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骨质疏松患者单髁置换过程中股骨假体置入位置优化的有限元分析

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中国组织工程研究 2025年第3期29卷 464-470页

作者：刘蒙飞陈刚史易晗曾林姜侃依力哈木江•吾斯曼新疆医科大学第六附属医院新疆维吾尔自治区乌鲁木齐市830000

背景:骨质疏松患者行单髁置换过程中,股骨假体的合理置入范围尚未见研究,既往的相关研究常建立在正常骨质的单髁置换模型上,而对于非正常骨质模型的力学研究较少。单髁置换后的并发症已经被证实与骨质疏松高度相关。目的:采用有限元法分... 详细信息

背景:骨质疏松患者行单髁置换过程中,股骨假体的合理置入范围尚未见研究,既往的相关研究常建立在正常骨质的单髁置换模型上,而对于非正常骨质模型的力学研究较少。单髁置换后的并发症已经被证实与骨质疏松高度相关。目的:采用有限元法分析Sled固定平台股骨假体冠状倾斜度对骨质疏松患者单髁置换后生物力学的影响,并且寻找骨质疏松与单髁置换后中远期并发症的相关性。方法:基于数字化影像技术获取膝关节和假体的数据,再通过Mimics、Geomagic studio等专用软件建立一个正常骨质膝关节模型。基于已验证的正常骨质膝关节模型,通过改变材料参数创建骨质疏松膝关节模型。以Sled固定平台股骨假体标准位置(0°)为基准,正常骨质组与骨质疏松组分别依次建立股骨假体内、外翻3°,6°,9°,共计14个单髁置换模型,计算并分析所有单髁置换模型中聚乙烯衬垫表面、胫骨假体下松质骨和皮质骨的应力变化。结果与结论:(1)在骨质疏松模型中,聚乙烯衬垫表面和胫骨假体下松质骨的高应力值随股骨假体倾斜角度的增加而增加,胫骨假体下皮质骨表面的高应力值随假体外翻角度的增加而增加,随内翻角度的增加而减小;(2)对于聚乙烯衬垫表面以及胫骨假体下皮质骨表面,骨质疏松组各倾斜角度模型的高应力值均大于正常骨质组中对应的模型;对于胫骨假体下松质骨表面,骨质疏松组各倾斜角度模型的高应力值均小于正常骨质组中对应的模型;(3)骨质疏松可能会引起单髁置换术后膝关节内部结构的生物力学异常,增加术后假体无菌性松动和假体周围骨折的潜在风险;骨质疏松性膝关节行Sled固定平台内侧单髁置换时应尽可能避免股骨假体在冠状面上内翻/外翻。

关键词：膝单髁置换骨质疏松股骨组件生物力学有限元分析

Locking plate versus Non-locking plate system in the treatment of Mandibular Fractures: A systematic review and meta-analysis

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Locking plate versus Non-locking plate system in the treatme...

Heat transfer characteristics of nanofluid through circular tube

第十四次中国口腔颌面外科学术会议

作者： Patiguli wusiman Department of Oral and Maxillofacial Surgery the Stomatology Affiliated Hospital of Xinjiang Medical University

Purpose:The study proposed to determine the superiority between locking plate and non-locking miniplate for mandibular fractures(MFs)***:A systematic review was conducted according to PRISMA guidelines,examining Medli...

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Journal of Central South University 2013年第1期20卷 142-148页

作者： wusiman ku-er-ban-jiang CHUNG Han-shik MD.J.Nine HANDRY Afrianto EOM Yoon-sub kIM Jun-hyo JEONG Hyo-min Department of Mechanical and Precision Engineering GyeongSang National University445 Inpyeong-dongTongYoungGyeongNam 650-160Korea Department of Energy and Mechanical Engineering The Institute of Marine IndustryGyeongSang National University445 Inpyeong-dongTongYoungGyeongNam 650-160Korea Division of Marine Engineering Mokpo National Maritime UniversityHaeyangdaehang-Ro 91Mokpo-siJeollanam-do530-729Korea

Nano fluid is considered to be a class of high efficient heat transfer fluid created by dispersing some special solid nanoparticles (normally less than 100 nm) in traditional heat transfer fluid. The present experiment was conducted aiming at investigating the forced heat transfer characteristics of aqueous copper (Cu) nanofluid at varying concentration of Cu nano-particles in different flow regimes (300

关键词： nanofluid heat transfer characteristic circular tube metallic particles

dbSCI:A manually curated database of SARS-CoV-2 inhibitors for COVID-19

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BIOCELL 2023年第2期47卷 367-371页

作者： QIANG WANG GUO ZHAO LONGXIANG XIE XUAN LI XIXI YU QIONGSHAN LI BAOPING ZHENG ZULIPINUER wusiman XIANGQIAN GUO Institute of Biomedical Informatics School of SoftwareBioinformatics CenterHenan Provincial Engineering Center for Tumor Molecular MedicineSchool of Basic Medical SciencesAcademy for Advanced Interdisciplinary StudiesHenan UniversityKaifeng475004China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the pathogen of the ongoing coronavirus disease 2019(COVID-19)global ***,by centralizing published cell-based experiments,clinical trials,and virtual drug screening data from the NCBI PubMed database,we developed a database of SARS-CoV-2 inhibitors for COVID-19,dbSCI,which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments,81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics *** provides four major functions:(1)search the drug target or its inhibitor for SARS-CoV-2,(2)browse target/inhibitor information collected from cell experiments,clinical trials,and virtual drug screenings,(3)download,and(4)submit *** entry in dbSCI contains 18 types of information,including inhibitor/drug name,targeting protein,mechanism of inhibition,experimental technique,experimental sample type,and reference *** summary,dbSCI provides a relatively comprehensive,credible repository for inhibitors/drugs against SARS-CoV-2 and their potential targeting mechanisms and it will be valuable for further studies to control COVID-19.

关键词： SARS-CoV-2 COVID-19 Inhibitors Drugs Database

双粒竖直勺盘式花生精量穴播器节本增效优化设计与应用

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农机化研究 2025年第2期47卷 114-121页

作者：吾斯曼·吾木尔阿拉法特·买尔旦沙塔尔·司马义克然木·热合木吐力祖丽皮亚·艾合买提新疆财经大学博士后流动站乌鲁木齐830011 新疆社会科学院农村发展研究所乌鲁木齐830011 新疆交通职业技术学院机电工程学院乌鲁木齐830011 新疆鄯善德丽然目农机有限公司新疆吐鲁番838011

根据目前新疆地区花生双粒播种需求,针对现有穴播器结构复杂、维修困难及精量穴播合格率低等问题,通过单粒取种、双粒排种的方式,设计了一种双粒竖直勺盘式花生精量穴播器。通过阐述穴播器结构组成及工作原理,清晰阐明了花生从取种到投... 详细信息

根据目前新疆地区花生双粒播种需求,针对现有穴播器结构复杂、维修困难及精量穴播合格率低等问题,通过单粒取种、双粒排种的方式,设计了一种双粒竖直勺盘式花生精量穴播器。通过阐述穴播器结构组成及工作原理,清晰阐明了花生从取种到投种整个工作过程,同时对穴播器关键部件取种盘和隔板的结构参数进行了设计。为验证穴播器结构尺寸及性能的可靠性,选取转速、取种窝眼宽度、开口角度为试验因素,以双粒率、漏播率、重播率为试验指标,进行三因素三水平正交试验,并运用Design-Expert软件进行试验分析及参数优化等,得出最优排种组合为转速26.04 r/min、取种窝眼宽度8.8 mm、开口角度52.96°。此时双粒率94.68%、漏播率2.85%、重播率2.47%,符合国家标准。

关键词：穴播器花生勺盘式双粒

Early initiation of ARBs without blood pressure risk via neutrophil membrane-fused pH-sensitive liposomes to reduce cardiomyocyte apoptosis after acute myocardial infarction

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Nano Research 2023年第7期16卷 9894-9905页

作者： Jinfeng Gao wusiman Yakufu Hongbo Yang Yanan Song Qiaozi Wang Qiyu Li Haipeng Tan Jing Chen Dili Sun Zhengmin Wang Jinyan Zhang Xueyi Weng Juying Qian Zhiqing Pang Qibing Wang Zheyong Huang Junbo Ge Department of Cardiology Zhongshan HospitalFudan University.Shanghai Institute of Cardiovascular DiseasesShanghai 200032China National Clinical Research Center for Interventional Medicine&Shanghai Clinical Research Center for Interventional Medicine 180 Feng Lin RoadShanghai 200032China Institute of Biomedical Sciences Fudan UniversityShanghai 200032China School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of Education826 Zhangheng RoadShanghai 200032China

Activation of the local renin-angiotensin system(RAS)promotes cardiomyocyte apoptosis and cardiac remodeling after acute myocardial infarction(AMI).As an anti-RAS drug,the effect of Valsartan in the early stage of acute MI is limited by its low drug concentration in the heart and low ***,by exploiting the inherent nature of neutrophils migrating to the injured myocardium and the local low-pH microenvironment caused by ischemia and hypoxia after myocardial infarction,we designed nanocarrier(NSLP)-hybridized neutrophil membranes and pH-sensitive liposomes(SLPs)for the delivery of Valsartan(NSLPVal).These functional nanocarriers could mimic neutrophils and are homed to the injured heart;they were also found to respond to a low-pH *** the mouse model of MI,we found that NSLP-Val could target the infarct marginal zone and release Valsartan locally in the low-pH microenvironment without affecting hemodynamic ***,locally released angiotensin receptor inhibitors reduced the infarct size and inflammatory response by inhibiting ***,NSLP-Val improved cardiac function and inhibited cardiac hypertrophy and fibrosis.

关键词： Valsartan early initiation cardiomyocyte apoptosis blood pressure myocardial infarction

Unraveling links between aging,circadian rhythm and cancer:Insights from evidence-based analysis

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Chinese Journal of Cancer Research 2024年第3期36卷 341-350页

作者： Dechao Feng Yuhan Xiao Jie Wang Ruicheng Wu Zhouting Tuo koo Han Yoo Wuran Wei Dilinaer wusiman Zhipeng Wang Dengxiong Li Yubo Yang William C.Cho Mang ke Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Division of Surgery&Interventional Science University College LondonLondon W1W 7TSUK Department of Urology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityTaizhou 317000China Department of Urology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China Department of Urology Kyung Hee UniversitySeoul 130-701South Korea Department of Comparative Pathobiology College of Veterinary MedicinePurdue UniversityWest LafayetteIN47907USA Purdue Institute for Cancer Research Purdue UniversityWest LafayetteIN 47907USA Department of Urology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Urology Three Gorges HospitalChongqing UniversityChongqing 404000China Department of Clinical Oncology Queen Elizabeth HospitalHong Kong SARChina

Aging and circadian rhythms have been connected for decades,but their molecular interaction has remained unknown,especially for *** this situation,we summarized the current research actuality and problems in this field using the bibliometric *** in the PubMed and Web of Science databases were ***,there is a rising trend in the publication volume regarding aging and circadian rhythms in the field of *** from USA,Germany,Italy,China and England have greater studies than *** three publication institutions are University of California System,UDICE-French Research Universities and University of Texas *** research hotspots include oxidative stress,breast cancer,melatonin,cell cycle,calorie restriction,prostate cancer and NF-κ*** conclusion,results generated by bibliometric analysis indicate that many approaches involve in the complex interactions between aging and circadian rhythm in *** established and emerging research directions guide our exploration of the regulatory mechanisms of aging and circadian rhythms in cancer and provide a reference for developing new research avenues.

关键词： Aging circadian rhythm human cancer bibliometric analysis oxidative stress

Isolation and Identification of High-Quality Lactic Acid Bacteria in Forage Corn

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Animal Husbandry and Feed Science 2011年第1期3卷 7-10页

作者： Mairemunisa.Aimaier Abudukeyoumu.Maimaiti wusiman.Yimiti College of Life Sciences and Technology Xinjiang University

[ Objective] To screen suitable lactic acid bacterium strains from forage corn which can be used as silage additives. [ Method] The lactic acid bacterium strains were isolated by inoculation on MRS solid medium containing calcium carbonate, and they were preliminarily identified through morphological, physiological and biochemical experiments. The acid production efficiency was determined. Twelve strains having strong acid-pro- duction ability were selected, and their salt tolerance and acid tolerance were detected. The sequences of their 16 S rDNA were also analyzed. [ Result] A total of 44 lactic acid bacterium strains were isolated from the forage com. As evidenced by the physiological and biochemical experi- ments, the twelve strains having strong acid-production ability belonged to Leuconostoc, Lactobacillus and Enterococcus, respectively, and they had strong salt tolerance and acid tolerance. According to the sequences of 16 S rDNA, A4, B9, B11, B12 and B14 were Lactobacillus plantarum; A1, A2., A7, A11 and B8 were Leuconostoc mesenteroides dextran subspecies; and AB and A9 were Enterococcus hirae. [ Conclusion ] The lactic acid bacterium strains with strong acid-production ability isolated from forage corn can be developed into silage additives.

关键词： Forage corn Lactic acid bacteria Isolation Identification 16 S rDNA

Isolation and Identification of High-Quality Lactic Acid Bacteria from Wheat Haulm

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Animal Husbandry and Feed Science 2011年第6期3卷 7-11,16页

作者： Abdukiyum.Mamat Rena.Mijiti Mramnisa.Amar wusiman.Yimit College of Life Sciences and Technology Xinjiang University

[Objective] The aim of this study was to isolate and identify lactic acid bacteria （LAB） from wheat haulm and to select efficient strains for silage fermentation. [ Method] From 78 LAB strains isolated on the MRS solid medium containing calcium carbonate, we selected 43 strains having better acid-production ability through morphological observation, Gram staining, physiological and biochemical tests, acid production test, acid tolerance test and salt tolerance test. These strains were finally identified by sequencing 16 S rDNA. [ Result] Of the 43 LAB strains having better acid-production ability, 37 belonged to Lactobacillus paracasei subsp., one belonged to Lactobacillus rhamnosus and five belonged to Enterococcus faecium, as shown by the sequences of 16 S rDNA. [ Conclusion ] A total of 43 LAB strains having better acid-production ability were selected, which may be developed as high-quality silage additives.

关键词： Wheat haulm Lactic acid bacteria Isolation Identification