Engineering Indian Institute of Technology HyderabadHyderabadTelangana 502285India

In this work,we propose a stateless blockchain called CompactChain,which compacts the entire state of the UtXO(Unspent transaction Output)based blockchain systems into two RSA *** first accumulator is called transaction Output(tXO)commitment which represents the tXO *** second one is called Spent transaction Output(StXO)commitment which represents the StXO *** this work,we discuss three algorithms:(i)to update the tXO and StXO commitments by the *** miner also provides the proofs for the correctness of the updated commitments;(ii)to prove the transaction’s validity by providing a membership witness in tXO commitment and non-membership witness against StXO commitment for a coin being spent by a user;(iii)to update the witness for the coin that is not yet spent;the experimental results evaluate the performance of the CompactChain in terms of time taken by a miner to update the commitments and time taken by a validator to verify the commitments and validate the *** compare the performance of CompactChain with the existing state-of-the-art works on stateless *** shows a reduction in commitments update complexity and transaction witness size which inturn reduces the mempool size and propagation latency without compromising the system throughput(transactions per second(tPS)).

关键词： stateless blockchain RSA Accumulator StXO commitment tXO commitment UtXO Non-interactive Proof of Exponentiation(NI-PoE) transactions per second(tPS)

Investigations on Heat transfer Enhancement in Pool Boiling with Water-CuO Nano-Fluids

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Journal of thermal Science 2012年第2期21卷 179-183页

作者： ramakrishna N. Hegde Dr. Shrikantha S. Rao R. P. reddy Research Scholar National Institute of Technology Surathkal/ Department of Mechanical Engineering M S R I T Bangalore 560054 Assistant Professor Department of Mechanical Engineering National Institute of Technology Surathkal Reva Institute of technology Yelahanka Bangalore 560064

the main focus of the present work is to investigate Critical Heat Flux (CHF) enhancement using CuO nanofluid relative to CHF of pure water. to estimate the effect of nanoparticles on the CHF, pool boiling CHF values were measured for various volume concentrations of CuO nanofluid and compared with pure water. CHF enhancement of 130% was recorded at 0.2 % by volume of CuO nano-fluids. Surface roughness of the heater surface exposed to three measured heating cycles indicated surface modifications at different volume concentrations of nanofluid. SEM image of the heater surface revealed porous layer build up, which is thought to be the reason for CHF enhancement.

关键词： Nanofluid pool boiling CHF enhancement nano-particle.

Predicting the strength properties of slurry infiltrated fibrous concrete using artificial neural network

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Frontiers of Structural and Civil Engineering 2018年第4期12卷 490-503页

作者： t.Chandra Sekhara reddy Civil Engineering G.P.R.Engineering CollegeKurnool 518002Andhra PradeshIndia

this paper is aimed at adapting Artificial Neural Networks (ANN) to predict the strength properties of SIFCON containing different minerals admixture. the investigations were done on 84 SIFCON mixes, and specimens were cast and tested after 28 days curing. the obtained experimental data are trained using ANN which consists of 4 input parameters like Percentage of fiber (PF), Aspect Ratio (AR), type of admixture (tA) and Percentage of admixture (PA). the corresponding output parameters are compressive strength, tensile strength and flexural strength. the predicted values obtained using ANN show a good correlation between the experimental data. the performance of the 4-14-3 architecture was better than other architectures. It is concluded that ANN is a highly powerful tool suitable for assessing the strength characteristics of SIFCON.

关键词： artificial neural networks root mean square error SIFCON silica fume metakaolin steel fiber