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Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit kumar Pradhan Rainer Rupprecht Gerhard Rammes klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

Q-Learning-Based Pesticide Contamination Prediction in Vegetables and Fruits

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Computer Systems Science & Engineering 2023年第4期45卷 715-736页

作者： kandasamy Sellamuthu vishnu kumar kaliappan Department of Computer Science and Engineering KPR Institute of Engineering and TechnologyCoimbatore641407Tamil NaduIndia

Pesticides have become more necessary in modern agricultural ***,these pesticides have an unforeseeable long-term impact on people's wellbeing as well as the *** to a shortage of basic pesticide exposure awareness,farmers typically utilize pesticides extremely close to *** residues within foods,particularly fruits as well as veggies,are a significant issue among farmers,merchants,and particularly *** residual concentrations were far lower than these maximal allowable limits,with only a few surpassing the restrictions for such pesticides in *** is an obligation to provide a warning about this amount of pesticide use in *** technologies failed to forecast the large number of pesticides that were dangerous to people,necessitating the development of improved detection and early warning systems.A novel methodology for verifying the status and evaluating the level of pesticides in regularly consumed veggies as well as fruits has been identified,named as the Hybrid Chronic Multi-Residual Framework(HCMF),in which the harmful level of used pesticide residues has been predicted for contamination in agro products using Q-Learning based Recurrent Neural Network and the predicted contamination levels have been analyzed using Complex Event Processing(CEP)by processing given spatial and sequential *** analysis results are used to minimize and effectively use pesticides in the agricultural field and also ensure the safety of farmers and ***,the technique is carried out in a Python environment,with the results showing that the proposed model has a 98.57%accuracy and a training loss of 0.30.

关键词： Pesticide contamination complex event processing recurrent neural network Q learning multi residual level and contamination level

COVID-19:Review on Its Etiology,Pathogenesis,and Existence in Humans

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BIOCELL 2020年第4期44卷 461-467页

作者： VIVEk kumar vishnu AGARWAL Department of Biotechnology Motilal Nehru National Institute of TechnologyAllahabad211004India

The world is facing a new healthcare crisis with the rise and spread of novel coronavirus since December *** known as Severe Acute Respiratory Syndrome Corona Virus-2(SARS-CoV-2),the disease associated with SARSCoV-2 is even called ***-19 is having a pulverizing impact on the scientific *** of August 13,2020,the number of confirmed cases had reached up to 20,439,814 and the death toll to 744,385,affecting more than 188 territories across the *** these difficult times,the world is looking towards research and clinical work from different scientific communities to lead the way to a solution to the *** this review,we are focusing on COVID-19 emergence,pathogenicity,and existence in humans,as well as the SARS-CoV-2 infection mechanism and its similarities to previous coronavirus strains.

关键词： COVID-19 SARS-CoV MERS-CoV

Market Drivers in India’s Smart Grid:Responsibilities and Roles of Stakeholders

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Energy Engineering 2025年第1期122卷 101-128页

作者： Abhay Sanatan Satapathy Suresh kumar Sahoo Asit Mohanty Yasser Fouad Manzoore ElahiMohammad Soudagar Erdem Cuce Faculty of Management Studies Sri Sri UniversityCuttack754006India Institute of Power Engineering National Energy UniversityJalan Ikram-UnitenKajangSelangor43000Malaysia Centre of Research Impact and Outcome Chitkara UniversityRajpura140417PunjabIndia Department of Applied Mechanical Engineering College of Applied EngineeringMuzahimiyah BranchKing Saud UniversityRiyadh11421Saudi Arabia College of Engineering Lishui UniversityLishui323000China Department of Mechanical Engineering Graphic Era(Deemed to be University)Dehradun248002UttarakhandIndia Department of Mechanical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur50603Malaysia Department of Mechanical Engineering Faculty of Engineering and ArchitectureRecep Tayyip Erdogan UniversityZihni Derin CampusRize53100Turkey Center for Research Impact&Outcome Chitkara UniversityRajpura140401PunjabIndia University Centre for Research and Development Chandigarh UniversityMohali140413PunjabIndia

The emergence of smart grids in India is propelled by an intricate interaction of market dynamics,regulatory structures,and stakeholder *** study analyzes the primary factors that are driving the widespread use of smart grid technologies and outlines the specific roles and obligations of different stakeholders,such as government entities,utility companies,technology suppliers,and *** activities and regulations are crucial in facilitating the implementation of smart grid technology by offering financial incentives,regulatory assistance,and strategic *** firms have the responsibility of implementing and integrating smart grid infrastructure,with an emphasis on improving the dependability of the grid,minimizing losses in transmission and distribution,and integrating renewable energy *** companies offer the essential hardware and software solutions,which stimulate creativity and enhance *** actively engage in the energy ecosystem by participating in demand response,implementing energy saving measures,and adopting distributed energy resources like solar panels and electric *** study examines the difficulties and possibilities in India’s smart grid industry,highlighting the importance of cooperation among stakeholders to build a strong,effective,and environmentally friendly energy future.

关键词： Smart grid stakeholders smart grid technology market drivers

Candida tropicalis infection in a term neonate with gall bladder masses and infective endocarditis

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 410-412页

作者： Mamta Jajoo Vishal kumar vishnu k.Goyal Amit Garg Department of Pediatrics Maulana Azad Medical College & Associated Chacha Nehru Bal Chikitsalaya New Delhi-110031India Department of Radiology Maulana Azad Medical couege & Associated Chacha Nehru Bal ChikisalayaNew pelhi-110031India.

Candida endocarditis is extremely rare in term neonates,and gall bladder involvement due to candidemia has never been reported amongst neonates and infants.A term,appropriate for gestational age neonate developed Candida tropicalis blood stream infection in second week of *** was started on conventional amphotericin ***,he failed to show any clinical improvement,and candidemia keep on *** sanctuary sites screening revealed multiple echogenic masses in heart(vegetations) and gall *** changing the treatment to liposomal amphotericin B and fluconazole,he recovered clinically,echogenic masses in gall bladder disappeared,and intracardiac vegetations decreased in size.

关键词： Candida tropicalis Endocarditis Gall bladder

Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Purification and characterization of CHpro1, a thermotolerant, alkali-stable and oxidation-resisting protease of Chumathang hotspring

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Science Bulletin 2015年第14期60卷 1252-1260页

作者： Reena Singh Chirag Chopra vishnu kumar Gupta Bashir Akhlaq Vijeshwar Verma Shafaq Rasool School of Biotechnology Shri Mata Vaishno Devi University Lovely Professional University Indian Institute of Toxicology Research

Metagenomic approaches are recently used for searching novel open reading frames （ORFs） coding enzymes employed in pharmaceutical, rood industries, etc. In this study, a metagenornic library was constructed from Chumathang hotspring sediment DNA. The library consisted of approximately 9,000 clones and was screened for protease activity. A clone exhibiting protease activity was identified and named CHprol. Sequencing of CHprol revealed that the ORF encoded a functional protein of 363 amino acids belonging to peptidase S8-S53 superfamily. CHprol shared 41% sequence similarity with a reported protease （subtilase family） and 35 % structural similarity with the crystal structure of Pro-Tk sps. of Thermococcus kodarkaenasis. In silico modeling the 3D structure of CHprol showed that it has two beta sheets, 10 alpha helices and 11 strands. Catalytic triad prediction implied CHprol to be a serine protease. The optimum temperature and pH of the purified protease were found to be 80 ℃ and 11.0, respectively. The enzyme was active at 5 % concentration of hydrogen peroxide and retained 60 % of activity at 10 % concentration. The thermotolerant, alkalophilic and oxidant stable properties of the protease make it a potential can- didate for biotechnological applications.

关键词： Thermotolerant. Alkalophilic Oxidantstable Protease Hotspring Metagenomics

A state-of-the-art review on recent advances in the fabrication and characteristics of magnesium-based alloys in biomedical applications

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Journal of Magnesium and Alloys 2024年第7期12卷 2569-2594页

作者： Fatemeh Zahra Akbarzadeh Masoud Sarraf Erfan Rezvani Ghomi vishnu Vijay kumar Mojtaba Salehi Seeram Ramakrishna Sungchul Bae Department of Materials Engineering Babol Noshirvani University of TechnologyShariati Ave.Babol 47148-71167Iran Deputy Vice Chancellor’s Office(Research&Innovation) University of MalayaKuala Lumpur 50603Malaysia Center of Advanced Manufacturing and Material Processing Department of Mechanical EngineeringFaculty of Engineering University of MalayaKuala Lumpur 50603Malaysia Department of Mechanical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia Center for Nanotechnology and Sustainability Department of Mechanical EngineeringNational University of SingaporeSingapore 117581Singapore Lee kong Chian School of Medicine Nanyang Technological University SingaporeClinical Sciences Building11 Mandalay RoadSingapore 308232Singapore Structural Engineering Division of EngineeringNew York University Abu Dhabi(NYUAD)PO Box 129188 Abu DhabiUnited Arab Emirates International Institute of Aerospace Engineering&Management JAIN(Deemed-to-be-university)JGI global campusBangalore562112India Additive Manufacturing Division Singapore Institute of Manufacturing Technology(SIMTech)Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech Loop 636732Singapore Department of Architectural Engineering Hanyang UniversitySeoulSouth Korea

Magnesium(Mg)and its alloys have recently gained increasing attention in the biomedical field as promising biodegradable materials with harmless degradation ***-based alloys have a wide range of biomedical applications because of their outstanding biocompatibility and unique mechanical *** use of Mg-based biomedical devices eliminates the need for post-healing biomaterial removal surgery and minimizes the negative consequences of the implantation of permanent biomaterials,including stress shielding and undesired metal ion release in the *** paper provides a literature review on the properties and manufacturing methods of Mgbased alloys for biomedical applications,including orthopedic implants,cardiovascular applications,surgical wires and staplers,and antitumor *** application of Mg-based biomaterials is investigated from a biological perspective,including matching functional properties,biocompatibility,host tissue responses,and anti-microbial strategies,along with potential additive manufacturing technologies for these ***,an outlook is presented to provide recommendations for Mg-based biomaterials in the future.

关键词： Mg-based alloys Biocompatibility Anti-microbial strategies Additive manufacturing Mg implants