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The 16th Annual Conference of Hong kong Society of Theoretical and Applied mechanics 2012、The 1st mainland-Hong kong Youth Forum on mechanics 2012、The 8th Shanghai-Hong kong Forum on mechanics and Its Application 2012

作者： S.k.Lai Abraham Y.S.Tang k.m.leung Gilberto k.k.leung k.W.Chow Department of mechanical Engineering University of Hong Kong Division of Neurosurgery Department of SurgeryLi Ka Shing Faculty of MedicineUniversity of Hong KongQueen Mary Hospital

Intracranial aneurysm,a localized dilation of arterial blood vessels in the brain,is a severe cerebrovascular *** appropriate medical treatment,the rupture of intracranial aneurysms will result in high mortality rate due to excessive bleeding into the cavity surrounding the *** modern technological advances,endovascular stenting technique has now proven to be one effective technique in the clinical management of intracranial *** prime advantage of endovascular intervention over traditional open surgery is that the former procedure is less invasive,and thus a shorter recovery time will *** a mechanical point of view,a metallic stent,serving as a flow diverter,can be deployed to cover the entire aneurysm *** the blood flow inside the aneurysmal sac becomes stagnant,and thrombus formation is likely to *** is expected that a larger extent of thrombosis is capable of reducing the risk of growth and rupture of *** assess this clinical objective quantitatively,we construct a three-dimensional(3D) aneurysm model (see Fig.1) to investigate the blood flow patterns in stented and non-stented *** many idealized models with straight or curved parent blood vessel,the aneurysm of the current model is placed at the bifurcation point of cerebral arteries,a geometric configuration occurring frequently for many *** fluid dynamics techniques are applied to perform the blood flow *** inlet and outlet boundary conditions of this model are subjected to pulsatile velocity and pressure waveforms *** on the present study,the impact of hemodynamic and biomechanical factors on the aneurysm can be *** quantitative findings can also provide valuable information for clinical practitioners to understand and predict the hemodynamic behaviour in patient-specific cases.

关键词： A Computational Fluid Dynamics Study on the Endovascular Treatment of Intracranial Aneurysms

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联用色谱用于冬虫夏草的化学成分测定

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药学学报 1999年第3期34卷 214-217页

作者：龚范彭源贵崔卉梁逸曾湖南大学化学化工学院化学计量学与化学传感技术研究所湖南省中医药研究院中药研究所香港理工大学应用生物与化学技术系

目的：对冬虫夏草虫体和子座部分的甾醇和核苷类化合物进行多组分定性定量分析，并比较核苷类化合物的提取方法。方法：用ＨＰＬＣＤＡＤ联用色谱检测，借助ＨＥＬＰ法解析，基于组分的色谱保留时间和光谱曲线进行定性，然后用总体积... 详细信息

目的：对冬虫夏草虫体和子座部分的甾醇和核苷类化合物进行多组分定性定量分析，并比较核苷类化合物的提取方法。方法：用ＨＰＬＣＤＡＤ联用色谱检测，借助ＨＥＬＰ法解析，基于组分的色谱保留时间和光谱曲线进行定性，然后用总体积积分法定量。结果：ＨＰＬＣＤＡＤ联用色谱检测和ＨＥＬＰ法解析相结合，可验证色谱峰的纯度，分辨重叠峰，得到各组分的纯色谱和光谱曲线。该法的样品回收率为９９９７％～１００８１％，虫体和子座部分的化学成分存在差异，用水提取核苷类化合物的效果较好。结论：综合利用色谱和光谱两方面信息，可提高组分定性定量结果的准确度。

关键词：联用色谱冬虫夏草化学成分高效液相色谱法

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Usefulness of Rule-based Solutions Generated by the DSE-RAm System for Solving Occupational Health Problems Associated with Computer Usage

Usefulness of Rule-based Solutions Generated by the DSE-RAM ...

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亚太地区职业安全卫生组织第二十届年会

作者： Connie Y.Y.Sung Stephen k.m.leung S.H.Chan Lewis C.F.Lau Gladys W.m Lee Noel Y.Wang Chetwyn C.H.Chan Ergonomics and Human Performance Laboratory Department of Rehabilitation Sciences The Hong kong Polytechnic University Hung Hom kowloon Hong kong SAR China. Ergonomics and Human Performance Laboratory Department of Rehabilitation Sciences The Hong kong Polytechnic University Hung Hom kowloon Hong kong SAR China. Ergonomics and Human Performance Laboratory Department of Rehabilitation Sciences The Hong kong Polytechnic University Hung Hom kowloon Hong kong SAR China. Ergonomics and Human Performance Laboratory Department of Rehabilitation Sciences The Hong kong Polytechnic University Hung Hom kowloon Hong kong SAR China. Ergonomics and Human Performance Laboratory Department of Rehabilitation Sciences The Hong kong Polytechnic University Hung Hom kowloon Hong kong SAR China. Ergonomics and Human Performance Laboratory Department of Rehabilitation Sciences The Hong kong Polytechnic University Hung Hom kowloon Hong kong SAR China. Ergonomics and Human Performance Laboratory Department of Rehabilitation Sciences The Hong kong Polytechnic University Hung Hom kowloon Hong kong SAR China.

Introduction: The Display Screen Equipment Risk Assessment and managementSystem (DSE-RAm) is designed to generate expert rule-based solutions for practitioners tosolve problems associated with improper workstation design. This study was aimed to test theusefulness of the System for facilitating the risk assessment process. mcthods: One hundred and eleven sedentary workers were randomly assigned to interven-tion group (n=56) and delayed-intervention group (n=55). The DSE-RAm guided risk as-sessments were conducted to the workers'workstations. The ergonomic solutions generatedby the DSE-RAm were immediately implemented to the intervention group. All workers wereassessed on their body discomfort, fatigue and satisfaction towards the workstation at the be-ginning and two weeks after. Results: When compared with the control group, workers in the intervention groupshowed significant decreases in both body discomfort (t(54)=2.51-5.43, pks after implementation of the modifica-tions. Significant differences were found in the satisfaction ratings with monitor height (F=11.74, df=1, 49, p= 0.001) when the perceived feasibility of the recommended solutions werecontrolled. Concusion: The DSE-RAm System appears to be useful and effective. Further studyshould explore ways to facilitate workers to adopt active roles and also focus on the cost-effec-tiveness and utility of the System.

关键词： Usefulness of Rule-based Solutions Generated by the DSE-RAm System for Solving Occupational Health Problems Associated with Computer Usage RAm DSE

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An improved pulse coupled neural networks model for semantic IoT

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Digital Communications and Networks 2024年第3期10卷 557-567页

作者： Rong ma Zhen Zhang Yide ma Xiping Hu Edith C.H.Ngai Victor C.m.leung School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China School of medical Technology Beijing Institute of TechnologyBeijing100081China Department of Electrical and Electronic Engineer The University of Hong KongHong Kong 999077China College of Computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Electrical and Computer Engineering the University of British ColumbiaVancouverBC V6T 1Z4Canada

In recent years,the Internet of Things(IoT)has gradually developed applications such as collecting sensory data and building intelligent services,which has led to an explosion in mobile data ***,with the rapid development of artificial intelligence,semantic communication has attracted great attention as a new communication ***,for IoT devices,however,processing image information efficiently in real time is an essential task for the rapid transmission of semantic *** the increase of model parameters in deep learning methods,the model inference time in sensor devices continues to *** contrast,the Pulse Coupled Neural Network(PCNN)has fewer parameters,making it more suitable for processing real-time scene tasks such as image segmentation,which lays the foundation for real-time,effective,and accurate image ***,the parameters of PCNN are determined by trial and error,which limits its *** overcome this limitation,an Improved Pulse Coupled Neural Networks(IPCNN)model is proposed in this *** IPCNN constructs the connection between the static properties of the input image and the dynamic properties of the neurons,and all its parameters are set adaptively,which avoids the inconvenience of manual setting in traditional methods and improves the adaptability of parameters to different types of *** segmentation results demonstrate the validity and efficiency of the proposed self-adaptive parameter setting method of IPCNN on the gray images and natural images from the matlab and Berkeley Segmentation *** IPCNN method achieves a better segmentation result without training,providing a new solution for the real-time transmission of image semantic information.

关键词： Internet of things(IoT) Semantic information Real-time application Improved pulse coupled neural network Image segmentation

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Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao Yu Wai Nok Chan Fuda Xie Yigan Zhang Li Liang kam Tong leung kwok Wai Lo Jun Yu Gary m.k.Tse Wei kang ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHk-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Department of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of Pediatrics The Chinese University of Hong KongHong KongChina Department of medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease *** an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer *** transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential element is predominantly mediated by metallothioneins(mTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on *** also compile a summary of clinical trials involving zinc *** the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement

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Advancements in Web3 Infrastructure for the metaverse

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ZTE Communications 2024年第2期22卷 1-2页

作者： Victor C.m.leung CAI Wei the Artificial Intelligence Research Institute Shenzhen MSU-BIT University Shenzhen mSU-BIT University Shenzhen University the Wireless Networks and mobile Systems(WiNmoS)Laboratory at UBC the School of Science and Engineering at The Chinese University of Hong kong Shenzhen the Human-Crypto Society Laboratory the CUHk(SZ)White matrix Joint metaverse Laboratory

Web3,also known as Web 3.0,has recently been attracting increasing attention from industry and *** the potential of blockchain technologies,Web3 has emerged as a pivotal foundation in the realm of metaverse development,which is considered by many as the next-generation ***,Web3 technologies such as smart contracts and protocols like non-fungible tokens(NFTs)have supported the immersive and content-rich experience of current Web3 metaverse projects.

关键词： Web token attracting

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Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival

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World Journal of Gastroenterology 2024年第7期30卷 714-726页

作者： Pui-Yin leung Wenjing Chen Anissa N Sari Poojitha Sitaram Pui-kei Wu Susan Tsai Jong-In Park Department of Biochemistry Medical College of WisconsinMilwaukeeWI 53226United States Department of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACkGROUND Pancreatic cancer is a leading cause of cancer-related *** activity of the epidermal growth factor receptor(EGFR)is often observed in pancreatic cancer,and the small molecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug ***,erlotinib alone is ineffective and should be combined with other drugs to improve therapeutic *** previously showed that certain receptor tyrosine kinase inhibitors can increase mitochondrial membrane potential(Δψm),facilitate tumor cell uptake ofΔψm-sensitive agents,disrupt mitochondrial homeostasis,and subsequently trigger tumor cell *** has not been tested for this *** To determine whether erlotinib can elevateΔψm and increase tumor cell uptake ofΔψm-sensitive agents,subsequently triggering tumor cell ***Δψm-sensitive fluorescent dye was used to determine how erlotinib affectsΔψm in pancreatic adenocarcinoma(PDAC)cell *** viability of conventional and patient-derived primary PDAC cell lines in 2D-and 3D cultures was measured after treating cells sequentially with erlotinib and mitochondria-targeted ubiquinone(mitoQ),aΔψm-sensitive *** synergy between erlotinib and mitoQ was then analyzed using SynergyFinder *** preclinical efficacy of the twodrug combination was determined using immune-compromised nude mice bearing PDAC cell line *** Erlotinib elevatedΔψm in PDAC cells,facilitating tumor cell uptake and mitochondrial enrichment ofΔψm-sensitive *** triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatment potentiated low doses of *** suggested that these drugs synergistically induced tumor cell *** with in vitro data,erlotinib and mitoQ combination suppressed human PDAC cell line xenografts in mice more effectively than single treatments of each *** Our findings suggest tha

关键词： Pancreatic cancer Erlotinib mitochondria-targeted ubiquinone mitochondria Combination therapy

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message from Deputy Editor-in-Chief Gabriel m leung—International Trade and Global Health Protection

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China CDC weekly 2019年第4期1卷 45-46页

作者： Gabriel m leung China CDC Weekly Dean of medicine The University of Hong KongHong Kong SARChina

It was external trade that first prompted the collection and reporting of surveillance data at the foreign ports from which the US imported *** established Bulletin of the Public Health—the first precursor to the US ... 详细信息

关键词： Trade prompt Health

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Chemical biology investigation of a triple-action,smart-decomposition antimicrobial booster based-combination therapy against“ESkAPE”pathogens

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Science China Chemistry 2024年第9期67卷 3071-3082页

作者： min Wang Huangsheng Pu Yangfan Xu Chenxuan Wu Yuanxin Gu Qingyun Cai Guoxing Yin Peng Yin Chunhui Zhang Wing-leung Wong muyang Wan Yugang Bai Xinxin Feng State key Laboratory of Chem-/Bio-Sensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biologyand School of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China College of Biology Hunan UniversityChangsha 410082China College of Advanced Interdisciplinary Studies&Hunan Provincial key Laboratory of Novel Nano Optoelectronic Information materials and Devices National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China key Laboratory of Chemical Biology and Traditional Chinese medicine Research(ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China State key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China Hunan Provincial key Laboratory of Anti-Resistance microbial Drugs The Third Hospital of Changsha(The Affiliated Changsha Hospital of Hunan University)Changsha 410015China

The global antibiotic resistance crisis necessitates urgent *** innovative approach involves potentiating antibiotics and non-antibiotic drugs with adjuvants or boosters.A major drawback of these membrane-active boosters is their limited biocompatibility,as they struggle to differentiate between prokaryotic and eukaryotic *** study reports the chemical biology investigation of a dual-action oligoamidine(OA1)booster with a glutathione-triggered decomposition ***1,when combined with other antimicrobial molecules,exhibits a triple-targeting mechanism including cell membrane disruption,DNA targeting,and intracellular enzyme *** multi-targeting mechanism not only enhances the in vitro and in vivo eradication of antibiotic-resistant“ESkAPE”pathogens,but also suppresses the development of bacterial ***,OA1 maintains its activity in bacterial cells by creating an oxidative environment,while it quickly decomposes in mammalian cells due to high glutathione *** mechanistic insights and design principles may provide a feasible approach to develop novel antimicrobial agents and effective anti-resistance combination therapies.

关键词： antimicrobial booster oligoamidine membrane disruption DNA targeting triggered degradation anti-resistance

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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel m.S.Cheng Carolyn A.Cohen Daniel leung Xiwei Wang Xiaofeng mu Yuet Chung Tsun ming Lau manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun kwan John k.C.Li karl C.k.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos m.T.Lee Jennifer H.Y.Lam Sau man Chan Wilfred H.S.Wong Issan Y.S.Tam masashi mori Sophie A.Valkenburg malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HkU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(Im)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over Im administration in *** Participants aged 11–17 years received two doses of Im or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(Im-CC versus ID-CC)and post-dose 3(ImCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNm[sum of individual(S),nucleocapsid protein(N),and membrane protein(m)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNm-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and m-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to Im-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,m-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for Im-CC,ID-CC,Im-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and m-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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