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Benefits of endoscopic gallbladder stenting following percutaneous transhepatic gallbladder drainage

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2902-2909页

作者： Fumitaka Niiya Naoki Tamai Masataka Yamawaki Jun Noda Tetsushi Azami Yuichi Takano Fumiya nishimoto Masatsugu Nagahama Division of Gastroenterology Department of Internal MedicineShowa University Fujigaoka HospitalYokohama 227-8501KanagawaJapan

BACkGROUND Endoscopic transpapillary gallbladder drainage is challenging because of the complexity of the procedure and high incidence of adverse events(AEs).To overcome these problems,endoscopic gallbladder stenting(EGBS)after percutaneous transhepatic gallbladder drainage(PTGBD)can be effective,as it mitigates inflammation and *** To examine the benefits of EGBS after PTGBD to assess its efficacy and impact on *** We retrospectively analyzed data from 35 patients who underwent EGBS after PTGBD at a single center between January 2016 and December *** primary outcomes were technical success and AEs,and the rate of recurrent cholecystitis was *** addition,the reasons for the failure of the procedure were *** Among the 35 patients,the technical success rate was 77.1%and the final contrast of the cystic duct was successful in 97.1%of *** incidence of early AEs was relatively low(11.4%),with no instances of cystic duct *** rate of recurrent cholecystitis was 3.7%,and no other biliary events were *** EGBS after PTGBD may be significantly beneficial,with a substantial success rate and minimal AEs in both short-and long-term follow-ups.

关键词： Endoscopy Gallbladder Stents Drainage Adverse events Cholecystitis Follow-up Cystic duct

Effective combinations of anti-cancer and targeted drugs for pancreatic cancer treatment

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World Journal of Gastroenterology 2022年第28期28卷 3637-3643页

作者： Arata nishimoto Division of Basic Pharmaceutical Science Department of PharmacyFaculty of Pharmaceutical SciencesSanyo-Onoda City UniversitySanyo-Onoda City 756-0884YamaguchiJapan

Pancreatic cancer is highly aggressive and *** to the lack of effective methods for detecting the disease at an early stage,pancreatic cancer is frequently diagnosed *** has been the standard chemotherapy drug for patients with pancreatic cancer for over 20 years,but its anti-tumor effect is ***,FOLFIRINOX(leucovorin,fluorouracil,irinotecan,oxaliplatin)as well as combination therapies using gemcitabine and conventional agents,such as cisplatin and capecitabine,has also been administered;however,these have not resulted in complete ***,there is a need to develop novel and effective therapies for pancreatic ***,some studies have reported that combinations of gemcitabine and targeted drugs have had significant antitumor effects on pancreatic cancer *** gemcitabine induced DNA damage response,the proteins related to DNA damage response can be suitable additional targets for novel gemcitabine-based combination ***,kRAS/RAF/MEk/ERk signaling triggered by oncogenic mutated kRAS and autophagy are frequently activated in pancreatic ***,these characteristics of pancreatic cancer are potential targets for developing effective novel *** this minireview,combinations of gemcitabine and targeted drugs to these characteristics,combinations of targeted drugs,combinations of natural products and anti-cancer agents,including gemcitabine,and combinations among natural products are discussed.

关键词： Pancreatic cancer Gemcitabine Targeted drug Combination therapy

Inherited multimodal microstructure evolution of high-fracture-toughness Mg-Zn-Y-Al alloys during extrusion for the consolidation of rapidly solidified ribbons

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Journal of Magnesium and Alloys 2022年第9期10卷 2433-2445页

作者： Soya nishimoto Michiaki Yamasaki Yoshihito kawamura Department of Materials Science Graduate School of Science and TechnologyKumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

The mechanisms of multimodal microstructure evolution and the effects of microstructural factors on mechanical properties must be elucidated to design new alloys with superior *** this study,high-fracture-toughness and ductile Mg_(96.75)Zn_(0.85)Y_(2.05)Al_(0.35) alloys were developed using rapidly solidified(RS)ribbon-consolidation technique,and the inherited multimodal microstructure evolution during plastic flow consolidation of the RS ribbons was *** use of extrusion for plastic flow consolidation of the heat-treated RS ribbons produced a multimodal microstructure consisting of the worked grains with high kernel average misorientation(kAM)angles(Group1),the ultrafine dynamically recrystallized(DRXed)grains with intermediate kAM angles(Group 2),and the fine DRXed grains with low kAM angles(Group 3).Groups 1 and 2 contribute to the alloy strengthening,while Group 3 contributes to improving ductility with strainhardening,resulting in enhancement of the fracture *** form the multimodal microstructure,it was necessary to apply plastic flow with equivalent strains of>2.3 to the heat-treated RS ribbons possessing duplex microstructures with different dispersions of the long-period stacking ordered phase.

关键词： Magnesium alloy Long-period stacking ordered phase Multimodal microstructure Rapid solidification Extrusion Dynamic recrystallization

Fabrication of a model specimen for understanding micro-galvanic corrosion at the boundary ofα-Mg andβ-Mg17Al12

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Journal of Magnesium and Alloys 2023年第1期11卷 137-153页

作者： Zheng Shao Masashi nishimoto Izumi Muto Yu Sugawara Department of Materials Science Graduate School of EngineeringTohoku University6-6-02 Aza-AobaAramakiAoba-kuSendai 980-0579Japan

A model specimen with a single boundary of theα/βphase simulating Mg-Al alloys was successfully fabricated by spark plasma sintering.A small electrode area ofαphase orβphase was prepared using the model specimen,and the OCPs(open-circuit potentials)of each phase and a small electrode area containing theα/βphase boundary in 0.1 M NaCl at pH 8.0 were compared:theβphase exhibited a higher potential,and theαphase showed a lower *** OCP of the small area containing theα/βphase boundary was the intermediate value of these *** a small area containingα/βphase boundary,discoloration and gas bubbles were observed on theαphase,but no bubble generation was detected on theβ*** gas bubbles were initially generated on theαphase near theβphase,but as the discoloration(corrosion)of theαphase approached theβphase,the bubbles were generated on theβ*** micro-galvanic corrosion of theαandβphases,theβphase did not always function as the preferred ***αphase partially corroded(or discolored)and became the anodes,so that the surrounding areas were most likely to be the *** corroded areas(anodes)in theαphase approached theβphase,theβphase would become *** addition to the micro-galvanic corrosion mechanism,the role of Al in corrosion resistance at theα/βphase boundary was determined by surface analysis.

关键词： Magnesium alloy α/βphase boundary Micro-scale observation technique Micro-galvanic corrosion Spark plasma sintering

Thermal Properties of Al-50%Si Alloys

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材料热处理学报 2004年第5期25卷 180-182页

作者： Akio nishimoto katsuya Akamatsu kazuyoshi Nakao kazuo Ichii Department of Materials Science and Engineering Kansai University Osaka JapanDepartment of Materials Science and Engineering Kansai University Osaka JapanDepartment of Materials Science and Engineering Kansai University Osaka JapanDepartment of Materials Science and Engineering Kansai University Osaka Japan

In order to prepare a hypereutectic Al-Si alloy with low coefficients of thermal expansion (CTE), Al-50%Si alloy was produced by powder metallurgy (P/M) and ingot metallurgy (I/M). P/M specimen was prepared by mechanical alloying (MA) and pulsed electric-current sintering (PECS). The microstructures of specimens were characterized by optical microscopy and scanning electron microscopy (SEM) equipped with energy dispersive X-ray spectroscopy (EDS). Vickers microhardness and CTE measurements were performed. The grains in the P/M specimen were refined with increasing MA time. Primary Si and eutectic Si in the I/M specimen were remarkably refined by adding minute amounts of Sr. The CTE of P/M and I/M specimens were estimated as ***"6 and 10.7xlO"6, respectively. These values were as same as a CTE of AlaOs ceramics.

关键词： Al-Si合金热膨胀系数焙烧浇铸锶增加

Influence of Fine Sediment on the Fluidity of Debris Flows

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Journal of Mountain Science 2013年第2期10卷 233-238页

作者： Norifumi HOTTA Takahiro kANEkO Tomoyuki IWATA Haruo nishimoto Faculty of Life and Environmental Sciences University of Tsukuba3058577 IbarakiJapan Faculty of Agriculture The University of Tokyo1138657 TokyoJapan Graduate School of Agricultural and Life Sciences The University of Tokyo1138657 TokyoJapan

Debris flows include a great diversity of grain sizes with inherent features such as inverse grading, particle size segregation, and liquefaction of fine sediment. The liquefaction of fine sediment affects the fluidity of debris flows, although the behavior and influence of fine sediment in debris flows have not been examined sufficiently. This study used flume tests to detect the effect of fine sediment on the fluidity of laboratory debris flows consisting of particles with various diameters. From the experiments, the greatest sediment concentration and flow depth were observed in the debris flows mixed with fine sediment indicating increased flow resistance. The experimental friction coefficient was then compared with the theoretical friction coefficient derived by substituting the experimental values into the constitutive equations for debris flow. The theoretical friction coefficient was obtained from two models with different fine-sediment treatments： assuming that all of the fine sediments were solid particles or that the particles consisted of a fluid phase involving pore water liquefaction. From the comparison of the friction coefficients, a fully liquefaction state was detected for the fine particle mixture. When the mixing ratio and particle size of the fine sediment were different, some other eases were considered to be in a partially liquefied transition state. These results imply that the liquefaction of fine sediment in debris flows was induced not only by the geometric conditions such as particle sizes, but also by the flow conditions.

关键词： Debris flow Fine sediment Friction coefficient Liquefaction Open channel Reynolds stress

Preparation of Fe-Al Binary System Intermetallic Compounds by Multi-Layered Roll-Bonding

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材料热处理学报 2004年第5期25卷 53-55页

作者： Akio nishimoto katsuya Akamatsu kazuyoshi Nakao kazuo Ichii Tomohiro Hiraki Department of Materials Science and Engineering Kansai University Osaka JapanDepartment of Materials Science and Engineering Kansai University Osaka JapanDepartment of Materials Science and Engineering Kansai University Osaka JapanDepartment of Materials Science and Engineering Kansai University Osaka JapanToho Zinc Co. Ltd. Gunma Japan

Iron aluminides exhibit good resistance to high-temperature sulfidizing and oxidizing environments and potential for structural applications at high temperatures under corrosive environments. In this study, Fe-Al intermetallic compound was prepared by multi-layered roll-bonding of elemental Fe and Al foils. The process consisted of the accumulative roll-bonding (ARE) for making a laminated Fe/Al sheet and the subsequent heat treatment promoting a solid phase reaction in the laminated Fe/Al sheet. The microstructures produced at each processing stage were characterized by optical microscopy and scanning electron microscopy (SEM) equipped with energy dispersive X-ray spectroscopy (EDS). Vickers microhardness testing was used for hardness determination. A homogeneous intermetallic compound of Fe3Al or FeAl could be obtained after the subsequent heat treatment for 1.8 ks at 973 k and for 10.8 ks at 1123 or 1173 k.

关键词：铁铝合金金属互化物辊压接合分界面反应反应扩散

The Process of Support by Nursing Professionals for Families Having a Member with Borderline Personality Disorder

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Open Journal of Nursing 2016年第1期6卷 24-36页

作者： Yasuyo nishimoto Naohiro Hohashi Division of Family Health Care Nursing Department of Nursing Graduate School of Health Sciences Kobe University Hyogo Japan

The purpose of this study was to explore the process of family support provided by nurses to families with a borderline personality disorder (BPD) patient. Semi-structured interviews were conducted with 16 nurses who had provided care to BPD patients. Data obtained from the interviews were qualitatively analyzed using a modified grounded theory approach. As an overall core category of family support processes practiced by nurses for families with BPD patients, family support practiced without awareness that the nurses were supporting families was extracted. Through this process, nurses held perceptions that were premises for family support, which were formed through their individual nursing experiences and perspectives. Nurses also had diverse perceptions concerning the image of families. Through the integration of perceptions that were premises for family support and perceptions of an image of the family, nurses underwent a process of “determination and ambivalence about the need for family support.” Then, nurses provided “family support practice” when they acknowledged the need for family support. During the “family support practice,” nurses had difficulties in providing family support. When family support was not successfully provided, nurses provided “family support practice with seeking more effective ways through trial and error.” For cases in which nurses did not acknowledge the need for intervention, they intentionally chose “not to provide family support.” Furthermore, during the “family support practice,” nurses had contradictory perspectives of family support. Such family support processes ultimately led to an awareness of the same family support required for the future. Family support was provided with “family support practice” and “family support practice with seeking more effective ways through trial and error.” In some cases, however, the process ended in “not to provide family support intentionally.” Experiences and perspectives in providing family s

关键词： Family Nursing Process of Family Support Borderline Personality Disorder (BPD) Modified Grounded Theory Approach (M-GTA)

Duodenal stenosis resulting from a preduodenal portal vein and an operation for scoliosis

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World Journal of Gastroenterology 2009年第31期15卷 3950-3953页

作者： kouji Masumoto Risa Teshiba Genshiro Esumi kouji Nagata Takanori Nakatsuji Yuko nishimoto Sadako Yamaguchi kenzo Sumitomo Tomoaki Taguchi Department of Pediatric Surgery Reproductive and Developmental MedicineGraduate School of Medical SciencesKyushu University Department of Clinical Nutrition Kyushu University Hospital Department of Pediatric Surgery Shimonoseki City Central Hospital

A preduodenal portal vein （PDPV） is known to be a rare cause of duodenal stenosis. We treated a 22-yearold male patient with malnutrition as a result of PDPV and a previously performed operation for scoliosis, who showed an improvement in quality of life after being treated with a combination of nutritional support and surgery. The patient with PDPV had been admitted to our department with duodenal stenosis, ranging from the first to third portions. He had suffered from vomiting since 1 year of age, and he developed malnutrition during the last 6-too period after orthopedic surgery for scoliosis. The stenosis was related to both the PDPV and the previously performed operation for scoliosis. After receiving nutritional support for 6 mo, a gastrojejunostomy with Braun＇s anastomosis for the first portion and a duodenojejunostomy for the second and third portions were performed. The postoperative course was almost uneventful. Three months later, he was discharged and able to attend university. In patients with widespread duodenal stenosis, there may be a complicated cause,such as PDPV and duodenal stretching induced by previous spinal surgery.

关键词： Preduodenal portal vein Duodenum Malnutrition Gastrojejunostomy Nutritional support Stenosis