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Lumped Parameter Outflow Models for 1-D Blood Flow Simulations:Effect on Pulse Waves and Parameter Estimation

Communications in Computational Physics 2008年第7期4卷 317-336页

作者： J.Alastruey k.h.parker J.Peiro S.J.Sherwin Department of Aeronautics Imperial College LondonSouth Kensington CampusLondon SW72AZU.K Department of Bioengineering Imperial College LondonSouth Kensington CampusLondon SW72AZU.K.

Several lumped parameter,or zero-dimensional(0-D),models of the microcirculation are coupled in the time domain to the nonlinear,one-dimensional(1-D)equations of blood flow in large arteries.A linear analysis of the coupled system,together with in vivo observations,shows that:(i)an inflow resistance that matches the characteristic impedance of the terminal arteries is required to avoid non-physiological wave reflections;(ii)periodic mean pressures and flow distributions in large arteries depend on arterial and peripheral resistances,but not on the compliances and inertias of the system,which only affect instantaneous pressure and flow waveforms;(iii)peripheral inertias have a minor effect on pulse waveforms under normal conditions;and(iv)the time constant of the diastolic pressure decay is the same in any 1-D model artery,if viscous dissipation can be neglected in these arteries,and it depends on all the peripheral compliances and resistances of the *** this analysis,we propose an algorithm to accurately estimate peripheral resistances and compliances from in vivo *** algorithm is verified against numerical data simulated using a 1-D model network of the 55 largest human arteries,in which the parameters of the peripheral windkessel outflow models are known a *** and flow waveforms in the aorta and the first generation of bifurcations are reproduced with relative root-mean-square errors smaller than 3%.

关键词： Pulse wave propagation one-dimensional modelling lumped parameter outflow models time-domain coupling arterial compliance peripheral compliance peripheral resistance multiscale modelling.

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Atmospheric and kinetic studies of Oh and hO_2 by the FAGE technique

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Journal of Environmental Sciences 2012年第1期24卷 78-86页

作者： D.Amedro k.Miyazaki A.parker C.Schoemaecker C.Fittschen Laboratoire PC2A Universit de Lille 1- Ba timent C1159655 Villeneuve d'AscqFrance Department of Applied Chemistry Tokyo Metropolitan UniversityJapan

A new FAGE setup has recently been built at the University of Lille,*** permits the quantification of Oh and hO 2 in the atmosphere with a detection limit of 3×10 5 molecules/（cm 3 ·min） for Oh and 1×10 6 molecules/（cm 3 ·min） for hO *** coupling to a photolysis cell enables the measurement of the total reactivity of the hydroxyl radical in ambient air and kinetic studies in *** configurations have been considered：one with the photolysis cell at 90° to the FAGE nozzle,the other on line with the FAGE *** two configurations have been tested and validated by measuring the well known rate constants of Oh with Ch 4,C 3 h 8 and *** advantages and drawbacks of each configuration have been *** ＂on line＂ configuration limits losses and permits measurements over a larger reactivity range but is affected by Oh formation from the laser beam striking the FAGE nozzle,thus limiting the ability to carry out energy dependence studies which can,in contrast,be successfully performed in the 90° configuration.

关键词： Oh kinetic reactivity laser induced fluorescence

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Nucleic acid-based diagnostics for infectious diseases in public health affairs

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Frontiers of Medicine 2012年第2期6卷 173-186页

作者： Albert Cheung-hoi Yu Greg Vatcher Xin Yue Yan Dong Mao hua Li Patrick h.k.Tam parker Y.L.Tsang April k.Y.Wong Michael h.k.hui Bin Yang hao Tang Lok-Ting Lau Neuroscience Research Institute/Department of Neurobiology School of Basic Medical Sciences/Key Laboratory for NeuroscienceMinistry of Education/Key Laboratory for NeuroscienceMinistry of HealthPeking UniversityBeijing 100191China hai kang Life Corporation Limited Hong Kong SARChina and Beijing 100176China

Infectious diseases,mostly caused by bacteria and viruses but also a result of fungal and parasitic infection,have been one of the most important public health concerns throughout human *** first step in combating these pathogens is to get a timely and accurate diagnosis at an affordable *** kinds of diagnostics have been developed,such as pathogen culture,biochemical tests and serological tests,to help detect and fight against the causative agents of ***,these diagnostic tests are generally unsatisfactory because they are not particularly sensitive and specific and are unable to deliver speedy *** acid-based diagnostics,detecting pathogens through the identification of their genomic sequences,have shown promise to overcome the above limitations and become more widely adopted in clinical *** we review some of the most popular nucleic acid-based diagnostics and focus on their adaptability and applicability to routine clinical *** also compare and contrast the characteristics of different types of nucleic acid-based diagnostics.

关键词： nucleic acid-based diagnostics infectious disease PCR NASBA LAMP microarray LOAC public health affairs

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Bioreactor technology for clonal propagation of plants and metabolite production

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Frontiers in Biology 2015年第2期10卷 177-193页

作者： Nazmul h. A. Mamun Ulrika Egertsdotter Cyrus k. Aidun G.W. WoodruffSchool of Mechanical Engineering Georgia Institute of Technology Atlanta GA 30332 USA Department of Forest Genetics and Plant Physiology Umea Plant Science Center Swedish University of Agricultural Sciences 901 83 Umea Sweden parker h. Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta GA 30332 USA

Plant cell culture in bioreactors is an enabling tool for large scale production of clonal elite plants in agriculture, horticulture, forestry, pharmaceutical sectors, and for biofuel production. Advantages of bioreactors for plant cell culture have resulted in various types of bioreactors differing in design, operating technologies, instrumentations, and construction of culture vessels. In this review, different types of bioreactors for clonal propagation of plants and secondary metabolites production are discussed. Mechanical and biochemical parameters associated with bioreactor design, such as aeration, flow rate, mixing, dissolved oxygen, composition of built-up gas in the headspace, and ph of the medium, are pivotal for cell morphology, growth, and development of cells within tissues, embryos, and organs. The differences in such parameters for different bioreactor designs are described here, and correlated to the plant materials that have been successfully cultured in different types of bioreactors.

关键词： bioreactor types mechanical and biochemical parameters plant cell culture plant clonal propagation secondary metabolite production

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Magnetic Field Intensity/Melatonin-Molarity Interactions: Experimental Support with Planarian (Dugesia sp.) Activity for a Resonance-Like Process

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Open Journal of Biophysics 2012年第4期2卷 137-143页

作者： Bryce P. Mulligan Noa Gang Glenn h. parker Michael A. Persinger Department of Biology Behavioural Neuroscience Program Department of Biology Behavioural Neuroscience Program Biomolecular Sciences Program Laurentian UniversitySudbury Canada Department of Biology Behavioural Neuroscience ProgramBiomolecular Sciences Program Laurentian UniversitySudbury Canada

Synergistic interactions between specific magnetic field intensities and chemical concentrations are challenging biophysical phenomena. Planarian were exposed to one of five different concentrations of melatonin and to a “geomagnetic”—patterned 7 hz amplitude modulated magnetic field for 6 min once per hour for 8 hr during six successive nights. The peak average strengths were within the range (50 nT) or outside the range (200 nT) derived by the equation. As predicted by a resonance equation planarian displayed highly statistically significant decreased relative activity within the 50 nT, 10–7 to 10–6 M melatonin conditions compared to lower or higher concentrations. The effect explained about 30% of the variance in these changes of activity. Activity of planarian exposed to the same melatonin concentrations but to the 200 nT field did not differ significantly from each other or from those exposed to the 50 nT field in concentrations of melatonin –7 M or >10–6 M. These results suggest the existence of non-linear, “narrow-band” mechanisms involving the numbers of molecules within a distance determined by the boundary of the organism and the intensity of naturally-patterned magnetic fields derived from energy rather than force-based resonances.

关键词： Resonance Planarian Melatonin Magnetic Fields 7 hz

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Quantifying E2F1 protein dynamics in single cells

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Quantitative Biology 2020年第1期8卷 20-30页

作者： Bernard Mathey-Prevot Bao-Tran parker Carolyn Im Cierra hong Peng Dong Guang Yao Lingchong You Department of Pharmacology and Cancer Biology Duke University School of MedicineDurhamNC 27710USA Duke University School of Medicine DurhamNC 27710USA Molecular and Cellular Biology University of ArizonaTucsonAZ 85721USA Department of Biomedical Engineering Duke UniversityDurhamNC 27705USA Center for Genomic and Computational Biology Duke UniversityDurhamNC 27705USA Department of Molecular Genetics and Microbiology Duke University School of MedicineDurhamNC 27708USA Department of Pediatrics Duke University School of MedicineDurhamNC 27708USA University of North Carolina School of Medicine Chapel HillNC 27516USA Janelia Research Campus Howard Hughes Medical InstituteAshburnVA 20147USA

Background:E2F1 protein,a major effector of the Rb/E2F pathway plays a central role in regulating cell-fate decisions involved in proliferation,apoptosis,and *** expression is highly dynamic and tightly modulated through a combination of transcriptional,translational and posttranslational ***,the mechanisms by which its expression and activity can promote different cellular outcomes remain to be fully *** better document E2F1 expression in live cells,we have engineered a series of fluorescent E2F1 protein reporters that quantitatively capture E2F1 protein ***:Reporter constructs,under the control of the mouse or human E2F1 proximal promoter,were designed to express an E2F1-Venus fusion protein incapable of binding *** addition,constructs either included or excluded the y untranslated region(3fUTR)of the E2F1 *** constructs were introduced into fibroblasts and epithelial cells,and expression of the fusion reporter protein was validated and quantified in single cells using live ***:In all cases,expression of the reporter protein effectively recapitulated the behavior of E2F1 under various conditions,including cell cycle progression and genotoxic *** or little fluorescent signal of the reporter was detected in G〇,but as the cycle progressed,expression of the reporter protein steadily increased in the nucleus,peaking a few hours before cell division,but declining to baseline 2-3 h prior to the onset of *** absence of the E2F13 fUTR in the constructs led to considerably higher steady-state levels of the fusion protein,which although normally regulated,exhibited a slightly less complex dynamic profile during the cell cycle or genotoxic ***,the presence or absence of Rb failed to impact the overall detection and levels of the reporter ***:Our validated E2F1 protein reporters complement nicely other reporters of the Rb/E2F pathway and provide a unique tool to f

关键词： protein E2F1 reporter cell cycle

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化学冶金学导论

化学冶金学导论

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作者： R.h.·帕克(P.h. parker)

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With Soap and Water or Sanitizer,a Cleaning That Can Stave Off the Flu

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科技英语学习 2009年第11期 3-5页

作者： Tara parker-Pope 刘志强

母亲们常教育孩子要“勤洗手”，保持个人卫生。这种方法听来简单，但最近的几项医学研究表明，在流感病毒大举袭来之际，勤用肥皂或消毒剂洗手可以有效地杀灭病毒，预防感染。不论在学校还是家中，无论对成人还是对儿童，勤洗手都可以... 详细信息

母亲们常教育孩子要“勤洗手”，保持个人卫生。这种方法听来简单，但最近的几项医学研究表明，在流感病毒大举袭来之际，勤用肥皂或消毒剂洗手可以有效地杀灭病毒，预防感染。不论在学校还是家中，无论对成人还是对儿童，勤洗手都可以减少人们与病毒的接触，从而降低感染几率。其中，加州大学洛杉矶分校的研究人员还得出结论：手与面部器官的直接接触是感染流感的一大因素。

关键词：勤洗手个人卫生流感病毒感染率

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Preparing for a Stressful Flu Season

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科技英语学习 2009年第10期 28-31页

作者： Tara parker Pope 丁立福淮南师范学院

【选注者言】自2009年3月18日墨西哥首都发现首例人感染猪流感疑似病例以来，疫情恶化的速度可谓一日千“例”，迫于严峻形势，世界卫生组织先后将流感大流行警戒级别从第三级提升至第四级、第五级，进而于6月11日提升至最级别第六级、... 详细信息

【选注者言】自2009年3月18日墨西哥首都发现首例人感染猪流感疑似病例以来，疫情恶化的速度可谓一日千“例”，迫于严峻形势，世界卫生组织先后将流感大流行警戒级别从第三级提升至第四级、第五级，进而于6月11日提升至最级别第六级、并宣布流感大流行的到来，不禁令人谈“猪”色变，“猪”流感因此改头换面成“甲型h1N1”流感。

关键词：英语学习方法翻译方法译文

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心力衰竭低危患者的保健措施:一项随机对照试验

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世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 2-3页

作者： DeBusk R.F. Miller N.h. parker k.M. 任付先 Stanford University School of Medicine 780 Welch Road #106 Stanford CA 94304-5735 United States Dr.

Background: Nurse care management programs for patients with chronic illness have been shown to be safe and effective. Objective: To determine whether a telephone-media-ted nurse care management program for heart failure reduced the rate of rehospitalization for heart failure and for all causes over a 1-year period. Design: Randomized, controlled trial of usual care with nurse management versus usual care alone in patients hospitalized for heart failure from May 1998 through October 2001. Setting: 5 northern California hospitals in a large health maintenance organization. Patients: Of 2786 patients screened, 462 met clinical criteria for heart failure and were randomly assigned (228 to intervention and 234 to usual care). Intervention: Nurse care management provided structured telephone surveillance and treatment for heart failure and coordination of patients’care with primary care physicians. Measurements: Time to first rehospitalization for heart failure or for any cause and time to a combined end point of first rehospitalization, emergency department visit, or death. Results: At 1 year, half of the patients had been rehospitalized at least once and 11%had died. Only one third of rehospitalizations were for heart failure. The rate of first rehospitalization for heart failure was similar in both groups (proportional hazard, 0.85[95%CI, 0.46 to 1.57]), The rate of all-cause rehospitalization was similar (proportional hazard, 0.98[CI, 0.76 to 1.27]). Limitations: The findings of this study, conducted in a single health care system, may not be generalizable to other health care systems. The overall effect of the intervention was minor. Conclusions: Among patients with heart failure at low risk on the basis of sociodemographic and medical attributes, nurse care management did not statistically significantly reduce rehospitalizations for heart failure or for any cause. Such programs may be less effective for patients at low risk than those at high risk.

关键词：低危患者随机对照试验再入院率保健措施护理保健复合终点初级保健医师北加利福尼亚保健体系临床标准

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