检索结果-南通市图书馆

RUFy4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

在线全文

学校读者我要写书评

暂无评论

Bone Research 2024年第2期12卷 407-420页

作者： Minhee kim Jin Hee Park Miyeon Go Nawon Lee Jeongin Seo hana Lee Doyong kim Hyunil ha Taesoo kim Myeong Seon Jeong Suree kim Taesoo kim han Sung kim Dongmin kang Hyunbo Shim Soo young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea kM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FyVE domain-containing protein 4(RUFy4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin k into the extracellular ***,RUFy4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFy4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

2018—2022年广东省5岁以下儿童意外死亡流行分析

在线全文

学校读者我要写书评

暂无评论

中国儿童保健杂志 2024年第2期32卷 218-222页

作者：哈林娜徐昊立暨南大学基础医学与公共卫生学院广东广州510632 广东省妇幼保健院保健部广东广州510632

目的了解2018—2022年广东省5岁以下儿童意外死亡的主要死因及其流行病学分布情况,为制订进一步的预防措施和干预方法提供理论依据。方法以广东省2018—2022年死亡的5岁以下儿童为研究对象,将ICD10中S00-T98和V01-y98系列疾病作为分... 详细信息

目的了解2018—2022年广东省5岁以下儿童意外死亡的主要死因及其流行病学分布情况,为制订进一步的预防措施和干预方法提供理论依据。方法以广东省2018—2022年死亡的5岁以下儿童为研究对象,将ICD10中S00-T98和V01-y98系列疾病作为分类标准筛选出其中意外原因导致死亡的个案,计算相关的率、构成比等,分析儿童意外死亡原因及三间分布。结果 2018—2022年广东省总死亡率为2.94‰,死亡人数21 329人,其中意外死亡人数3 819人(0.53‰),男女性别比为1.29∶1,不同年龄组间意外伤害的性别构成差异有统计学意义(χ^(2)=16.38,P<0.01)。意外死亡原因前三位为意外窒息(1 590/3 819)、溺水(926/3 819)和交通意外(527/3 819)。各年龄段男童意外死亡率均高于女童,差异无统计学意义(χ^(2)=13.68,P=0.19),不同意外死因儿童的年龄组差异有统计学意义(χ^(2)=1 723.28,P<0.01),死前救治情况差异有统计学意义(χ^(2)=174.31,P<0.01)。结论广东省5岁以下儿童死亡的主要原因为意外窒息、溺水。应分年龄采取不同的预防措施提高儿童及家长的意外伤害识别防范意识,降低5岁以下儿童意外死亡率。

关键词： 5岁以下儿童意外死亡意外伤害

应用剪切波离散成像斜率值预测移植肾急性排异反应

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2024年第05期 620-621页

作者： T.M.kim H.Ahn J.y.Cho A.han S.I .Min J.ha 郑永利

目的评价剪切波离散成像斜率值预测移植肾功能不全的价值。方法回顾性分析2022年11月—2023年2月期间行肾移植的128例受试者资料[中位年龄，55(43～62)

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 1997年第6期110卷 96-98页

作者： RaymondLiang C.k.Lee FrederickChen y.L.kwong C.S.Chim W.y.Au S.y.ha C.F.Chan Department of Medicine University of Hong Kong Queen Mary Hospital Pokfulam Hong Kong Department of Peadiatrics University of Hong Kong Queen Mary Hospital Pokfulam Hong Kong Department of Pathology University of Hong Kong Queen Mary Hospital Pokfulam Hong Kong

ＵｎｒｅｌａｔｅｄｍａｒｏｗｄｏｎｏｒｒｅｇｉｓｔｒｙｆｏｒＣｈｉｎｅｓｅＲａｙｍｏｎｄＬｉａｎｇ，Ｃ．Ｋ．Ｌｅｅ，ＦｒｅｄｅｒｉｃｋＣｈｅｎ，Ｙ．Ｌ．Ｋｗｏｎｇ，Ｃ．Ｓ．Ｃｈｉｍ，Ｗ．Ｙ．Ａｕ，Ｓ．Ｙ．Ｈａ，Ｃ．Ｆ... 详细信息

ＵｎｒｅｌａｔｅｄｍａｒｏｗｄｏｎｏｒｒｅｇｉｓｔｒｙｆｏｒＣｈｉｎｅｓｅＲａｙｍｏｎｄＬｉａｎｇ，Ｃ．Ｋ．Ｌｅｅ，ＦｒｅｄｅｒｉｃｋＣｈｅｎ，Ｙ．Ｌ．Ｋｗｏｎｇ，Ｃ．Ｓ．Ｃｈｉｍ，Ｗ．Ｙ．Ａｕ，Ｓ．Ｙ．Ｈａ，Ｃ．Ｆ．Ｃｈａｎ，Ｙ．Ｌ．ＬａｕａｎｄＢ...

关键词： registry donor

Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第44期20卷 16498-16517页

作者： Connie Wy ha yan y Lam Andrew J Holmes School of Molecular Bio-science and Charles Perkins Centre The University of Sydney Pennington Biomedical Research Center

Gut microbes comprise a high density, biologically active community that lies at the interface of an animal with its nutritional environment. Consequently their activity profoundly influences many aspects of the physiology and metabolism of the host animal. A range of microbial structural components and metabolites directly interact with host intestinal cells and tissues to influence nutrient uptake and epithelial health. Endocrine, neuronal and lymphoid cells in the gut also integrate signals from these microbial factors to influence systemic responses. Dysregulation of these host-microbe interactions is now recognised as a major risk factor in the development of metabolic dysfunction. This is a two-way process and understanding the factors that tip host-microbiome homeostasis over to dysbiosis requires greater appreciation of the host feedbacks that contribute to regulation of microbial community composition. To date, numerous studies have employed taxonomic profiling approaches to explore the links between microbial composition and host outcomes(especially obesity and its comorbidities), but inconsistent host-microbe associations have been reported. Available data indicates multiple factors have contributed to discrepancies between studies. These include the high level of functional redundancy in host-microbiome interactions combined with individual variation in microbiome composition; differences in study design, diet composition and host system between studies; and inherent limitations to the resolution of r RNA-based community profiling. Accounting for these factors allows for recognition of the common microbial and host factors driving community composition and development of dysbiosis on high fat diets. New therapeutic intervention options are now emerging.

关键词： Microbiome Dysbiosis High fat diet Bile Intestinal mucosa Microbe-associated molecular patterns Short chain fatty acids Immunomodulation Enteroendocrine cells

Design of small-area multi-bit antifuse-type 1 kbit OTP memory

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2009年第3期16卷 467-473页

作者：李龙镇 LEE J H kIM T H JIN k H PARk M H ha P B kIM y H Department of Electronic Engineering Changwon National University Department of Computer Science and Technology Yanbian University

A multi-bit antifuse-type one-time programmable （OTP） memory is designed, which has a smaller area and a shorter programming time compared with the conventional single-bit antifuse-type OTP memory. While the conventional antifuse-type OTP memory can store a bit per cell, a proposed OTP memory can store two consecutive bits per cell through a data compression technique. The 1 kbit OTP memory designed with Magnachip 0.18 μm CMOS （complementary metal-oxide semiconductor） process is 34% smaller than the conventional single-bit antifuse-type OTP memory since the sizes of cell array and row decoder are reduced. And the programming time of the proposed OTP memory is nearly 50% smaller than that of the conventional counterpart since two consecutive bytes can be compressed and programmed into eight OTP cells at once. The layout area is 214 μm× 327 μ,, and the read current is simulated to be 30.4 μA.

关键词： multi-bit OTP programming time antifuse memory data compression

Power management unit chip design for automobile active-matrix organic light-emitting diode display module

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2009年第4期16卷 621-628页

作者： kIM J H PARk J H kIM J H CAO T V LEE T y BAN H J yANG k kIM H G ha P B kIM y H Department of Electronic Engineering Changwon National University 9 Sarim-Dong Changwon 641-773 Korea Denso PS Electronics Corporation 47 Seongsan-Dong Changwon 641-315 Korea

A power management unit （PMU） chip supplying dual panel supply voltage, which has a low electro-magnetic interference （EMI） characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip＇s 0.25 μ high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done.

关键词： DC-DC converter AMOLED charge pumping power management unit (PMU) dual panel supply voltage

Engineering hyaluronic acid-based nanoassemblies for monoclonal antibody delivery-design,characterization,and biological insights

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第10期17卷 9111-9125页

作者： Ana M.López-Estévez y.Zhang María Medel Iker Arriaga Lucía Sanjurjo Cristian Huck-Iriart Nicola G.A.Abrescia María J.Vicent Defang Ouyang Dolores Torres María José Alonso Center for Research in Molecular Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmacology Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Health Research Institute of Santiago de Compostela(IDIS) Santiago de Compostela 15782Spain State key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Polymer Therapeutics Laboratory and CIBERONC Prince Felipe Research Centre Valencia E-46012Spain Structure and Cell Biology of Viruses Lab CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain ALBA Synchrotron Light Source Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IkERBASQUE Basque Foundation for ScienceBilbao 48009Spain

The current spotlight of cancer therapeutics is shifting towards personalized medicine with the widespread use of monoclonal antibodies(mAbs).Despite their increasing potential,mAbs have an intrinsic limitation related to their inability to cross cell membranes and reach intracellular *** offers promising solutions to overcome this limitation,however,formulation challenges *** challenges are the limited loading capacity(often insufficient to achieve clinical dosing),the complex formulation methods,and the insufficient characterization of mAb-loaded ***,we present a new nanocarrier consisting of hyaluronic acid-based nanoassemblies(haNAs)specifically designed to entrap mAbs with a high efficiency and an outstanding loading capacity(50%,w/w).haNAs composed by an mAb,modified ha and phosphatidylcholine(PC)resulted in sizes of~100 nm and neutral surface *** modeling identified the principal factors governing the high affinity of mAbs with the amphiphilic ha and *** composition and structural configuration were analyzed using the orthogonal techniques cryogenic transmission electron microscopy(cryo-TEM),asymmetrical flow field-flow fractionation(AF4),and small-angle X-ray scattering(SAXS).These techniques provided evidence of the formation of core-shell nanostructures comprising an aqueous core surrounded by a bilayer consisting of phospholipids and amphiphilic *** vitro experiments in cancer cell lines and macrophages confirmed haNAs’low toxicity and ability to transport mAbs to the intracellular *** reproducibility of this assembling process at industrial-scale batch sizes and the long-term stability was *** conclusion,these results underscore the suitability of haNAs technology to load and deliver biologicals,which holds promise for future clinical translation.

关键词： monoclonal antibody nanoparticles hyaluronic acid characterization particle size computational modeling

Automated extraction of expressway road surface from mobile laser scanning data

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2020年第7期27卷 1917-1938页

作者： TRAN Thanh ha TAWEEP Chaisomphob School of Civil Engineering and Technology Sirindhorn International Institute of TechnologyThammasat UniversityPathumthani 12121Thailand

This paper presents a voxel-based region growing method for automatic road surface extraction from mobile laser scanning point clouds in an expressway *** proposed method has three major steps:constructing a voxel model;extracting the road surface points by employing the voxel-based segmentation algorithm;refining the road boundary using the curb-based segmentation *** evaluate the accuracy of the proposed method,the two-point cloud datasets of two typical test sites in an expressway environment consisting of flat and bumpy surfaces with a high slope were *** proposed algorithm extracted the road surface successfully with high *** was an average recall of 99.5%,the precision was 96.3%,and the F1 score was 97.9%.From the extracted road surface,a framework for the estimation of road roughness was *** agreement was achieved when comparing the results of the road roughness map with the visual image,indicating the feasibility and effectiveness of the proposed framework.

关键词： mobile laser scanning segmentation road surface expressway voxelization point cloud