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world Journal of Gastroenterology 2022年第5期28卷 588-593页

作者： Lars Lindgaard Morten Laksáfoss Lauritsen Srdan Novovic Erik Feldager hansen John Gásdal karstensen Palle Nordblad Schmidt Pancreatitis Centre East(PACE) Gastro UnitCopenhagen University Hospital-Amager and HvidovreHvidovre 2650Capital RegionDenmark Department of Clinical Medicine University of CopenhagenCopenhagen 2100Capital RegionDenmark

BACkGROUND Infected walled-off necrosis is a potentially life-threatening complication of necrotizing *** some patients can be treated by drainage alone,many patients also need evacuation of the infected *** necroses in relation to the pancreatic bed are easily reached via an endoscopic transluminal approach,whereas necroses that involve the paracolic gutters and the pelvis are most efficiently treated via a percutaneous *** and complex necroses may need a combination of the two *** SUMMARY Transluminal and percutaneous drainage followed by simultaneous endoscopic and modified video-assisted retroperitoneal debridement was carried out in two patients with very large(32-38 cm),infected walled-off necroses using a laparoscopic access *** 34 d and 86 d and a total of 9 and 14 procedures,respectively,complete regression of the walled-off necroses was *** laparoscopic access platform improved both access to the cavities as well as the *** transluminal and percutaneous necrosectomy are feasible with the laparoscopic access platform serving as a useful *** This approach may be necessary to control infection and achieve regression in some patients with complex collections.

关键词： Acute necrotizing pancreatitis walled-off necroses Minimally invasive surgical procedures

采用动态磁敏感对比增强技术测量氧合和微血管通过时间异质性来预测胶质母细胞瘤治疗后的假性进展

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国际医学放射学杂志 2024年第4期 497-497页

作者： J.E.Park H.S.kim N.Y.kim R.Borra k.Mouridsen M.B.hansen 胡佳圆

摘要目的评估MR动态磁敏感对比（DSC）灌注加权成像（PwI）的肿瘤微血管和氧代谢信息对脑血容量（CBV）鉴别胶质母细胞瘤治疗后的假性进展和真性进展（TP）的附加价

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Hepatocellular carcinoma surveillance:An evidence-based approach

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world Journal of Gastroenterology 2019年第13期25卷 1550-1559页

作者： Patrick S Harris Ross M hansen Meagan E Gray Omar I Massoud Brendan M McGuire Mohamed G Shoreibah Tinsley Harrison Internal Medicine Residency Program Department of Medicine University of Alabama at Birmingham Division of Gastroenterology and Hepatology Department of Medicine University of Alabama at Birmingham

Hepatocellular carcinoma(HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. All patients with cirrhosis and high-risk hepatitis B patients are at risk for HCC and should undergo surveillance. The recommended surveillance modality is abdominal ultrasound(US) given that it is cost effective and noninvasive with good sensitivity. However, US is limited in obese patients and those with non-alcoholic fatty liver disease(NAFLD). with the current obesity epidemic and rise in the prevalence of NAFLD, abdominal computed tomography or magnetic resonance imaging may be indicated as the primary screening modality in these patients. The addition of alpha-fetoprotein to a surveillance regimen is thought to improve the sensitivity of HCC *** investigation of serum biomarkers is needed. Semiannual screening is the suggested surveillance interval. Surveillance for HCC is underutilized and low adherence disproportionately affects certain demographics such as nonCaucasian race and low socioeconomic status.

关键词： Liver cancer Hepatocellular carcinoma Surveillance

Intra-operative consult for cystic struma ovarii—An experience in an academic medical center: A study of 53 cases over 21 years

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Open Journal of Obstetrics and Gynecology 2013年第7期3卷 1-6页

作者： M. Ruhul Quddus Jinjun Xiong S. M. k. Nahar Begum Michele Lomme katrine hansen C. James Sung w. Dwayne Lawrence Department of Pathology Women & Infants’ Hospital and the Warren Alpert Medical School of Brown University Providence USA

Struma ovarii often escapes recognition during intraoperative consultation because of its rarity, subtle characteristic gross appearance, and lack of clinical suspicion. An intraoperative diagnosis of benign struma ovarii enables the general gynecologic surgeon to continue the planned surgery. However, a diagnosis of malignnancy in a struma ovarii would alter the course of surgery with the involvement of a gynecologic oncology surgeon. we present here that our experience with intraoperative consultation for preoperatively undiagnosed struma ovarii presenting as an adnexal cystic or solid mass at our teaching hospital. Fifty-three cases of struma ovarii, 5.2% of all cystic teratoma of the same period, were diagnosed between January 1991 and March 2011. All intraoperative consultation reports, gross descriptions and final pathology reports were reviewed. The H&E stained slides and in selected cases, immunohistochemistry stained slides, were reviewed. Of the 53 cases of struma ovarii, intraoperative consultation was requested on 48 cases. Frozen section was done on 24 cases and only gross examination was felt appropriate in remaining 24 cases. 83% cases were diagnosed when a frozen section was done. None of the remaining 24 cases were recognized as struma by gross inspection. Our findings reveal that in a large number of cases the diagnosis of struma ovarii remained unrecognized during intraoperative consultation, indicating its often subtle/deceptive gross morphologic appearance. However, the purpose of the intraoperative consultation was served, as appropriate information was provided to the surgeon to guide the surgical management.

关键词： Struma Ovarii Intraoperative Consult Ovarian Cyst

Comparative methane estimation from cattle based on total CO_2 production using different techniques

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Animal Nutrition 2017年第2期3卷 175-179页

作者： Md N.Haque Hanne H.hansen Ida M.L.D.Storm Jφrgen Madsen Department of Large Animal Sciences Faculty of Health and Medical SciencesUniversity of Copenhagen

The objective of this study was to compare the precision of CH4 estimates using calculated CO_2(HP) by the CO_2 method(CO_2 T) and measured CO_2 in the respiration chamber(CO_2 R). The CO_2 R and CO_2 T study was conducted as a 3 × 3 Latin square design where 3 Dexter heifers were allocated to metabolic cages for 3 periods. Each period consisted of 2 weeks of adaptation followed by 1 week of measurement with the CO_2 R and CO_2 T. The average body weight of the heifer was 226 ± 11 kg(means±SD). They were fed a total mixed ration, twice daily, with 1 of 3 supplements: wheat(w), molasses(M), or molasses mixed with sodium bicarbonate(Mbic). The dry mater intake(DMI: kg/day) was significantly greater(P with that in the respiration chamber. The daily CH4(L/day) emission was strongly correlated(r=0.78) between CO_2 T and CO_2 R. The daily CH4(L/kg DMI) emission by the CO_2 T was in the same magnitude as by the CO_2 R. The measured CO_2(L/day) production in the respiration chamber was not different(P = 0.39) from the calculated CO_2 production using the CO_2 T. This result concludes a reasonable accuracy and precision of CH4 estimation by the CO_2 T compared with the CO_2 R.

关键词： Carbon dioxide Precision Methane Measurement Respiration chamber

An in vitro prototype of a porcine biomimetic testis-like cell culture system： a novel tool for the study of reassembled Sertoli and Leydig cells

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Asian Journal of Andrology 2018年第2期20卷 160-165页

作者： Iva Arato Giovanni Luca Francesca Mancuso Catia Bellucci Cinzia Lilli Mario Calvitti Barbara C hansen Domenico Milardi Giuseppe Grande Riccardo Calafiore Department of Experimental Medicine University of Perugia Perugia 06100 Italy Division of Medical Andrology and Endocrinology of Reproduction University of Perugia and Saint Mary Hospital Terni 05100 Italy Department of Internal Medicine and Pediatrics Morsani College of Medicine University of South Florida Tampa 33612 FL USA Division of Endocrinology Fondazione Policlinico Universitario 'A. Gemelli' 00168 Rome Italy Department of Medicine University of Perugia Perugia 06100 Italy

At present, there is no reliable in vitro assembled prepubertal testis-like biomimetic organ culture system designed to assess the functional effects of human gonadotropins on Sertoli and Leydig cells. Spermatogenesis is regulated by endocrine, paracrine, and juxtacrine factors （testicular cross-talk）, mainly orchestrated by gonadotropins such as luteinizing hormone （LH） and follicle-stimulating hormone （FSH） that play a pivotal role by stimulating Leydig and Sertoli cells, respectively. The aim of our study was to set up an in vitro prepubertal porcine bioengineered construct as a new model for experimental studies on reassembled Sertoli and Leydig cells. we have evaluated Sertoli and Leydig cells obtained from 15- to 20-day-old neonatal pig testes in terms of purity and function. Subsequently, purified Sertoli and enriched Leydig cells were subjected to coincubation to obtain an in vitro prepubertal porcine testis-like culture system. we performed enzyme-linked immunosorbent assay （ELISA） for anti-Mullerian hormone （AMH）, inhibin B, and testosterone secretion in the medium, and Real-lime PCR analysis of AMH, inhibin B, FSH-r, aromatase, LHr, and 3βHSD mRNA expression levels. This in vitro testis-like system was highly responsive to the effects of human gonadotropins and testosterone. AMH mRNA expression and secretion declined, and inhibin-B increased, while FSH-receptor expression was downregulated upon FSH/LH exposure/treatment. Finally, the production of testosterone was increased selectively upon LH treatment. In summary, our proposed model could help to better determine the action of human gonadotropins on Sertoli and Leydig cells. The potential usefulness of the system for shedding light into male infertility-related issues is evident.

关键词： human gonadotropins Leydig cells prepubertal biomimetic testis Sertoli cells

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荷兰铁路最新研究成果

中国铁道科学 2002年第6期23卷 1-14页

作者： I.A.hansen 宇红代尔夫特理工大学土木工程与地球科学系运输计划与交通工程部，荷兰

荷兰铁路最新研究集中在开发用户友好工具以利用标准的列车检测数据对车站晚点列车进行实验分析、建立不同线路列车到发晚点时间分布的随机模型。根据位于荷兰车站HagueHS的轨道电路对近10000次列车运行自动检测可以证明,TNV Prepare软... 详细信息

荷兰铁路最新研究集中在开发用户友好工具以利用标准的列车检测数据对车站晚点列车进行实验分析、建立不同线路列车到发晚点时间分布的随机模型。根据位于荷兰车站HagueHS的轨道电路对近10000次列车运行自动检测可以证明,TNV Prepare软件工具可以很好地记录列车占用和释放时间以及列车速度。若一条线路上晚点时间很短(1分钟以下)或晚点时间长(5分钟以上)的次数不是太大,发车晚点分布在很多情况下符合一种指数分布。用一种新的工具对大铁路网的时刻表以及在中转车站的相互连接的线路之间的晚点的扩散进行了分析,将列车描述成一个基于Max Plus线性系统的间断事件系统(DES)。它有助于确定网络中的关键环路,交叉线路时刻表的剩余间隙以及网络中的晚点扩散。另一个铁路研究领域是线路基础设施养护维修与更新改造的寿命周期成本估算的决策支持系统,该系统经证明对不同线路上部结构设计的寿命周期成本的估算非常有效,对轨道和道岔养护维修与更新改造计划规则的修改也十分有效。

关键词：荷兰铁路列车晚点分析网络时刻表决策支持系统列车检测数据线路养护维修

2019—2023年重庆市登革热媒介伊蚊监测结果分析

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热带病与寄生虫学 2024年第4期22卷 204-207,222页

作者：肖汉森涂涛田王政张应魏晶季恒青重庆市疾病预防控制中心消毒与媒介生物控制所高致病性病原微生物重庆市重点实验室重庆市公共卫生重点学科重庆市疾病预防控制与公共卫生研究中心重庆400700

目的了解重庆市登革热媒介伊蚊密度、季节消长等规律,为制定登革热防控策略提供科学依据。方法收集2019—2023年重庆市39个区(县)媒介伊蚊监测结果,该监测每年4—11月进行,每月开展1次,于全市选择不同生境对其媒介伊蚊成蚊和幼蚊分别采... 详细信息

目的了解重庆市登革热媒介伊蚊密度、季节消长等规律,为制定登革热防控策略提供科学依据。方法收集2019—2023年重庆市39个区(县)媒介伊蚊监测结果,该监测每年4—11月进行,每月开展1次,于全市选择不同生境对其媒介伊蚊成蚊和幼蚊分别采用双层叠帐法、布雷图指数法进行监测;通过中国疾病预防控制信息系统收集同期重庆市登革热病例资料并分析。结果2019—2023年,重庆市媒介伊蚊成蚊平均帐诱指数为1.63只/(顶·h),居民区、旧轮胎堆放地/废品站/工地、公园/竹林的帐诱指数分别为2.23、1.82、0.83只/(顶·h);媒介伊蚊幼蚊平均布雷图指数为5.25,废旧物品堆放处和医院的平均布雷图指数分别为66.77、20.64,居民区、公园和工地的布雷图指数每年均处于相对较低水平,分别为4.38、4.12和2.46。2019—2023年重庆市报告登革热病例1539例,其中输入性病例269例,本地病例1270例;报告病例主要集中于2019年(输入性病例168例,本地病例1243例)和2023年(输入性病例95例,本地病例27例);所有本地病例均在8—11月报告;输入病例数与本地病例数具有相关性(r=0.857,P<0.05)。结论夏秋季重庆市应重点做好居民区、医院、废旧物品堆放处等生境的媒介伊蚊监测与控制工作,将蚊媒密度控制在传播风险阈值以内,防范由输入性病例引起本地病例甚至点状聚集性疫情的发生。

关键词：登革热传播媒介伊蚊监测重庆市

An empirical method to correct the saturation seen in the SOHO/MDI magnetograms

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Research in Astronomy and Astrophysics 2010年第10期10卷 1041-1048页

作者： George Zhendong Gao Yong-Heng Zhao Yang Liu National Astronomical Observatories of China Chinese Academy of Sciences Beijing 100012 China w. w. hansen Experimental Physics Laboratory Stanford University Stanford CA 94305-4085 USA

The magnetic field of the umbrae is sometimes found to be saturated in the magnetograms taken by the Michelson Doppler Imager （MDI） onboard the Solar and Heliospheric Observatory （SOHO）. It is suggested that the combination of the low intensity of sunspot umbrae and the limitation of the 15-bit onboard numerical data acquisition leads to this saturation. In this paper, we propose to use the MDI＇s intensity data to correct this saturation. This method is based on the well-established relationship between the continuum intensity and the magnetic field （the so-called I-B relationship）. A comparison between the corrected magnetic field and the data taken by the Stokes-Polarimeter of the Solar Optical Telescope （SOT/SP） onboard Hinode shows a reasonable agreement, suggesting that this correction is effective.

关键词： Sun solar magnetic field -- Sun MDI magnetograms -- Sun Saturation

HIGH POwER TUNABLE UV LASER RADIATION PRODUCED BY SECOND-HARMONIC GENERATION IN β-BaB_(2)O_(4)

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Chinese Physics Letters 1988年第9期5卷 389-392页

作者： XU Zuyan DENG Daoqun ZHAO Tienan SHOU hansen Institute of Physics Academia SinicaBeijing Institute of Photographic Chemistry Academia SinicaBeijing

High power tunable UV laser radiation from 2750Åto 3200 Åhas been obtained by second-harmonic generation in aβ-BaB_(2)O_(4) crystal.A maximum frequency doubling efficiency of 41%and a UV output power of 3.7Mw have be... 详细信息

关键词： power tunable RADI