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Miniature,highly sensitive MOSCAP ring modulators in co-optimized electronic-photonic CMOS

第十五届国际药理学大会

作者： Hudomal Snezana Rasic Julijana popovic Mira kaurinovic Biljana Mitic Radoslav Instutute of Pharmacology. SCG. Instutute of Pharmacology. SCG. Department of Chemistry.SCG. Department of Chemistry.SCG. Instutute of Pharmacology. SCG.

＜正＞ Azitromycin was applied daily orally. 5 days before stress, and the animals were sacrified 1 hour after oral administrated ImL absolute ethanol. under the ether anesthesia. Antioxidative parameters （the value of reduced glutatione - GSH and the activity of glutatione paroxidase - GSHPx. glutatione reductase - GSHR. and peroxidase） were determined in liver homogenate. The quntity of GSH was lower in stressed animals, and olso was lower （p ＜ 0. 001） in animals treated by azitromycin either control and stressed animals. The activity of GSHPx was very reduced in stressed animals comparing to the control, and lower in azitromycintreated animals（p ＜ 0.001） comparing to the control and higher than in stressed animals （p＜0.001）.The activity of GSHR was not statistically diferent in each of compared group. The activity of Px was statistically higher in stressed animals comparing to the control, and olso higher in animals treated by azitromycin either in control （p ＜ 0.01） and stressed animals （p ＜ 0. 001）. Azitromicin protected gastric mucosa against ethanol damage, but reduced glutatione and increased peroxidase activity in the liver of stress - ulcer rats.

关键词： stress - ulcer azitromycin. enzyme liver.

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Photonics Research 2022年第1期10卷 I0001-I0007页

作者： HAYk GEVORGYAN ANATOL kHILO MARk T.WADE VLADIMIR M.STOJANOVIC MILOS A.popovic Department of Electrical and Computer Engineering Boston UniversityBostonMassachusetts 02215USA Ayar Labs Inc. EmeryvilleCalifornia 94608USA Department of Electrical Engineering and Computer Sciences University of California BerkeleyBerkeleyCalifornia 94709USA

Convergence of high-performance silicon photonics and electronics,monolithically integrated in state-of-the-art CMOS platforms,is the holy grail for enabling the ultimate efficiencies,performance,and scaling of electronicphotonic *** requires the emergence of platforms that combine state-of-the-art RF transistors with optimized silicon photonics,and a generation of photonic device technology with ultralow energies,increased operating spectrum,and the elimination of power-hungry thermal *** this paper,in a co-optimized monolithic electronics-photonics platform(GlobalFoundries 45 CLO),we turn the metal-oxide-semiconductor(MOS) field-effect transistor’s basic structure into a novel,highly efficient MOS capacitor ring *** has the smallest ring cavity(1.5 μm radius),largest corresponding spur-free free spectral range(FSR=8.5 THz),and record 30 GHz/V shift efficiency in the O-band among silicon modulators demonstrated to *** 1 V_(pp) RF drive,we show an open optical eye while electro-optically tuning the modulator to track over 400 pm(69 GHz) change in the laser wavelength(using 2.5 V_(DC) range).A 90 GHz maximum electro-optic resonance shift is demonstrated with under 40 nW of power,providing a strong nonthermal tuning mechanism in a CMOS photonics *** modulator has a separately optimized body layer but shares the gate device layer and the gate oxide with 45 nm transistors,while meeting all CMOS manufacturability design *** type of convergent evolution of electronics and photonics may be the future of platforms for high-performance systemson-chip.

关键词： tuning modulator electronic

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非常规X射线能量探测技术

岩矿测试 2006年第1期25卷 49-54页

作者：罗立强 Marija popovic 国家地质实验测试中心北京100037 Mc Master University Ontario

硅锂半导体探测器在常规X射线光谱分析中已得到广泛应用,目前已发展多种非常规X射线探测器,如四叶花瓣型Ge探测器、Si漂移与电耦合阵列探测器、超导探测器、CdZnTe探测器、钻石探测器和无定型硅探测器等。文章对其工作原理、进展和应用... 详细信息

硅锂半导体探测器在常规X射线光谱分析中已得到广泛应用,目前已发展多种非常规X射线探测器,如四叶花瓣型Ge探测器、Si漂移与电耦合阵列探测器、超导探测器、CdZnTe探测器、钻石探测器和无定型硅探测器等。文章对其工作原理、进展和应用等作了介绍。

关键词： X射线能量探测器评述

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Bilateral vs unilateral internal mammary revascularization in patients with left ventricular dysfunction

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World Journal of Cardiology 2017年第4期9卷 339-346页

作者： Batric popovic Pablo Maureira Yves Juilliere Nicolas Danchin Damien Voilliot Fabrice Vanhuyse Jean Pierre Villemot Département de Cardiologie CHU Nancy Service de Chirurgie des Maladies Cardiovasculaires et TransplantationsCHU Nancy Hopital Européen Georges Pompidou Assistance Publique des Hopitaux de Paris(AP-HP)UniversitéParis Descartes

AIM To investigate the survival benefit of bilateral internal mammary artery(BIMA) grafts in patients with left ventricular *** Between 1996 and 2009,we performed elective,isolated,primary,multiple cardiac arterial bypass grafting in 430 consecutive patients with left ventricular ejection fraction ≤ 40%. The early and long-term results were compared between 167 patients undergoing BIMA grafting and 263 patients using left internal mammary artery(LIMA)-saphenous venous grafting(SVG).RESULTS The mean age of the overall population was 60.1 ± 15 years. In-hospital mortality was not different between the two groups(7.8% vs 10.3%,P = 0.49). Early postoperative morbidity included myocardial infarction(4.2% vs 3.8%,P = 0.80),stroke(1.2% vs 3.8%,P = 0.14),and mediastinitis(5.3% vs 2.3%,P = 0.11). At 8-year follow-up,kaplan-Meier-estimated survival(74.2% vs 58.9%,P = 0.02) and kaplan-Meier-estimated event-free survival(all cause deaths,myocardial infarction,stroke,target vessel revascularization,heart failure)(61.7% and 41.1%,P < 0.01) were significantly higher in the BIMA group compared with the LIMA-SVG group in univariate analysis. The propensity score matching analysis confirmed that BIMA grafting is a safe revascularization procedure but there was no long term survival(P = 0.40) and event-free survival(P = 0.13) in comparison with LIMA-SVG *** Our longitudinal analysis suggests that BIMA grafting can be performed with acceptable perioperative mortality in patients with left ventricular dysfunction.

关键词： Bilateral internal mammary artery grafting Heart failure Coronary artery disease

人逆转录病毒(人T细胞白血病病毒)的分离和传染

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国外医学.流行病学传染病学分册 1983年第6期10卷 259-261页

作者： popovic M 姜鸿发

人T细胞白血病——淋巴瘤病毒(HTLV)是一种C型逆转录病毒,已从美国罹患成熟的T细胞白血病和淋巴瘤成年病人的细胞中分离成功,在日本成年人T细胞白血病(ATL)病人中也分离到这种病毒。本文报道从世界各地的病人中所获得新的9株HTLV的分离... 详细信息

人T细胞白血病——淋巴瘤病毒(HTLV)是一种C型逆转录病毒,已从美国罹患成熟的T细胞白血病和淋巴瘤成年病人的细胞中分离成功,在日本成年人T细胞白血病(ATL)病人中也分离到这种病毒。本文报道从世界各地的病人中所获得新的9株HTLV的分离情况,显示分离的每株毒株对人脐带血的传染性,并表明HTLV不仅能从罹患攻击性ATL患者中分离到,而且从尚无攻击性的外围淋巴瘤患者甚至在T细

关键词：逆转录病毒阳性人脐带血日本单克隆抗体 Tk 病人细胞株 HTLV

The pathologic relevance of metabolic criteria in patients with biopsy-proven nonalcoholic fatty liver disease and metabolic dysfunction associated fatty liver disease:A multicenter cross-sectional study in China

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 426-432页

作者： Rui-Xu Yang Zheng-Sheng Zou Bi-Hui Zhong Hong Deng Fang-Ping He Jun-Ping Shi Cai-Yan Zhao Yu-Qiang Mi Yong-Jian Zhou Fu-Sheng Di Rui-Dan Zheng Qin Du Jia Shang Branko popovic Jin Jun Chen Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Liver Disease Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Gastroenterology the First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080China Department of Infectious Diseases the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Gastroenterology II the First Affiliated Hospital of Xinjiang Medical UniversityXinjiang Uygur Autonomous RegionsUrumqi 830011China The Affiliated Hospital of Hangzhou Normal University Hangzhou 310015China Department of Infectious Disease the Third Hospital of Hebei Medical UniversityShijiazhuang 050051China Department of Infectious Diseases Tianjin Second People's HospitalTianjin 300192China Department of Gastroenterology and Hepatology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China Department of Endocrinology and Metabolism The Third Central Hospital of TianjinTianjin 300170China Diagnosis and Treatment Center for Liver Diseases Zhengxing HospitalZhangzhou 363000China Department of Gastroenterology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 450003China Sanofi-Aventis Deutschland GmbH Frankfurt 65929Germany Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515China

Background:This study aimed to assess the association between metabolic syndrome(Met S)and severity of nonalcoholic fatty liver disease(NAFLD),and to discuss the pathological relevance of the diagnostic criteria in metabolic(dysfunction)associated fatty liver disease(MAFLD).Methods:This was a multicenter,cross-sectional *** with NAFLD confirmed by liver biopsy were enrolled between July 2016 and December 2018 from 14 centers across the mainland of *** and metabolic parameters were collected to assess the pathological ***:Of 246 enrolled patients with NAFLD,150(61.0%)had the comorbidity of Met *** the increase of metabolic components,the proportions of nonalcoholic steatohepatitis(NASH)and significant fibrosis were notably *** comorbid three metabolic components significantly increased the proportion of NASH,and further increase of metabolic components did not increase the proportion of ***,the increase of metabolic components was parallel to the increase of the proportion of liver *** the 246 patients,239(97.2%)met the diagnostic criteria of *** non-MAFLD patients had less NASH,they present with similar proportion of significant fibrosis and *** the diagnostic criteria of MAFLD,BMI≥23 kg/m2 was related to NASH(Mantel-Haenszel Common Estimate OR:2.975;95%CI:1.037–8.538;P=0.043),and T2 DM was related to significant fibrosis(Mantel-Haenszel Common Estimate OR:2.531;95%CI:1.388–4.613;P=0.002).The homeostasis model assessment of insulin resistance(HOMA-IR)≥2.5 was the most significant factor for NASH(OR:4.100;95%CI:1.772–9.487;P=0.001)and significant factor for liver fibrosis(OR:2.947;95%CI:1.398–6.210;P=0.004)after the adjustments of the BMI and ***:Metabolic dysregulations are important risk factors in NAFLD *** insulin resistance status may play a predominant role in the progression in MAFLD patients.

关键词： Nonalcoholic fatty liver disease Metabolic syndrome Insulin resistance

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