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World Journal of Gastroenterology 2005年第44期11卷 6905-6909页

作者： Tadayuki Shishido Taketo Yamaguchi takeo Odaka Masanori Seimiya Hiromitsu Saisho Fumio Nomura Department of Medicine and Clinical Oncology Department of Molecular Diagnosis

AIM： To investigate the usefulness of sucrose permeability test using serum in the diagnosis of gastric diseases, with special reference to early gastric cancer （EGC）. METHODS： A total of 63 subjects, including 11 patients with gastric ulcer, 20 patients with gastric cancer （13, early; 7, advanced） and 32 healthy controls, were studied. Blood and urine samples were collected repeatedly for 5 h before and after the sucrose loading. Sucrose levels were measured by a newly developed RESULTS： Serum sucrose levels started to increase 15 min after loading, and peaked at 60 min in the gastric disease groups. The levels for gastric ulcer, EGC and advanced gastric cancer （AGC） at 60 min were significantly higher than that in the healthy controls （26.9±2.4, 34.4±5.0, and 71.8±15.6 vs 7.9±0.7 mol/L, respectively, P〈0.01）. The cut-off level set at 15.4 mol/L （60 min） offered the best distinction between EGC patients and healthy controls; and the sensitivity and specificity were 92.3% and 93.8%, respectively, while those of the urine method were 76.9% and 93.8%, respectively. CONCLUSIONS： The gastric permeability test using serum is reliable for the detection of EGC, and this test can provide results much earlier than the conventional urine method. This test may offer a useful alternative to more invasive tests for EGC.

关键词： Sucrose test Gastric permeability Early gastric cancer Advanced gastric cancer Gastric ulcer

Genetic polymorphisms of MAFk, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan

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World Journal of Gastroenterology 2017年第29期23卷 5364-5370页

作者： Tomiyasu Arisawa Masakatsu Nakamura Toshimi Otsuka Wu Jing Naoko Sakurai Hikaru Takano Tasuku Hayashi Masafumi Ota Tomoe Nomura Ranji Hayashi takeo Shimasaki Tomomitsu Tahara Tomoyuki Shibata Department of Gastroenterology Kanazawa Medical University Department of Gastroenterology Fujita Health University

To investigate whether single nucleotide polymorphisms in maf protein k (MAFk), which encodes the MAFk, lead to increased susceptibility to ulcerative colitis in the Japanese population. METHODSThis case control study examined the associations between MAFk single nucleotide polymorphisms (rs4268033 G>A, rs3735656 T>C and rs10226620 C>T) and ulcerative colitis susceptibility in 174 patients with ulcerative colitis (UC) cases, and 748 subjects without no lower abdominal symptoms, diarrhea or hematochezia (controls). In addition, as the second controls, we set 360 subjects, who have an irregular bowel movement without abnormal lower endoscopic findings (IBM controls). RESULTSThe genotype frequency of rs4268033 AA and allelic frequency of the rs4268033A allele were significantly higher in the UC cases than in both controls (P = 0.0005 and k genetic polymorphisms are significantly associated with susceptibility to UC development. In particular, rs4268033 is closely associated with an increased risk for the development of UC.

关键词： Maf protein k Genetic polymorphism Reactive oxygen species Ulcerative colitis Nuclear factor-erythroid 2-related factor 2

Fatal submucosal invasive gastric adenosquamous carcinoma detected at surveillance after gastric endoscopic submucosal dissection

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World Journal of Gastroenterology 2015年第14期21卷 4385-4390页

作者： Akinori Shirahige Haruhisa Suzuki Ichiro Oda Masau Sekiguchi Genki Mori Seiichiro Abe Satoru Nonaka Shigetaka Yoshinaga Shigeki Sekine Ryoji kushima Yutaka Saito takeo Fukagawa Hitoshi katai Endoscopy Division National Cancer Center Hospital Pathology Division National Cancer Center Hospital Department of Clinical Laboratory Medicine and Diagnostic Pathology Shiga University of Medical Science Gastric Surgery Division National Cancer Center Hospital

An 80-year-old man was under annual surveillance esophagogastroduodenoscopy after endoscopic submucosal dissection(ESD) for early gastric cancer(EGC).Two years after the initial ESD, a 0-Ⅱc type metachronous EGC lesion, 8 mm in size, without an ulcer scar, was found in the gastric *** estimated tumor depth was up to the mucosa, and biopsy revealed well and poorly differentiated *** was performed for this lesion and en bloc resection with negative margins was *** examination revealed an adenosquamous carcinoma 8 mm in size invading the deep submucosal layer(1600 μm), with lymphovascular invasion, consistent with the diagnosis of non-curative *** gastrectomy was recommended for this patient; however, two months after the ESD, preoperative computed tomography revealed multiple liver metastases, and the patient was considered as an unsuitable candidate for surgical *** chemotherapy was therefore started; however, the patient died of gastric cancer 27 mo after the second *** gastric adenosquamous carcinoma localized to the mucosa and submucosa is extremely rare and its clinical behavior is not well *** present report is very significant in that it underscores the distinct possibility of gastric adenosquamous carcinoma being very aggressive and fatal even when detected at an early cancer.

关键词： Early gastric cancer Endoscopic submucosal dissect

A novel mouse model of adult T-cell leukemia cell invasion into the spinal cord

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Animal Models and Experimental Medicine 2019年第1期2卷 64-67页

作者： takeo Ohsugi Shuhei Tanaka keigo Iwasaki Yusuke Nagano Tomohiro kozako kazuya Matsuda Takuya Hirose kazushige Takehana Department of Laboratory Animal Sciences School of Veterinary MedicineRakuno Gakuen University Faculty of Pharmaceutical Sciences Department of BiochemistryFukuoka University Department of Veterinary Pathology School of Veterinary MedicineRakuno Gakuen University Department of Veterinary Microanatomy School of Veterinary MedicineRakuno Gakuen University

Adult T-cell leukemia( ATL) is a mature T-cell malignancy caused by human T-cell leukemia virus type I infection, and 10%-25% of patients show central nervous system( CNS) involvement. CNS involvement significantly reduces survival and there are no effective treatments for CNS involvement. Therefore, an appropriate animal model is required to evaluate the inhibitory effects of novel drugs on the progression of ATL with CNS involvement. Here, we established a mouse model of ATL with CNS involvement using ***-Prkdc~ (scid) Il2 rg ^(tm1Wjl)/SzJ mice inoculated with ATL cells intramuscularly in the postauricular region, and these mice showed paraparesis. Of the 10 mice inoculated with ATL cells intramuscularly(I.M.) at 5 weeks of age, 8(80%) showed paraparesis, whereas none of the 10 mice inoculated with ATL cells subcutaneously(S.C.) showed paraparesis. In the I.M. group, PCR detected HTLV-1-specific genes in the thoracic and lumbar vertebrae; however, in the S.C. group, the vertebrae were negative for HTLV-1 genes. Histological analysis revealed a particularly high incidence of tumors, characterized by accumulation of the injected cells, in the thoracic vertebrae of mice in the I.M. group. Tumor cell infiltration was relatively high in the bone marrow. Spinal cord compression caused by invasion of the tumor mass outside the pia mater was observed in the thoracic vertebrae of the spinal cord. In conclusion, we have reported a mouse model of tumor growth with paraparesis that may be used to assess novel therapeutic agents for ATL with CNS involvement.

关键词： adult T-cell leukemia(ATL) central nervous system(CNS) human T-cell leukemia virus type I(HTLV-1) mice NOD.Cg-Prkdc scid Il2rg tm1Wjl/SzJ mice

Determining Nodulation Regulatory (Rj) Genes of Myanmar Soybean Cultivars and Their Symbiotic Effectiveness with Bradyrhizobium japonicumUSDA110

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American Journal of Plant Sciences 2015年第18期6卷 2799-2810页

作者： Aung Zaw Htwe Yuichi Saeki kyi Moe takeo Yamakawa Laboratory of Plant Nutrition Graduate School of Bioresource and Bioenvironmental Sciences Faculty of Agriculture Kyushu University Fukuoka Japan Department of Biochemistry and Applied Biosciences Faculty of Agriculture Miyazaki University Miyazaki Japan Department of Agronomy Yezin Agricultural University Naypyitaw Myanmar Laboratory of Plant Nutrition Division of Molecular Biosciences Department of Bioresource and Bioenvironmental Sciences Faculty of Agriculture Kyushu University Fukuoka Japan

Soybean (Glycine max L.) plays an essential role in human nutrition as a protein source, and in plant nutrition as a N source. The rate of N fixation varies depending on the cultivars and compatibility between the inoculated Rhizobium strain and the host cultivar. Characterizing the nodulation regulatory (Rj) genes is necessary to determine the compatibility of cultivars and Rhizobium strains. Rj genes were previously identified based on inoculation tests and PCR analyses. The six cultivars Yezin-3, Yezin-7, Yezin-11, Shan Seine (Local), Madaya (Local), and Hinthada (Local) were identified as harboring the Rj4 gene. Two cultivars, Yezin-6 and Yezin-8, were classified as non-Rj-gene harboring. Two other cultivars, Yezin-9 and Yezin-10, were identified as Rj3- and Rj2Rj3-gene harboring, respectively. Ours is the first report on Rj3- and Rj2Rj3-gene harboring cultivars in Myanmar. We evaluated Myanmar soybean cultivars for symbiotic effectiveness, relying on the standard strain Bradyrhizobium japonicum USDA110. In our first experiment, the soybean cultivar Yezin-11 (Rj4) showed the highest N fixing potential. Based on their potential for fixing N and nodulation, the top six soybean cultivars were Yezin-11 (Rj4), Yezin-9 (Rj3), Yezin-6 (non-Rj), Yezin-8 (non-Rj), Yezin-3 (Rj4) and Yezin-10 (Rj2Rj3). These cultivars were selected for a second experiment, which revealed that the N fixation, nodulation, and plant growth of Yezin-11 (Rj4) *Corresponding author. A. Z. Htwe et al. 2800 were superior to the other cultivars. We conclude that Yezin-11 (Rj4) is the most efficient cultivar for nodulation and N fixation when inoculated with B. japonicum USDA110.

关键词： B. japonicum USDA110 Inoculation Test PCR Analysis Nodulation Regulatory Genes (Rj Gene) Symbiotic Effectiveness

The clinicopathological difference according to the location of the primary colon cancer

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The clinicopathological difference according to the location...

Preparation of Y(Mn1−xFex)O3and Electrical Properties of the Sintered Bodies

第六次全国大肠癌会议暨中日韩大肠癌会议

作者： Hiroko Bando takeo Mori keiichi Takahasi Masamichi Yasuno Department of Surgery Tokyo Metropolitan Komagome HospitalTokyo Japan Department of Surgery Tokyo Metropolitan Komagome HospitalTokyo Japan Department of Surgery Tokyo Metropolitan Komagome HospitalTokyo Japan Department of Surgery Tokyo Metropolitan Komagome HospitalTokyo Japan

＜正＞To characterize the prognostic features, we analyzed 575 patients with primary right colon cancer（cecum, appendix, ascending colon, and transverse colon;supplied with blood from the superior mesenteric artery） and 688 patients with primary left colon cancer（descending colon and sigmoid colon;supplied by branches of the inferior mesenteric artery）.

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Open Journal of Inorganic Chemistry 2015年第1期5卷 7-11页

作者： Shin Nishiyama Isao Asako Yasuhiko Iwadate takeo Hattori Graduate School of Engineering Chiba University Chiba-Shi Japan

YMnO3 and the Fe doped samples were prepared and the lattice constants, electrical conductivities and Seebeck coefficients were measured. The solubility limit of Fe for Mn of YMnO3 was 25 atomic %, the electrical conductivity increased in the range of 350°C - 700°C as Fe increased up to 10%, and the doped samples showed larger Seebeck coefficient than undoped samples.

关键词： Yittrium Manganite Iron Doping Solubility Limit Electrical Conductivity Seebeck Coefficient

Theoretical Study of Gallium Phthalocyanine Dimer-Fullerene Complex for Photovoltaic Device

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Journal of Modern Physics 2011年第9期2卷 966-969页

作者： Akihiro Takeda takeo Oku Atsushi Suzuki Yasuhiro Yamasaki 不详

Geometry and electronic structures of gallium phthalocyanine dimer and fullerene molecules were investigated by theoretical calculation. The highest occupied molecular orbital was localized on the donor site, and the lowest unoccupied molecular orbital were localized on accepter site. The present results indicate that high conversion efficiency would be expected when phthalocyanine dimers were used as solar cell materials.

关键词： Phthalocyanine Dimer Fullerene Solar Cell

Clinical experience of hyperthermia for deep-seated malignant glioma

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Clinical experience of hyperthermia for deep-seated malignan...