检索结果-南通市图书馆

World Journal of Gastroenterology 2017年第38期23卷 7047-7053页

作者： Shigeo Manabe ken-ichi Mukaisho Takayuki yasuoka Fumitaka Usui Tatsuzo Matsuyama Ikuhiro Hirata Yoshio Boku Shuji Takahashi Department of Gastroenterology Kouseikai Takeda Hospital Department of Pathology Shiga University of Medical Science Fujita Clinic

Herein, we present a case of gastric adenocarcinoma of fundic gland type(GA-FG) spreading to heterotopic gastric glands(HGG) in the submucosa. A 58-year-old man with epigastric pain was referred to our hospital and underwent an esophagogastroduodenoscopy. A Borrmann type II gastric cancer at the antrum and a 10 mm submucosal tumor-like lesion in the lesser curvature of the upper third of the stomach were detected. Histological examination of the biopsy specimens obtained from the submucosal tumorlike lesion suggested a GA-FG. Therefore, endoscopic submucosal dissection was performed as excisional biopsy, and histopathological examination of the resected specimen confirmed a GA-FG and HGG proximal to the GA-FG. Although the GA-FG invaded the submucosal layer slightly, the submucosal lesion of the GA-FG had a poor stromal reaction and was located just above the HGG in the submucosa. Therefore, wefinally diagnosed the lesion as a GA-FG invading the submucosal layer by spreading to HGG.

关键词： Gastric adenocarcinoma of fundic gland type Heterotopic gastric glands Endoscopic submucosal dissection Paracancerous lesion Pepsinogen-I H/k-ATPase

MD Simulations of the P53 oncoprotein structure: the effect of the Arg273→His mutation on the DNA binding domain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2011年第5期2卷 330-335页

作者： kholmirzo kholmurodov Ermuhammad Dushanov kenji yasuoka Laboratory of Radiation Biology Joint Institute for Nuclear Research Dubna University Institute of Nuclear Physics Department of Mechanical Engineering Keio University

A comparative molecular dynamics (MD) simulation study was performed on the p53 oncoprotein to investigate the effect of the Arg273His (R273H) mutation on the p53→DNA Binding Domain (DBD). The two p53 dimer structures of the wild-type and mutant Arg273His (R273H) were simulated with the same thermodynamic and environmental parameters. The obtained results demonstrate that the induced Arg273His mutation has a considerable effect on the p53→DNA close contact interaction and changes the picture of hydrogen formation. The Arg273His mutation, in some cases, destroys the existing native hydrogen bond, but, in other cases, forms a strong p53→DNA hydrogen bond, which is not proper for the native protein. The MD simulation results illustrate some molecular mechanism of the conformational changes of the Arg273His key amino acid residue in the p53→DNA binding domain, which might be important for the understanding of the physiological functioning of the p53 protein and the origin of cancer.

关键词： Molecular Dynamics Simulations p53 Oncoprotein Effect of the R273H Mutation DNA Binding Domain

Molecular dynamics simulations of valinomycin interactions with potassium and sodium ions in water solvent

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2010年第3期1卷 216-223页

作者： kholmirzo kholmurodov Maria Abasheva kenji yasuoka Laboratory of Radiation Biology Joint Institute for Nuclear Research Dubna International University Department of Mechanical Engineering Keio University

The aim of this work is to estimate the value of the electric field (potentials) for the system of valinomycin + К+ and Na+ ions based on a molecular dynamics (MD) study. An analysis has been performed of the interaction processes for the system of valinomycin + К+(Na+) ion in water solvent. It is obtained that capturing a К+(Na+) ion in the valinomycin cavity is not possible for all values of the electric field strength. Each of the two kinds of ions (К+ or Na+) has its own critical electric field associated with ion binding to valinomycin, for which to exist, the ion has to remain localized inside the valinomycin cavity. The results obtained for the electrical potential reveal a stronger valinomycin binding—especially with the potassium ion. Valinomycin’s molecular structure efficiently surrounds the k+ ion, as this structure has to exactly correspond to the k+ ion in size. MD simulation results could be a prerequisite for studying a more complex scenario—for estimating ion transport in the cell membrane or physiological electric potential which is formed in the membrane or inside the cell relative to its surrounding medium.

关键词： Molecular Dynamics Simulations Valinomycin Potassium and Sodium Ions

Molecular dynamics simulations of the interaction of carbon nanotube and a carbon disulfide solvent

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Science 2010年第8期2卷 902-910页

作者： kholmirzo kholmurodov Guzel Aru kenji yasuoka 不详

An analysis of the molecular dynamics (МD) of the interaction between a carbon nanotube (CNT) and a carbon disulfide active solvent (CS2) has been carried out. The aim of the present work is to estimate the dynamical and structural behavior of the CNTCS2 system at different relative atomic concentrations and under temperature changes. The structural radial distribution functions and the dynamical configurations have been built for a CNT interacting with a CS2 solvent. A nontrivial observation for the CNTCS2 system is that the solvent carbon disulfide atoms make up a patterned (layered) formation around the carbon nanotube.

关键词： Molecular Dynamics Carbon Nanotube Carbon Disulfide Solvent

Molecular dynamics simulations of a DNA photolyase protein: High-mobility and conformational changes of the FAD molecule at low temperatures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2012年第3期3卷 169-180页

作者： kholmirzo kholmurodov Ermuhammad Dushanov kenji yasuoka Department of Mechanical Engineering Keio University Yokohama Japan Laboratory of Radiation Biology Joint Institute for Nuclear Research Dubna Russia

A molecular dynamics (MD) simulation is performed on a DNA photolyase to study the conformational behavior of the photoactive cofactor flavin adenine dinucleotide (FAD) inside the enzyme pocket. A DNA photolyase is a highly efficient light-driven enzyme that repairs the UV-induced cyclobutane pyrimidine dimer in damaged DNA. In this work, the FAD conformational and dynamic changes were studied within the total complex structure of a DNA photolyase protein (containing FADH–, MTHF, and DNA molecules) embedded in a water solvent. We aimed to compare the conformational changes of the FAD cofactor and other constituent fragments of the molecular system under consideration. The obtained results were discussed to gain insight into the light-driven mechanism of DNA repair by a DNA photolyase enzyme—based on the enzyme structure, the FAD mobility, and conformation shape.

关键词： Molecular Dynamics Simulations DNA Photolyase Conformation Change FAD MTHF DNA

The diffusion and concentration effects of formamide on a TiO<sub>2</sub>surface in the presence of a water solvent

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Science 2012年第5期4卷 313-323页

作者： Ermuhammad Dushanov kholmirzo kholmurodov kenji yasuoka Department of Mechanical Engineering Keio University Yokohama Japan Laboratory of Radiation Biology Joint Institute for Nuclear Research Dubna Russia

The formamide-titanium oxide interaction mechanism is a research target of great importance for understanding the elementary events of the origin of life: the synthesis of nucleoside bases and formation of biological molecules needed for life. Titanium oxide (TiO2) can act as a strongly adsorbing surface or a catalytic material. In the present study, a comparative molecular dynamics analysis performed to clarify the adsorbing and diffusion properties of liquid formamide on a TiO2 surface in the presence of water molecules. The structural features of the formamide concentration effect (the accumulation of molecules) on a TiO2 surface in the presence and absence of water solvent are cleared up. Modification of the formamide diffusion abilities mediated by a water solvent is observed to correlate with the formamide-water concentration distribution on the surface.

关键词： Molecular Dynamics Simulations Formamide Molecule Water Solvent Diffusion Coefficient Anatase Surface RDF Graphs

Surgery for pancreatic tumors in the midst of COVID-19 pandemic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第18期9卷 4460-4466页

作者： Hiroyuki kato Yukio Asano Satoshi Arakawa Masahiro Ito Norihiko kawabe Masahiro Shimura Chihiro Hayashi Takayuki Ochi Hironobu yasuoka Takahiko Higashiguchi Yuka kondo Hidetoshi Nagata Akihiko Horiguchi Department of Gastroenterological Surgery Fujita Health University School of Medicine Bantane HospitalNagoya 454-8509Japan

The spread of the new coronavirus(COVID-19)infection in 2020 has had a significant impact on the treatment of cancer *** the COVID-19 pandemic,the biggest challenge for pancreatic surgeons is the difficulty in providing oncological *** this review article,from the standpoint of surgeons,we explain the concept of triaging of patients with pancreatic tumors under the COVID-19 pandemic,and the actual impact of COVID-19 on the treatment of patients with pancreatic *** most vital points in selecting the best therapeutic approach for patients with pancreatic tumors during this pandemic are(1)Oncologists need to tailor the treatment plan based on the COVID-19 phase,tumor malignant potential,and patients’comorbidities;and(2)Optimal treatment for pancreatic cancer should be planned according to the condition of each patient and tumor resectability based on national comprehensive cancer network resectability *** choose the best therapeutic approach for patients with pancreatic tumors during this pandemic,we need to tailor the treatment plan based on elective surgery acuity scale(ESAS).Newly established ESAS for pancreatic tumor and flowchart indicating the treatment strategy of pancreatic cancer,are feasible to overcome this situation.

关键词： COVID-19 Pancreatic ductal adenocarcinoma Surgical treatment Pancreatic tumor Pandemic National comprehensive cancer network resectability criteria

Electrical Resistance Change of Carbon/Epoxy Composite Laminates under Cyclic Loading under Damage Initiation Limit

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Composite Materials 2014年第1期4卷 22-31页

作者： Akira Todoroki Daichi Haruyama Yoshihiro Mizutani Yoshiro Suzuki Tesuo yasuoka Department of Mechanical Sciences and Engineering Tokyo Institute of Technology Tokyo Japan Department of Mechanical Sciences and Engineering Tokyo Institute of Technology Tokyo Japan.

Self-sensing multifunctional composite has sensing function using electrical resistance changes. Carbon Fiber Reinforced Polymer (CFRP) composite is one of the self-sensing multifunctional composites. For the reliability of the self-sensing, electrical contact between the lead wire and the carbon fibers is the most important issue. The present study focuses on the effect of the cyclic loading of lower applied strain range than the fatigue damage level. As a result, the electrical contact resistance at the copper electrode increased with the increase of cycles. That means that the electrical change at the electrodes must be considered for the long-term self-sensing monitoring system. When a four-probe method is used to measure the electrical resistance, the contact resistance effect is minimized. Moreover, angle-ply laminates have plastic deformation caused by shear loading, and that causes electrical resistance decrease during the cyclic loading. Cross-ply laminates of CFRP composites have no electrical resistance increase without damage. Quasi-isotropic laminates of CFRP composites, however, have electrical resistance decrease with the increase of the number of cycles because of the plastic deformation of the angle-ply laminates.

关键词： Carbon Fiber Electrical Properties Non-Destructive Testing Smart Materials

Molecular dynamics simulation of the interaction of ethanol-water mixture with a Pt surface

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Science 2011年第12期3卷 1011-1021页

作者： kholmirzo kholmurodov Ermuhammad Dushanov kenji yasuoka Hagar khalil Ahmed Galal Sameh Ahmed Nasser Sweilam Hatem Moharram 不详

An analysis of the molecular dynamics of ethanol solvated by water molecules in the absence and presence of a Pt surface has been performed using DL_POLY_2.19 code. The structure and diffusion properties of an ethanol–water system have been studied at various temperatures from 250 to 600 k. We have measured the self-diffusion coefficients of the 50:50% ethanol–water solution;in the absence of a Pt surface our results show an excellent agreement–within an error of 7.4% – with the experimental data. An increase in the self-diffusion coefficients with the inclusion of a Pt surface has been observed. The estimation of the diffusion coefficients of both water and ethanol in the presence of a Pt surface shows that they obey the Arrhenius equation;the calculated activation energies of diffusion of ethanol and water are 2.47 and 2.98 kcal/mole, respectively. The radial distribution function graphs and density profiles have been built;their correlations with the self-diffusion coefficients of both ethanol and water molecules are also illustrated.

关键词： Molecular Dynamics Simulations Ethanol Molecule Water Active Solvent Diffusion Coefficient Pt Surface RDF Graphs