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Functional roles of ornithine decarboxylase and arginine decarboxylase during the peri-implantation period of pregnancy in sheep

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Journal of Animal Science and Biotechnology 2018年第2期9卷 306-318页

作者： Yasser Y.Lenis Gregory A.Johnson Xiaoqiu wang wendy w.Tang kathrin A.Dunlap M.Carey Satterfield Guoyao wu Thomas R.hansen Fuller w.Bazer Department of Animal Science Texas A&M UniversityCollege StationTX 77843-2471USA Center for Animal Biotechnology and Genomics Texas A&M UniversityCollege StationTX 77843USA Centauro Research Group School of Veterinary MedicineFaculty of Agrarian ScienceUniversidad de AntioquiaCalle 70 No52-21 MedellínColombia Faculty of Agricultural Sciences Calle 222 No.55-37UDCABogotaColombia Present address:National Institute of Environmental Health Sciences Research Triangle ParkNC 27709USA Animal Reproduction and Biotechnology Laboratory Department of Biomedical SciencesCollege of Veterinary Medicine and Biomedical SciencesColorado State UniversityFort CollinsCO 80523USA

Background: Polyamines stimulate DNA transcription and m RNA translation for protein synthesis in trophectoderm cells, as well as proliferation and migration of cells; therefore, they are essential for development and survival of conceptuses(embryo/fetus and placenta). The ovine conceptus produces polyamines via classical and non-classical pathways. In the classical pathway, arginine(Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase(ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine. In the non-classical pathway, Arg is converted to agmatine(Agm) by arginine decarboxylase(ADC), and Agm is converted to putrescine by agmatinase(AGMAT).Methods: Morpholino antisense oligonucleotides(MAOs) were designed and synthesized to inhibit translational initiation of the m RNAs for ODC1 and ADC, in ovine ***: The morphologies of MAO control, MAO-ODC1, and MAO-ADC conceptuses were normal. Double knockdown of ODC1 and ADC(MAO-ODC1:ADC) resulted in two phenotypes of conceptuses; 33% of conceptuses appeared to be morphological y and functional y normal(phenotype a) and 67% of the conceptuses presented an abnormal morphology and functionality(phenotype b). Furthermore, MAO-ODC1:ADC(a) conceptuses had greater tissue concentrations of Agm,putrescine, and spermidine than MAO control conceptuses, while MAO-ODC1:ADC(b) conceptuses only had greater tissue concentrations of Agm. Uterine flushes from ewes with MAO-ODC1:ADC(a) had greater amounts of arginine, aspartate, tyrosine, citrulline, lysine, phenylalanine, isoleucine, leucine, and glutamine, while uterine flushes of ewes with MAO-ODC1:ADC(b) conceptuses had lower amount of putrescine, spermidine, spermine, alanine, aspartate,glutamine, tyrosine, phenylalanine, isoleucine, leucine, and ***: The double-knockdown of translation of ODC1 and ADC m RNAs was most detrimental to conceptus development and their production of int

关键词： Agmatine Arginine Interferon tau Polyamines Trophectoderm cells

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ACOUSTIC STARTLE RESPONSE AFFECTED BY AGING AND CHOLINERGIC NEUROTRANSMITTERS

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Journal of Otology 2014年第2期9卷 73-80页

作者： Anna hansen SUN wei Department of Communicative Disorders and Sciences State University of New York at Buffalo137 Cary Hall3435 Main StreetBuffaloNY 14214

The acoustic startle response has been used to evaluate tinnitus and hyperacusis in animal models. Gap induced prepulse in- hibition of the acoustic startle reflex （gap-PPI） is affected by tinnitus and loudness changes. Since tinnitus and reduced sound tolerance are commonly seen in elderly, we measured gap-PPI in Fischer 344 rats, an aging related hearing loss model, at dif- ferent agcs： 3-5 months, 9-12 months, and 15-17 months. The startle response was induced by three different intensity of sound： 105, 95 and 85 dB SPL. Gap-PPI was induced by different duration of silent gaps from 1 to 100 ms. when thc startle was induced by 105 dB SPL sound intensity, the gap-PPI induced by 50 ms silent gap was significantly lower than those in- duced by 25 or 100 ms duration, showing a ＂notch＂ in the gap-PPI function. The ＂notch＂ disappeared with the reduction of startle sound, suggesting the ＂notch＂ may be related with hyper-sensitivity to loud sound. As the intensity of the stimulus de- creased, the appearance of the hyperacusis-like effect decreased more quickly for the youngest group of rats. we also tested scopolamine, a muscarinic acetylcholine receptor antagonist, and mecamylamine, a nicotinic acetylcholine receptor antago- nist, on the effect of gap-PPI. when scopolamine was administered, the results indicated no addition effect on the hyperacu- sis-like phenomenon in the two older groups. Mecamylamine, the nicotinic antagonist also showed effects on the appearance of hyperacusis on rats in different ages. The information derived from the study will be fundamental for the further research in determining the cause and treatment for hyperacusis.

关键词： startle reflex hyperacusis acetylcholine scopolamine

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Phenology of high-arctic butterflies and their floral resources： Species-specific responses to climate change

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Current Zoology 2014年第2期60卷 243-251页

作者： Toke T.HФYE Anne ESkILDSEN Rikke R. hansen Joseph J.BOwDEN Niels M.SCHMIDT w.Daniel kISSLING Aarhus Institute of Advanced Studies Hoegh-Guldbergs Gade 6B bldgs. 1630-1632 DK-8000 Aarhus C Denmark Department ofBioscience Kalo Aarhus University Grenaivej 14 DK-8410 Ronde Denmark Arctic Research Centre Aarhus University C.F. Mollers Allé 8 bldg. 1110 DK-8000 Aarhus C Denmark Department of Bioscience Aarhus Aarhus University Ny Munkegade bldg. 1540 DK-8000 Aarhus C Denmark Department of Bioscience Aarhus University Frederiksborgvej 399 DK-4000 Roskilde Denmark Institute for Biodiversity and Ecosystem Dynamics (IBED) University of Amsterdam P.O. Box 94248 1090 GE AmsterdamThe Netherlands

Current global warming is particularly pronounced in the Arctic and arthropods are expected to respond rapidly to these changes. Long-term studies of individual arthropod species from the Arctic are, however, virtually absent. we examined butterfly specimens collected from yellow pitfall traps over 14 years （1996-2009） at Zackenberg in high-arctic, north-east Greenland. Specimens were previously sorted to the family level. we identified them to the species level and examined long-term species-specific phenological responses to recent summer wanning. Two species were rare in the samples （Polaris fritillary Boloria polaris and Arctic blue Plebejus glandon） and statistical analyses of phenological responses were therefore restricted to the two most abundant species （Arctic fritillary, B. chariclea and Northern clouded yellow Colias hecla）. Our analyses demonstrated a trend towards earlier flight seasons in B. chariclea, but not in C. hecla. The timing of onset, peak and end of the flight season in B. chariclea were closely related to snowmelt, July temperature and their interaction, whereas onset, peak and end of the flight season in C. hecla were only related to timing of snowmelt. The duration of the butterfly flight season was significantly positively related to the temporal overlap with floral resources in both butterfly species. we further demonstrate that yellow pitfall traps are a useful alternative to transect walks for butterfly recording in tundra habitats. More phenological studies of Arctic arthropods should be carded out at the species level and ideally be analysed in context with interacting species to assess how ongoing climate change will affect Arctic biodiversity in the near future [Current Zoology 60 （2）： 243-251, 2014].

关键词： Arctic Arthropod Flight period Greenland Pitfall trap Zackenberg

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腐蚀产物对2A12/TC4偶合体系盐雾腐蚀性能影响及仿真

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电镀与精饰 2024年第3期46卷 6-15页

作者：陈亚军陈卓王汉森隋泽寰周延峰中国民航大学中欧航空工程师学院天津300300 中国民航大学航空工程学院天津300300 上海飞机制造有限公司上海201324 中国民航大学工程技术训练中心天津300300

研究了2A12/TC4偶合体系腐蚀机制以及腐蚀产物对腐蚀进程的影响。采用中性盐雾试验、腐蚀形貌观测、产物分析以及电化学测试等方法研究腐蚀产物对2A12/TC4偶合体系腐蚀进程的影响。搭建薄液膜环境下材料电化学测试平台,测量了500μm NaC... 详细信息

研究了2A12/TC4偶合体系腐蚀机制以及腐蚀产物对腐蚀进程的影响。采用中性盐雾试验、腐蚀形貌观测、产物分析以及电化学测试等方法研究腐蚀产物对2A12/TC4偶合体系腐蚀进程的影响。搭建薄液膜环境下材料电化学测试平台,测量了500μm NaCl液膜下2A12铝合金、TC4钛合金的极化曲线,建立了腐蚀产物影响下的双金属电偶腐蚀模型,分析比对了偶合体系下电解质电位、电流密度、腐蚀深度以及腐蚀产物孔隙率等关键参数。由于腐蚀产物的阻碍作用,2A12铝合金腐蚀速率由1.99 mm/a降低至0.97 mm/a,腐蚀电流密度由2.01×10^(-5)A/cm^(2)降低至1.17×10^(-5)A/cm^(2),耐蚀性逐渐提高。生成的Al_(2)O_(3)、AlOOH及Al(OH)3等产物使结构逐渐致密,有效阻碍了腐蚀介质与基体的接触及带电粒子的扩散行为,因而腐蚀进程逐渐减缓。由构建的腐蚀产物影响下电偶腐蚀模型可知,在腐蚀过程中,腐蚀产物的孔隙率由0.8逐渐降低至0.2,极大地阻碍了离子的扩散和迁移过程,使得电化学腐蚀效应减弱。由试验及模拟的腐蚀深度值对比可知,试验值均落在模拟结果的10%误差范围内。

关键词：电偶腐蚀腐蚀仿真盐雾环境腐蚀行为

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Integrating the ISO 14034 standard as a platform for carbon capture and utilization technology performance evaluation

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Clean Energy 2021年第4期5卷 600-610页

作者： Tim hansen kevin McCabe Bill Chatterton Michael Leitch 350Solutions Inc.1053 E.Whitaker Mill RdSuite 115RaleighNC 27604USA XPRIZE Foundation 800 Corporate PointeSuite 350Culver CityCA 90230USA

Independent testing and verification of emerging technologies are vital parts of the technology-commercialization *** the rapid development of carbon capture and utilization(CCU)technologies,where existing standards and certifications do not exist,independent verification approaches and guidelines can provide a means to obtain credible information for an emerging *** ISO 14034:2016-Environmental Management:Environmental Technology Verification(ETV)standard can serve as a foundational platform to ensure the consistency,quality and credibility of data on CCU technology performance,enabling direct comparisons between technologies and reducing risk to decision-makers regarding potential investment,future deployment and ultimate impacts of CCU *** the fundamental principles of ISO 14034 to the evaluation of nine finalist CCU technologies competing in the NRG COSIA Carbon XPRIZE ensured that data used to evaluate competitors was of high quality,consistent across technologies and met the information needs of the XPRIZE and competition judges responsible for selecting *** approaches outlined here,including verification parameters and verification tasks for both XPRIZE-specific technology evaluations and full CCU technology evaluation by an accredited entity in conformance with the ISO 14034 standard,provide insight into the potential benefits-methodological consistency,high-quality data,independent oversight,methodological flexibility and broad applicability-and limitations-technology readiness and applicability,verification and instrumentation costs and lack of specificity-of the approach in an application for the evaluation of emerging *** application of the ISO 14034 standard and principles,developed through a consensus approach that incorporates other developing guidelines,can drive consistency and credibility for technology-performance evaluations across the CCU sector,ultimately leading to reduced risk and impr

关键词： carbon capture CCUS chemical engineering coal energy and environment fossil energy

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Impacts of Norwegian large carnivore management strategy on national grazing sector

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Journal of Mountain Science 2019年第11期16卷 2470-2483页

作者： Inger hansen Geir-Harald STRAND Auvikki de BOON Camilla SANDSTROM Norwegian Institute of Bioeconomy Research Box 115N-1431 AsNorway Department of Political Science Umea University90187 UmeaSweden

Increasing populations of large carnivores are leading to tension and conflicts with livestock production,a situation that potentially might *** Norway the objective of the large carnivore policy is two-folded:to ensure viable carnivore populations and to secure a sustainable grazing *** main instrument is zonation,with carnivore management zones(CMZs)prioritized for reproduction of the large carnivore species separated from other areas prioritized for grazing *** objective of this paper is to describe current knowledge about the impact of the zoning management strategy on the grazing *** is done by documenting status and changes in sheep production,losses of livestock to predating carnivores,and the use of grazing areas inside and outside the *** protection for lynx,wolverine,bear and wolf cover 55%of the Norwegian mainland.30%of the sheep and 50%of the Sami reindeer grazing areas are found inside the ***(semi-domestic reindeer excluded)is using 59%of the available natural pasture areas outside the CMZs,but only 26%inside the *** lowest use of available grazing areas was found inside zones for wolves(12%)and brown bears(6%).Livestock in these zones are confined to fenced enclosures,mostly on the farm itself,or moved to pastures outside the management zone for summer *** losses increased in the affected regions during the period when carnivores were ***,losses declined when CMZs were established and mitigation efforts were implemented in these *** bulk of sheep and reindeer killed by carnivores are now found in boundary areas within 50 km off the CMZs,where sheep are still grazing on open mountain and forest ***,instruments to protect livestock in areas close to the CMZs are also *** number of sheep declined inside the CMZs from 1999 to 2014,but increased outside the *** reduction in the absolute number of sheep in the CMZs is balanced by

关键词： Carnivore management Depredation Management zones Rangeland Sheep Large carnivore policy

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Like or dislike:Response of rodents to the odor of plant secondary metabolites

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Integrative Zoology 2017年第5期12卷 428-436页

作者： Sabine C.hansen Caroline STOLTER Christian IMHOLT Jens JACOB Julius-kühn Institute for Plant Protection in Horticulture and Forests Vertebrate ResearchMünsterGermany University Hamburg Biocenter Grindel and Zoological MuseumHamburgGermany

Rodents,including common voles(Microtus arvalis)and house mice(Mus musculus)cause immense pre-harvest and post-harvest ***,developing methods that mitigate these losses while maintaining their role in ecosystems is a *** plant secondary metabolites(PSM)which significantly reduce food intake of both species under laboratory conditions have been ***,before these can be used in rodent pest management,they must be tested under more natural conditions where other food sources are *** this study,the odors of 4 PSMs were evaluated for their repellent effects in experiments conducted in semi-natural *** treated with PSMs or untreated soil(experimental control)was placed in an underground box containing food(rolled oats).we quantified the number of visits to each box and could demonstrate that all 4 PSMs reduced the number of visits to treatment boxes in both rodent *** common voles the combination of methyl nonyl ketone+black pepper oil was the most repellent *** mice made fewer visits to all PSM boxes;boxes with the anthraquinone were visited ***,house mice consumed less food from boxes containing soil treated with all 4 *** results suggest that PSMs are repellent in murid and microtine rodents under semi-field *** addition,the future use of PSM odors for repelling both pest species,especially house mice,seems *** investigations with other PSMs,different concentrations as well as alternative application methods are needed to repel common voles from attractive crops.

关键词： enclosure trials odor plant secondary metabolites repellents rodents

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Measuring the resilience of an airport network

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Chinese Journal of Aeronautics 2019年第12期32卷 2694-2705页

作者： Yanjun wANG Jianming ZHAN Xinhua XU Lishuai LI Ping CHEN Mark hansen College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Aeronautics and Astronautics Massachusetts Institute of TechnologyCambridge 02139USA Air Traffic Management Bureau Beijing 100012China Xiamen Airlines Xiamen 361006China Department of Systems Engineering and Engineering Management City University of Hong KongKowloonHong KongChina State key Laboratory of Air Traffic Management System and Technology Nanjing 210000China Department of Civil and Environmental Engineering University of CaliforniaBerkeleyCA 94720USA

Resilience is the ability of a system to withstand and stay operational in the face of an unexpected disturbance or unpredicted changes. Recent studies on air transport system resilience focus on topology characteristics after the disturbance and measure the robustness of the network with respect to connectivity. The dynamic processes occurring at the node and link levels are often ignored. Here we analyze airport network resilience by considering both structural and dynamical aspects. we develop a simulation model to study the operational performance of the air transport system when airports operate at degraded capacity rather than completely shutting down. Our analyses show that the system deteriorates soon after disruptive events occur but returns to an acceptable level after a period of time. Static resilience of the airport network is captured by a phase transition in which a small change to airport capacity will result in a sharp change in system punctuality. After the phase transition point, decreasing airport capacity has little impact on system performance. Critical airports which have significant influence on the performance of whole system are identified, and we find that some of these cannot be detected based on the analysis of network structural indicators alone. Our work shows that air transport system’s resilience can be well understood by combining network science and operational dynamics.

关键词： Air transport Complex networks Network resilience Resilience indicator Transportation resilience

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Global transcriptional changes in response to cGAMP depend on STING in human THP-1 cells

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Cellular & Molecular Immunology 2018年第11期15卷 983-985页

作者： Anne Louise hansen Aske M.Brandtoft Mette Nyegaard Anne L.Thielke David Olagnier Christian k.Holm Department of Biomedicine Aarhus Research Center for Innate ImmunologyAarhus UniversityAarhusDenmark

Cytosolic detection of foreign or misplaced self-DNA through the cGAS-STING pathway leads to cGAS-mediated synthesis of the second messenger molecule *** immune signaling molecule STING binds cGAMP directly,and thus functions as a cGAMP *** of cGAMP induces the activation of STING with the subsequent induction of anti-viral and proinflammatory ***,it is not known whether STING is the only cellular sensor of cGAMP,and it has not been reported whether stimulation with cGAMP can induce gene transcription independently of *** we analyzed the global cGAMP-induced transcriptional gene program in STING-deficient human monocyte-derived THP-1 *** found that the global cGAMP-induced transcriptional response was dependent on STING and failed to identify groups of genes that were affected by cGAMP in the absence of *** data therefore strongly indicate that STING is the sole receptor for cGAMP in human macrophages.

关键词： stimulation STING transcriptional

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Pioneer of prostate cancer: past, present and the future of FOXA1

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Protein & Cell 2021年第1期12卷 29-38页

作者： Mona Teng Stanley Zhou Changmeng Cai Mathieu Lupien Housheng hansen He Princess Margaret Cancer Centre University Health NetworkTorontoCanada Department of Medical Biophysics University of TorontoTorontoCanada Center for Personalized Cancer Therapy University of Massachusetts BostonBostonMA 02125USA Ontario Institute for Cancer Research TorontoONCanada

Prostate cancer is the most commonly diagnosed noncutaneous cancers in North American *** androgen deprivation has remained as the cornerstone of prostate cancer treatment,resistance ensues leading to lethal *** box A1(FOXA1)encodes a pioneer factor that induces open chromatin conformation to allow the binding of other transcription *** direct interactions with the Androgen Receptor(AR),FOXA1 helps to shape AR signaling that drives the growth and survival of normal prostate and prostate cancer ***1 also possesses an AR-independent role of regulating epithelial-to-mesenchymal transition(EMT).In prostate cancer,mutations converge onto the coding sequence and c/s-regulatory elements(CREs)of FOXA1,leading to functional *** addition,FOXA1 activity in prostate cancer can be modulated post-translationally through various mechanisms such as LSD1-mediated protein *** this review,we describe the latest discoveries related to the function and regulation of FOXA1 in prostate cancer,pointing to their relevance to guide future clinical interventions.

关键词： FOXA1 cancer alterations

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