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国际医学放射学杂志 2013年第6期 590-590页

作者： J.Y.sung J.H.Baek k.s.kim D.Lee H.Yoo J.k.kim 赵博 Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine Asan Medical Center86 Asanbyeongwon-Gil Songpa-guSeoul 138-736 Korea

摘要目的分别应用乙醇消融和射频消融方法治疗甲状腺囊性结节后,比较病变体积变化的程度。材料与方法本研究得到了伦理审查委员会的认可,所有病人均签署知情同

关键词：甲状腺粒子肉内分泌腺结节囊性乙醇酒醇一元醇置信区间置信距

Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期 479-499页

作者： Ernesto s.Nakayasu Marina A.Gritsenko Young-Mo kim Jennifer E.kyle kelly G.stratton Carrie D.Nicora Nathalie Munoz kathleen M. Navarro Daniel Claborne Yuqian Gao karl k.Weitz Vanessa L. Paurus kent J. Bloodsworth kelsey A. Allen Lisa M. Bramer Fernando Montes kathleen A. Clark Grant Tietje Justin Teeguarden kristin E.Burnum-Johnson Biological sciences Division Pacific Northwest National Laboratory Environmental and Molecular sciences Division Pacific Northwest National Laboratory Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Western States Division Computational Analytics Division Pacific Northwest National Laboratory National security Directorate Pacific Northwest National Laboratory Los Angeles County Fire Department Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Respiratory Health Division Environmental and Molecular Toxicology Oregon State University

Background: Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***: To study regulatory processes in intense physical activity simulating real-life conditions, we performed a multi-omics analysis of 3 biofluids(blood plasma, urine, and saliva) collected from 11 wildland firefighters before and after a 45 min, intense exercise regimen. Omics profiles post-vs. pre-exercise were compared by student's t-test followed by pathway analysis and comparison between the different omics ***: Our multi-omics analysis identified and quantified 3835 proteins, 730 lipids and 182 metabolites combining the 3 different types of samples. The blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy demands. The urine analysis showed a strong, concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites, reabsorption of nutrients and maintenance of fluid balance. In saliva, we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides. A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***: This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility, suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

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细针穿刺活检与粗针穿刺活检对甲状腺恶性肿瘤的诊断准确性的临床研究

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国际医学放射学杂志 2012年第5期 499-499页

作者： J.Y.sung k.s.kim H.Yoo H.Lee J.H.kim 童明敏 Department of Radiology Human Medical Imaging and Intervention Center12-25Jamwon-dongSeocho-guSeoul 137-902South Korea

摘要目的回顾性对比分析细针穿刺(FNA)与粗针穿刺活检(CNB)对甲状腺恶性肿瘤的诊断准确性。方法我们在555例确诊的甲状腺结节(恶性318例,良性237例)中评估了FNA和CNB的诊断价值。所有病人每个结节同时采用FNA和CNB方法。从敏感性、特异... 详细信息

摘要目的回顾性对比分析细针穿刺(FNA)与粗针穿刺活检(CNB)对甲状腺恶性肿瘤的诊断准确性。方法我们在555例确诊的甲状腺结节(恶性318例,良性237例)中评估了FNA和CNB的诊断价值。所有病人每个结节同时采用FNA和CNB方法。从敏感性、特异性和准确性方面评估FNA、CNB及FNA联合CNB对恶性甲状腺肿瘤的诊断。结果FNA、CNB及FNA联合CNB的敏感度68.6%、86.8%、90.6%;特异度分别为100%、99.2%、99.2%

关键词：甲状腺超声细胞穿刺组织活检甲状腺癌

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz ki Chan Dohyun Ahn Vladimir kushnarev Tsz kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong kim Hill Lam Lau Ying Lo Law Chi seng Leung Chun Yin Tong kai kap Wong Wing Lam Yim Nikolay s.karnaukhov Richard Y.C.kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.s.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products sesterterpenoids synthetic biology Terpene synthases Variecolin

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spontaneous splenic rupture associated with scrub typhus: a case report

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Infectious Diseases of Poverty 2024年第1期13卷 97-97页

作者： Hong Pil Hwang kyoung Min kim Hyojin Han Jeong-Hwan Hwang Department of surgery Jeonbuk National University Hospital Jeonbuk National University Medical School Jeonju Republic of Korea Research Institute of Clinical Medicine of Jeonbuk National University Jeonju Korea Biomedical Research Institute of Jeonbuk National University Hospital Jeonju Korea Department of Pathology Jeonbuk National University Hospital Jeonbuk National University Medical School Jeonju Republic of Korea Department of Internal Medicine Jeonbuk National University Hospital Jeonbuk National University Medical School Jeonju-Si Republic of Korea

Background scrub typhus,an acute febrile disease with mild to severe,life-threatening manifestations,potentially presents with a variety of complications,including pneumonia,acute respiratory distress syndrome,cardiac arrhyth-mias(such as atrial fibrillation),myocarditis,shock,peptic ulcer,gastrointestinal bleeding,meningitis,encephalitis,and renal *** the various complications associated with scrub typhus,splenic rupture has rarely been reported,and its mechanisms are *** study reports a case of scrub typhus-related spontaneous splenic rupture and identifies possible mechanisms through the gross and histopathologic *** presentation A 78-year-old man presented to our emergency room with a 5-day history of fever and skin *** physical examination,eschar was observed on the left upper abdominal *** abdomen was not ten-der,and there was no history of *** Orientia tsutsugamushi antibody titer using the indirect immunofluo-rescent antibody test was 1:*** Day 6 of hospitalization,he complained of sudden-onset left upper abdominal quadrant pain and showed mental *** vital signs were a blood pressure of 70/40 mmHg,a heart rate pf 140 beats per min,and a respiratory rate of 20 breaths per min,with a temperature of 36.8℃.There were no signs of gastrointestinal bleeding,such as hematemesis,melena,or *** Turner's sign was suspected during an abdominal *** ultrasonography showed retroperitoneal bleeding,so an emergency exploratory laparotomy was performed,leading to a diagnosis of hemoperitoneum due to splenic rupture and a *** patient had been taking oral doxycycline(1o0 mg twice daily)for 6 days;after surgery,this was dis-continued,and intravenous azithromycin(500 mg daily)was *** arrhythmia associated with azithro-mycin was ***,renal failure with hemodialysis,persistent hyperbilirubinemia,and multiorgan failure *** patient did not recover and d

关键词： scrub typhus Complication splenic rupture

应用物联网技术加速畜禽精准饲喂:从概念到实施

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science Bulletin 2024年第14期69卷 2156-2160页

作者：苏家宜谭碧娥蒋宗勇吴德 C.M.Nyachoti sung Woo kim 印遇龙王婧 key Laboratory of Hunan Province for the Products Quality Regulation of Livestock and Poultry College of Animal Science and TechnologyHunan Agricultural UniversityChangsha 410128China Institute of Animal science Guangdong Academy of Agricultural SciencesGuangzhou 510640China key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China and Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China Department of Animal science University of ManitobaWinnipeg R3T 2N2Canada Department of Animal science North Carolina State UniversityRaleigh 27695USA Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410128China Yuelushan Laboratory Changsha 410128China

Maximizing sow reproductive performance is vital for ensuring healthy piglet supply,feed efficiency,and profitability,which requires understanding factors such as nutrition,disease control,genetics,herd management,and their *** is well documented that most reproductive issues in sows stem from extreme fluctuations in body reserves[1].Thus,optimizing reproduction should prioritize regulating body reserves and making continuous nutritional adjustments throughout a sow’s life[1,2].However,the traditional one-size-fits-all feeding strategy may not meet individual sow needs under varying *** feeding strategy leads to nutrient under-or over-feeding,which may result in a lack of performance and health issues on the one hand,and economic loss and negative environmental effects on the other.

关键词： feeding extreme reserves

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Hetero-deformation promoted strengthening and toughening in BCC rich eutectic and near eutectic high entropy alloys

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Journal of Materials science & Technology 2023年第15期146卷 1-9页

作者： D.H.Chung J.Lee Q.F.He Y.k.kim k.R.Lim H.s.kim Y.Yang Y.s.Na Department of special Alloys Extreme Materials Research InstituteKorea Institute of Materials ScienceChangwonThe Republic of Korea Department of Mechanical Engineering City University of Hong KongKowloon TongKowloonHong KongChina Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohangThe Republic of Korea Center for Heterogenic Metal Additive Manufacturing Pohang University of Science and TechnologyPohangThe Republic of Korea Department of Materials science and Engineering City University of Hong KongKowloon TongKowloonHong KongChina

Heterostructured eutectic high-entropy alloys(EHEAs)have attracted significant attention owing to their novel properties,such as balanced combinations of strength and fracture ***,the toughening/strengthening mechanisms of these EHEAs have not been thoroughly *** this study,we developed a series of dual-phase Al_((18–2x))Co_(30)Cr_((11+x))Fe_((11+x))Ni_(3)0(x=-1,0,1)eutectic and neareutectic HEAs containing face-centered cubic(FCC)and body-centered cubic(BCC)*** the high amount of BCC,which is referred to as the brittle phase,newly developed EHEAs exhibited superior fracture ***,we discovered that a fully eutectic HEA exhibited further improvements in both yield stress and fracture toughness,outperforming our off-eutectic and other previously reported *** combining experiments and theoretical models,we demonstrated that the synergistic increase in both strength and toughness in our fully eutectic HEA was derived from the high hetero-deformationinduced(HDI)strengthening/toughening associated with a high misorientation angle at the grain/phase boundaries.

关键词： Eutectic high entropy alloy Fracture toughness Heterogeneous structure Hetero deformation induced strengthening Misorientation angle

基于RsV预融合F蛋白的母体疫苗-早产和其他结局

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中国临床药理学杂志 2024年第9期40卷 1330-1330页

作者： DIEUssAERT I kim J H LUIk s 王超群

妊娠期间接种呼吸道合胞病毒(RsV)疫苗可以保护婴儿免受RsV疾病的侵害。因此需要一种基于RsV预融合F蛋白的候选母源疫苗(RsVPreF3-Mat)的有效性和安全性数据。研究进行了一项涉及18~49岁孕妇的3期试验,以评估RsVPreF3-Mat的有效性和安... 详细信息

妊娠期间接种呼吸道合胞病毒(RsV)疫苗可以保护婴儿免受RsV疾病的侵害。因此需要一种基于RsV预融合F蛋白的候选母源疫苗(RsVPreF3-Mat)的有效性和安全性数据。研究进行了一项涉及18~49岁孕妇的3期试验,以评估RsVPreF3-Mat的有效性和安全性。这些妇女在妊娠24周0天至34周0天以2:1的比例随机分配接受RsVPreF3-Mat或安慰剂。主要结局是出生至6个月龄婴儿出现任何或严重医学评估的RsV相关下呼吸道疾病,以及出生至12个月龄婴儿的安全性。

关键词：下呼吸道疾病有效性和安全性安慰剂 F蛋白随机分配 RsV 疫苗妊娠期间

Is a Mini-screen for Fetal Alcohol spectrum Disorder Feasible?

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Open Journal of Pediatrics 2024年第4期14卷 767-781页

作者： Tyler Mueller Devin Evavold June-Yung kim Marilyn G. klug Larry Burd school of Medicine and Health sciences University of North Dakota Grand Forks USA Department of social Work University of North Dakota Grand Forks USA

Background: Fetal Alcohol spectrum Disorders (FAsDs) are a global public health concern with lifelong consequences for affected individuals. Recent prevalence studies suggest FAsD prevalence rates range from 1-5% among school age children. Most people with FAsD are not correctly diagnosed and inadequate screening to identify patients with increased risk may contribute to under-diagnosis. This study developed a 10-item screening tool for FAsD and examined its feasibility. Methods: The sample consisted of 355 children who had been evaluated at an FAsD clinic. Data from the 33-item Alcohol Related Neurodevelopmental Disorder Behavioral Checklist was used to develop a brief FAsD screen by comparing the changes in Cronbach’s alpha for different combinations of items. The validity of the brief scale was then further examined using receiving operating characteristic analyses. Results: The 10-item screen demonstrated acceptable sensitivity, specificity, and accuracy to identify children at high risk for FAsD. The percentage correctly classified was 91.3 and the area under the receiving operating characteristic curve was 0.971. Conclusions: This feasibility study demonstrated that a screen for FAsD consisting of 10 items with yes or no responses can be completed in 3 - 4 minutes. The tool is brief, with a low administration burden and has acceptable epidemiologic performance characteristics including accuracy. Future research should examine the performance of this tool when used in larger, community-based populations where screening for FAsD would be appropriate.

关键词： Fetal Alcohol spectrum Disorders (FAsDs) Children screening Prevalence