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遗传性溶血性贫血

广东医学 1984年第9期 44-46页

作者： Shiro miwa 杜传书中山医学院医学遗传学教研室

一、概述遗传性溶血性贫血是先天性代谢缺陷引起的一种综合征,其主要病因为:膜缺陷、血红蛋白病、两种珠蛋白链生成缺如或减少,红细胞酶病(红细胞酶异常)或卟啉代谢异常。本文先介绍日本有关流行病学调查的结果,然后简要复习膜缺陷所致... 详细信息

一、概述遗传性溶血性贫血是先天性代谢缺陷引起的一种综合征,其主要病因为:膜缺陷、血红蛋白病、两种珠蛋白链生成缺如或减少,红细胞酶病(红细胞酶异常)或卟啉代谢异常。本文先介绍日本有关流行病学调查的结果,然后简要复习膜缺陷所致溶血性贫血、血红蛋白病和地中海贫血。最后主要部分介绍伴有遗传性溶血性贫血的红细胞酶病。这是本人24年来主要从事的工作。本文重点介绍红细胞酶病。二、日本遗传性溶血性贫血的流行病学调查此项研究是在卫生及公共福利部资助下,于1974年由我们进行的。结果表明,日本人的发病率为5.7-20.3/100万人。70%为遗传性球形细胞增多症。此外,血红蛋白病占15%,地中海贫血占3.6%,红细胞酶病占6.4%。曾认为,白种人中遗传性球形细胞增多症发生率为200～300/100万人。因此,日本人的发病率约为白种人的1/7～1/10。其他遗传性溶血性贫血如镰状细胞性贫血(一种血红蛋白病)、地中海贫血和葡萄糖6磷酸脱氢酶(G6PD)缺乏症(一种

关键词：遗传性溶血性贫血血红蛋白病珠蛋白小体地中海贫血

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U形预应力砼板桩的开发

港工技术与管理 1991年第5期 49-55页

作者：倪玉明 miwa,Y

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致未来的自己

疯狂英语（初中天地） 2018年第3期 18-21页

作者： miwa 抱朴子

假如现在给你一个魔法水晶球,让你可以预知十年后的自己,你最想知道自己哪方面的变化呢?是外貌?职业?朋友关系?还是性情?我们先来看看这位喜欢小动物、喜欢吃糖果、喜欢动漫,每天晚上因为'stay up late'而被妈妈催着睡觉的异国同龄人,T... 详细信息

假如现在给你一个魔法水晶球,让你可以预知十年后的自己,你最想知道自己哪方面的变化呢?是外貌?职业?朋友关系?还是性情?我们先来看看这位喜欢小动物、喜欢吃糖果、喜欢动漫,每天晚上因为'stay up late'而被妈妈催着睡觉的异国同龄人,TA对自己未来的憧憬吧。

关键词：毕业典礼火影忍者设计师

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Journal of Behavioral and Brain Science 2013年第7期3卷 509-517页

作者： Yuko Mizuno-Matsumoto Takuto Hayashi Eika Okamoto Daisuke miwa Tetsuya Asakawa Ayumi Muramatsu Makoto kato Tsutomu Murata Center for Information and Neural Networks Advanced ICT Research Institute National Institute of Information and Communications Technology (NICT) Hyogo Japan Center for Information and Neural Networks Advanced ICT Research InstituteNational Institute of Information and Communications Technology (NICT) Hyogo Japan Department of Medical Engineering Aino University Osaka Japan Faculty of Physical Education Osaka University of Health and Sport Sciences Osaka Japan Graduate School of Applied Informatics University of Hyogo Hyogo Japan

Hippocampus is crucial for the formation of emotional memory. We found the relationship between hippocampal responses to emotional stimuli and the mental stabilities of people in our preliminary study. In this study, we have also evaluated how the emotional stimuli would affect amygdala and thalamus in the brain, and how the personality stabilities could relate to the responses in the brain using functional magnetic resonance imaging (fMRI). We evaluated the subjects’ personality features with the Yatabe-Guilford Personality Test (Y-G test) and psychosomatic symptoms with the Cornell Medical Index (CMI). The subjects were categorized into the mentally stable group and the mentally unstable group according to the total scores of the Y-G test and the CMI. The brain functional responses under emotional stimuli were measured using fMRI. The region of interest (ROI) analysis was performed to abstract significant changes in order to compare responses among the different emotional stimuli. We conducted the regression analysis to abstract the relationship between the mean % signal change from fMRI and the personality stability. The fMRI results showed that the hippocampus, thalamus, and right amygdala activities under the human relationship stimuli increased with ascending value of mental instability. Our findings suggest that the memory process in the hippocampus and the threat alarm system in the thalamus under the human-related stimuli crucially influence the emotional reaction of mentally unstable people. These processes in the brain would affect the event that stresses on human relationships that often cause people to suffer from mental disorders.

关键词： fMRI Emotion Personality Hippocampus Thalamus Amygdala

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地物杂波对雷达寻的导弹脱靶量的影响

贵州航天 1991年第4期 1-8页

作者： miwa,S. 谭孝春

Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by <i>Helicobacter pylori</i>

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Open Journal of Blood Diseases 2013年第1期3卷 32-35页

作者： Naoki Takezako Naohiro Sekiguchi Akira Tanimura Chiho Homma Tateki Shikai Yayoi Takezako Noboru Yamagata Akiyoshi miwa Department of Hematology National Center for Global Health and Medicine Tokyo Japan. Department of Hematology National Hospital Organization Disaster Medical Center of Japan Tokyo Japan

Background and Objectives: Several recent reports have demonstrated a close linkage between idiopathic thrombocytopenic purpura (ITP) and Helicobacter pylori (H. pylori) infection in some patient’s populations. However, the pathogenetic mechanisms of H. pylori-induced thrombocytopenia remain obscure. Therefore, we investigated the prevalence of H. pylori infection pylori and performed a comparative analysis of a subset of H. pylori-infected patients (group A) with non-infected patients (group B) using the standard statistical methods. Design and Methods: From December 2001 to October 2002, we investigated the presence of gastric H. pylori infection in 30 adult ITP patients and 19 patients were treated with standard antibiotic therapy for H. pylori eradication (amoxicillin and clarithromycin plus lansoprazole combination). We used the standard statisticsto analyze the difference between group A and group B. Results: H. pylori eradication was achieved in 17/19 (89.4%) ***-infected patients. An improvement of platelet count was observed in 14/19 patients (73.6%) who achieved the eradication. Five of these patients achieved CR (two patients were with the acute ITP) and nine patients reached PR. The difference between the mean platelet count ± S.D. before and after H. pylori therapy was statistically significant in patients with successful decontamination (65 ± 48 × 109/L vs. 200 ± 140 × 109/L;p = 0.018). Lymphocyte counts at the diagnosis of H. pylori infected cases were significant higher than those of non-infected cases (1.58 ± 0.13 ×

关键词： Idiopathic Thrombocytopenic Purpura Helicobacter pylori Eradication Lymphocytosis Helper Th1 Lymphocyte

与溶血性贫血有关的突变型红细胞酶类的临床和生化研究

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国外医学.遗传学分册 1981年第3期04卷 131-135页

作者： Shiro miwa 彭愈生

1950年作者在加利福尼亚大学Valentine实验室开始研究与遗传性溶血性贫血有关的红细胞酶异常,第二年发现丙酮酸激酶缺乏的溶血性贫血症。回日本后,作者继续开展这方面的研究工作,在本文中介绍作者研究工作情况。丙酮酸激酶缺陷的发现 Se... 详细信息

1950年作者在加利福尼亚大学Valentine实验室开始研究与遗传性溶血性贫血有关的红细胞酶异常,第二年发现丙酮酸激酶缺乏的溶血性贫血症。回日本后,作者继续开展这方面的研究工作,在本文中介绍作者研究工作情况。丙酮酸激酶缺陷的发现 Selwyn和Dacie(1954)开展自家溶血实验,发现了所谓先天性非球形细胞溶血

关键词：红细胞病例遗传性溶血性贫血丙酮酸激酶红血球非球形细胞溶血性贫血生化研究酶类突变型突变体

Measurement of Gamma-Rays from ^11 A B and ^12 A C

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Chinese Physics Letters 2007年第8期24卷 2216-2218页

作者：傅元勇周书华 T. koike S. kinoshita Y. Ma Y. Miura k. miwa Y. Miyagi k. Shirotori T. Suzuki H. Tamura k. Tsukada M. Ukai k. Futatsukawa k. Hosomi M. kawai M. Mimori N. Terada N. Maruyama k. Aoki H Fujioka Y kakiguchi T. Nagae D. Nakajima H Noumi T Takahashi T.N. Takahashi A. Toyota M. Dairaku T. Fukuda S. Minami W. Imoto S. Aiimura k. Tanida China Institute of Atomic Energy PO Box 275(18) Beijing 102413 Department of Physics Tohoku University Sendal 980-8578 Japan High Energy Accelerator Research Organization (kEk) Tsukuba Ibaraki 305-0801 Japan Department of Physics Kyoto University Kyoto 606-8502 Japan Osaka Electro-Communication University Osaka 572-8530 Japan Department of Physics Osaka University Osaka 560-0043 Japan RIkEN Wako 351-0198 Japan

From the ^12 C（π^＋,k^＋）^12 AC reaction the γ -rays of 261.6±0.24 ke V（7/2^＋ →5/2^＋）and 1481.7±0.7 ke V（1/2^＋ →5/2^＋） of ^11 A B,and 2667.3±2.8 keV（1^- 2 → 2^- 1）of ^12 A C hypernuclei have been identified using a large germanium detector array Hyperball2 at k6 beam line of kEk. The observed energies of the transitions 1481.7keV and 261.6 keV are significantly different from the values predicted by the shell model using the △ and SN parameters determined from the ^7 △ Li data.

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Copper Accumulates in Hemosiderins in Livers of Patients with Iron Overload Syndromes

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Journal of Clinical and Translational Hepatology 2015年第2期3卷 85-92页

作者： Yukiya Ono Masatoshi Ishigami kazuhiko Hayashi Shinya Wakusawa Hisao Hayashi kotaro kumagai Natsuko Morotomi Tetsuji Yamashita miwa kawanaka Minemori Watanabe Hiroaki Ozawa Mayumi Tai Hiroaki Miyajima kentarou Yoshioka Yoshiki Hirooka Hidemi Goto Department of Gastroenterology Nagoya University Graduate School of Medicine Nagoya Japan Department of Medical Laboratory Sciences Nagoya University Graduate School of Medicine Nagoya Japan Department of Medicine Aichi Gakuin University School of Pharmacy Nagoya Japan Digestive Disease and Lifestyle Related Disease Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan Department of Internal Medicine Moji Hospital Kitakyushu Japan Department of Medicine Yoshida Hospital Matsuyama Japan General Internal Medicine 2 Kawasaki Hospital Kawasaki Medical School Okayama Japan Department of Endocrinology and Diabetes Okazaki City Hospital Okazaki Japan Department of Pathology Okazaki City Hospital Okazaki Japan Department of Gastroenterology Fukushima Rohsai Hospital Fukushima Japan First Department of Medicine Hamamatsu University School of Medicine Hamamatsu Japan Department of Liver Biliary Tract and Pancreas Diseases Fujita Health University Toyoake Japan

In biology,redox reactions are essential and sometimes harmful,and therefore,iron metabolism is tightly regulated by *** the state of copper in iron overload syndromes remains unclear,we investigated whether copper metabolism is altered in these *** patients with iron overload syndromes participated in this *** clinical diagnoses were aceruloplasminemia (n=2),hemochromatosis (n=5),ferroportin disease (n=2),and receiving excess intravenous iron supplementation (n=2).Liver specimens were analyzed using a light microscope and transmission electron microscope equipped with an X-ray *** addition to a large amount of iron associated with oxygen and phosphorus,the iron-rich hemosiderins of hepatocytes and kupffer cells contained small amounts of copper and sulfur,regardless of disease ***-dimensional imaging clearly showed that cuproproteins were distributed homogenously with iron complexes within *** stasis was unlikely in noncirrhotic *** enhanced induction of cuproproteins by excess iron may contribute to copper accumulation in *** conclusion,we have demonstrated that copper accumulates in hemosiderins in iron overload conditions,perhaps due to alterations in copper metabolism.

关键词： Aceruloplasminemia Cuproprotein induction Ferroportin disease Hemochromatosis Hemosiderin Iron copper interaction Iron overload syndromes