检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

重载直流牵引电动机的运用和维修经验

国外内燃机车 1991年第12期 42-49页

作者： k.p.ramalingam 方一

本文论述了作者本人在印度铁路重载客货运输用直流牵引电动机运用和维修管理方面的经验,着重论述了牵引负载的性质及其对可靠性和性能问题的改善之影响。还介绍了他对消除这些问题的产生根源所采取的成功的方法,这些方法甚至对最佳的牵... 详细信息

本文论述了作者本人在印度铁路重载客货运输用直流牵引电动机运用和维修管理方面的经验,着重论述了牵引负载的性质及其对可靠性和性能问题的改善之影响。还介绍了他对消除这些问题的产生根源所采取的成功的方法,这些方法甚至对最佳的牵引电动机的设计和制造也起了作用。

关键词：牵引电动机直流电机维修

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.Li Nagendran ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Novel technique(ramalingam technique)of port site retrograde intra renal surgery through exteriorized ureter during laparoscopy

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Urology 2023年第3期10卷 372-375页

作者： Manickam ramalingam kallappan Senthil Sivasankaran Nachimuthu Urology Department Hindusthan HospitalCoimbatoreIndia

Occurrence of significant sized renal calculi along with ureteric pathology is not *** presented two patients:one with significant sized renal calculi along with lower ureteric stricture,and second case with significant sized renal calculi with primary obstructive mega ureter needing surgery for both the renal calculi and ureteric *** both patients laparoscopy was done,and the ureter was mobilised and divided just above the level of the pathology and exteriorised through the nearest sited port,and retrograde intra-renal surgery(RIRS)was done using flexible ureteroscope and *** laparoscopy was resumed,and ureteric reimplantation directly into the bladder or with a Boari flap was *** entire procedure was completed in a single *** novel technique of exteriorizing the ureter through the laparoscopic port site for flexible ureteroscopy in a case of lower ureteric pathology with renal stone is an advantageous option to manage both pathologies in a single *** has a better stone clearance than shock wave lithotripsy and less morbidity than percutaneous nephrolithotomy(pCNL).

关键词： ureter surgery bladder

Development of CeO_2 nanorods reinforced electrodeposited nickel nanocomposite coating and its tribological and corrosion resistance properties

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2018年第12期36卷 1319-1325页

作者： S.Shanmugasamy k.Balakrishnan A.Subasri S.ramalingam A.Subramania Centre for Nanoscience and Technology Pondicherry University Department of Chemistry Kalasalingam University

A simple electrodeposition technique was used to prepare Ni-CeOnanorods composite coating(Ni-CeONRs) using Watt’s nickel plating bath containing CeOnanorods(NRs) as the reinforcement phase under optimized process conditions. The X-ray diffraction analysis(XRD) was used for the structural analysis of Ni-CeONRs composite coatings and their average crystalline size is ～22 nm for pure Ni and ～18 nm,respectively. The crystalline structure is fcc for the Ni-CeOnanocomposite coatings. The surface morphology of the electrodeposited Ni-CeONRs composite coatings was analyzed by scanning electron microscopy(SEM). Microhardness of pure Ni and Ni-CeONRs composite coatings are found to be 253 HV and 824 HV, respectively. The inclusion of CeONRs increases the microhardness of Ni-CeONRs composite coatings. The corrosion resistance behavior of Ni-CeONRs composite coating was evaluated by Tafel polarization and AC impedance methods. It is revealed that CeONRs reinforced Ni matrix shows higher microhardness and corrosion resistance than existing reported electrodeposited pure Ni and CeOnanoparticles reinforced Ni coatings.

关键词： CeO_2 nanorods Rare earths Electrodeposition Nanocomposite coating Microhardness

Multi-targeting cytotoxic drug leads from mushrooms

在线全文

学校读者我要写书评

暂无评论

Asian pacific Journal of Tropical Medicine 2019年第12期12卷 531-536页

作者： MVNL Chaitanya Asha Jose p ramalingam SC Mandal p Narendra kumar phytomedicine&phytochemistry Division Raghavendra Institute of Pharmaceutical Education&Research(RIPER)(AUTONOMOUS)campusAnantapuramuAPIndia Department of pharmacology Karpagam College of PharmacyOthakkalmadapamCoimbatore 32TamilnaduIndia RERDS-CpR Raghavendra Institute of Pharmaceutical Education&Research(RIPER)(AUTONOMOUS)AnantapuramuAPIndia pharmacognosy and phytotherapy Research Laboratory Division of PharmacognosyDepartment of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India School of Crop production Technology Suranaree University of TechnologyThailand

Due to genetic and epigenetic mechanisms, cancer have become a resistant disease and there is a need for new molecules having multiple targeting action that promotes apoptosis. phytomolecules having multiple targeting anticancer activity are in high demand and there is less documentation or information available on these metabolites. It is evident that mushrooms are became the store houses of new anticancer molecules and mushrooms like Agaricus blazei, Antrodia camphorate, Albatrellus confluens, Bolteus badius, Cordyceps militaris, Clitocybe maxima, Funalia trogii, Grifola frondosa, and Inocybe umbrinella, are some of the medicinal mushrooms reported for their cytotoxic activity. Cytotoxic molecules like lentinan, grifolin, illudin-S, psilocybin, ganoderic acid, theanine, and hispolon, have been isolated from various mushroom species. However, studies have been limited only to in vitro cytotoxic mechanisms and very few trials have been conducted to prove the clinical efficacy of these drug leads. Hence, the current review focuses on new anticancer metabolites isolated from various mushrooms having multiple targeting mechanisms in cancer. However, an extensive research is needed to define the biosynthesis and clinical mechanism of these multiple acting metabolites. This review provides a platform for researchers new anticancer drugs and to bring out potent multiple acting anticancer newer drugs.

关键词： Cancer phytomolecules Multiple targeting Anticancer Drugs Leads

performance studies on recycled aggregate concrete with treated recycled aggregates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Waste Disposal and Sustainable Energy 2023年第4期5卷 451-459页

作者： Malathy ramalingam Jagan Sivamani karuppasamy Narayanan Faculty Department of Civil EngineeringSona College of TechnologySalemTamil NaduIndia

Excessive construction activities generate huge quantities of waste that are disposed of in nearby sites,leading to environmental *** the concrete fractions of construction wastes for their utilization as aggregates has been predominant among industrialists and researchers in recent ***,the smearance of cement mortar on the recycled aggregates affects the concrete *** treatments were developed to remove the weak cement mortar or seal the micro-pores on the adhered cement mortar of recycled *** paper investigates the comparative efficiency of acid and carbonation treatment on recycled coarse aggregate(RCA)properties and its behaviour on recycled aggregate concrete(RAC).The RCA was treated with HCl acid at 0.1 mol/L,0.5 mol/L,and 0.8 mol/L and CO_(2) at 0.1 bar,0.2 bar,and 0.4 bar and tested for their physical properties,and the concrete mixtures with treated recycled aggregates were tested for fresh and hardened *** could be observed that the properties of RAC were affected owing to the smearance of weak mortar,whereas for the concrete with carbonated(RACc)and chemically treated aggregates(RACa),the concrete properties tended to *** strength of RAC was 28.59%less than that of normal aggregate concrete(NAC),whereas the strength of RACc and RACa was enhanced by 16.44%and 9.7%compared to that of RAC at 28 *** water absorption of RAC was 47.51%more than that of NAC,whereas the water absorption of RACa and RACc was 28.67%and 33.75%lesser than ***-soaking the RCA with acids removes the adhered mortar due to its acidic *** contrast,in carbonation,the CO_(2) reacts with the Ca(OH)_(2) on the cement mortar to form CaCO_(3),filling the micro-cracks in the cement mortar on the RCA.

关键词： Recycled aggregates Chemical Carbonation Adhered mortar Recycled aggregate concrete Strength Water absorption

Emerging mosquito-borne arboviral infection Zika-An epidemiological review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian pacific Journal of Tropical Biomedicine 2020年第5期10卷 193-200页

作者： Ashwini Malla Balamurugan Shanmugaraj Sathishkumar ramalingam plant Genetic Engineering Laboratory Department of BiotechnologyBharathiar UniversityCoimbatoreTamil NaduIndia

The unprecedented resurgence and geographical expansion of arboviral infections such as dengue, chikungunya, yellow fever, and Zika have a significant impact on human health and pose a serious threat to public health globally in recent years. Zika virus is a Flavivirus and is transmitted to humans through an infected mosquito bite. The Zika virus has been identified in many countries in Africa, Asia, and pacific islands and sporadic human cases have been reported since 1947. The non-specific clinical symptoms of Zika fever are often misdiagnosed with other arboviral infections, especially dengue and chikungunya. Till now, there is no vaccine or specific antiviral treatment for Zika infection. The recent emergence of Zika is alarming and highlights the need for arboviral research to develop an effective treatment. Here in this review, we discussed the epidemiology of Zika, which has re-emerged in the recent decade and caused international concern.

关键词： Arboviruses Epidemiology Mosquito Zika

Dye-tolerant marine Acinetobacter baumannii-mediated biodegradation of reactive red

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Water Science and Engineering 2018年第4期11卷 265-275页

作者： Sneha Unnikrishnan Mohd Hashim khan karthikeyan ramalingam School of Life Sciences B.S.Abdur Rahman Crescent Institute of Science and Technology

The objective of this study was to isolate a potent dye-degrading microbe that can be used to reduce the pollution caused by industrial *** red 198 is an extensively used textile dye and is a major environmental pollutant in water bodies. In this study, a bacterial strain was isolated from sea sediments and identified as Acinetobacter baumannii with 16S rRNA sequencing. The isolated bacteria were immobilized in calcium alginate and decolorization studies were carried out to determine the optimum pH, temperature, dye concentration, inoculum volume,and static/agitated condition using the one factor at a time(OFAT) approach. The Box-Behnken design, a type of response surface methodology,was adopted to improve the degradation efficiency. At 37℃ using an inoculum volume of six beads, 96.20% decolorization was observed in 500 mg/L of reactive red 198 after 72 h. Dye degradation was confirmed with UV-visible spectroscopy and Fourier-transform infrared(FTIR)spectroscopy studies of the dye and degraded metabolites. Microbial toxicity studies using Escherichia coli, Staphylococcus aureus, and pseudomonas aeruginosa and phytotoxicity studies using Vigna radiata proved that the toxicity of the dye was significantly reduced after degradation. We can conclude that the isolated A. baumannii strain is an efficient dye-degrading microbe that can be used to reduce the pollution caused by industrial dyes.

关键词： Immobilization Box-Behnken design Response surface methodology Microbial toxicity Dye degradation

Chikungunya infection:A potential re-emerging global threat

在线全文

学校读者我要写书评

暂无评论

Asian pacific Journal of Tropical Medicine 2016年第10期9卷 910-915页

作者： Shanmugaraj Bala Murugan ramalingam Sathishkumar plant Genetic Engineering Laboratory Department of BiotechnologyBharathiar University

Infectious diseases are indeed a lifelong threat to everyone irrespective of age, sex, lifestyle and socio-economic status. The infectious diseases have persisted among the prominent causes of death globally. Recently, re-emergence of Chikungunya viral infection harmed many in Asian and African countries. Chikungunya was considered as a major threat in developing and underdeveloped countries; the recent epidemiological outbreak of Chikungunya in La Reunion urges the global researchers to develop effective vaccine against this viral disease. In this review, Chikungunya, pathogenesis and epidemiology were briefly described.

关键词： Aedes mosquitoes Alphavirus Arthropod-borne disease Chikungunya Non-Structural proteins Structural proteins