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Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert R.Wang Andrew M.Baschnagel Zijian Ni Sean R.Brennan Hypatia k.newton Darya Buehler Christina kendziorski Randall J.kimple Gopal lyer Department of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Carbone Cancer Center MadisonWI 53705USA Department of Biostatistics and Medical Informatics University of Wisconsin-MadisonMadisonWI 53706USA Department of Biology Tufts UniversityMedfordMA 02155USA Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(AR)is a major transcription factor that plays a role in inflammatory response including interleukin-6(IL6)signaling.1 While AR regulation through paracrine loop signaling in prostate tissue is well-studied,its impact through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and RNA knockdown of AR identified a bZIP transcription factor MAF to be a common target of inflammation using these perturbations in lung cells.

关键词： inflammation lung respiratory

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工业城市的末日及城市财政危机

地理译报 1989年第1期8卷 26-29页

作者： k.newton 阎小培苏林

本文论述了当代社会后工业化阶段经济需求和技术能力使得大城市、尤其是工业城市过多,从而出现了普遍的城市衰退以及城市购政危机等方面的问题。然而与“城市末日”这一理论相反,本文认为城市并非正在丧失经济基础,而是在转换其经济基... 详细信息

本文论述了当代社会后工业化阶段经济需求和技术能力使得大城市、尤其是工业城市过多,从而出现了普遍的城市衰退以及城市购政危机等方面的问题。然而与“城市末日”这一理论相反,本文认为城市并非正在丧失经济基础,而是在转换其经济基础。过去城市是生产中心,而现在城市却成为生产、分配,消费协调中心。英国的一些实际情况可以说明这一论点。本文最后得出一些切实可行的政策结论。

关键词：工业城市城市财政危机经济

Design of Differential Multi-Point Feeding Dual-Polarized SISL Antenna Based on CM Analysis

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Chinese Journal of Electronics 2024年第5期33卷 1245-1252页

作者： Bin TANG kaixue MA Eric newton MORO Yu LUO Tianjin key Laboratory of Imaging and Sensing Microelectronics Technology School of MicroelectronicsTianjin University

Dual-polarized antennas are required in the current mobile communication to increase the channel capacity and reducing multi-path effects. Utilizing characteristic mode(CM) analysis, this paper presents a five-patch substrate integrated suspended line(SISL) antenna with suppressed unwanted higher-order modes, and achieves an enhanced bandwidth by using differential multi-point feeding(MPF) systems. Compared to single-point feeding systems, the proposed dual-polarized SISL antenna with the MPF system demonstrates a bandwidth 1.87 times wider. The novel SISL feeding system incorporates two pairs of differentially-fed branch line feed structures. A prototype of the proposed differential-fed antenna is fabricated and measured, showing good agreement between simulated and measured results. The dual-polarization SISL antenna can achieve realized gain from 8.1 dBi to 10.8 dBi within a working frequency from 3.17 GHz to 3.61 GHz(12.98%). Moreover, utilizing low-cost substrates, the proposed SISL antenna has the potential for 5G applications.

关键词： Dual polarized Characteristic mode analysis Feeding system Broadband 5G Substrate integrated suspended line antenna Bandwidth enhanced Suppressed higher-order modes Characteristic mode analysis Feeding system Broadband 5G Substrate integrated suspended line antenna Bandwidth enhanced Suppressed higher-order modes MICROSTRIP PATCH ANTENNA LEAkY-WAVE ANTENNA LOW-PROFILE BANDWIDTH ENHANCEMENT ORDER MODES RADIATION REDUCTION OPERATION TM10

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Suppressive effects of exercise-conditioned serum on cancer cells:A narrative review of the influence of exercise mode,volume,and intensity

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Journal of Sport and Health Science 2024年第4期13卷 484-498,F0003页

作者： Francesco Bettariga Dennis R.Taaffe Daniel A.Galvao Chris Bishop Jin-Soo kim Robert U.newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK School of Human Movement and Nutrition Sciences University of QueenslandSt.LuciaQLD 4072Australia

Cancer is a major cause of morbidity and mortality worldwide,and the incidence is increasing,highlighting the need for effective strategies to treat this *** has emerged as fundamental therapeutic medicine in the management of cancer,associated with a lower risk of recur-rence and increased *** avenues of research demonstrate reduction in growth,proliferation,and increased apoptosis of cancer cells,including breast,prostate,colorectal,and lung cancer,when cultured by serum collected after exercise in vitro(i.e.,the cultivation of cancer cell lines in an experimental setting,which simpliﬁes the biological system and provides mechanistic insight into cell responses).The underlying mechanisms of exercise-induced cancer suppressive effects may be attributed to the alteration in circulating factors,such as skeletal muscle-induced cytokines(i.e.,myokines)and ***,exercise-induced tumor suppressive effects and detailed information about training interventions are not well investigated,constraining more precise application of exercise medicine within clinical *** date,it remains unclear what role different training modes(i.e.,resistance and aerobic training)as well as volume and intensity have on exercise-condi-tioned serum and its effects on cancer ***,the available evidence is that a single bout of aerobic training at moderate to vigorous intensity has cancer suppressive effects,while for chronic training interventions,exercise volume appears to be an inﬂuential candidate driving cancer inhibitory effects regardless of training *** for future research investigating training modes,volume and intensity are provided to further our understanding of the effects of exercise-conditioned serum on cancer cells.

关键词： Cancer cells High intensity interval training Moderate intensity continuous training Resistance training Myokines

Exercise training mode effects on myokine expression in healthy adults:A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第6期13卷 764-779页

作者： Francesco Bettariga Dennis R.Taaffe Daniel A.Galvao Pedro Lopez Chris Bishop Anna Maria Markarian Valentina Natalucci Jin-Soo kim Robert U.newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Pleural Medicine Unit Institute for Respiratory HealthPerthWA 6009Australia Medical School Faculty of Health&Medical SciencesUniversity of Western AustraliaPerthWA 6009Australia Grupo de Pesquisa em Exercicio para Populacoes Clinicas(GPCLIN) Universidade de Caxias do SulCaxias do SulRio Grande do Sul 95070-560Brazil London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK Department of Pathophysiology and Transplantation University of MilanMilan 20133Italy School of Human Movement and Nutrition Sciences University of QueenslandSt.LuciaQLD 4072Australia

Background:The benefits of exercise are well known;however,many of the underlying molecular mechanisms are not fully *** muscle secretes myokines,which mediate muscleorgan *** regulate satellite-cell proliferation and migration,inflammatory cascade,insulin secretion,angiogenesis,fatty oxidation,and cancer *** date,the effects of different exercise modes(namely,aerobic and resistance exercise)on myokine response remain to be *** is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical ***:A systematic search was undertaken in PubMed,MEDLINE,CINAHL,Embase,SPORTDiscus,andWeb of Science in April *** studies examining the effects of a single bout of exercise on interleukin15(IL-15),irisin,secreted protein acidic and rich in cysteine(SPARC),oncostatinM(OSM),and decorin were included.A random-effects meta-analysis was also undertaken to quantify the magnitude of ***:Sixty-two studies were included(n=1193).Overall,exercise appeared to induce small to large increases in myokine expression,with effects observed immediately after to 60 min post-exercise,although these were mostly not statistically *** aerobic and resistance exercise resulted in changes in myokine levels,without any significant difference between training modes,and with the magnitude of change differing across *** levels returned to baseline levels within 180 min to 24 h ***,owing to potential sources of heterogeneity,most changes were not statistically significant,indicating that precise conclusions cannot be ***:knowledge is limited but expanding with respect to the impact of overall and specific effects of exercise on myokine expression at different time points in the systemic *** research is required to investigate the effects of different exercise modes at multiple time points on myok

关键词： Myokine Resistance exercise Aerobic exercise Cytokine Systemic circulation

Aqueous-phase reforming of hydroxyacetone solution to bio-based H_(2)over supported Pt catalysts

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Green Energy & Environment 2024年第4期9卷 777-788页

作者： A.k.k.Vikla k.koichumanova Songbo He k.Seshan Joint International Research Laboratory of Circular Carbon Nanjing Tech UniversityNanjing211816China Faculty of Science and Technology University of Twente7500 AE EnschedeThe Netherlands CoRe Pro 9723 BL GroningenThe Netherlands

Aqueous-phase reforming(APR)is an attractive process to produce bio-based hydrogen from waste biomass streams,during which the catalyst stability is often challenged due to the harsh reaction *** this work,three Pt-based catalysts supported on C,AlO(OH),and ZrO_(2)were investigated for the APR of hydroxyacetone solution in afixed bed reactor at 225℃and 35 *** them,the Pt/C catalyst showed the highest turnover frequency for H_(2)production(TOF of 8.9 molH_(2)molPt^(-1)min^(-1))and the longest catalyst *** the AlO(OH)and ZrO_(2)supported Pt catalysts,the side reactions consuming H_(2),formation of coke,and Pt sintering result in a low H_(2)production and the fast catalyst *** proposed reaction pathways suggest that a promising APR catalyst should reform all oxygenates in the aqueous phase,minimize the hydrogenation of the oxygenates,maximize the WGS reaction,and inhibit the condensation and coking reactions for maximizing the hydrogen yield and a stable catalytic performance.

关键词： APR Hydroxyacetone TOF Bio-based H_(2) Support effect

Direct scaling of residual displacements for bilinear and pinching oscillators

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 129-149页

作者： Mohammad Saifullah Vinay k.Gupta Department of Civil Engineering Indian Institute of Technology KanpurKanpur 208016India

The estimation of residual displacements in a structure due to an anticipated earthquake event has increasingly become an important component of performance-based earthquake engineering because controlling these displacements plays an important role in ensuring cost-feasible or cost-effective repairs in a damaged structure after the *** attempt is made in this study to obtain statistical estimates of constant-ductility residual displacement spectra for bilinear and pinching oscillators with 5%initial damping,directly in terms of easily available seismological,site,and model *** of the available models for the bilinear and pinching oscillators are useful when design spectra for a seismic hazard at a site are not *** statistical estimates of a residual displacement spectrum are proposed in terms of earthquake magnitude,epicentral distance,site geology parameter,and three model parameters for a given set of ductility demand and a hysteretic energy capacity coefficient in the case of bilinear and pinching models,as well as for a given set of pinching parameters for displacement and strength at the breakpoint in the case of pinching model *** proposed scaling model is applicable to horizontal ground motions in the western *** earthquake magnitudes less than 7 or epicentral distances greater than 20 km.

关键词： residual displacement spectrum bilinear hysteresis model pinching hysteresis model nonlinear analysis scaling model

Analysis of the Oscillatory Flows of Multiple Shock Waves in a Constant Area Duct

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Journal of Thermal Science 2024年第3期33卷 794-806页

作者： k JAMES Jintu kIM Heuy Dong Department of Mechanical Engineering Andong National UniversityAndong36729Republic of Korea CAD-IT korea Co. Ltd.Seoul08591Republic of Korea

The oscillatory response of multiple shock waves to downstream perturbations in a supersonic flow is studied numerically in a rectangular *** shock waves are formed inside the duct at a shock Mach number of *** duct has an exit height of H,and the effect of duct resonance on multiple shock oscillations is investigated by attaching exit ducts of lengths 0H,50H,and *** downstream disturbance frequency varied from 10 Hz to 200 Hz to explore the oscillation characteristics of the multiple shock *** oscillatory response of shock waves under self-excited and forced oscillation conditions are analyzed in terms of wall static pressure,shock train leading-edge location,shock train length,and the size of the separation *** extent of the initial shock location increases with an increase in exit duct length for the self-excited oscillation *** analysis of the shock train leading edge and the spectral analysis of wall static pressure variations are *** variation in the shock train length is analyzed using the pressure ratio method for self-excited as well as forced *** RMS amplitude of the normalized shock train length(ζ_(ST))increases with an increase in the exit duct length for the self-excited oscillation *** the downstream perturbation frequency is increased,ζ_(ST)is decreased for exit duct *** all exit duct designs and downstream forcing frequencies,the size of the separation bubble grows and shrinks during the shock oscillations,demonstrating the dependence on duct resonance and forced oscillations.

关键词： shock train downstream disturbance supersonic flow shock wave boundary layer interaction duct resonance flow separation

Impact of Fin Arrangement on Heat Transfer and Melting Characteristics of Phase Change Material

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Journal of Thermal Science 2024年第2期33卷 435-456页

作者： Arun UNIYAL Yogesh k.PRAJAPATI Department of Mechanical Engineering National Institute of Technology UttarakhandSrinagar(Garhwal)246174India Department of Mechanical Engineering BIT SindriDhanbadJharkhand828123India

Present work investigates the heat transfer and melting behaviour of phase change material(PCM) in six enclosures(enclosure-1 to 6) filled with paraffin *** enclosures are equipped with distinct arrangements of the fins while keeping the fin's surface area equal in each *** analysis has been presented to recognize the suitable fin arrangements that facilitate improved heat transfer and melting rate of the *** wall of the enclosure is maintained isothermal for the temperature values 335 k,350 k and 365 *** length of the enclosure including fins is ranging between 0 and *** have been illustrated through the estimation of important performance parameters such as energy absorbing capacity,melting rate,enhancement ratio,and Nusselt *** has been found that melting time(to melt 100% of the PCM) is 60.5%less in enclosure-2(with two fins of equal length) as compared to the enclosure-1,having no *** the fin surface area equal,if the longer fin is placed below the shorter fin(enclosure-3),melting time is further decreased by 14.1% as compared to ***,among all the configurations,enclosure-6 with wire-mesh fin structure exhibits minimum melting time which is 68.4% less as compared to the *** on the findings,it may be concluded that fins are the main driving agent in the enclosure to transfer the heat from heated wall to the *** design and positioning of the fins improve the heat transfer rate followed by melting of the PCM in the entire area of the *** of the favourable vortices and natural convection current in the enclosure accelerate the melting phenomenon and help to reduce charging time.

关键词： phase change material enclosure fin melting fraction energy storage heat transfer

Radiative heat transfer analysis of a concave porous fin under the local thermal non-equilibrium condition:application of the clique polynomial method and physics-informed neural networks

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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1613-1632页

作者： k.CHANDAN k.kARTHIk k.V.NAGARAJA B.C.PRASANNAkUMARA R.S.VARUN kUMAR T.MUHAMMAD Amrita School of Artificial Intelligence Amrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Studies in Mathematics Davangere UniversityDavangere 577002KarnatakaIndia Computational Science Lab Amrita School of EngineeringAmrita Vishwa VidyapeethamBengaluru 560035KarnatakaIndia Department of Pure and Applied Mathematics School of Mathematical SciencesSunway UniversityPetaling Jaya 47500Malaysia Department of Mathematics College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia

The heat transfer through a concave permeable fin is analyzed by the local thermal non-equilibrium(LTNE)*** governing dimensional temperature equations for the solid and fluid phases of the porous extended surface are modeled,and then are nondimensionalized by suitable dimensionless ***,the obtained nondimensional equations are solved by the clique polynomial method(CPM).The effects of several dimensionless parameters on the fin's thermal profiles are shown by graphical ***,the current study implements deep neural structures to solve physics-governed coupled equations,and the best-suited hyperparameters are attained by comparison with various network *** results of the CPM and physicsinformed neural network(PINN)exhibit good agreement,signifying that both methods effectively solve the thermal modeling problem.

关键词： heat transfer fin porous fin local thermal non-equilibrium(LTNE)model physics-informed neural network(PINN)