检索结果-南通市图书馆

Biomimetic nanoparticles directly remodel immunosuppressive microenvironment for boosting glioblastoma immunotherapy

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第10期7卷 418-432页

作者： tingting Wang hao Zhang Weibao qiu Yaobao han hanghang liu Zhen li Center for Molecular Imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and ProtectionSchool for Radiological and Interdisciplinary Sciences(RAD-X)Soochow UniversityCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSuzhou215123PR China Paul C.lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055PR China

Glioblastoma(GBM),as a very aggressive cancer of central nervous system,is very challenging to completely cure by the conventional combination of surgical resection with radiotherapy and *** success of emerging immunotherapy in hot tumors has attracted considerable interest for the treatment of GBM,but the unique tumor immunosuppressive microenvironment(tIME)of GBM leads to the failure of ***,we show the significant improvement of the immunotherapy efficacy of GBM by modulating the tIME through novel all-in-one biomimetic nanoparticles(***-I/J@CM NPs).the nanoparticles consist of utrasmall Cu2-xSe nanoparticles(NPs)with outstanding intrinsic properties(e.g.,photo-responsive Fenton-like catalytic property for inducing immunogenic cell death(ICD)and alleviating the hypoxia of tumor),indoximod(IND,an inhibitor of indoleamine-2,3-dioxygenease in tumor),Jq1(an inhibitor for reducing the expression of PD-l1 by tumor cells),and tumor cell membrane for improving the targeting capability and accumulation of nanoparticles in *** reveal that these smart CS-I/J@CM NPs could drastically activate the immune responses through remodeling tIME of GBM by multiple *** could(1)increase M1-phenotype macrophages at tumor site by promoting the polarization of tumor-associated macrophages through the reactive oxygen species(ROS)and oxygen generated from the Fenton-like reaction between nanoparticles and H2O2 within tumor under NIR II irradiation;(2)decrease the infiltration of tregs cells at tumor site through the release of IND;(3)decrease the expression of PD-l1 on tumor cells through *** notable increments of anti-tumor CD8+t cells in the tumor and memory t cells(tEM)in the spleen show excellent therapy efficacy and effectively prevent the recurrence of GBM after modulation of the *** work demonstrates the modulation of tIME could be a significant strategy to improve the immunotherapy of GBM and other cold tumors.

关键词： Glioblastoma Immunotherapy Ultrasmall copper selenide nanoparticles tumor immune microenvironment Immune checkpoint blockade therapy

Searching for^(76)Ge neutrinoless double beta decay with the CDEx-1B experiment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-tao Zhang Jun-Zheng Wang li-tao Yang qian Yue ke-Jun kang Yuan-Jing li Hai-Peng An C.Greeshma Jian-Ping Chang Yun-Huan Chen Jian-Ping Cheng Wen-han Dai Zhi Deng Chang-hao Fang xin-Ping Geng Hui Gong qiu-Ju Guo xu-Yuan Guo li He Sheng-Ming He Jin-Wei Hu han-xiong Huang tu-Chen Huang Hai-tao Jia xi Jiang S.karmakar hao-Bin li Jian-Min li Jin li qian-Yun li Ren-Ming-Jie li xue-qian li Yu-lan li Yi-Fan liang Bin liao Fong-kay lin Shin-ted lin Jia-xuan liu Shu-kui liu Yan-Dong liu Yu liu Yuan-Yuan liu Zhong-Zhi liu hao Ma Yu-Cai Mao qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun qi Jie Ren xi-Chao Ruan Ze She Manoj kumar Singh tian-xi Sun Chang-Jian tang Wei-You tang Yang tian Guang-Fu Wang li Wang qing Wang Yu-Feng Wang Yun-xiang Wang Henry-tsz-king Wong Shi-Yong Wu Yu-Cheng Wu hao-Yang xing Rui xu Yin xu tao xue Yu-lu Yan Nan Yi Chun-xu Yu Hai-Jun Yu Jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou Zhang lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang kang-kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou key laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCtECH Company Beijing 100084 Yalong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEx-1B,1.008 kg)in the China Jinping Underground laboratory(CJPl)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as t_(1/2)^(0ν)>1.0×10^(23)yr(90%C.l.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEx point-contact germanium detector ^(76)Ge

信迪利单抗注射液联合xElOx方案对晚期胃癌患者PD-1、PD-l1表达和外周血髓源性抑制细胞、调节性t细胞的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代生物医学进展 2024年第14期24卷 2790-2793,2800页

作者：王浩韩尚纪雅玲张瑶汪海岩徐州医科大学附属医院肿瘤科江苏徐州221000

目的:观察信迪利单抗注射液联合奥沙利铂联合卡培他滨(xElOx)方案对晚期胃癌患者程序性死亡受体-1(PD-1)、程序性死亡配体-1(PD-l1)表达和外周血髓源性抑制细胞(MDSCs)、调节性t细胞(treg)的影响。方法:选择2021年4月~2023年3月期间我... 详细信息

目的:观察信迪利单抗注射液联合奥沙利铂联合卡培他滨(xElOx)方案对晚期胃癌患者程序性死亡受体-1(PD-1)、程序性死亡配体-1(PD-l1)表达和外周血髓源性抑制细胞(MDSCs)、调节性t细胞(treg)的影响。方法:选择2021年4月~2023年3月期间我院接收的121例晚期胃癌患者。按照随机数字表法将患者分为对照组(n=60,接受xElOx方案)和观察组(n=61,接受信迪利单抗注射液联合xElOx方案)。对比两组疗效、不良反应发生率、肿瘤标志物、PD-1、PD-l1 m RNA相对表达量、treg和MDSCs所占外周血单个核细胞(PBMC)比率。结果:与对照组的ORR(25.00%)、DCR(48.33%)相比,观察组的ORR(40.98%)、DCR(73.77%)更高(Pl1m RNA相对表达量、treg和MDSCs所占PBMC比率均低于对照组(P0.05)。结论:信迪利单抗注射液联合xElOx方案治疗晚期胃癌患者,可降低血清肿瘤标志物水平,调节PD-1、PD-l1表达和treg和MDSCs所占PBMC比率,有效控制疾病进展。

关键词：信迪利单抗注射液 xElOx方案晚期胃癌 PD-1 PD-l1 髓源性抑制细胞调节性t细胞

A New Perspective about Climate Change

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

地球科学期刊（中英文版） 2015年第1期5卷 12-17页

作者： k. B. Mao Y. Ma t.R. xu q. liu J q. han l. xia x. Y. Shen t. J. He National Hulunber Grassland Ecosystem Observation and Research Station Institute of Agricultural Resources and RegionalPlanning Chinese Academy of Agricultural Sciences Beijing 100081 China Chinese Agricultural Big Data and Nutrition Research Institute Pokfulam Hong Kong State key laboratory of Remote Sensing Science Jointly Sponsored by the Institute of Remote Sensing Applications ofChinese Academy of Sciences and Beijing Normal University Beijing 100875 China Hydrometeorology and Remote Sensing laboratory University of Oklahoma Norman 73072 USA Department of Geography University of Toronto Toronto M5 S 3G3 Canada

基于UHPlC-q-Orbitrap-MS技术分析肝豆扶木汤中化学成分

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华中医药杂志 2024年第4期39卷 2001-2009页

作者：杨玉龙杨文明魏涛华杨悦郝文杰尚展鹏董婷韩燕全安徽中医药大学第一附属医院合肥230031 新安医学教育部重点实验室合肥230012 北京大学药学院北京100191

目的:采用超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法(UHPlC-q-Orbitrap-MS)对肝豆扶木汤(GDFMD)中化学成分进行快速鉴定和归属。方法:选择thermo Fisher Vanquish UHPlC仪器,Aglient SB C_(18)色谱柱(2.1 mm×150 mm,1.8μm),流动相为0.1%甲酸水(A)和乙腈(B),洗脱梯度:0—2 min,3%B;2—7 min,3%~15%B;7—15 min,15%B;15—20 min,15%~40%B;20—22 min,40%~100%B;22—24 min,100%B;流速:0.4 ml/min;柱温:50℃;进样量:2μl。通过正、负离子模式采集质谱数据,根据精确相对分子质量、二级质谱裂解碎片等信息,结合对照品及相关文献信息比对,对GDFMD中化学成分进行鉴定,并对这些化合物的药材来源进行归属。结果:共鉴别了82个化合物,包括26个酚类、25个生物碱、18个皂苷、5个倍半萜、4个游离酚和4个有机酸;其中归属制何首乌8个、枸杞子24个、白芍15个、柴胡4个、三七粉14个、土茯苓16个、郁金6个。结论:采用UHPlC-q-Orbitrap-MS可实现对GDFMD中化学成分的快速、准确鉴定,基本涵盖了组方中各药材的成分信息,可为完善该复方的质量评价体系和阐明其药效机制奠定基础。

关键词：肝豆扶木汤超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法酚类生物碱皂苷倍半萜游离酚有机酸

Mechanisms of the formation of wind-blown sand hazards and the sand control measures in Gobi areas under extremely strong winds along the lanzhou-xinjiang high-speed railway

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2023年第2期66卷 292-302页

作者： Jianjun qU tao WANG qinghe NIU Benli lIU lihai tAN qingjie han Yang GAO Jianhua xIAO key laboratory of Desert and Desertification/Dunhuang Gobi and Desert Ecology and Environment Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou730000China Southern Marine Science and Engineering Guangdong laboratory(Guangzhou) Guangzhou511458China

the lanzhou-xinjiang high-speed railway(HSR)traverses areas of the Gobi Desert where extremely strong winds are *** strong winds cause sand/gravel hazards,an unaddressed issue that often seriously compromises the safe operation of the *** paper studies the mechanisms leading to wind-blown sand hazards and the outcomes of sand control projects in these *** main findings are as follows:(1)Cold northern airflows over the tian Shan mountain range are accelerated by the wind tunnels and downslope effect as they pass over complex terrain comprising passes,gullies,and proluvial ***,the wind intensity often increases two-to threefold,creating frequent high-speed winds that lead to severe sand damage along the HSR.(2)In the Gobi areas with extremely strong winds,sand grains can be lifted as high as 9 m from the ground into the air,far higher than in other areas of the *** sand transport rate decreases exponentially with increasing *** wind speed and particle size determine saltation *** particles and stronger winds provide the particles with a higher kinetic energy as they collide with the *** the wind zones of Baili and Yandun,the analysed study areas,the saltation layer height of wind-blown sand/gravel exceeds 3 and 2 m,respectively.(3)Based on the above findings,recently emerging sand control materials,suitable for the areas of interest,were screened and ***,under the proposed principle of‘supplementing blocking with trapping’,a comprehensive sand control measure was established,featuring sandblocking belts comprised of multiple rows,and high,vertical sand-trapping installations with a large grids *** installed system showed a high efficacy,reducing sand transport rate by 87.87%and significantly decreasing the deposition of sand along a trial section of the HSR.

关键词： Gobi areas with extremely strong winds Wind-blown sand hazards Complex terrain Sand/gravel flow Wind-blown sand control

Protective effect of heme oxygenase-1 on Wistar rats with heart failure through the inhibition of inflammation and amelioration of intestinal micro- circulation

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2015年第4期12卷 353-365页

作者： li ZhanG Zhuo-kun GAN li-Na han hao WANG Jie BAI Guo-Juan tAN xiao-xia lI Ya-Ping xU Yu ZHOU Mei-liang GONG Mo-Si lIN xiao-Yang han Department of Cardiology Internal Medicine Nanlou Branch of Chinese PLA General Hospital Beijing China VIP Cardiovascular Department Navy General Hospital Beijing China Department of Clinical laboratory Nanlou Branch of Chinese PLA General Hospital Beijing China Department of Ultrasonography Nanlou Branch of Chinese PLA General Hospital Beijing China School of Chemical Biology and Pharmaceutical Sciences Capital Medical University Beijing China Department of Pharmacy Out-patient Clinic of Aerospace City General Armament Hospital Beijing China

Background Myocardial infarction （MI） has likely contributed to the increased prevalence of heart failure （HF）. As a result of re- duced cardiac function, splanchnic blood flow decreases, causing ischemia in villi and damage to the intestinal barrier. the induction of heme oxygenase-1 （HO-1） could prevent, or lessen the effects of stress and inflammation. thus, the effect and mechanism thereof of HO-1 on the intestines of rats with HF was investigated. Methods Male Wistar rats with heart failure through ligation of the left coronary artery were identified with an left ventricular ejection fraction of 〈 45% through echocardiography and then divided into various experimental groups based on the type of peritoneal injection they received [MI： saline; MI ＋ Cobalt protoporphyrin （CoPP）： CoPP solution; and MI ＋ tin mesoporphyrin Ix dichloride （SnMP）： SnMP solution]. the control group was comprised of rats without coronary ligation. Echocardiogra- phy was performed before ligation for a baseline and eight weeks after ligation in order to evaluate the cardiac function of the rats. the bac- terial translocation （Bt） incidence, mesenteric microcirculation, amount of endotoxins in the vein serum, ileum levels of HO- 1, carbon oxide （CO）, nitric oxide （NO）, intedeuldn （Il）-10, turnour necrosis factor-et （tNF-ct）, and the ileum morphology were determined eight weeks after the operation. Results the rats receiving MI ＋ CoPP injections exhibited a recovery in cardiac function, an amelioration of mesenteric microcirculation and change in morphology, a lower Bt incidence, a reduction in serum and ileac NO and tNF-ct levels, and an elevation in ileac HO-1, CO, and interleukin-10 （[l-10） levels compared to the MI group （P 〈 0.05）. the rats that received the MI ＋ SnMP injections exhibited results inverse to the MI （P 〈 0.05） group. Conclusions HO-1 exerted a protective effect on the intestines of rats with HF by inhibiting the inflammation and amelioration of microcirculation through t

关键词： Carbon monoxide Heart failure Heme oxygenase-1 Intestine

Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason lynch Christopher E.Stevens Christopher Munley Chentao li Jin Hou hao Zhang Andrew torma thomas Darlington Francis Coen kevin li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA19104USA kBR Inc. BeavercreekOH45431USA Air Force Research laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular Engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical Engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer Engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

饲料添加谷氨酸对草鱼生长、抗氧化能力和肌肉品质性状的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水生生物学报 2024年第9期48卷 1509-1518页

作者：杨婉愉巫丽云张月星韩冬张志敏刘昊昆金俊琰杨云霞朱晓鸣解绶启浙江海洋大学国家海洋设施养殖工程技术研究中心舟山316022 中国科学院水生生物研究所淡水生态与生物技术国家重点实验室武汉430072

实验以草鱼(Ctenopharyngodon idella)为研究对象,探究饲料中添加谷氨酸对草鱼生长性能、肌肉品质和血浆抗氧化能力的影响。研究配制3组等氮等脂实验饲料:对照饲料(Con)、在对照饲料中添加质量分数0.8%和1.6%的l-谷氨酸(分别为0.8%GlU组... 详细信息

实验以草鱼(Ctenopharyngodon idella)为研究对象,探究饲料中添加谷氨酸对草鱼生长性能、肌肉品质和血浆抗氧化能力的影响。研究配制3组等氮等脂实验饲料:对照饲料(Con)、在对照饲料中添加质量分数0.8%和1.6%的l-谷氨酸(分别为0.8%GlU组和1.6%GlU组)。将540尾初始质量为(37.0±0.2)g的草鱼分为3个处理,分别投喂1种实验饲料,每个处理设3个重复网箱,每个网箱放养60尾鱼,养殖周期85d。研究结果发现,饲料中添加谷氨酸组草鱼的生长性能与对照组无显著差异;与对照相比,1.6%GlU组草鱼的背肌肌肉间隙减小,肌纤维密度显著增加(PlU组和1.6%GlU组草鱼背肌的硬度、咀嚼性、黏附性、内聚性和回复性显著增加,0.8%HYP组肌肉弹性显著增加(PlU组草鱼血浆碱性磷酸酶AkP活性显著增加(PlU组和1.6%GlU组草鱼血浆谷丙转氨酶活性显著下降(PlU组和1.6%GlU组草鱼血浆超氧化物歧化酶SOD活性和总抗氧化能力t-AOC均显著增加(P<0.05)。综上,饲料中添加谷氨酸有助于改善草鱼肌肉品质性状,提高草鱼血浆抗氧化能力。

关键词：谷氨酸肌肉品质抗氧化能力草鱼