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miniSCIDOM: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches

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High Power Laser Science and Engineering 2024年第2期12卷 41-50页

作者： A.Corvino M.Reimold E.Beyreuther F.-E.Brack F.kroll J.Pawelke J.D.Schilz M.Schneider U.Schramm M.E.P.Umlandt k.zeil T.Ziegler J.Metzkes-Ng Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum Freiburg FreiburgGermany

Laser plasma accelerators(LPAs)enable the generation of intense and short proton bunches on a micrometre scale,thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material *** spectrally broadband,laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample *** rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm^(3) for single proton bunches to allow for fast online *** we present the scintillator-based miniSCIDOM detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm^(3).The detector achieves a spatial resolution below 500μm and a sensitivity of 100 *** detector performance is tested at a proton therapy cyclotron and an LPA proton *** experiments’primary focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam monitoring detectors laser-driven proton beams scintillator-based diagnostics ultra-high dose rate

OCTOPOD:single-bunch tomography for angular-spectral characterization of laser-driven protons

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High Power Laser Science and Engineering 2023年第6期11卷 16-28页

作者： M.Reimold S.Assenbaum E.Beyreuther E.Bodenstein F.-E.Brack C.Eisenmann F.Englbrecht F.kroll F.Lindner U.Masood J.Pawelke U.Schramm M.Schneider M.Sobiella M.E.P.Umlandt M.Vescovi k.zeil T.Ziegler J.Metzkes-Ng Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay-National Center for Radiation Research in Oncology DresdenGermany Ludwig-Maximilians-Universität München Garching/MünchenGermany Universitätsklinikum Freiburg FreiburgGermany

Laser-plasma accelerated(LPA)proton bunches are now applied for research fields ranging from ultra-high-dose-rate radiobiology to material ***,the capabilities to characterize the spectrally and angularly broad LPA bunches lag behind the rapidly evolving *** OCTOPOD translates the angularly resolved spectral characterization of LPA proton bunches into the spatially resolved detection of the volumetric dose distribution deposited in a liquid *** to 24 multi-pinhole arrays record projections of the scintillation light distribution and allow for tomographic reconstruction of the volumetric dose deposition pattern,from which proton spectra may be *** the OCTOPOD at a cyclotron,we show the reliable retrieval of various spatial dose deposition patterns and detector sensitivity over a broad dose ***,the OCTOPOD was installed at an LPA proton source,providing real-time data on proton acceleration performance and attesting the system optimal performance in the harsh laser-plasma environment.

关键词： laser-plasma acceleration of protons proton detector tomographic reconstruction

Targets for high repetition rate laser facilities:needs,challenges and perspectives

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High Power Laser Science and Engineering 2017年第3期5卷 10-40页

作者： I.Prencipe J.Fuchs S.Pascarelli D.W.Schumacher R.B.Stephens N.B.Alexander R.Briggs M.Büscher M.O.Cernaianu A.Choukourov M.De Marco A.Erbe J.Fassbender G.Fiquet P.Fitzsimmons C.Gheorghiu J.Hund L.G.Huang M.Harmand N.J.Hartley A.Irman T.kluge Z.konopkova S.kraft D.kraus V.Leca D.Margarone J.Metzkes k.Nagai W.Nazarov P.Lutoslawski D.Papp M.Passoni A.Pelka J.P.Perin J.Schulz M.Smid C.Spindloe S.Steinke R.Torchio C.Vass T.Wiste R.Zaffino k.zeil T.Tschentscher U.Schramm T.E.Cowan Lawrence Berkeley National Laboratory USA 25Institute of Microelectronics of Barcelona National Center of Microelectronic Spanish Research Council Spain 26University of St. Andrews UK

A number of laser facilities coming online all over the world promise the capability of high-power laser experiments with shot repetition rates between 1 and 10 Hz. Target availability and technical issues related to the interaction environment could become a bottleneck for the exploitation of such facilities. In this paper, we report on target needs for three different classes of experiments: dynamic compression physics, electron transport and isochoric heating, and laser-driven particle and radiation sources. We also review some of the most challenging issues in target fabrication and high repetition rate operation. Finally, we discuss current target supply strategies and future perspectives to establish a sustainable target provision infrastructure for advanced laser facilities.

关键词： high-energy density physics target design and fabrication

Awareness of non-alcoholic steatohepatitis and treatment guidelines:What are physicians telling us?

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World Journal of Hepatology 2021年第2期13卷 233-241页

作者： David Hermanus Wessels zeil Rosenberg Medical Office A.E.S.Chorley PR71NYLancashireUnited Kingdom Chief Medical Office Accelerated Enrollment SolutionsHorshamPA 19044United States

BACkGROUND There is an acute need to raise awareness of non-alcoholic fatty liver disease/nonalcoholic steatohepatitis(NAFLD/NASH)among primary care physicians,endocrinologists and diabetologists to improve patient identification and address the current difficulties in NASH clinical trial *** examined the extent of knowledge and practice regarding NASH diagnosis and management guidelines.A randomized online convenience survey of 12869 physicians drawn from a national physician database of primary care physicians(PCPs),and gastroenterology and endocrinology specialists were queried via online *** results,based on a cohort of 185 respondents,showed gaps in knowledge and practice between these three groups of practitioners,with primary care providers having the lowest adherence to published guidelines for diagnosis of *** clear knowledge and patient identification at the point of presentation-which is often in primary care or with specialties other than hepatology–many patients with NAFLD and NASH will remain undiagnosed and untreated,and clinical studies will continue to struggle with patient recruitment,hindering clinical development and optimal patient *** To determine knowledge base concerning NASH diagnosis amongst gastroenterologists,endocrinologists and primary care physicians to improve referrals into clinical *** A randomized online convenience survey of 12869 physicians drawn from a national physician database of PCPs,and gastroenterology and endocrinology specialists was conducted yielding a sample of 185 *** The survey revealed that many physicians are either unaware of testing options other than biopsy,or do not use them in *** 46%of endocrinologists and 42%of primary care physicians indicated they would refer a patient for specialist workup if they suspected ***(25%)and inconvenience to patients(18%)are given as reasons for not referring those with suspected NASH for *** stan

关键词： Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Enrollment Screening Diagnostics Guidelines

Validation of Automatically Extracted Metadata

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Validation of Automatically Extracted Metadata

Dynamic convergent shock compression initiated by return current in high-intensity laser-solid interactions

第19届计算机技术与应用（CACIS·2008）学术会议

作者： kurt Maly Mohammad Zubair Steven zeil

Problem and Challenges Approach Target Collections Architecture and Implementation Validation Conclusion

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Matter and Radiation at Extremes 2024年第4期9卷 40-53页

作者： Long Yang Martin Rehwald Thomas kluge Alejandro LasoGarcia Toma Toncian karl zeil Ulrich Schramm Thomas E.Cowan Lingen Huang Helmholtz-Zentrum Dresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01062 DresdenGermany

We investigate the dynamics of convergent shock compression in solid cylindrical targets irradiated by an ultrafast relativistic laser *** particle-in-cell simulations and coupled hydrodynamic simulations reveal that the compression process is initiated by both magnetic pressure and surface ablation associated with a strong transient surface return current with density of the order of 10^(17) A/m^(2) and lifetime of 100 *** results show that the dominant compression mechanism is governed by the plasma β,i.e.,the ratio of thermal pressure to magnetic *** targets with small radius and low atomic number Z,the magnetic pressure is the dominant shock compression *** to a scaling law,as the target radius and Z increase,the surface ablation pressure becomes the main mechanism generating convergent ***,an indirect experimental indication of shocked hydrogen compression is provided by optical shadowgraphy measurements of the evolution of the plasma expansion *** results presented here provide a novel basis for the generation of extremely high pressures exceeding Gbar(100 TPa)to enable the investigation of high-pressure physics using femtosecond J-level laser pulses,offering an alternative to nanosecond kJ-laser pulse-driven and pulsed power Z-pinch compression methods.

关键词： shock convergent return

Distortions in focusing laser pulses due to spatio-temporal couplings:an analytic description

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High Power Laser Science and Engineering 2024年第3期12卷 20-40页

作者： klaus Steiniger Fabia Dietrich Daniel Albach Michael Bussmann Arie Irman Markus Loeser Richard Pausch Thomas Püschel Roland Sauerbrey Susanne Schöbel Ulrich Schramm Mathias Siebold karl zeil Alexander Debus Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany CASUS-Center for Advanced Systems Understanding GörlitzGermany Technische Universität Dresden DresdenGermany

In ultra-short laser pulses,small changes in dispersion properties before the final focusing mirror can lead to severe pulse distortions around the focus and therefore to very different pulse properties at the point of laser±matter interaction,yielding unexpected interaction *** mapping between far-and near-field laser properties intricately depends on the spatial and angular dispersion properties as well as the focal *** a focused Gaussian laser pulse under the influence of angular,spatial and group-delay dispersion,we derive analytical expressions for its pulse-front tilt,duration and width from a fully analytic expression for its electric field in the time±space domain obtained with scalar diffraction *** expression is not only valid in and near the focus but also along the entire propagation distance from the focusing mirror to the *** relating angular,spatial and group-delay dispersion before focusing at an off-axis parabola,where they are well measurable,to the respective values in the pulse’s focus are obtained by a ray tracing ***,these formulas are used to show in example setups that the pulse-front tilts of lasers with small initial dispersion can become several tens of degrees larger in the vicinity of the focus while being small directly in the *** formulas derived here provide the analytical foundation for observations previously made in numerical *** numerically simulating Gaussian pulse propagation and measuring properties of the pulse at distances several Rayleigh lengths off the focus,we verify the analytic expressions.

关键词： group-delay dispersion pulse-front tilt spatio-temporal couplings third-order dispersion ultra-short laser pulses

Enhanced ion acceleration from transparency-driven foils demonstrated at two ultraintense laser facilities

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Light(Science & Applications) 2023年第4期12卷 593-604页

作者： Nicholas P.Dover Tim Ziegler Stefan Assenbaum Constantin Bernert Stefan Bock Florian-Emanuel Brack Thomas E.Cowan Emma J.Ditter Marco Garten Lennart Gaus Ilja Goethel George S.Hicks Hiromitsu kiriyama Thomas kluge James k.koga Akira kon kotaro kondo Stephan kraft Florian kroll Hazel F.Lowe Josefine Metzkes-Ng Tatsuhiko Miyatake Zulfikar Najmudin Thomas Püschel Martin Rehwald Marvin Reimold Hironao Sakaki Hans-Peter Schlenvoigt keiichiro Shiokawa Marvin E.P.Umlandt Ulrich Schramm karl zeil Mamiko Nishiuchi kansai Photon Science Institute National Institutes for Quantum Science and Technology8-1-7 UmemidaiKizugawaKyoto 619-0215Japan The John Adams Institute for Accelerator Science Blackett LaboratoryImperial College LondonLondon SW72AZUnited Kingdom Helmholtz-Zentrum Dresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01069 DresdenGermany Interdiscipllinary Graduate School of Engineering Sciences Kyushu University6-1Kasuga-KoenKasugaFukuoka 816-8580Japan

Laser-driven ion sources are a rapidly developing technology producing high energy,high peak current *** suitability for applications,such as compact medical accelerators,motivates development of robust acceleration schemes using widely available repetitive ultraintense femtosecond *** applications not only require high beam energy,but also place demanding requirements on the source stability and *** can be seriously affected by the laser temporal contrast,precluding the replication of ion acceleration performance on independent laser systems with otherwise similar ***,we present the experimental generation of>60 MeV protons and>30 MeV u-1 carbon ions from sub-micrometre thickness Formvar foils irradiated with laser intensities>1021 *** are accelerated by an extreme localised space charge field≥30TVm-1,over a million times higher than used in conventional *** field is formed by a rapid expulsion of electrons from the target bulk due to relativistically induced transparency,in which relativistic corrections to the refractive index enables laser transmission through normally opaque *** replicate the mechanism on two different laser facilities and show that the optimum target thickness decreases with improved laser contrast due to reduced *** demonstration that energetic ions can be accelerated by this mechanism at different contrast levels relaxes laser requirements and indicates interaction parameters for realising application-specific beam delivery.

关键词： acceleration intense transparency

Characterization of the plasma mirror system at the J-kAREN-P facility

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High Power Laser Science and Engineering 2022年第4期10卷 26-35页

作者： Akira kon Mamiko Nishiuchi Yuji Fukuda kotaro kondo koichi Ogura Akito Sagisaka Yasuhiro Miyasaka Nicholas P.Dover Masaki kando Alexander S.Pirozhkov Izuru Daito Liu Chang Il Woo Choi Chang Hee Nam Tim Ziegler Hans-Peter Schlenvoigt karl zeil Ulrich Schramm Hiromitsu kiriyama kansai Photon Science Institute National Institutes for Quantum Science and TechnologyKyoto 619-0215Japan Center for Relativistic Laser Science Institute for Basic ScienceGwangju 61005Republic of Korea Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Physics and Photon Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Helmholtz-ZentrumDresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01062 DresdenGermany

We report on the design and characterization of the plasma mirror system installed on the J-kAREN-P laser at the kansai Photon Science Institute,National Institutes for Quantum Science and *** reflectivity of the single plasma mirror system exceeded 80%.In addition,the temporal contrast was improved by two orders of magnitude at 1 ps before the main ***,the laser near-field spatial distribution after the plasma mirror was kept constant at plasma mirror fluence of less than 100 kJ/cm^(2).We also present the results of investigating the difference and the fluctuation in energy,pulse width and pointing stability with and without the plasma mirror system.

关键词： high-powerlasers laser plasma plasma mirror