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Polymeric micelle nanocarriers in cancer research

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Frontiers of Chemical science and Engineering 2016年第3期10卷 348-359页

作者： Dae Hwan shin Yu Tong Tam Glen s. kwon school of Pharmacy University of Wisconsin Madison WI 53705 USA

Amphiphilic block copolymers （ABCs） assem- ble into a spherical nanoscopic supramolecular core/shell nanostructure termed a polymeric micelle that has been widely researched as an injectable nanocarrier for poorly water-soluble anticancer agents. The aim of this review article is to update progress in the field of drug delivery towards clinical trials, highlighting advances in polymeric micelles used for drug solubilization, reduced off-target toxicity and tumor targeting by the enhanced permeability and retention （EPR） effect. Polymeric micelles vary in stability in blood and drug release rate, and accordingly play different but key roles in drug delivery. For intravenous （IV） infusion, polymeric micelles that disas- semble in blood and rapidly release poorly water-soluble anticancer agent such as paclitaxel have been used for drug solubilization, safety and the distinct possibility of toxicity reduction relative to existing solubilizing agents, e.g., Cremophor EL. stable polymeric micelles are long- circulating in blood and reduce distribution to non-target tissue, lowering off-target toxicity. Further, they participate in the EPR effect in murine tumor models. In summary, polymeric micelles act as injectable nanocarriers for poorly water-soluble anticancer agents, achieving reduced toxi- city and targeting tumors by the EPR effect.

关键词： nanomedicine parenteral poly(ethylene glycol) poly(lactic acid) reformulation

Characteristics of High speed Electro-thermal Jet Activated by Pulsed DC Discharge

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Chinese Journal of Aeronautics 2010年第5期23卷 518-522页

作者： Jichul shin Department of Aerospace Engineering University of Ulsan

Experimental study of synthetic jet produced by pulsed direct current （DC） discharge is presented. High velocity jet is acti- vated electro-thermally by high frequency pulsed DC discharge in small cavity. A cavity of 2.38 mm diameter cylinder bounded by circular electrode is made in a ceramic plate and a small orifice of 1.78 mm diameter is drilled in the middle of cavity. High frequency pulsed DC discharge instantaneously heats air in the cavity and produces high velocity jet at the exit of the orifice. schlieren imaging at high framing rate of 100 kHz reveals the presence of supersonic precursor shock followed by the jet emerg- ing from the orifice. The jet velocity reaches as high as about 300 m/s. Jet with smaller cavity volume produces lesser effect and jet velocity reaches maximum at certain cavity volume with given discharge current and orifice size. As duty time of pulse increases from 5 to 20 μs at fixed frequency of 5 kHz, the jet velocity also increases and becomes nearly constant with further increase in duty time. At fixed duty time of 20 μs, higher frequency pulsing of 10 kHz produces degradation of the jet as the discharge pulse continues. The jet developed in this study is demonstrated to be strong enough to penetrate deep into supersonic boundary layer and to produce a bow shock when the jet is issued into Mach 3 supersonic flow.

关键词： synthetic jet pulsed DC plasma supersonic flow actuation

Effect of sorafenib in a murine high risk penetrating keratoplasty model

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 834-839页

作者： Yang kyung Cho Eun Young shin Hironori Uehara Balamurali k Ambati Department of Ophthalmology St.Vincent＇s Hospital College of Medicine the Catholic University of Korea Suwon Gyeonggi-Do 16247 Korea Research Institute of Medical science St.Vincent＇s Hospital College of Medicine the Catholic University of Korea Suwon Gyeonggi-Do 16247 Korea Department of Ophthalmology University of Utah School of Medicine Salt Lake City Utah 84132 USA

AIM： To evaluate the effect of sorafenib in murine high risk keratoplasty model. ~ METHODs： Graft survival, corneal neovascularization, and corneal lymphangiogenesis were compared among the sorafenib, dexamethasone, dimethyl sulfoxide （DMsO）, and phosphate buffered saline （PBs） groups following subconjunctival injection in mice that underwent high risk penetrating keratoplasty （HRPk）. Real-time polymerase chain reaction was performed to quantify the expression of inflammatory cytokines and vascular endothelial growth factor （VEGF）-A, VEGF-C, vascular endothelial growth factor receptor （VEGFR）-2, VEGFR-3. REsULTs： The two-month graft survival rate for HRPk was 42.86% in sorafenib group, 37.50% in dexamethasone group, 0 in DMsO group, and 0 in PBs group. sorafenib significantly increased graft survival compared to the DMsO and PBs group （P〈0.05）. The sorafenib didn＇t show significant effect in decreasing neovascularization compared with dexamethsone, DMsO, and PBs group. The sorafenib showed less total lymphangiogenesis than the dexamethasone, DMsO, and PBs group （P=0.011, P〈0.001, P〈0.001, respectively）. The sorafenib group showed reduced expression of VEGF-C, tumor necrosis factor （TNF）-alpha, interleukin （IL）-6, VEGFR-2 and VEGFR-3 compared with DMsO group and PBs group （all P〈0.05）. The sorafenib group didn＇t show difference in the expression of VEGF-A compared with DMsO, neither withPBs. The sorafenib group showed reduced expression of VEGFR-3 compared with dexamethasone （/〉=-0.051）. CONCLUsION： The subconjunctivally administered sorafenib shows significant anti-lymphangiogenic effect, resulting in increased transplant survival in a murine high risk keratoplasty model. We suggest that a close linkage between decreased VEGF-C/VEGFR-2 and -3 signaling and increased corneal graft survival by sorafenib seems to exist.

关键词： sorafenib neovascularization graft survival lymphangiogenesis dexamethasone

A characterization of Burniat surfaces with k^2 = 4 and of non nodal type

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science China Mathematics 2016年第5期59卷 839-848页

作者： shin YongJoo shanghai Center for Mathematical sciences Fudan University

Let s be a minimal surface of general type with pg(s) = 0 and k_s^2= 4. Assume the bicanonical map ψ of s is a morphism of degree 4 such that the image of ψ is smooth. Then we prove that the surface s is a Burniat ... 详细信息

关键词： bicanonical map Burniat surface surface of general type

用于诊断肝细胞癌的肝脏影像报告及数据系统2018版5类：一项最新Meta分析

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国际医学放射学杂志 2024年第3期 373-374页

作者： s.Lee Y.Y.kim J.shin Y.H.Roh J.Y.Choi V.Chernyak 吴玉平

摘要目的该项更新的Meta分析旨在确定使用肝脏影像报告和数据系统（LI-RADs）2018版本（v2018）的LI-RADs LR-5类对肝细胞癌（HCC）的诊断能力，并通过评估成像方

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Destruction of hexafluoroethane in a dielectric-packed bed plasma reactor

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Journal of Zhejiang University-science A(Applied Physics & Engineering) 2010年第7期11卷 538-544页

作者： D. H. kIM Y. s. MOk s. B. LEE s. M. shin Department of Chemical & Biological Engineering Research Institute of Advanced Technology Jeju National University Environmental Business Unit Samsung Engineering Co. Ltd. Hwasung Gyeonggido Korea

The destruction of hexafluoroethane (C2F6), also known as R-116, was investigated in a nonthermal plasma reactor packed with dielectric pellets. The effects of the feed gas composition and the input power on the destruction of C2F6 were examined. The feed gas composition was varied by changing the oxygen content, the argon content and the initial C2F6 concentration. An increased input power led to increased C2F6 destruction as a result of promoting the electron-molecule collisions to dissociate C2F6 molecules. The addition of argon to the feed gas greatly improved the C2F6 destruction by reducing the energy losses due to vibrational excitation and dissociation of N2 molecules, while the increases in the oxygen content and the initial C2F6 concentration decreased the destruction efficiency. The byproducts including CO2, CO, COF2, CF4, siF4, NO2, and N2O were identified, and the destruction mechanisms were elucidated, referring to these compounds. The most abundant byproduct was found to be carbonyl fluoride (COF2), indicating that it serves as an important medium to convert C2F6 into CO2. The energy requirement for the C2F6 destruction was in the range of 8.2–45.3 MJ/g, depending on the initial concentration.

关键词： Hexafluoroethane (C2F6) Nonthermal plasma Gas composition Destruction mechanisms

A Generalization of Haussler's Convolution kernel——Mapping kernel and Its Application to Tree kernels

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Journal of Computer science & Technology 2010年第5期25卷 1040-1054页

作者： kilho shin Tetsuji kuboyama Graduate school of Applied Informatics University of HyogoKobeJapan Carnegie Mellon CyLab PittsburghU.S.A Computer Center Gakushuin UniversityTokyoJapan

Haussler＇s convolution kernel provides an effective framework for engineering positive semidefinite kernels, and has a wide range of *** the other hand,the mapping kernel that we introduce in this paper is its natural generalization,and will enlarge the range of application *** main theorem with respect to positive semidefiniteness of the mapping kernel（1） implies Haussler＇s theorem as a corollary,（2） exhibits an easy-to-check necessary and sufficient condition for mapping kernels to be positive semidefinite,and（3） formalizes the mapping kernel so that significant flexibility is provided in engineering new *** an evidence of the effectiveness of our results,we present a framework to engineer tree *** tree is a data structure widely used in many applications,and tree kernels provide an effective method to analyze tree-type ***,not only is the framework important as an example but also as a practical research *** description of the framework accompanies a survey of the tree kernels in the literature,where we see that 18 out of the 19 surveyed tree kernels of different types are instances of the mapping kernel,and examples of novel interesting tree kernels.

关键词： kernel convolution kernel tree edit distance

Tri-directional shaking table tests of vibration sensitive equipment with static dynamics interchangeable-ball pendulum system

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Earthquake Engineering and Engineering Vibration 2010年第1期9卷 103-112页

作者： C.s. Tsai Yung-Chang Lin Wen-shin Chen H.C. su D G epartment of Civil Engineering Feng Chia University Taichung Chinese Taipei Graduate Institute of Civil and Hydraulic Engineering Feng Chia University Taichung Chinese Taipei Department of Water Resources Engineering and Conservation Feng Chia University Taichung Chinese Taipei

Recently, the high-tech industry has become a key industry for economic development in many countries. However, vibration sensitive equipment located in these industrial buildings is vulnerable during earthquakes, which may cause huge economic loss. In this study, an innovative isolator for safeguarding the vibration sensitive equipment, namely, the static dynamics interchangeable^all pendulum system （sDI-BPs） is proposed and investigated to examine its protective capability for the vibration sensitive equipment during earthquakes through a series of tri-directional shaking table tests. The experimental results illustrate that the sDI-BPs isolator can provide significant damping to rolling types of base isolation systems for reducing the bearing displacement and size, and avoid the stress concentration, which can cause damage or scratches on the rolling surface of the isolator, to prolong its life span of service. The sDI-BPs isolator also provides excellent capability in protecting the vibration sensitive equipment and exhibits a stable behavior under long terms of service loadings and earthquakes.

关键词： ball pendulum system critical equipment base isolation vibration sensitive equipment base isolator passive control earthquake engineering structural control

Tunable ferroelectricity in oxygen-deficient perovskites with Grenier structure

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npj Computational Materials 2023年第1期9卷 118-125页

作者： Yongjin shin Giulia Galli Pritzker school of Molecular Engineering University of ChicagoChicagoIL 60637USA Department of Chemistry University of ChicagoChicagoIL 60637USA Center for Molecular Engineering and Materials science Division Argonne National LaboratoryLemontIL 60439USA

Using first-principles calculations,we predict that tunable ferroelectricity can be realized in oxide perovskites with the Grenier structure and ordered oxygen ***,we show that R_(1/3)A_(2/3)FeO_(2.67) solids(where R is a rare-earth ion and A an alkaline-earth cation)exhibit polar phases,with a spontaneous polarization tunable by an appropriate choice of R and *** find that larger cations combined with small R elements lead to a maximum in the polarization and to a minimum in the energy barriers required to switch the sign of the *** arises from cooperative distortions of octahedral and tetrahedral units,where a combination of rotational and sliding modes controls the emergence of polarization within three-dimensional connected *** results indicate that polar Grenier phases of oxide perovskites are promising materials for microelectronic applications and,in general,for the study of phenomena emerging from breaking inversion symmetry in solids.

关键词： polarization ferroelectric structure