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胸部活检及二次活检评价非小细胞型肺癌免疫疗法程序性细胞死亡配体-1表达的可行性和安全性

国际医学放射学杂志 2018年第3期 358-359页

作者： E.B.Tsai k.pomykala k.Ruchalski S.Genshaft F.Abtin A.Gutierrez 孙鹤 Department of Radiological Sciences University of California Los Angeles

摘要目的采用活检及二次活检评价程序化细胞死亡配体-1(PD-L1)状态的可行性及安全性。材料与方法本回顾性研究共纳入2012年5月—2014年9月期间的101例

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Role of one-step nucleic acid amplification in colorectal cancer lymph node metastases detection

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World Journal of Gastroenterology 2022年第30期28卷 4019-4043页

作者： Francesco Crafa Serafino Vanella Onofrio A Catalano kelsey L pomykala Mario Baiamonte Division of General and Surgical Oncology St.Giuseppe Moscati HospitalCenter of National Excellence and High SpecialtyAvellino 83100Italy Department of Radiology Athinoula A.Martinos Center for Biomedical ImagingMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Department of Nuclear Medicine Department of Radiological SciencesDavid Geffen School of Medicine at University of CaliforniaLos AngelesUniversity Hospital EssenUniversity of Duisburg-EssenEssen 45141Germany

Current histopathological staging procedures in colorectal cancer(CRC)depend on midline division of the lymph nodes(LNs)with one section of hematoxylin and eosin *** cells outside this transection line may be missed,which could lead to understaging of Union for International Cancer Control Stage II high-risk *** one-step nucleic acid amplification(OSNA)assay has emerged as a rapid molecular diagnostic tool for LN metastases *** is a molecular technique that can analyze the entire LN tissue using a reversetranscriptase loop-mediated isothermal amplification reaction to detect tumorspecific cytokeratin 19 *** findings suggest that the OSNA assay has a high diagnostic accuracy in detecting metastatic LNs in CRC and a high negative predictive *** is a standardized,observer-independent technique,which may lead to more accurate *** has been suggested that in stage II CRC,the upstaging can reach 25%and these patients can access postoperative adjuvant ***,intraoperative OSNA sentinel node evaluation may allow early CRC to be treated with organ-preserving surgery,while in more advanced-stage disease,a tailored lymphadenectomy can be performed considering the presence of aberrant lymphatic drainage and skip metastases.

关键词： Colorectal malignancies One-step nucleic acid amplification Diagnostic accuracy Negative predictive value Upstaging Organ-sparing surgery Tailored lymphadenectomy

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Non-exposed endoscopic wall-inversion surgery with one-step nucleic acid amplification for early gastrointestinal tumors:Personal experience and literature review

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World Journal of Gastroenterology 2023年第24期29卷 3883-3898页

作者： Francesco Crafa Serafino Vanella Aristide Morante Onofrio A Catalano kelsey L pomykala Mario Baiamonte Maria Godas Alexandra Antunes Joaquim Costa Pereira Valentina Giaccaglia Division of General and Surgical Oncology St.Giuseppe Moscati HospitalCenter of National Excellence and High SpecialtyAvellino 83100Italy Division of Gastorenterology and Endoscopy St.Giuseppe Moscati HospitalCenter of National Excellence and High SpecialtyAvellino 83100Italy Department of Radiology Athinoula A Martinos Center for Biomedical ImagingMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Department of Nuclear Medicine Department of Radiological SciencesUniversity Hospital EssenUniversity of Duisburg-EssenEssen 45141Germany Department of General Surgery Braga HospitalBraga 4710-243Portugal Department of Surgery Medclinic City HospitalDubai 505004United Arab Emirates

BACkGROUND Laparoscopic and endoscopic cooperative surgery is a safe,organ-sparing surgery that achieves full-thickness resection with adequate *** studies have demonstrated the safety and efficacy of these ***,these techniques are limited by the exposure of the tumor and mucosa to the peritoneal cavity,which could lead to viable cancer cell seeding and the spillage of gastric juice or enteric liquids into the peritoneal ***-exposed endoscopic wallinversion surgery(NEWS)is highly accurate in determining the resection margins to prevent intraperitoneal contamination because the tumor is inverted into the visceral lumen instead of the peritoneal *** intraoperative assessment of the nodal status could allow stratification of the extent of ***-step nucleic acid amplification(OSNA)can provide a rapid method of evaluating nodal tissue,whilst nearinfrared laparoscopy together with indocyanine green can identify relevant nodal tissue *** To determine the safety and feasibility of NEWS in early gastric and colon cancers and of adding rapid intraoperative lymph node(LN)assessment with *** The patient-based experiential portion of our investigations was conducted at the General and Oncological Surgery Unit of the *** Moscati Hospital(Avellino,Italy).Patients with early-stage gastric or colon cancer(diagnosed via endoscopy,endoscopic ultrasound,and computed tomography)were *** lesions were treated by NEWS procedure with intraoperative OSNA assay between January 2022 and October *** were examined intraoperatively with OSNA and postoperatively with conventional *** analyzed patient demographics,lesion features,histopathological diagnoses,R0 resection(negative margins)status,adverse events,and follow-up *** were collected prospectively and analyzed *** A total of 10 patients(5 males and 5 females)with an average age of 70.4±4.5 years(range:62

关键词： Laparoscopic and endoscopic cooperative surgery Non-exposed endoscopic wall inversion surgery Early gastric cancer Early colorectal cancer Sentinel lymph node One-step nucleic acid amplification Endoscopic full-thickness resection

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