检索结果-南通市图书馆

NeCAB family of neuronal calcium-binding proteins in health and disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

effects of rare-earth Pr3+-Dy3+ doping on structural,magnetic,optical and dielectric properties of Zn2Y hexaferrite

在线全文

学校读者我要写书评

暂无评论

Journal of Rare earths 2025年第2期43卷 329-336页

作者： Ibrahim Mohammed Mohamed e.el Sayed Ali Shawabkeh Mohammad N.Murshed Ibtehaj F.Alshdoukhi Zeinhom M.el-Bahy J.Mohammed A.k.Srivastava Department of Physics Lovely Professional University Department of Science Technology Waziri Umaru Federal Polytechnic Birnin Kebbi Physics Department Faculty of Science and ArtsKing Khalid University College of engineering and Technology American University of the Middle East Department of Basic Sciences College of Science and Health ProfessionsKing Saud Bin Abdulaziz University for Health ScienceKing Abdullah International Medical Research Center Department of Chemistry Faculty of ScienceAl-Azhar University Department of Physics Faculty of ScienceFederal University Dutse

This study was conducted to investigate the properties of Pr3+-Dy3+doped Zn2Y-type hexaferrite for potential technological applications.X-ray diffraction（XRD）,Fourier transform infrared spectroscopy（FTIR） and field-emission scanning electron microscopy（FeSeM） were used to analyze structural *** crystallite size in the synthesized samples varies between 57.54 and 68.57 *** vibrational bands at 400 and 600 cm-1,common to all hexaferrites,were confirmed through *** FeSeM analysis reveals an agglomeration of magnetic grains and a decrease in the average grain size from 1.24 to1.06 μ*** M-H loops show that,with x values of 0.0,0.1,and 0.2,the saturation magnetization is determined to be 34.76,34.23,and 32.52 emu/g,*** corresponding coercivity values are21.24,30.39,and 33.99 ***-visible spectroscopy using Tauc theory reveals an increase in the optical band gap from 2.32 to 2.50 eV,indicating a tunable energy band structure by incorporating Pr3+-Dy3+*** dielectric constant increases,whereas AC conductivity decreases with increased Pr3+-Dy3+*** obtained results suggest the potential suitability of these materials for various technological applications.

关键词： Dielectric constant Magnetic hysteresis Optical band gap Pr3+-Dy3+ Rare earths Zn2Y-type hexaferrite

effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris k.Salgado Jose M.Santiago Samuel e.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Continuous-flow columns packed with zero-valent iron and iron sulfide as a feasible strategy to remediate the persistent contaminant nitroguanidine

在线全文

学校读者我要写书评

暂无评论

Defence Technology(防务技术) 2025年第1期43卷 26-34页

作者： Youngjae Yu erika e.Rios-Valenciana Robert A.Root Reyes Sierra-Alvarez Jon Chorover Jim A.Field Department of Chemical and environmental engineering The University of ArizonaP.O.Box 210011TucsonAZ 85721USA Department of environmental Science The University of ArizonaTucsonAZ 85721USA

The insensitive munitions compound nitroguanidine(NQ)is used by the *** to avoid unintended ***,NQ also represents an emerging contaminant whose environmental emissions can cause toxicity toward aquatic organisms,indicating the need for effective remediation ***,we investigated the feasibility of treating water contaminated with NQ in continuous-flow columns packed with zero-valent iron(ZVI)or iron sulfide(FeS).Initially,the impact of pH on NQ transformation by ZVI or FeS was evaluated in batch *** pseudo first-order rate constant for NQ transformation(k_(1,NQ))by ZVI was 8-10 times higher at pH 3.0 compared to pH 5.5 and 7.0,whereas similar k_(1,NQ)values were obtained for FeS at pH *** on these findings,the influent p H fed to the ZVIand Fe S-packed columns was adjusted to 3.0 and 5.5,*** reactors transformed NQ into nitrosoguanidine(Nso Q).Further transformation of Nso Q by ZVI produced aminoguanidine,guanidine,and cyanamide,whereas Nso Q transformation by Fe S produced guanidine,ammonium,and traces of *** outperformed Fe S as a reactive material to remove *** ZVI-packed column effectively removed NQ below detection even after 45 d of operation(490 pore volumes,PV).In contrast,NQ breakthrough(removal efficiencyerved after 18 d(180 PV)in the Fe S-packed *** high NQ removal efficiency and long service life of the ZVI-packed column(>490 PV)suggest that the technology is a promising approach for NQ treatment in packed-bed reactors and in situ remediation.

关键词： Continuous water treatment Iron-based minerals Chemical reduction pH Aminoguanidine Guanidine

Critical quality indicators of high-performance polyetherimide(ULTeM)over the MeX 3D printing key generic control parameters:Prospects for personalized equipment in the defense industry

在线全文

学校读者我要写书评

暂无评论

Defence Technology(防务技术) 2025年第1期43卷 150-167页

作者： Nectarios Vidakis Markos Petousis Constantine David Nektarios k.Nasikas Dimitrios Sagris Nikolaos Mountakis Mariza Spiridaki Amalia Moutsopoulou emmanuel Stratakis Dept.of Mechanical engineering Hellenic Mediterranean UniversityHeraklion 71410Greece Dept.of Mechanical engineering International Hellenic UniversitySerres Campus 62124Greece Division of Mathematics and engineering Sciences Department of Military SciencesHellenic Army AcademyGR 16673VariAtticaGreece Institute of electronic Structure and Laser(IeSL) Foundation for Research and Technology(FORTH)N.Plastira 100Vassilika Vouton 70013HeraklionCreteGreece Qingdao Innovation and Development Center Harbin Engineering UniversityQingdao 266000China

Additive Manufacturing(AM)can provide customized parts that conventional techniques fail to *** important parameter in AM is the quality of the parts,as a result of the material extrusion 3D printing(3D-P)*** can be very important in defense-related applications,where optimum performance needs to be *** quality of the Polyetherimide 3D-P specimens was examined by considering six control parameters,namely,infill percentage,layer height,deposition angle,travel speed,nozzle,and bed *** quality indicators were the root mean square(Rq)and average(Ra)roughness,porosity,and the actual to nominal dimensional *** examination was performed with optical profilometry,optical microscopy,and micro-computed tomography *** Taguchi design of experiments was applied,with twenty-five runs,five levels for each control parameter,on five *** additional confirmation runs were conducted,to ensure *** equations were constructed to express the quality indicators in terms of the control *** modeling approaches were applied to the experimental data,to compare their efficiency,i.e.,Linear Regression Model(LRM),Reduced Quadratic Regression Model,and Quadratic Regression Model(QRM).QRM was the most accurate one,still the differences were not high even considering the simpler LRM model.

关键词： Polyetherimide(PeI) Material extrusion(MeX) Three-dimensional printing(3D-P) Critical quality indicators(CQIs) Quadratic regression model(QRM) Taguchi

enhanced engineering and biocidal polypropylene filaments enabling melt reduction of AgNO_(3) through PVP agent:A scalable process for the defense industry with MeX additive manufacturing

在线全文

学校读者我要写书评

暂无评论

Defence Technology(防务技术) 2025年第2期44卷 52-66页

作者： Markos Petousis Nikolaos Michailidis Vassilis Papadakis Apostolos Argyros Mariza Spiridaki Nikolaos Mountakis John Valsamos Nektarios k.Nasikas Amalia Moutsopoulou Nectarios Vidakis Department of Mechanical engineering Hellenic Mediterranean UniversityHeraklion 71410Greece Physical Metallurgy Laboratory Mechanical Engineering DepartmentSchool of EngineeringAristotle University of ThessalonikiThessaloniki 54124Greece Centre for Research&Development of Advanced Materials(CeRDAM) Centre for Interdisciplinary Research and InnovationBalkan CentreBuilding B’10th Km Thessaloniki-Thermi RoadThessaloniki 57001Greece Institute of electronic Structure and Laser of the Foundation for Research and Technology-Hellas(IeSL-FORTH)e Hellas N.Plastira 100mHeraklion 70013Greece Department of Industrial Design and Production engineering University of West AtticaAthens 12243Greece Division of Mathematics and engineering Sciences Department of Military SciencesHellenic Army AcademyGR 16673VariAtticaGreece

This study focused on the production of polypropylene(PP)/silver(Ag)composites via additive *** study aimed to enhance the quality of medical-grade PP in material extrusion(MeX)three-dimensional printing(3DP)by improving its mechanical properties while simultaneously adding antibacterial *** latter can find extremely important and versatile properties that are applicable in defense and security ***/Ag nanocomposites were prepared using a novel method based on a reaction occurring while mixing appropriate quantities of the starting polymers and additives,namely polyvinylpyrrolidone(PVP)as the matrix material and silver nitrate(AgNO_(3))as the *** process produced three-dimensional(3D)printed filaments,which were then used to create specimens for a series of standardized *** was found that the mechanical properties of the nanocomposites were enhanced in relation to pristine PP,especially for the PP matrix with various loadings of AgNO_(3)and PVP,such as 5.0 wt%and 2.5 wt%,*** voids,inclusions,and actual-to-nominal dimensions also showed improved *** 3DP specimens exhibited a more effective biocidal performance against Staphylococcus aureus than escherichia coli,which developed an inhibition zone only in the case of PP with filler loading percentages of AgNO_(3)and PVP at 10.0 wt%and 5.0 wt%,respectively Compounds possessing such properties can be beneficial for various applications requiring increased mechanical properties and biocidal capabilities,such as in the Defence or medical industries.

关键词： Polypropylene(PP) Polyvinyl pyrrolidone(PVP) Silver nitride(AgNO_(3)) In-situ reactive melt mixing process Material extrusion(MeX)3D printing Biocidal performance

Implementation of a double trigger condition system based on charge comparison and TOF measurement for the NeDA detector array

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2025年第2期36卷 40-48页

作者： J.M.Deltoro A.Goasduff F.J.egea V.González A.Gadea R.M.Pérez-Vidal I.Lazarus M.kogimtzis L.McNicholl M.Palacz G.Jaworski J.J.Valiente-Dobón J.Nyberg S.Casans A.e.Navarro-Antón e.Sanchis A.Boujrad e.Clément T.Hüyük R.Illicachi O.Stezowski V.Modamio Department of electronic engineering University of ValenciaBurjassotValenciaSpain Istituto Nazionale di Fisica Nucleare Laboratori Nazionali di LegnaroLaboratori Nazionali di LegnaroLegnaroPadovaItaly Instituto de Física Corpuscular CSIC-Universidad de ValenciaCSIC-Universidad de Valencia46980 PaternaValenciaSpain Science and Technology Facilities Council DaresburyUK Heavy Ion Laboratory University of Warsaw02-093 WarsawPoland Department of Physics and Astronomy Uppsala UniversityUppsalaSweden Grand Accélérateur National d’Ions Lourds(GANIL) CEA/DRF-CNRS/IN2P3CEA/DRF-CNRS/IN2P3CaenFrance Universitéde Lyon UniversitéLyon-1CNRS/IN2P3UMR5822IP2IIP2I4 Rue Enrico Fermi69622 Villeurbanne CedexFrance Department of Physics University of Oslo0316 OsloNorway

The Neutron Detector Array(NeDA)is designed to be coupled to gamma-ray spectrometers to enhance the sensitivity of the setup by enabling reaction channel selection through counting of the evaporated *** article presents the implementation of a double trigger condition system for NeDA,which improves the acquisition of neutrons and reduces the number of gamma rays *** independent triggers are generated in the double trigger condition system:one based on charge comparison(CC)and the other on time-of-flight(TOF).These triggers can be combined using OR and AND logic,offering four distinct trigger *** developed firmware is added to the previous one in the Virtex 6 field programmable gate array(FPGA)present in the system,which also includes signal processing,baseline correction,and various trigger logic *** performance of the trigger system is evaluated using data from the e703 experiment performed at *** four trigger modes are applied to the same data,and a subsequent offline analysis is *** is shown that most of the detected neutrons are preserved with the AND mode,and the total number of gamma rays is significantly *** with the CC trigger mode,the OR trigger mode allows increasing the selection of *** addition,it is demonstrated that if the OR mode is selected,the online CC trigger threshold can be raised without losing neutrons.

关键词： Neutron detector Neutron-gamma discrimination Pulse shape analysis Time-of-flight Charge comparison

Three subspecies of Black-tailed Godwit share non-breeding sites in the world's largest river delta

在线全文

学校读者我要写书评

暂无评论

Avian Research 2025年第01期 1-10页

作者： Delip k.Das Wouter M.G.Vansteelant Bingrun Zhu Shariful Islam Naim khandakar Marco van der Velde Chris J.Hassell Jesse R.Conklin Pierrick Bocher Jos C.e.W.Hooijmeijer Yvonne I.Verkuil Theunis Piersma Department of Zoology Faculty of Life and Earth Sciences Jagannath University Conservation ecology Group Groningen Institute for Evolutionary Life Sciences University of Groningen Bird eyes Centre for Global Ecological Change at the Faculties of Science & Engineering and Campus Fryslan University of Groningen Theoretical and Computational ecology Institute for Biodiversity and Ecosystem Dynamics University of Amsterdam Hunan Global Messenger Technology Co. Ltd Behavioural & Physiological ecology Groningen Institute for Evolutionary Life Sciences University of Groningen Global Flyway Network Littoral environnement et Sociétés UMR LIeNSs 7266 CNRS La Rochelle University NIOZ Royal Netherlands Institute for Sea Research Department of Coastal Systems

During the non-breeding season(September–April), Black-tailed Godwits(Limosa limosa) are commonly seen in coastal and inland wetlands of the Ganges-Brahmaputra-Meghna Delta in Bangladesh. We hypothesize that the Ganges-Brahmaputra-Meghna Delta, at the overlap between the Central Asian and east Asian–Australasian flyways, may host three subspecies that breed in disjunct areas of temperate and northern Asia: L. l. limosa, L. l. melanuroides, and L. l. bohaii. We used mitochondrial DNA(mt DNA) haplotype network and biometric analysis to determine subspecies in captured individuals, and deployed GPS–GSM transmitters to verify breeding areas of individuals with subspecies assignments. To test for differential habitat preferences, we sampled birds at two ecologically distinct habitats known to host the largest concentrations of non-breeding Black-tailed Godwits in Bangladesh: Nijhum Dweep National Park, a tidal coastal habitat with brackish water on the south-central coast, and Tanguar Haor(‘backmarsh'), a seasonal freshwater floodplain in the north. During the non-breeding seasons of 2021–2022 and 2022–2023, we sampled and measured 93 Black-tailed Godwits, 54 of which were equipped with GPS–GSM transmitters. Our mt DNA haplotype network analysis confirmed the presence of limosa, melanuroides, and bohaii subspecies at the study sites. Thus, indeed, Black-tailed Godwits subspecies, despite having distinct breeding ranges, exhibit(partially) overlapping non-breeding ranges in Asia. The subspecies composition differed significantly between sites, with limosa and bohaii dominating in Tanguar Haor and melanuroides in Nijhum Dweep. Of the 21 individuals that were tracked to their breeding grounds, 18 migrated to the expected breeding range of their respective subspecies. However, one bird with a limosa haplotype migrated to a known breeding area of bohaii, whereas two birds with melanuroides haplotypes migrated to the supposed breeding range of limosa. Therefore, while ecologic

关键词：