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Effect of stress-dependent microannulus aperture on well leakage

journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1967-1976页

作者： Meng Meng Luke P.Frash j.William carey Mohamed Mehana Wenfeng Li Bailian Chen Earth and Environmental Sciences Los Alamos National LaboratoryLos AlamosNMUSA

Debonding at the cement-casing interface is recognized as a principal failure mechanism leading to CO_(2) leakage in *** detachment gives rise to a microannulus,which notably possesses greater permeability than undamaged cement,undermining its sealing ***,the permeability of the microannulus is regarded as a uniform value throughout the ***,fundamentally,a microannulus is one type of fracture,and its gap or aperture size is affected by the effective *** this work,we developed a unique experimental *** equipment facilitates the curing of cement inside a steel casing,the formation of a microannulus between the casing and the cement,and the investigation of the fluid flow dynamics along the microannulus under laboratory-replicated in situ *** microannulus was formed by injecting fluid from one end of the setup,and receiving similar amount of fluid on the other end signified the development of the leakage ***,strain gauges affixed to the casing’s external surface yielded key information on the microannulus’s opening and *** observed a noticeable decline in microannulus hydraulic aperture(or permeability)in relation to effective stress and an exponential equation fits their *** findings also indicate a distinct behavior when comparing liquid CO_(2) with ***,it is easier for liquid CO_(2) to create the ***,the hydraulic aperture range for this microannulus(0.7-6 mm)is considerably smaller than that created by water flow(2-17 mm).Finally,we integrated the stressdependent microannulus aperture size into the combined analysis of well mechanical integrity and well *** outcomes consistently demonstrated that when factoring in the stress-dependent aperture sizes,the leakage rates are 3e5 times compared to a fixed aperture *** traditional assumption of a constant aperture significantly underestimates fluid leakage risks.

关键词： Microannulus Leakage assessment Aperture size Triaxial experiment Carbon sequestration

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Hydromechanical characterization of gas transport amidst uncertainty for underground nuclear explosion detection

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journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2019-2032页

作者： Wenfeng Li Chelsea W.Neil j William carey Meng Meng Luke P.Frash Philip H.Stauffer Earth and Environmental Sciences Los Alamos National LaboratoryLos AlamosNM87544USA Department of Mineral Engineering New Mexico TechSocorroNM87801USA

Given the challenge of definitively discriminating between chemical and nuclear explosions using seismic methods alone,surface detection of signature noble gas radioisotopes is considered a positive identification of underground nuclear explosions(UNEs).However,the migration of signature radionuclide gases between the nuclear cavity and surface is not well understood because complex processes are involved,including the generation of complex fracture networks,reactivation of natural fractures and faults,and thermo-hydro-mechanical-chemical(THMC)coupling of radionuclide gas transport in the *** this study,we provide an experimental investigation of hydro-mechanical(HM)coupling among gas flow,stress states,rock deformation,and rock damage using a unique multi-physics triaxial direct shear rock testing *** testing system also features redundant gas pressure and flow rate measurements,well suited for parameter uncertainty *** porous tuff and tight granite samples that are relevant to historic UNE tests,we measured the Biot effective stress coefficient,rock matrix gas permeability,and fracture gas permeability at a range of pore pressure and stress *** Biot effective stress coefficient varies from 0.69 to 1 for the tuff,whose porosity averages 35.3%±0.7%,while this coefficient varies from 0.51 to 0.78 for the tight granite(porositykey engineering implications on transport of radionuclide gases post a UNE event:(1)The porous tuff shows apparent fracture dilation or compression upon stress changes,which does not necessarily change the gas permeability;(2)The granite fracture permeability shows strong stress sensitivity and is positively related to shear displacement;and(3)Hydromechanical coupling among stress states,rock damage,and gas flow appears to be

关键词： Underground nuclear explosion uncertainty quantification Radionuclide transport Biot effective stress coefficient Fracture permeability Matrix permeability

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肺超极化129Xe MR波谱显示特发性肺纤维化的1年肺功能降低

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国际医学放射学杂志 2023年第1期46卷 112-112页

作者： A.D.Hahn k.j.carey G.P.Barton L.A.Torres j.kammerman R.V.Cadmad 王天灏

摘要特发性肺纤维化（IPF）是一种时间和空间异质性肺疾病。确定病人的IPF是进展还是稳定,对于治疗方案至关重要。目的评估超极化129Xe MRI测量IPF病人通气和气

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CT检查中哮喘病人黏液阻塞与3He-MRI局部通气受限相关

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国际医学放射学杂志 2022年第3期 361-361页

作者： D.G.Mummy E.M.Dunican k.j.carey M.D.Evans B.M.Elicker j.D.N.jr 马伟玲

摘要哮喘病人气道黏液阻塞与急性加重频率、嗜酸性粒细胞增多和肺功能降低相关。黏液阻塞与超极化气体MRI观察到的空间重叠通气异常之间的关系尚未有定量评估指

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Effects of temperature and hydric environment on survival of the Panamanian Golden Frog infected with a pathogenic chytrid fungus

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Integrative Zoology 2010年第2期5卷 143-153页

作者： Heidi M.BUSTAMANTE Lauren j.LIVO Cynthia carey Department of Integrative Physiology University of ColoradoBoulderColoradoUSA

Considerable controversy exists concerning whether or not climate changes(particularly global warming)are causing outbreaks of a lethal amphibian pathogen,the chytrid fungus Batrachochytrium dendrobatidis(Longcore,Pessier&*** 1999).In the present study,groups of Panamanian golden frogs(Atelopus zeteki Dunn,1993),a critically endangered amphibian thought to be nearly extinct in Panama,were exposed to varying dosages of zoospores of Batrachochytrium dendrobatidis,temperatures and hydric environments in order to learn whether this species is susceptible to this pathogen and,if so,how environmental factors affect *** pathogen proved to be highly lethal for *** exposed to a dosage of 100 Bd zoospores survived significantly(P<0.0001)longer than those that had been exposed to 104 or 106 *** frogs housed at 23℃survived significantly(P<0.0001)longer than those that were housed at 17℃.Exposed frogs held in dry conditions survived significantly longer than those in wet conditions(P<0.0001).As a laboratory study,these results do not directly test hypotheses about the relation between climate change and the decline of these frogs in the field,but they inform the discussion about how environmental conditions can have an impact on the interaction between a susceptible amphibian and this *** data do not support the contention that rising global temperatures are necessary to cause the death of amphibians infected with this pathogen because the pathogen was equally lethal at 17 as at 23℃,and frogs at the warmer temperature lived significantly longer than those at the cooler one.

关键词： amphibian declines Atelopus zeteki Batrachochytrium dendrobatidis chytridiomycosis climatelinked-epidemic hypothesis

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Multi-Pass Simulation of Heavy Plate Rolling Including Intermediate Forced Cooling

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journal of Iron and Steel Research International 2011年第S1期18卷 506-510页

作者： E.j.Palmiere A.A.Howe H.C.carey Institute for Microstructural and Mechanical Process Engineering:The University of Sheffield (IMMPETUS) Sir Robert Hadfield BuildingMappin StreetSheffieldS1 3JDUK Tata Steel Research Development &Technology Swinden Technology CentreMoorgateRotherham S60 3ARUK

Thermomechanical Controlled Processing (TMCP) including accelerated cooling after the final hot rolling pass is a well-established technology,widely applied in HSLA steel plate ***,there are still certain limitations,especially for thicker *** rolling schedule includes a long holding period (HP) after the roughing stage to allow the temperature to fall sufficiently for optimised TMCP during *** Forced Cooling (IFC) applied during the HP can increase productivity by decreasing the required hold time,can restrict austenite grain growth,and can also improve the subsequent strain penetration in thick plate with further metallurgical ***-pass plane strain compression (PSC) tests have been performed on the thermomechanical compression (TMC) machine at Sheffield University including different severities of *** it is impossible to simulate all aspects of the temperature and strain gradients present in thick plates in laboratory specimens,and most of the tests were conducted at temperatures and strains calculated by Finite Element modelling as relevant to specific positions through the plate ***,some aspects of the gradients were addressed with tests using cold *** results have indeed shown that IFC can shorten the HP and reduce austenite grain growth and its variation across thick plate.

关键词： Steel plate rolling intermediate forced cooling plane strain compression recrystallisation grain growth finite element modelling temperature and strain distribution

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Regulation of Arabidopsis Early Anther Development by the Mitogen-Activated Protein kinases, MPk3 and MPk6, and the ERECTA and Related Receptor-Like kinases

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Molecular Plant 2008年第4期1卷 645-658页

作者： carey L.H. Hord Yu-jin Sun Lynn j. Pillitteri keiko U. Torii Huachun Wang Shuqun Zhang Hong Ma Department of Biology and the Huck Institutes of the Life Sciences Pennsylvania State University University Park PA 16802 USA The Intercollege Graduate Program in Plant Biology Pennsylvania State University University Park PA 16802 USA Present address: 3015 Quinby Dr. Columbus OH 43232 USA Present address: 318 Coker Hall (CB# 3280) Department of Biology University of North Carolina at Chapel Hill Chapel Hill NC 27599-3280 USA Department of Biology University of Washington Seattle WA 98195 USA Present address: Monsanto Company 700 Chesterfield Pkwy North Mailzone GG4G Chesterfield MO 63017 USA Department of Biochemistry and Bond Life Sciences Center University of Missouri Columbia MO 65211 USA

Mitogen-activated protein kinase （MAPk） and leucine-rich repeat receptor-like kinase （LRR-RLk） signaling pathways have been shown to regulate diverse aspects of plant growth and development. In Arabidopsis, proper anther development relies on intercellular communication to coordinate cell proliferation and differentiation. Two closely related genes encoding MAPks, MPk3 and MPk6, function redundantly in regulating stomatal patterning. Although the mpk6 mutant has reduced fertility, the function of MPk3 and MPk6 in anther development has not been characterized. Similarly, the ERECTA （ER）, ERECTA-LIkE1 （ERL1） and ERL2 genes encoding LRR-RLks function together to direct stomatal cell fate specification and the er-105 erll-2 erl2-1 triple mutant is sterile. Because the mpk3 rnpk6 double null mutant is embryo lethal, anther development was characterized in the viable mpk3/＋ mpk6/- and er-105 erll-2 erl2-1 mutants. We found that both mutant anthers usually fail to form one or more of the four anther lobes, with the er-105 erl1-2 erl2-1 triple mutant exhibiting more severe phenotypes than those of the mpk3/＋ mpk6/- mutant. The somatic cell layers of the differentiated mutant lobes appeared larger and more disorganized than that of wild-type. In addition, the er-105 erll-2 erl2ol triple mutant has a reduced number of stamens, the majority of which possess completely undifferentiated or under-differentiated anthers. Furthermore, sometimes, the mpk3/＋ mpk6/- mutant anthers do not dehisce, and the er-105 erl1-2 erl2-1 anthers were not observed to dehisce. Therefore, our results indicate that both ER/ERL 1/ERL2 and MPk3/MPk6 play important roles in normal anther lobe formation and anther cell differentiation. The close functional relationship between these genes in other developmental processes and the similarities in anther developmental phenotypes of the two types of mutants reported here further suggest the possibility that these genes might also function in the same pathway

关键词： Mitogen-activated protein kinase (MAPk) leucine-rich repeat receptor-like kinase (LRR-RLk)

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Risk of liver disease in methotrexate treated patients

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World journal of Hepatology 2017年第26期9卷 1092-1100页

作者： Richard Conway john j carey Centre for Arthritis and Rheumatic Diseases St. Vincent’s University Hospital CARD Newman Research Fellow University College Dublin Department of Rheumatology Galway University Hospitals Clinical Sciences Institute National University of Ireland Galway

Methotrexate is the first line drug treatment for anumber of rheumatic and non-rheumatic diseases. It is effective in controlling disease activity and preventing disease-related damage, and significantly cheaper than many alternatives. Use in rheumatoid arthritis infers a significant morbidity and mortality benefit. Methotrexate is generally well tolerated but can cause symptomatic adverse events. Multiple serious adverse events have been attributed to methotrexate, based largely on older reports using high or daily doses, and subsequent case reports and circumstantial evidence. The risk with modern dosing regimens: Lower doses, weekly schedules, and concomitant folic acid is less clear. Clarification and dissemination of the actual risk is crucial so appropriate judgements can be made for patients who may benefit from this treatment. Methotrexate has been associated with a range of liver related adverse events ranging from asymptomatic transaminase elevations to fibrosis and fatal hepatic necrosis. Concern over potential liver toxicity has resulted in treatment avoidance, cessation, or recommendations for investigations which may be costly, invasive and unwarranted. Modern laboratory monitoring of liver blood tests may also influence the risk of more serious complications. The majority of present day studies report an approximate doubling of the relative risk of elevated transaminases in methotrexate treated patients but no increased risk of symptomatic or severe liver related adverse events. In this article we will review the evidence around methotrexate and liver related adverse events.

关键词： Liver disease Transaminases Fibrosis Cirrhosis Methotrexate Hepatic

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Integrative taxonomy of the Russet Bush Warbler Locustella mandelli complex reveals a new species from central China

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Chinese Birds 2015年第2期6卷 60-91页

作者： Per Alstrom Canwei Xia Pamela C Rasmussen Urban Olsson Bo Dai jian Zhao Paul j Leader Geoff j carey Lu Dong Tianlong Cai Paul I Holt Hung Le Manh Gang Song Yang Liu Yanyun Zhang Fumin Lei key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of Sciences Swedish Species Information Centre Swedish University of Agricultural Sciences Ministry of Education key Laboratory for Biodiversity and Ecological Engineering College of Life SciencesBeijing Normal University Department of Integrative Biology and MSU Museum Michigan State University Bird Group The Natural History Museum at Tring Department of Biology and Environmental Sciences Systematics and BiodiversityUniversity of Gothenburg College of Life Sciences Leshan Normal University State key Laboratory of Biocontrol and College of Ecology and Evolution Sun Yat-sen University c/o AEC Ltd 121–127 Commercial CentrePalm SpringsYuen LongHong Kong College of Life Sciences University of Chinese Academy of Sciences Bracken Dean PendletonClitheroeLancashire BB7 1PTUK Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology

Background: The Russet Bush Warbler Locustella(previously Bradypterus) mandelli complex occurs in mountains in the eastern Himalayas, southern China, Vietnam, the Philippines, and Indonesia. The taxonomy has been debated,with one(L. seebohmi) to four(L. seebohmi, L. mandelli, L. montis and L. timorensis) species having been ***: We used an integrative approach, incorporating analyses of morphology, vocalizations and a molecular marker, to re-evaluate species limits in the L. mandelli ***: We found that central Chinese L. mandelli differed from those from India through northern Southeast Asia to southeast China in plumage, morphometrics and song. All were easily classified by song, and(wing + culmen)/tail ratio overlapped only marginally. Both groups were reciprocally monophyletic in a mitochondrial cytochrome b(cytb) gene tree, with a mean divergence of 1.0 ± 0.2%. They were sympatric and mostly altitudinally segregated in the breeding season in southern Sichuan province. We found that the Mt Victoria(western Myanmar) population differed vocally from other L. mandelli, but no specimens are available. Taiwan Bush Warbler L. alishanensis was sister to the L. mandelli complex, with the most divergent song. Plumage, vocal and cytb evidence supported the distinctness of the south Vietnamese L. mandelli idonea. The Timor Bush Warbler L. timorensis, javan Bush Warbler *** and Benguet Bush Warbler L. seebohmi differed distinctly in plumage, but among-population song variation in L. montis exceeded the differences between some populations of these taxa, and mean pairwise cytb divergences were only 0.5–0.9%. We also found that some L. montis populations differed ***: We conclude that the central Chinese population of Russet Bush Warbler represents a new species,which we describe herein, breeding at mid elevations in Sichuan, Shaanxi, Hubei, Hunan and Guizhou *** taxonomic status of the other allopatric populati

关键词： Bradypterus Cryptic species Locustella seebohmi Locustella mandelli Locustella montis Locustella timorensis Locustella alishanen

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FTY720,a sphingosine analog,altered placentome histoarchitecture in ewes

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journal of Animal Science and Biotechnology 2020年第2期11卷 380-392页

作者： kathrin A.Dunlap Bryan G.White David W.Erikson M.carey Satterfield Christiane Pfarrer Guoyao Wu Fuller W.Bazer Robert C.Burghardt kayla j.Bayless Greg A.johnson Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA Okanagan College Salmon Arm Campus Salmon ArmBritish ColumbiaCanada Endocrine Technologies Core Oregon National Primate Research CenterOregon Health&Science UniversityBeavertonORUSA Department of Anatomy University of Veterinary Medicine HannoverBischofsholer Damm 1530173 HannoverGermany Department of Veterinary Integrative Biosciences College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843USA Department of Molecular and Cellular Medicine Texas A&M Health Science CenterCollege StationTX 77843USA

Background:The lysosphingolipid,sphingosine-1-phosphate,is a well-described and potent pro-angiogenic ***,as well as the sphingosine phosphorylating enzyme sphingosine kinase 1,are expressed in the placentomes of sheep and the decidua of rodents;however,a function for this signaling pathway during pregnancy has not been *** objective of this study was to investigate whether sphingosine-1-phosphate promoted angiogenesis within the placentomes of pregnant *** were given daily jugular injections of FTY720(2-amino-2[2-(−4-octylphenyl)ethyl]propate-1,3-diol hydrochloride),an S1P ***:FTY720 infusion from days 30 to 60 of pregnancy did not alter maternal organ weights nor total number or mass of placentomes,but did alter placentome *** of caruncular crypts and cotyledonary villi was decreased,as was the relative area of cotyledonary tissue within ***,the percentage of area occupied by cotyledonary villi per unit of placentome was increased,while the thickness of the caruncular capsule was decreased in ewes treated with ***,FTY720 infusion decreased the number and density of blood vessels within caruncular tissue near the placentome capsule where the crypts emerge from the ***,FTY720 infusion decreased asparagine and glutamine in amniotic fluid and methionine in allantoic fluid,and decreased the crown rump length of day 60 ***:While members of the sphingosine-1-phosphate signaling pathway have been characterized within the uteri and placentae of sheep and mice,the present study uses FTY720 to address the influence of S1P signaling on placental *** present evidence that modulation of the S1P signaling pathway results in the alteration of caruncular vasculature,placentome architecture,abundance of amino acids in allantoic and amniotic fluids,and fetal growth during pregnancy in *** marked morphological changes in placentome histoarchitec

关键词： Placentome Pregnancy Sheep Sphingosine1 phosphate(S1P)

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