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当代医学科学(英文) 2023年第3期43卷 423-433页

作者： joyce Peper Michiel L.Bots Tim Leiner Martin J.Swaans Department of Cardiology St.Antonius HospitalNieuwegein 3435 CMThe Netherlands Department of Radiology University Medical Center UtrechtUtrecht 3508 GAThe Netherlands Julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht 3584 CGThe Netherlands

New non-and less-invasive techniques have been developed to overcome the procedural and operator related burden of the fractional flow reserve(FFR)for the assessment of potentially significant stenosis in the coronary *** FFR-techniques can obviate the need for the additional flow or pressure wires as used for FFR *** review provides an overview of the developments and validation of the virtual FFR-algorithms,states the challenges,discusses the upcoming clinical trials,and postulates the future role of virtual FFR in the clinical practice.

关键词： coronary artery disease quantitative flow ratio fractional flow reserve diagnostic accuracy physiology guided percutaneous coronary intervention

Exosomes:Small vesicles with big roles in cancer,vaccine development,and therapeutics

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Bioactive Materials 2022年第4期7卷 281-294页

作者： Abhimanyu Thakur Diana Carolina Parra Pedram Motallebnejad Marcelo Brocchi Huanhuan joyce Chen Pritzker School of Molecular Engineering The University of ChicagoUnited States Ben May Department for Cancer Research The University of ChicagoUnited States Tropical Disease Laboratory Department of GeneticsEvolutionMicrobiology and ImmunologyInstitute of BiologyUniversity of Campinas(UNICAMP)S˜ao PauloBrazil

Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every *** the availability of chemotherapy,radiotherapy,immunotherapy,and surgery,a cure for cancer has not been ***,exosomes have gained significant attention due to the therapeutic potential of their various components including proteins,lipids,nucleic acids,miRNAs,and *** constitute a set of tiny extracellular vesicles with an approximate diameter of 30-100 *** are released from different cells and are present in biofluids including blood,cerebrospinal fluid(CSF),and *** perform crucial multifaceted functions in the malignant progression of cancer via autocrine,paracrine,and endocrine *** ability of exosomes to carry different cargoes including drug and molecular information to recipient cells make them a novel tool for cancer *** this review,we discuss the major components of exosomes and their role in cancer *** also review important literature about the potential role of exosomes as vaccines and delivery carriers in the context of cancer therapeutics.

关键词： Cancer Exosome Therapeutics Extracellular vesicles Exosomal vaccine Exosomal delivery system

High-g Shocking Testing of the Martlet Wireless Sensing System

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Sound & Vibration 2018年第3期52卷 6-11页

作者： Xi Liu Xinjun Dong Yang Wang Lauren Stewart Jacob Dodson Bryan joyce School of Civil and Environmental Engineering Georgia Inst.of TechnologyAtlantaGAUSA Air Force Research Laboratory Munitions DirectorateEglin AFBFLUSA Energy Technology and Materials Division University of Dayton Research Inst.Eglin AFBFLUSA

This article reports the latest development of a wireless sensing system,named Martlet,on high-g shock acceleration *** Martlet sensing node design is based on a Texas Instruments Piccolo microcontroller,with clock frequency programmable up to 90 *** high clock frequency of the microcontroller enables Martlet to support high-frequency data acquisition and high-speed onboard *** addition,the extensible design of the Martlet node conveniently allows incorporation of multiple sensor *** this study,a high-g accelerometer interface board is developed to allow Martlet to work with the selected microelectromechanical system(MEMS)high-g *** low-pass and highpass filters,amplification gains are also implemented on the high-g accelerometer interface *** impact experiments are conducted to validate the performance of the Martlet wireless sensing system with the high-g accelerometer *** results of this study show that the performance of the wireless sensing system is comparable to the cabled system.

关键词： Shock test wireless sensors data acquisition system hydraulic blast actuator Martlet wireless sensing unit

Climatic zoning for energy efficiency applications in buildings based on multivariate statistics:The case of the Brazilian semiarid region

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Frontiers of Architectural Research 2022年第1期11卷 161-177页

作者： Mariana Navarro Benevides David Bruno de Sousa Teixeira joyce Correna Carlo Department of Architecture and Urban Planning Federal University of ViçosaViçosaMG36570-900Brazil Department of Agricultural Engineering Federal University of ViçosaViçosaMG36570-900Brazil

This study aimed to propose climatic zones in the Brazilian semiarid region using multivariate statistical techniques and to characterize these zones for energy efficiency applications in *** component analysis(PCA)was used to select the variables with the greatest practical *** this selection,hierarchical cluster analysis(HCA)was used to spatially define climatically homogeneous *** each defined zone,the most feasible constructive thermal conditioning strategies were defined,and the thermal indexes of heat and degree-hours of cooling and heating were *** result,PCA reduced the dimensionality of the initial database from 104 to 48 variables,among which the climatic and bioclimatic variables related to temperature stood *** the HCA,three climatic zones were defined for the Brazilian semiarid *** all zones,there was a high demand for constructive conditioning strategies,which have to be adopted in more than half of the total annual *** proposed zoning is adapted to the climatic aspects of the Brazilian semiarid and has significant potential for applications in construction planning in this ***,the methodology presented can be applied for establishing climatic zones in other regions,which can contribute to increasing the energy efficiency of buildings.

关键词： Principal component analysis Hierarchical cluster analysis Psychrometric chart Heat index Degree-hours

The mini player with diverse functions:extracellular vesicles in cell biology,disease,and therapeutics

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Protein & Cell 2022年第9期13卷 631-654页

作者： Abhimanyu Thakur Xiaoshan ke Ya-Wen Chen Pedram Motallebnejad kui Zhang Qizhou Lian Huanhuan joyce Chen The Pritzker School of Molecular Engineering The University of ChicagoChicagoIllinoisUSA The Ben May Department for Cancer Research The University of ChicagoChicagoIllinoisUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineKeck School of MedicineHastings Center for Pulmonary ResearchUniversity of Southern CaliforniaLos AngelesCA 90089USA Department of Stem Cell Biology and Regenerative Biology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089USA Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong Prenatal Diagnostic Center and Cord Blood Bank Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouChina HkUMed Laboratory of Cellular Therapeutics the University of Hong KongPok Fu LamHong Kong

Extracellular vesicles(EVs)are tiny biological nanovesicles ranging from approximately 30–1000 nm in diameter that are released into the extracellular matrix of most cell types and in *** classification of EVs includes exosomes,microvesicles,and apoptotic bodies,dependent on various factors such as size,markers,and biogenesis *** transition of EV relevance from that of being assumed as a trash bag to be a key player in critical physiological and pathological conditions has been revolutionary in many *** have been recently revealed to play a crucial role in stem cell biology and cancer progression via intercellular communication,contributing to organ development and the progression of *** review focuses on the significant research progress made so far in the role of the crosstalk between EVs and stem cells and their niche,and cellular communication among different germ layers in developmental *** addition,it discusses the role of EVs in cancer progression and their application as therapeutic agents or drug delivery *** such discoveries have been facilitated by tremendous technological advancements in EV-associated research,especially the microfluidics *** pros and cons in the context of characterization of EVs are also extensively discussed in this *** review also deliberates the role of EVs in normal cell processes and disease conditions,and their application as a diagnostic and therapeutic ***,we propose future perspectives for EV-related research in stem cell and cancer biology.

关键词： extracellular vesicles exosomes stem cells cancer exosomal communication exosomal therapeutics

Do assortative mating and immigrant inviability help maintain population genetic structuring of an herbivore on a crop and a wild relative?

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Insect Science 2019年第2期26卷 283-296页

作者： Ricardo Ramirez-Romero Delia Garibay-Benitez Ofelia Vargas-Ponce Andrea joyce Julio S. Bernal Departamento de Produccion Agricola CUCBA Universidad de Guadalajara Zapopan Jalisco Mexico Departamento de Botanica y Zoologia CUCBA Universidad de Guadalajara Zapopan Jalisco Mexico Sierra Nevada Research Institute University of California Merced California USA Department of Entomology Texas A&M University College Station. Texas USA

Population genetic structuring is common among herbivorous insects and frequently is associated with divergent host plants, such as crops and their wild relatives. Previous studies showed population genetic structuring in corn leafhopper Dulbulus maidis in Mexico, such that the species consists of two sympatric, host plant-associated populations: an abundant and widespread "pestiferous” population on maize (Zea mays mays), and a small and localized "wild" population on perennial teosinte (Zea diploperennis). a maize wild relative with a limited distribution. This study addressed whether assortative mating and immigrant inviability mediate genetic structuring of corn leafliopper by comparing the mating and reproductive successes of pestiferous and wild females that colonize their nonassociated host plants against the successes of females colonizing their associated host plants. Assortative mating was assessed by comparing mating frequencies and premating and mating times among females of each population on each host plant: immigrant inviability was assessed by comparing, across two generations, the fecundity, survival, development time, sex ratio, and population growth rate among leafhopper populations and host plants. Our results showed that on maize, and compared to resident, pestiferous females, wild females were more likely to mate, and greater proportions of their offspring survived to adult stage and were daughters;consequently, the per-generation population growth rate on maize was greater for immigrant, wild leafhoppers compared to resident, pestiferous leafhoppers. Our results suggested that wild leafhoppers emigrating to maize have a fitness advantage over resident, pestiferous leafhoppers, while immigrant pestiferous and resident wild leafhoppers on teosinte have similar fitnesses.

关键词： crop domestication Dalbulus maidis ecological speciation host associated differentiation Zea diploperennis Zea mays mays

Simple Food Group Diversity as a Proxy Indicator for Iron and Vitamin A Status of Rural Primary School Children in Uganda

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Food and Nutrition Sciences 2013年第12期4卷 1271-1280页

作者： Hedwig Acham Gaston Ampek Tumuhimbise joyce k. kikafunda Department of Food Technology and Nutrition School of Food Technology Nutrition and Bioengineering College of Agricultural and Environmental Sciences Makerere University Kampala Uganda.

Children in resource poor settings are at a high risk of inadequate iron and vitamin A intake when diets lack diversity and are dominated by staple foods. Yet comparative information on diet quality among school children is scarce. The objective of the study was to assess the potential of simple food group diversity to serve as a proxy indicator of iron and vitamin A status among rural school children in Uganda. A cross sectional correlation model of associations between Food Group Diversity (FGD) and iron and vitamin A status was used. We analyzed 8 schools in kumi District, Uganda, randomly selected from the 34 schools that participated in the main part of the study. Our sample included primary school children, aged between 9-15 years (n = 172). Food group diversity and food variety (FV) were calculated from both a food frequency questionnaire (FFQ) and a 24-hour dietary recall. The FGD and FVS were tested against iron (as serum ferritin) and vitamin A (as serum retinol) status. The FGD (based on FFQ data) was 9.6 (±1.9). There was a positive correlation between 24-hour recall and FFQ for consumption of cereals (Corr. Coef = 0.28;p 0.05), which was also the most highly consumed group (98.9% & 86.9% by FFQ and 24-hour recall;respectively). Consistent with other studies, increase in the number of food groups significantly increased serum ferritin and serum retinol measures (p 0.001). Presence of at least one food item in the “roots & tubers”;“cereals”;and “pulses/nuts”, significantly increased serum ferritin and serum retinol concentrations (p 0.01). We speculate that simple food group diversity may reflect intake and serve as a simple indicator of iron and vitamin A status among school children. Strategies aimed at increasing dietary diversity in the community may benefit the families of these children and improve their micronutrient status.

关键词： Food Group Diversity Iron Vitamin A Proxy Indicator

A successful TB defaulter control in a war zone with high HIV prevalence

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 78-80页

作者： Giovanni Landoni Chiara Pierotti Barbara Nattabi joyce Nono Camilla Biselli Bruno Corrado AISPO(Italian Association for Solidarity among People)

War zones in Sub-Saharan Africa represent a challenge for public health projects like TB control programs because planning and communication have been disrupted,doctors and medical workers flied to secure *** present a TB control program carried out by an Italian NGO,Italian Association for Solidarity among People(AISPO) in a referral Hospital of North Uganda(Lacor H).

关键词： Community capacity domains Dengue Thailand Qualitative study

Extract of Codiaeum luzonicum Merr. overcomes multidrug resistance in human colon cancer cells by modulating P-glycoprotein

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Asian Pacific Journal of Tropical Biomedicine 2022年第9期12卷 400-410页

作者： Regina joyce E.Ferrer Marc Justin C.Ong Sonia D.Jacinto Institute of Biology University of the Philippines DilimanQuezon CityMetro ManilaPhilippines

Objective:To investigate anti-multidrug resistance(MDR)activity and safety of the bioactive fraction(CL11)from Codiaeum luzonicum crude leaf ***:Cytotoxic activity of CL11 against MDR and nonresistant colon cancer cells was assessed using MTT *** of cell death was investigated by annexin V-propidium iodide staining,TUNEL,and JC-1 *** examine mechanism of action,the effect on the expression and function of the MDR-implicated protein P-glycoprotein was tested using Western blotting and calcein assay,***:CL11 had an EC50 of 0.18,1.03 and 38.52µg/mL against HCT-15,HCT-15/Dox and HCT116,*** was mediated by inhibition of P-glycoprotein function and *** mode of cell death involved mitochondrial membrane depolarization and was mostly non-apoptotic at EC50 concentrations against HCT-15 and HCT-15/***:Fraction CL11 of Codiaeum luzonicum induces nonapoptotic cell death in MDR cancer cells by overcoming MDR through inhibition of P-glycoprotein expression and function.

关键词： Natural product Leaf extract Codiaeum luzonicum MDR cancer P-gp inhibitor Colorectal cancer

Homicidal Abuse of Young Children:A Historical Perspective

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Journal of Forensic Science and Medicine 2017年第2期3卷 97-110页

作者： Rudy J Castellani joyce L deJong Carl J Schmidt Department of Pathology Western Michigan University Homer Stryker M.D.School of MedicineKalamazoo Department of Pathology Wayne County Medical ExaminerUniversity of MichiganDetroitMlUSA

The past 50 years has seen a heightened awareness of abusive injury patterns and increased concern for the plight of children victimized by their *** of the young,however,has been embedded in society since the beginning of recorded ***,nature provides abundant examples of infanticide in lower animals,raising the question of whether exploitation,apathy,and violence toward children are on some level evolutionarily *** human antiquity,selective killing of females,the illegitimate,and the malformed,killing by ritualistic sacrifice or to conserve resources was carried out with *** middle ages and later saw a decline in these practices albeit *** hundred years into the industrial revolution,with harsh child labor in public view,legal remedies were sought to protect children but with little *** domestic abuse of children was not addressed until a pivotal 19^(th)-century case,in which the rights of animals were invoked to intervene on behalf of a *** the 20th century,physicians began to look closely at anatomical findings;patterns due to trauma,especially inflicted trauma,began to emerge.“Battered child syndrome”was followed by“shaken baby syndrome”,the latter prompted by the recurrent findings of subdural hematoma,retinal hemorrhages,and brain injury with the absence of impact injuries and no plausible accidental or natural disease *** the 21st century,high-quality studies and an emphasis on evidenced-based medicine substantiated the existence ofiiijury patterns resulting from homicidal ***,progress has been uneven.A case of child abuse that reached the US Supreme Court resulted in an ill-cited dissent that seems to have amplified an already toxic medicolegal environment,perhaps *** difficulties in balancing the welfare of society with that of caregivers in the aftermath of homicidal abuse will no doubt continue.

关键词： Abusive head trauma child abuse homicide infanticide