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Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth factor

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World Journal of Stem Cells 2024年第8期16卷 811-823页

作者： Qi-Hong Chen Ying Zhang Xue Gu Peng-Lei yang Jun Yuan Li-Na Yu Jian-Mei Chen Department of Critical Care Medicine Jiangdu People’s Hospital of YangzhouJiangdu People’s Hospital Affiliated to Yangzhou UniversityYangzhou 225200Jiangsu ProvinceChina Department of Critical Care Medicine Jiangdu People’s Hospital of YangzhouYangzhou 225200Jiangsu ProvinceChina Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACkGROUND Pulmonary fibrosis is one of the main reasons for the high mortality rate among acute respiratory distress syndrome(ARDS)*** stromal cell-derived microvesicles(MSC-MVs)have been shown to exert antifibrotic effects in lung *** To investigate the effects and mechanisms of MSC-MVs on pulmonary fibrosis in ARDS mouse *** MSC-MVs with low hepatocyte growth factor(HGF)expression(siHGF-MSC-MVs)were obtained via lentivirus transfection and used to establish the ARDS pulmonary fibrosis mouse *** intubation,respiratory mechanics-related indicators were measured via an experimental small animal lung function *** of MSC-MVs in lung tissues was investigated by near-infrared live ***,western blotting,ELISA and other methods were used to detect expression of pulmonary fibrosis-related proteins and to compare effects on pulmonary fibrosis and fibrosis-related *** The MSC-MVs gradually migrated and homed to damaged lung tissues in the ARDS model *** with MSC-MVs significantly reduced lung injury and pulmonary fibrosis ***,low expression of HGF(siHGF-MSC-MVs)significantly inhibited the effects of MSC-MVs(P<0.05).Compared with the ARDS pulmonary fibrosis group,the MSC-MVs group exhibited suppressed expression of type I collagen antigen,type III collagen antigen,and the proteins transforming growth factor-βandα-smooth muscle actin,whereas the siHGF-MVs group exhibited significantly increased expression of these *** addition,pulmonary compliance and the pressure of oxygen/oxygen inhalation ratio were significantly lower in the MSC-MVs group,and the effects of the MSC-MVs were significantly inhibited by low HGF expression(all P<0.05).CONCLUSION MSC-MVs improved lung ventilation functions and inhibited pulmonary fibrosis in ARDS mice partly via HGF mRNA transfer.

关键词： Microvesicles derived from mesenchymal stem cells Acute respiratory distress syndrome Pulmonary fibrosis Hepatocyte growth factor Mesenchymal stromal cells

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Fluorogenic sensing of amorphous aggregates,amyloid fibers,and chaperone activity via a near-infrared aggregation-induced emission-active probe

Aggregate

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Aggregate 2024年第1期5卷 309-320页

作者： Wei He Yuanyuan yang Yuhui Qian Zhuoyi Chen Yongxin Zheng Wenping Zhao Chenxu Yan Zhiqian Guo Shu Quan State key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for Biomanufacturing(SCICB)East China University of Science and TechnologyShanghaiChina key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Shanghai Key Laboratory of Functional Materials ChemistryFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghaiChina Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism East China University of Science and TechnologyShanghaiChina

The presence of protein aggregates in numerous human diseases underscores the significance of detecting these aggregates to comprehend disease mechanisms and develop novel therapeutic approaches for combating these *** the development of various biosensors and fluorescent probes that selectively target amyloid fibers or amorphous aggregates,there is still a lack of tools capable of simultaneously detecting both types of ***,we demonstrate the quantitative discernment of amorphous aggregates by QM-FN-SO3,an aggregationinduced emission(AIE)probe initially designed for detecting amyloid *** probe easily penetrates the membranes of the widely-used prokaryotic model organism Escherichia coli,enabling the visualization of both amorphous aggregates and amyloid fibers through near-infrared ***,the probe exhibits sensitivity in distinguishing the varying aggregation propensities of proteins,regardless of whether they form amorphous aggregates or amyloid fibers in *** properties contribute to the successful application of the QM-FN-SO3 probe in the subsequent investigation of the antiaggregation activities of two outer membrane protein(OMP)chaperones,both in vitro and in their physiological ***,our work introduces a near-infrared fluorescent chemical probe that can quantitatively detect amyloid fibers and amorphous aggregates with high sensitivity in vitro and in ***,it demonstrates the applicability of the probe in chaperone biology and its potential as a high-throughput screening tool for protein aggregation inhibitors and folding factors.

关键词： aggregation-induced emission fluorescence molecular chaperone protein aggregation

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基于单辆通行车激励的车桥耦合理论梁式桥阻尼比识别研究

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力学学报 2024年第4期56卷 1098-1109页

作者：杨仕骏阳洋王者伟程赟许文明陶帅重庆大学土木工程学院重庆400030 重庆大学溧阳智慧城市研究院江苏溧阳213332 军事科学院国防工程研究院北京100036

提出一种在单辆通行车激励的情况下,基于车桥耦合理论识别桥梁阻尼比的方法.首先,将集成化检测车设计为单自由度体系,利用集成在检测车上的传感器采集信号并滤波获取桥梁一阶响应信号,通过相邻峰值点做比值并取平均得到桥梁一阶阻尼比,... 详细信息

提出一种在单辆通行车激励的情况下,基于车桥耦合理论识别桥梁阻尼比的方法.首先,将集成化检测车设计为单自由度体系,利用集成在检测车上的传感器采集信号并滤波获取桥梁一阶响应信号,通过相邻峰值点做比值并取平均得到桥梁一阶阻尼比,理论推导出检测车停靠在桥面任一位置均可识别出桥梁一阶阻尼比.其次,考虑通行车车速、检测车停靠位置、环境噪音、桥梁阻尼比和通行车阻尼对识别结果的影响,通过数值模拟验证该方法的有效性,并与工程上经典的随机子空间法和文献方法进行对比.最后,在梁式桥实桥试验进行初步验证,说明本文方法的工程适用性.研究结果表明:所提方法对检测车在桥面上的停靠位置没有具体要求,避免了路面粗糙度对阻尼比识别结果的影响,通行车的阻尼和车速在一定范围内对阻尼比识别无明显影响,并且在信噪比30 dB以上可识别出桥梁一阶阻尼比,具有较好的鲁棒性,操作简单且不需要封桥,可有效促推在实际工程中进行桥梁一阶阻尼比识别.

关键词：通行车激励车桥耦合阻尼比梁式桥

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Supposition of graphene stacks to estimate the contact resistance and conductivity of nanocomposites

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 663-676页

作者： Y.ZARE M.T.MUNIR G.J.WENG k.Y.RHEE Biomaterials and Tissue Engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait Department of Mechanical and Aerospace Engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Department of Mechanical Engineering(Bk21 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study,the effects of stacked nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity of samples are evaluated with developed equations superior to those previously *** contact resistance and nanocomposite conductivity are modeled by several influencing factors,including stack properties,interphase depth,tunneling size,and contact *** developed model's accuracy is verified through numerous experimental *** further validate the models and establish correlations between parameters,the effects of all the variables on contact resistance and nanocomposite conductivity are ***,the contact resistance is primarily dependent on the polymer tunnel resistivity,contact area,and tunneling *** dimensions of the graphene nanosheets significantly influence the conductivity,which ranges from 0 S/m to90 S/*** increased number of nanosheets in stacks and a larger gap between them enhance the nanocomposite's ***,the thicker interphase and smaller tunneling size can lead to higher sample conductivity due to their optimistic effects on the percolation threshold and network efficacy.

关键词： graphene polymer composite stacked nanosheet tunneling conductivity contact resistance interphase

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Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer:A metaanalysis

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 214-233页

作者： Mao-Xiu Yuan Qi-Gui Cai Zhen-yang Zhang Jian-Zhong Zhou Cai-Yun Lan Jiang-Bo Lin The Graduate School Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350000Fujian ProvinceChina

BACkGROUND The effectiveness of neoadjuvant therapy in esophageal cancer(EC)treatment is still a subject of *** To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy(nCRT)and neoadjuvant chemotherapy(nCT)for locally advanced EC(LAEC).METHODS A comprehensive search was conducted using multiple databases,including PubMed,EMBASE,MEDLINE,Science Direct,The Cochrane Library,China National knowledge Infrastructure,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biomedical Literature Database *** up to December 2022 comparing nCRT and nCT in patients with EC were *** The analysis revealed significant differences between nCRT and nCT in terms of disease-free *** results indicated that nCRT provided better outcomes in terms of the 3-year overall survival rate(OSR)[odds ratio(OR)=0.95],complete response rate(OR=3.15),and R0 clearance rate(CR)(OR=2.25).However,nCT demonstrated a better 5-year OSR(OR=1.02)than ***,when compared to nCRT,nCT showed reduced risks of cardiac complications(OR=1.15)and pulmonary complications(OR=1.30).CONCLUSION Overall,both nCRT and nCT were effective in terms of survival outcomes for ***,nCT exhibited better performance in terms of postoperative complications.

关键词： Esophageal cancer Neoadjuvant chemoradiotherapy Radical resection for esophageal cancer Neoadjuvant chemotherapy Meta-analysis

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An early scoring system to predict mechanical ventilation for botulism: a single-center-based study

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World Journal of Emergency Medicine 2024年第5期15卷 365-371页

作者： Yaqing An Tuokang Zheng Yanling Dong yang Wu Yu Gong Yu Ma Hao Xiao Hengbo Gao Yingping Tian Dongqi Yao Emergency Department the Second Hospital of Hebei Medical UniversityShijiazhuang 050051China

BACkGROUND: Early identification of patients requiring ventilator support will be beneficial for the outcomes of botulism. The present study aimed to establish a new scoring system to predict mechanical ventilation(MV) for botulism ***: A single-center retrospective study was conducted to identify risk factors associated with MV in botulism patients from 2007 to 2022. Univariate analysis and multivariate logistic regression analysis were used to screen out risk factors for constructing a prognostic scoring system. The area under the receiver operating characteristic(ROC) curve was ***: A total of 153 patients with botulism(66 males and 87 females, with an average age of 43 years) were included. Of these, 49 patients(32.0%) required MV, including 21(13.7%) with invasive ventilation and 28(18.3%) with non-invasive ventilation. Multivariate analysis revealed that botulinum toxin type, pneumonia, incubation period, degree of hypoxia, and severity of muscle involvement were independent risk factors for MV. These risk factors were incorporated into a multivariate logistic regression analysis to establish a prognostic scoring system. Each risk factor was scored by allocating a weight based on its regression coefficient and rounded to whole numbers for practical utilization([botulinum toxin type A: 1], [pneumonia: 2], [incubation period ≤1 day: 2], [hypoxia k factors for MV in botulism patients. A score ≥9 in our scoring system is associated with a higher likelihood of requiring MV in botulism patients. This scoring

关键词： Botulism Scoring system Botulinum toxin type Incubation period Hypoxia Pneumonia Severity of muscle involvement

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Smart mid-infrared metasurface microspectrometer gas sensing system

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Microsystems & Nanoengineering 2024年第3期10卷 273-281页

作者： Jiajun Meng Sivacarendran Balendhran Ylias Sabri Suresh k.Bhargava kenneth B.Crozier School of Physics University of MelbourneVictoriaAustralia Australian Research Council(ARC)Centre of Excellence for Transformative Meta-Optical Systems(TMOS) University of MelbourneVictoriaAustralia Centre for Advanced Materials&Industrial Chemistry(CAMIC) STEM collegeRMIT UniversityVictoriaAustralia Department of Electrical and Electronic Engineering University of MelbourneVictoriaAustralia

Smart,low-cost and portable gas sensors are highly desired due to the importance of air quality monitoring for environmental and defense-related ***,electrochemical and nondispersive infrared(IR)gas sensors are designed to detect a single specific *** IR spectroscopy-based sensors provide superior performance,their deployment is limited due to their large size and high *** this study,a smart,low-cost,multigas sensing system is demonstrated consisting of a mid-infrared microspectrometer and a machine learning *** microspectrometer is a metasurface filter array integrated with a commercial IR camera that is consumable-free,compact(~1 cm^(3))and lightweight(~1 g).The machine learning algorithm is trained to analyze the data from the microspectrometer and predict the gases *** system detects the greenhouse gases carbon dioxide and methane at concentrations ranging from 10 to 100%with 100%*** also detects hazardous gases at low concentrations with an accuracy of 98.4%.Ammonia can be detected at a concentration of 100 ***,methyl-ethyl-ketone can be detected at its permissible exposure limit(200 ppm);this concentration is considered low and *** study demonstrates the viability of using machine learning with IR spectroscopy to provide a smart and low-cost multigas sensing platform.

关键词： Smart gases system

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Simulation of rice grain breakage process based on Tavares UFRJ model

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Particuology 2024年第10期93卷 65-74页

作者： Shaohang Shen Shouyu Ji Dan Zhao Yanlong Han Hao Li Ze Sun Zhuozhuang Li Anqi Li Wenyu Feng Jiaming Fei Fuguo Jia yang Li College of Engineering Northeast Agricultural UniversityHarbin150030China School of Water Conservancy and Civil Engineering Northeast Agricultural UniversityHarbin150030China College of Food Science Northeast Agricultural UniversityHarbin150030China

Understanding the breakage characteristics of rice grains is an important means to reduce rice breakage rate. However, the dynamic breakage mechanism of rice grain is unclear due to the lack of a reasonable breakage model. In this study, the uniaxial compression test and drop weight test of single rice were carried out, the breakage model of rice grain was constructed, the reliability of rice model was verified by the experiment and simulation results. The results showed that the fracture energy distribution of rice can be obtained by uniaxial compression test, the specific fracture energy of rice accords with a lognormal distribution, and the median specific fracture energy of rice is 479.75 J/kg. The damage accumulation coefficient and fragment size distribution of rice can be acquired by drop test, the result of damage accumulation coefficient of rice was 4.3. Rice grain breakage mainly occurs in the milling section of the vertical circulation rice mill.

关键词： Rice breakage mechanism Discrete element method Parameter calibration

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人文地理方法论视角下的乡村聚落景观流派进展及展望

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地理科学进展 2024年第1期43卷 163-178页

作者：杨阳房艳刚梁璐东北师范大学地理科学学院长春130024 东北师范大学长白山地理过程与生态安全教育部重点实验室长春130024 西安外国语大学旅游学院/人文地理研究所西安710128

人文地理学方法论在经历了实证主义、人文主义、结构主义三种主要流派的过程探索之后逐渐趋向体系化、完整化,构成了整个现代地理学的思想轮廓和学术分期。论文在人文地理学哲学思潮的基础上,对国内外地理学视角下的乡村聚落景观流派成... 详细信息

人文地理学方法论在经历了实证主义、人文主义、结构主义三种主要流派的过程探索之后逐渐趋向体系化、完整化,构成了整个现代地理学的思想轮廓和学术分期。论文在人文地理学哲学思潮的基础上,对国内外地理学视角下的乡村聚落景观流派成果开展整合性归纳与总结,研究发现三种流派范式下的乡村聚落景观研究内涵各有侧重,呈现出“传统—批判—整合—超越”的更新路径,相互之间兼收并蓄,并行不悖。其中,实证主义地理学主要以刻画乡村聚落景观的空间性、区域性为主,表现为“空间化秩序特征描述”;人文主义地理学热衷于对景观地方性、象征性意义的探索,充满了“多元化人文情感关怀”;结构主义地理学注重景观的阶级性和社会性,关注景观背后的“因果化博弈机制解释”。总体来看,乡村聚落景观框架下的流派研究成果微观多于宏观、静态多于动态、物质空间多于社会经济空间,对指导中国乡村振兴实践各有所长,各有所短。未来应从人文地理方法论的视角创建中国特色乡村聚落景观研究的“中国范式”,针对不同类型乡村的聚落景观有所侧重地强化“短板研究”,以综合并充分发挥各个流派的优长。

关键词：乡村聚落景观人文地理学方法论流派进展研究展望

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Grindability Evaluation of Ultrasonic Assisted Grinding of Silicon Nitride Ceramic Using Minimum Quantity Lubrication Based SiO_(2)Nanofluid

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 115-136页

作者： Yusuf Suleiman Dambatta Changhe Li Mohd Sayuti Ahmed A D Sarhan Min yang Benkai Li Anxue Chu Mingzheng Liu Yanbin Zhang Zafar Said Zongming Zhou School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266520China Mechanical Engineering Department Ahmadu Bello UniversityZaria 810106Nigeria Mechanical Engineering Department University of Malaya50603 Kuala LumpurMalaysia Department of Mechanical Engineering King Fahd University of Petroleum&Minerals31261 DhahranSaudi Arabia State key Laboratory of Ultra-Precision Machining Technology Department of Industrial and Systems Engineer-ingThe Hong Kong Polytechnic UniversityHong KongChina College of Engineering University of Sharjah27272 SharjahUnited Arab Emirates Hanergy(Qingdao)Lubrication Technology Co. Ltd.Qingdao 266100China

Minimum quantity Lubrication(MQL)is a sustainable lubrication system that is famous in many machining *** involve the spray of an infinitesimal amount of mist-like lubricants during machining *** MQL system is affirmed to exhibit an excellent machining performance,and it is highly *** nanofluids are understood to exhibit excellent lubricity and heat evacuation capability,compared to pure oil-based MQL *** have shown that the surface quality and amount of energy expended in the grinding operations can be reduced considerably due to the positive effect of these *** work presents an experimental study on the tribological performance of SiO_(2)nanofluid during grinding of Si_(3)N_(4)*** effect different grinding modes and lubrication systems during the grinding operation was also *** concentrations of the SiO_(2)nanofluid was manufactured using canola,corn and sunflower *** quantitative evaluation of the grinding process was done based on the amount of grinding forces,specific grinding energy,frictional coefficient,and surface *** was found that the canola oil exhibits optimal lubrication performance compared to corn oil,sunflower oil,and traditional lubrication ***,the introduction of ultrasonic vibrations with the SiO_(2)nanofluid in MQL system was found to reduce the specific grinding energy,normal grinding forces,tangential grinding forces,and surface roughness by 65%,57%,65%,and 18%***,regression analysis was used to obtain an optimum parameter *** observations from this work will aid the smooth transition towards ecofriendly and sustainable machining of engineering ceramics.

关键词： Minimum quantity lubrication(MQL) Ultrasonic assisted grinding(UAG) Eco-friendly lubricants Nanofluid Grinding Ceramic

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