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Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT1R axis and attenuates cardiac inflammation and apoptosis

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亚太热带生物医学杂志:英文版 2023年第9期13卷 384-392页

作者： Anitha Roy Vasantha Mallenahalli Neelakantappa jayashree Ganesan Balakrishnan Ramajayam Asokan Srinivasan kulandaivel V.V.Sathibabu Uddandrao Sengottuvelu Singaravel Center for Transdisciplinary Research Department of PharmacologySaveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennaiTamil NaduIndia-600077 Department of Pharmacology Kasturba Medical CollegeMangoloreManipal Academy of Higher EducationManipalIndia-5750013 Department of Pharmacology Aarupadai Veedu Medical College&HospitalVinayaka Mission Research FoundationPuducherryIndia-607403 Department of Pharmaceutical Chemistry Nandha College of PharmacyErodeTamilnaduIndia-638052 Department of Biochemistry K.S.Rangasamy College of Arts and Science(Autonomous)TiruchengodeNamakkal DistrictTamilnaduIndia-637215 Department of Pharmacology Nandha College of PharmacyErodeTamil NaduIndia-638052

Objective:To investigate the cardioprotective effect of beta-glucan against isoproterenol-induced cardiotoxicity in rats,and elucidate the underlying ***:Rats were orally pretreated with beta-glucan(40 mg/kg body weight)for 30 d,and isoproterenol(20 mg/100 g body weight)was administered on days 31 and *** effects of beta-glucan on markers of cardiac injury,hemodynamic changes,production of proinflammatory cytokines,and the corresponding mRNA expressions were *** addition,histological analysis was ***:Pretreatment with beta-glucan prevented isoproterenol-induced cardiac injury by preserving the structural and functional integrity of the plasma membrane and attenuating the production of proinflammatory cytokines(NF-κB,TNF-α,IL-6,IL-1β,and IFN-γ)in the ***,beta-glucan significantly downregulated the mRNA expression of ACE,AT1R,TNF-α,IL-6,NF-κB,caspase-3,TLR-4,and Bax,and upregulated Bcl-2 in the *** the same time,pretreatment with beta-glucan alleviated myocardial damage as reflected in a reduction in myonecrosis,edema,and erythrocyte extravasation with almost imperceptible ***:Beta-glucan can protect against isoproterenol-induced cardiotoxicity by attenuating cardiac inflammation and apoptosis and regulating the ACE-AT1R axis,thereby preventing cardiac remodeling.

关键词： Βeta-glucan Isoproterenol Cardiac inflammation Cardiac apoptosis Cardiovascular diseases Heart failure Myocardial infarction

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Standardization of choroidal thickness measurements using enhanced depth imaging optical coherence tomography

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 484-491页

作者： Nattapon Boonarpha Yalin Zheng Alexandros N.Stangos Huiqi Lu Ankur Raj Gabriela Czanner Simon P.Harding jayashree Nair-Sahni Department of Eye and Vision Science Institute of Ageing and Chronic Disease University of Liverpool St.Paul's Eye Unit Royal Liverpool University Hospital Department of Biostatistics University of Liverpool

AIM: To describe and evaluate a standardized protocol for measuring the choroidal thickness(Ch T) using enhanced depth imaging optical coherence tomography(EDI OCT).METHODS: Single 9 mm EDI OCT line scans across the fovea were used for this study. The protocol used in this study classified the EDI OCT images into four groups based on the appearance of the choroidal-scleral interface and suprachoroidal space. Two evaluation iterations of experiments were performed: first, the protocol was validated in a pilot study of 12 healthy eyes. Afterwards, the applicability of the protocol was tested in 82 eyes of patients with diabetes. Inter-observer and intra-observer agreements on image classifications were performed using Cohen’s kappa coefficient(κ). Intraclass correlation coefficient(ICC) and Bland-Altman’s methodology were used for the measurement of the Ch ***: There was a moderate(κ=0.42) and perfect(κ =1) inter- and intra-observer agreements on image classifications from healthy eyes images and substantial(κ =0.66) and almost perfect(κ =0.86) agreements from diabetic eyes images. The proposed protocol showed excellent inter- and intra-observer agreements for the Ch T measurements on both, healthy eyes and diabetic eyes(ICC >0.90 in all image categories). The Bland-Altman plot showed a relatively large Ch T measurement agreement in the scans that contained less visible choroidal outer boundary. CONCLUSION: A protocol to standardize Ch T measurements in EDI OCT images has been developed;the results obtained using this protocol show that the technique is accurate and reliable for routine clinical practice and research.

关键词： choroid enhanced depth imaging choroidal thickness optical coherence tomography diabetes

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AstroSat Observations of the Be/X-Ray Binary XTE J1946+274 During 2018 and 2021 Outbursts

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Research in Astronomy and Astrophysics 2023年第4期23卷 26-43页

作者： Amar Deo Chandra jayashree Roy P.C.Agrawal Indian Institute of Science Education and Research kolkata Mohanpur 741246West BengalIndia Inter-University Center for Astronomy and Astrophysics Post Bag 4Pune 411007MaharashtraIndia Department of Astronomy and Astrophysics Tata Institute of Fundamental ResearchHomi Bhabha RoadMumbai 400005MaharashtraIndia

We present the timing and spectral studies of the Be/X-ray binary XTE J1946+274 during its 2018 and 2021 giant outbursts using observations with the SXT and LAXPC instruments on the AstroSat *** the 1998 and 2010 outbursts,where a giant outburst was followed by several low intensity periodic outbursts,the 2018 and 2021 outbursts were single *** X-ray pulsations are detected over a broad energy band covering 0.5–80 keV from the compact *** construct the spin evolution history of the pulsar over two decades and find that the pulsar spins-up during the outbursts but switches to spin-down state in the quiescent periods between the *** resolved pulse profiles generated in several bands in 0.5–80 keV show that the pulse shape varies with the *** energy spectrum of the pulsar is determined for the 2018 and 2021 *** best fit spectral models require presence of cyclotron resonant scattering feature at about 43 keV in the energy spectra of both the *** find indication of possible reversal in the correlation between the cyclotron line energy and luminosity which needs to be ascertained from future *** the best fit spectra the X-ray luminosity of XTE J1946+274 is inferred to be 2.7×10^(37) erg s^(-1) for the 2018 observations and 2.3×10^(37) erg s^(-1) for the 2021 *** discuss possible mechanisms which can drive outbursts in this transient Be X-ray binary.

关键词： accretion-accretion disks-stars neutron-(stars:)pulsars general-X-rays binaries-stars emission-line-Be-X-rays bursts

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Psycho-physiological analysis of soccer referees

Psycho-physiological analysis of soccer referees

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2008奥林匹克科学大会

作者： Mohan,Shailaja Acharya,jayashree Lakshmibai National College of Physical Education India

Introduction Soccer or Football is the world's most popular form of sport,being played in every *** referee is the key official in regulating the behaviour of soccer participants by implementing the rules of play. Referees decisions on points of facts connected with the play shall be final,so far as the result of the game is *** referee is not only the director of the match but acts at the same time as

关键词： Psycho-physiological analysis of soccer referees

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A High Sensitive LC-MS/MS Method for the Simultaneous Determination of Potential Genotoxic Impurities Carboxy Phenyl Boronic Acid and Methyl Phenyl Boronic Acid in Lumacaftor

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American Journal of Analytical Chemistry 2021年第3期12卷 74-86页

作者： kartheek Srinivas Chidella Vijaya Bharathi Dasari A. jayashree Center for Chemical Sciences and Technology Institute of Science and Technology Jawaharlal Nehru Technological University Hyderabad Hyderabad Telangana Aurobindo Pharma Laboratory Research Center II Hyderabad Telangana

A simple, rapid, and highly sensitive LC-MS/MS method has been developed for the simultaneous and trace level quantification of underivatized boronic acids in lumacaftor active pharmaceutical ingredient. Chromatographic separation of boronic acids and lumacaftor achieved using Agilent Poroshell HPH C18 150 × 4.6 mm 2.7 μ column with 0.1% ammonia in water as mobile phase A and 100% acetonitrile as mobile phase B at a flow rate of 0.25 ml/min. Gradient elution was used with a total method run time of 14 minutes. Boronic acids were successfully ionized and quantified without derivatization using electrospray ionization in negative mode using tandem quadrupole mass spectrometry in multiple reactions monitoring mode. Method validation was performed as per ICH guidelines with good linearity over the concentration range of 0.05 ppm to 5 ppm of Lumacaftor test concentration for both the boronic acids with a correlation coefficient of >0.99. Recoveries were found good at different concentration levels and within the range of 80% - 120%. The developed method can be successfully used for the routine quantification of boronic acids at a concentration level of 20 ng/ml (1 ppm with respect to 20 mg/ml lumacaftor).

关键词： Boronic Acid Genotoxic LC-MS/MS Lumacaftor

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Performance comparison of three artificial neural network methods for classification of electroencephalograph signals of five mental tasks

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Journal of Biomedical Science and Engineering 2010年第2期3卷 200-205页

作者： Vijay khare jayashree Santhosh Sneh Anand Manvir Bhatia 不详

In this paper, performance of three classifiers for classification of five mental tasks were investigated. Wavelet Packet Transform (WPT) was used for feature extraction of the relevant frequency bands from raw Electroencephalograph (EEG) signal. The three classifiers namely used were Multilayer Back propagation Neural Network, Support Vector Machine and Radial Basis Function Neural Network. In MLP-BP NN five training methods used were a) Gradient Descent Back Propagation b) Levenberg-Marquardt c) Resilient Back Propagation d) Conjugate Learning Gradient Back Propagation and e) Gradient Descent Back Propagation with movementum.

关键词： Electroencephalogram (EEG) Wavelet Packet Transform (WPT) Support Vector Machine (SVM) Radial Basis Function Neural Network (RBFNN) Multilayer Back Propagation Neural Network (MLP-BPNN) Brain Computer Interface (BCI)

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Ultra-Sensitive LC-MS/MS Method for the Trace Level Quantification of Six Potential Genotoxic Nitrosamine Impurities in Telmisartan

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American Journal of Analytical Chemistry 2021年第6期12卷 227-240页

作者： kartheek Srinivas Chidella Vijaya Bharathi Dasari jayashree Anireddy Center for Chemical Sciences and Technology Institute of Science and Technology Jawaharlal Nehru Technological University Hyderabad Hyderabad India Aurobindo Pharma Laboratory Research Center II Hyderabad India

Nitrosamine impurities are potentially genotoxic which are considered under cohort of concern as per ICH M7 guidelines and need to be controlled at trace levels during quantification in drug substances and drug products for safe human consumption. Recent regulatory requirements also suggest the need to have highly sensitive analytical methods for the accurate quantification of Nitrosamine impurities. In this paper we have presented simple, rapid and ultra-sensitive LC-MS/MS method for six potential genotoxic nitrosamine impurities: N-Nitroso dimethyl amine (NDMA), N-Nitroso diethyl amine (NDEA), N-Nitroso Ethyl Iso propylamine (NEIPA), N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) N-Nitroso diisopropylamino (NDIPA) and N-Nitroso dibutyl amine (NDBA) with a LOQ of 0.004 ppm. Chromatographic separation is achieved using Zorbax SB C18 150 × 3.0 mm, 3.5 μ column with 0.1% formic acid in water as mobile phase A and 0.1% formic acid in methanol as mobile phase B at a flow rate of 0.3 ml/min using gradient mode of elution at a total run time of 18 minutes. Six nitrosamine impurities are successfully ionized and quantified in positive mode of atmospheric pressure chemical ionization (APCI) using multiple reaction monitoring (MRM). Method validation is performed as per ICH guidelines evaluating the limit of quantification and detection and found to give good S/N ratios with good linearity range of 0.002 - 2 ppm with regression coefficient >0.99 for all the six nitrosamine impurities. Method recoveries are established using three-step sample preparation protocol and are found to be satisfactory within 80% - 120%. The method can be used routinely applied for the detection of Nitrosamines in Telmisartan at a concentration of 1.5 ng/ml (0.03 ppm with respect to telmisartan concentration of 50 mg/ml).

关键词： Nitrosamine NDMA Genotoxic LC-MS/MS Telmisartan Impurities

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Simultaneous and Trace Level Quantification of Five Potential Genotoxic Impurities in Ranolazine Active Pharmaceutical Ingredient Using LC-MS/MS

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American Journal of Analytical Chemistry 2021年第1期12卷 1-14页

作者： kartheek Srinivas Chidella Vijaya Bharathi Dasari jayashree Anireddy Center for Chemical Sciences and Technology Institute of Science and Technology Jawaharlal Nehru Technological University Hyderabad Telangana India Aurobindo Pharma Laboratory Research Center II Hyderabad Telangana India

Highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for the simultaneous determination of five potential genotoxic impurities in ranolazine active pharmaceutical ingredient. Chromatographic separation achieved using Poroshell C18 PFP 150 × 3.0 mm 2.7 μ column and 0.1% formic acid in water as Mobile phase A and 0.1% formic acid in methanol as mobile phase B using gradient elution and a flow rate of 0.4 ml/min with a run time of 18 minutes. Mass spectrometric conditions were optimized using electrospray ionization in positive mode. Method shows excellent linearity from 0.05 - 5.0 ppm of the ranolazine test concentration for all the five impurities. The correlation coefficient was observed greater than 0.99. Satisfactory recoveries were observed for all the five impurities within the range of 102.9% - 112.3%. Method has been validated as per ICH recommended guidelines with a LOQ of 0.15 ppm achieved. The developed method was able to quantify all the five impurities at a concentration level of 1 ng/ml (0.5 ppm with respect to 2 mg/ml ranolazine).

关键词： Genotoxic Impurities LC-MS/MS Sensitive

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Diversity of Primate Lentiviruses Rebooted

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Journal of Biosciences and Medicines 2019年第12期7卷 126-138页

作者： jayashree S. Nandi Anil k. Chhangani Shravan Singh Rathore Bajrang Raj J. Mathur Department of Microbiology & Immunology Albert Einstein College of Medicine New York USA Department of Environmental Science Maharaja Ganga Singh University Bikaner India Department of Wildlife Machiya Biological Park Jodhpur India Department of Veterinary Sciences Patanjali Products 1-B-1 Kamla Nehru Nagar Behind Konark School Jodhpur India

Highlight: The present report reveals for the first time natural lentiviral infection of wild Indian NHPs, rhesus monkeys (Macaca mulatta) and langurs (Semnopithecus entellus) by SIVs that are phylogenetically diverse from all known SIVs, including “SIVmac”, which infects captive rhesus monkeys. The novel SIVs are intriguingly homologous to HIV-1, based on serology and partial lentiviral genomic sequence analyses. Diverse lenti-viruses infect human and nonhuman primates (NHPs). There are more than 45 different “species-specific” simian immunodeficiency viruses (SIVs) that infect their cognate NHP hosts in natural habitats in Africa. Indian NHPs are not known to be infected by SIVs in the wild. Conventionally SIVs are named after their natural hosts, except for SIVmac, which infects captive rather than wild rhesus macaques. SIVmac is therefore a misnomer. It is a genetic variant of the African SIVsmm, which infects wild African sooty mangabey monkeys. SIVsmm is the progenitor of human immunodeficiency virus (HIV-2), while SIVcpz that infects wild chimpanzees is the progenitor of HIV-1. Although natural infections cannot be easily studied in wild NHP populations, we have previously reported co-infection of wild Indian NHPs by other retroviruses: simian retroviruses (SRVs) and Simian Foamy viruses (SFV). Apart from zoonosis, transmission of pathogens from humans to animals: anthroponosis, has also been reported in literature.

关键词： Lentivirus HIV-1 SIV Wild Indian Langur Rhesus Monkey Zoonosis Anthroponosis

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Comparison of SVM and ANN for classification of eye events in EEG

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Journal of Biomedical Science and Engineering 2011年第1期4卷 62-69页

作者： Rajesh Singla Brijil Chambayil Arun khosla jayashree Santosh 不详

The eye events (eye blink, eyes close and eyes open) are usually considered as biological artifacts in the electroencephalographic (EEG) signal. One can con-trol his or her eye blink by proper training and hence can be used as a control signal in Brain Computer Interface (BCI) applications. Support vector ma-chines (SVM) in recent years proved to be the best classification tool. A comparison of SVM with the Artificial Neural Network (ANN) always provides fruitful results. A one-against-all SVM and a multi-layer ANN is trained to detect the eye events. A com-parison of both is made in this paper.

关键词： ANN BCI EEG Eye Event kurtosis SVM

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