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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz ki Chan Dohyun Ahn Vladimir kushnarev Tsz kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong kim Hill Lam Lau Ying Lo Law Chi Seng leung Chun Yin Tong kai kap Wong Wing Lam Yim Nikolay S.karnaukhov Richard Y.C.kong maria V.Babak Yudai matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEm Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Innovating for Health in China’s Greater Bay Area

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China CDC weekly 2022年第1期4卷 1-3页

作者： Feichau Pang Puihong Chung Gabriel m leung School of Public Health LKS Faculty of MedicineThe University of Hong KongHong KongChina

The Success of World metropolitan and Bay Areas The Tokyo Bay Area,the New York metropolitan Area,and the San Francisco Bay Area are leading regions for science and *** share an economic transformation from industrial or manufacturing bases to predominantly service-based economies with this sector contributing 75%of their gross domestic product(GDP)in *** companies in these locations accounted for 60%of the revenue of the top 100 global tech companies in 2018(1).The success of these locations stems from the convergence of academia,technology giants,government support,and a high density of investors,as well as innovative entrepreneurs(2).

关键词： companies revenue bases

Staphylococcal-scalded skin syndrome:evaluation,diagnosis,and management

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World Journal of Pediatrics 2018年第2期14卷 116-120页

作者： Alexander k.C.leung Benjamin Barankin kin Fon Leong Department of Pediatrics The Alberta Children's HospitalThe University of CalgaryCalgary#200233-16th Avenue NWCalgaryAB T2M 0H5Canada Toronto Dermatology Centre TorontoONCanada The Pediatric Institute Kuala Lumpur General HospitalKuala LumpurMalaysia

Background Staphylococcal-scalded skin syndrome(SSSS),also known as Ritter disease,is a potentially life-threatening disorder and a pediatric *** diagnosis and treatment is imperative to reduce the morbidity and mortality of this *** purpose of this article is to familiarize physicians with the evaluation,diagnosis,and treatment of *** sources A Pubmed search was completed in Clinical Queries using the key terms"Staphylococcal scalded skin syn-drome"and"Ritter disease".Results SSSS is caused by toxigenic strains of Staphylococcus *** of the amino-terminal extracellular domain of desmoglein 1 by staphylococcal exfoliative toxins results in disruption of keratinocytes adhesion and cleavage within the stratum granulosum which leads to bulla *** diagnosis is mainly clinical,based on the findings of tender erythroderma,bullae,and desquamation with a scalded appearance especially in friction zones,periorificial scabs/crusting,positive Nikolsky sign,and absence of mucosal *** empiric treatment with intravenous anti-staphylococcal antibiotic such as nafcillin,oxacillin,or flucloxacillin is essential until cultures are available to guide *** or cefuroxime may be used should the patient have penicillin *** the patient is not improving,critically ill,or in com-munities where the prevalence of methicillin-resistant *** is high,vancomycin should be *** A high index of suspicion is essential for an accurate diagnosis to be made and treatment promptly initiated.

关键词： Blisters Desquamation Erythroderma Exfoliative toxins Staphylococcus aureus

Recent advances and future challenges for mobile network virtualization

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Science China(Information Sciences) 2017年第4期60卷 5-16页

作者： Xiaofeng TAO Yan HAN Xiaodong XU Ping ZHANG Victor C.m.leung National Engineering Lab for mobile Network Technologies Beijing University of Posts and Telecommunications State key Lab of Networking & Switching Technology Beijing University of Posts and Telecommunications Department of Electrical and Computer Engineering The University of British Columbia

Recently, network function virtualization(NFV) was proposed as a paradigm shift in the telecommunication industry. Both industry and academia have drawn significant attention in mobile network *** decouples the software implementation of network functions from the underlying hardware, leading to considerable reductions in operating expenses(OPEX) and capital expenses(CAPEX), and facilitating the network deployment. However, as an emerging technology, NFV brings both challenges and opportunities in developing new architectures, applying and deployment. In this paper, we first survey the related work of NFV, and then propose promising research directions in this area.

关键词： network function virtualization mobile networks software defined networking network functions 5G network slicing

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Advances in Atmospheric Sciences 2022年第1期39卷 67-79页

作者： Paxson k.Y.CHEUNG Wen ZHOU Dongxiao WANG marco Y.T.leung Guy-Carpenter Asia-Pacific Climate Impact Centre School of Energy and EnvironmentCity University of Hong KongHong KongChina Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China School of marine Sciences Sun Yat-sen UniversityGuangdong 510275China

This study focuses on the temporal variation of dissimilarity in heat content(HC)anomalies in the upper 300 m of ocean(HC300A)in the equatorial Pacific(±10°N)and its response to the El Ni?o-Southern Oscillation(ENSO).The HC300A anomalies are derived from four ocean reanalyses that are commonly used in ENSO studies and are compared using a simple differencing *** dissimilarity in HC300A is found to vary closely with the magnitude of ENSO(regardless of phase),meaning that it tends to be greater during strong ENSO ***,the dissimilarity among ocean reanalyses persists after the event *** effect is more pronounced after strong *** persistence of the dissimilarity after ENSO events is a result of a late maturation of the ENSO signal,its persistence,and the interruption of the signal decay due to follow-up ENSO *** combined effect of these three factors slows down the decay of HC300A in the region and hence results in the slow decay of *** is also found that areas with a significant spread in vertical temperature profiles collocate with the ENSO signal during warm ENSO ***,differences in subsurface process reconstruction are a significant factor in the dissimilarity among ocean reanalyses during warm ENSO events.

关键词： ocean reanalysis ocean heat content intercomparison ENSO equatorial Pacific

Engineered polycaprolactone–magnesium hybrid biodegradable porous scaffold for bone tissue engineering

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Progress in Natural Science:materials International 2014年第5期24卷 561-567页

作者： Hoi man Wong Paul k.Chu Frankie k.L.leung kenneth m.C.Cheung keith D.k.Luk kelvin W.k.Yeung Department of Orthopaedics and Traumatology The University of Hong Kong Shenzhen key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen Hospital Department of Physics and materials Science City University of Hong Kong Peking University Shenzhen Institution

In this paper, we describe the fabrication of a new biodegradable porous scaffold composed of polycaprolactone(PCL) and magnesium(mg)micro-particles. The compressive modulus of PCL porous scaffold was increased to at least 150% by incorporating 29% mg particles with the porosity of 74% using micro-CT analysis. Surprisingly, the compressive modulus of this scaffold was further increased to at least 236% when the silane-coupled mg particles were added. In terms of cell viability, the scaffold modified with mg particles significantly convinced the attachment and growth of osteoblasts as compared with the pure PCL scaffold. In addition, the hybrid scaffold was able to attract the formation of apatite layer over its surface after 7 days of immersion in normal culture medium, whereas it was not observed on the pure PCL scaffold. This in vitro result indicated the enhanced bioactivity of the modified scaffold. moreover, enhanced bone forming ability was also observed in the rat model after 3 months of implantation. Though bony in-growth was found in all the implanted scaffolds. High volume of new bone formation could be found in the mg/PCL hybrid scaffolds when compared to the pure PCL scaffold. Both pure PCL and mg/PCL hybrid scaffolds were degraded after 3 months. However, no tissue inflammation was observed. In conclusion, these promising results suggested that the incorporation of mg micro-particles into PCL porous scaffold could significantly enhance its mechanical and biological properties. This modified porous bio-scaffold may potentially apply in the surgical management of large bone defect fixation.

关键词： magnesium Polycaprolactone Biodegradability Biocompatibility mechanical properties

Special Focus on machine-Type Communications

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Science China(Information Sciences) 2017年第10期60卷 5-6页

作者： Xiaofeng TAO Ping ZHANG Victor C.m.leung Songwu LU Yu CHEN Beijing University of Posts and Telecommunications The University of British Columbia The University of California

machine-type communication(mTC)refers to the communication between devices with or without the involvement of the network *** recent years,we have witnessed a rapid penetration of embedded devices;and we believed that... 详细信息

关键词： mTC In Special Focus on machine-Type Communications HTC ATS

Arm PSA-Certified IoT Chip Security: A Case Study

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Tsinghua Science and Technology 2023年第2期28卷 244-257页

作者： Fei Chen Duming Luo Jianqiang Li Victor C.m.leung Shiqi Li Junfeng Fan College of Computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Electrical and Computer Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada Open Security Research Inc.Shenzhen 518000China

With the large scale adoption of Internet of Things(IoT)applications in people’s lives and industrial manufacturing processes,IoT security has become an important problem *** security significantly relies on the security of the underlying hardware chip,which often contains critical information,such as encryption *** understand existing IoT chip security,this study analyzes the security of an IoT security chip that has obtained an Arm Platform Security Architecture(PSA)Level 2 *** analysis shows that the chip leaks part of the encryption key and presents a considerable security ***,we use commodity equipment to collect electromagnetic traces of the *** a statistical T-test,we find that the target chip has physical leakage during the AES encryption *** further use correlation analysis to locate the detailed encryption interval in the collected electromagnetic trace for the Advanced Encryption Standard(AES)encryption *** the basis of the intermediate value correlation analysis,we recover half of the 16-byte AES encryption *** repeat the process for three different tests;in all the tests,we obtain the same result,and we recover around 8 bytes of the 16-byte AES encryption ***,experimental results indicate that despite the Arm PSA Level 2 certification,the target security chip still suffers from physical *** layer application developers should impose strong security mechanisms in addition to those of the chip itself to ensure IoT application security.

关键词： Internet of Things(IoT)security chip Arm Platform Security Architecture(PSA)certification electromagnetic side-channel attack Advanced Encryption Standard(AES)encryption key leakage

Homogentisic acid γ-lactone suppresses the virulence factors of Pseudomonas aeruginosa by quenching its quorum sensing signal molecules

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Chinese Chemical Letters 2018年第2期29卷 313-316页

作者： Shuihong Li Polly H.m. leung Xinya Xu Chunhui Wu Department of Health Technology and Informatics The Hong Kong Polytechnic University Hong Kong China Hunan Province Cooperative Innovation Center for molecular Target New Drug Study University of South China Hengyang 421001 China key Laboratory of Tropical marine Bio-resources and Ecology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510201 Chino Center for Informational Biology University of Electronic Science and Technology of China Chengdu 610054 China

Bacterial quorum sensing（QS） molecules are involved in the coordination of certain behaviors such as biofilm formation, virulence and antibiotic resistance. QS molecules（autoinducers） and their corresponding receptors have been recognized as important therapeutic targets for drug-resistant infections and biofilm-associated infections（BAI）. This study assessed the multiple biological effects of homogentisic acid y-lactone（HgAL）, a furanone derivative. The anti-QS and anti-biofilm effects of HgAL against PAO1 strain were evaluated using CLSm, SEm, HPLC and other biochemical methods The results showed that HgAL could effectively inhibit the production of pyocyanin and extracellular matrix, as well as reduce the adherence ability and biofilm formation of Pseudomonas aeruginosa. Inhibition of virulence is attributed to the suppressive effect of HgAL on biosynthesis of 3-oxo-C12-HSLand C4-HSL（two kinds of QS signaling molecules in P. aeruginosa）. Our results support HgAL as a potential agent for prevention of BAI in the healthcare settings.

关键词： Homogentisicacid γ-lactone Quorum sensing Biofilm Pseudomonas aeruginosa Pyocyanin

Wireless Acoustic Sensor Networks and Edge Computing for Rapid Acoustic monitoring

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IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 64-74页

作者： Zhengguo Sheng Saskia Pfersich Alice Eldridge Jianshan Zhou Daxin Tian Victor C.m.leung the Department of Engineering and Design University of Sussex Infineon Technologies AG the Department of music University of Sussex Beijing Advanced Innovation Center for Big Data and Brain Computing (BDBC) Beijing Key Laboratory for Cooperative Vehicle Infrastructure Systems & Safety ControlSchool of Transportation Science and EngineeringBeihang University the Department of Electrical and Computer Engineering The University of British Columbia

Passive acoustic monitoring is emerging as a promising solution to the urgent, global need for new biodiversity assessment methods. The ecological relevance of the soundscape is increasingly recognised, and the affordability of robust hardware for remote audio recording is stimulating international interest in the potential for acoustic methods for biodiversity *** scale of the data involved requires automated methods,however, the development of acoustic sensor networks capable of sampling the soundscape across time and space and relaying the data to an accessible storage location remains a significant technical challenge, with power management at its core. Recording and transmitting large quantities of audio data is power intensive,hampering long-term deployment in remote, off-grid locations of key ecological interest. Rather than transmitting heavy audio data, in this paper, we propose a low-cost and energy efficient wireless acoustic sensor network integrated with edge computing structure for remote acoustic monitoring and in situ *** and computation of acoustic indices are carried out directly on edge devices built from low noise primo condenser microphones and Teensy microcontrollers, using internal FFT hardware support. Resultant indices are transmitted over a ZigBee-based wireless mesh network to a destination *** tests of audio quality, indices computation and power consumption demonstrate acoustic equivalence and significant power savings over current solutions.

关键词： Acoustic sensor networks edge computing energy efficiency