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A Graded Speed Control Method for Cyborg Rats Based on Electrical Stimulation of the Cuneiform Nucleus

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Journal of Bionic Engineering 2024年第3期21卷 1334-1346页

作者： hanyi ling le han Nenggan Zheng Qiushi Academy for Advanced Studies(QAAS) Zhejiang UniversityHangzhou310007China the State key lab of Brain-Machine Intelligence Zhejiang UniversityHangzhou310007China College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou310007China College of Computer Science and technology Zhejiang UniversityHangzhou310007China CCAI by MOE and Zhejiang Provincial Government(ZJU) Hangzhou310007China

the precise movement speed regulation is a key factor to improve the control effect and efficiency of the cyborg ***,the current stimulation techniques cannot realize the graded control of the *** this study,we achieved the multi-level speed regulation of cyborg rats in the large open field and treadmill by specifically targeting the Cuneiform Nucleus(Cnf)of the Mesencephalic locomotor Region(MlR).Detailed,we measured the influence of each stimulation parameter on the speed control process which included the real-time speed,accelerated speed,response time,and acceleration *** concluded that the pulse period and the pulse width were the main determinants influencing the accelerated speed of cyborg *** the amplitude of stimulation was found to affect the response time exhibited by the cyborg *** study provides valuable insights into the regulation of rat locomotion speed and highlights the potential for utilizing this approach in various experimental settings.

关键词： Cyborg rats Cuneiform nucleus Graded control Speed regulation

Reactor field reconstruction from sparse and movable sensors using Voronoi tessellation-assisted convolutional neural networks

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Nuclear Science and techniques 2024年第5期35卷 173-185页

作者： He-lin Gong han li Dunhui Xiao Sibo Cheng Paris Elite Institute of technology Shanghai Jiao Tong UniversityShanghai 200240China school of Mathematical Sciences Tongji UniversityShanghai 200092China Department of Computing Data Science InstituteImperial College LondonLondon SW72AZUK

the aging of operational reactors leads to increased mechanical vibrations in the reactor *** vibration of the incore sensors near their nominal locations is a new problem for neutronic field *** field-reconstruction methods fail to handle spatially moving *** this study,we propose a Voronoi tessellation technique in combination with convolutional neural networks to handle this *** from movable in-core sensors were projected onto the same global field structure using Voronoi tessellation,holding the magnitude and location information of the *** convolutional neural networks were used to learn maps from observations to the global *** proposed method reconstructed multi-physics fields(including fast flux,thermal flux,and power rate)using observations from a single field(such as thermal flux).Numerical tests based on the IAEA benchmark demonstrated the potential of the proposed method in practical engineering applications,particularly within an amplitude of 5 cm around the nominal locations,which led to average relative errors below 5% and 10% in the l_(2) and l_(∞)norms,respectively.

关键词： Voronoi tessellation field reconstruction Nuclear reactors Reactor physics On-line monitoring

Melt flow,heat transfer and solidification in a flexible thin slab continuous casting mold with vertical-combined electromagnetic braking

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Journal of Iron and Steel Research International 2024年第2期31卷 401-415页

作者： lin Xu Ze-feng han Christian karcher En-gang Wang key laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang110819LiaoningChina key laboratory of liaoning Province for Clean Combustion Power Generation and Heating technology Shenyang Institute of EngineeringShenyang110136LiaoningChina Institute of thermodynamics and fluid Mechanics Technische Universität IlmenauIlmenau98684Germany

During continuous casting of steel slabs,the application of electromagnetic braking technology(EMBr)provides an effective tool to influence solidification by controlling the pattern of melt flow in the ***,the quality of the final product can be improved considerably.A new electromagnetic braking(EMBr)method,named vertical-combined electromagnetic braking(VC-EMBr),is proposed to be applied to a flexible thin slab casting(ftSC)*** evaluate the beneficial effects of the VC-EMBr,the melt flow,heat transfer,and solidification processes in the ftSC mold are studied by means of numerical *** detail,a Reynolds-averaged Navier–Stokes turbulence model together with an enthalpy-porosity approach was *** numerical findings are compared with respective simulations using the traditional *** results demonstrate that the application of the VC-EMBr contributes significantly to preventing relative slab *** contrast to the Ruler-EMBr,the additional vertical magnetic poles of the VC-EMBr preferentially suppress the direct impact of jet flow on the narrow face of fStC mold and considerably diminish the level fluctuation near the meniscus *** instance,by applying a magnetic flux density of 0.3 t,the maximum amplitude of meniscus deflection reduces by about 80%.Moreover,the braking effect of the VC-EMBr effectively improves the homogeneity of temperature distribution in the upper recirculation region and increases the solidified shell thickness along the casting *** this basis,the newly proposed VC-EMBr shows a beneficial effect in preventing relative slab defects for ftSC thin slab continuous casting.

关键词： Electromagnetic braking Mold Melt flow Heat transfer Solidification

Accumulated-state-error-based event-triggered sampling scheme and its application to H∞ control of sampled-data systems

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Science China(Information Sciences) 2024年第6期67卷 328-341页

作者： Xian-Ming ZhanG Qing-long han Bao-lin ZhanG Xiaohua GE Dawei ZhanG school of Science Computingand Engineering TechnologiesSwinburne University of Technology College of Automation and Electronic Engineering Qingdao University of Science & Technology school of Mathematics Shandong University

this paper is concerned with event-triggered H∞control of sampled-data systems. Its novelties lie in three aspects:（i） A novel accumulated-state-error-based event-triggered scheme is introduced by comparing the integral of the state error from tk to t with the system state sampled at tk. this condition works well due to the fact that the so-called Zeno behaviour does not occur.（ii） A novel lyapunov functional is constructed to establish a criterion to ensure some certain H∞performance of the closed-loop system. this lyapunov functional is dependent on the integral of the state error involved in the event-triggered scheme.（iii） Under the event-triggered sampling scheme, suitable state-feedback controllers can be designed rather than be given a priori. Moreover, a self-triggered implementation of the proposed event-triggered sampling scheme is presented as well. finally, a batch reactor model and an inverted pendulum system are given to demonstrate the effectiveness of the proposed method.

关键词： event-triggered sampling self-triggered implementation $H_\infty$ control looped-functional

Detoxification strategy of Microcystis aeruginosa to the toxicity of Cd(Ⅱ):role of EPS in alleviating toxicity

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Journal of Oceanology and limnology 2024年第3期42卷 802-815页

作者： Xingye han fangyuan lIU Yibo ZhanG kai CHENG Heyun WANG Hongmei GE Innovation Demonstration Base of Ecological Environment Geotechnical and Ecological Restoration of Rivers and lakes School of Civil EngineeringArchitecture and EnvironmentHubei University of TechnologyWuhan 430068China school of Environmental Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China National Engineering Research Center of Advanced technology and Equipment for Water Environment Pollution Monitoring Wuhan 430068China

Although many studies have found that cadmium(Cd)can be toxic to microalgae,only a few reports focused on the role of extracellular polymeric substances(EPS)in Cd(Ⅱ)*** biochemical and physiological endpoints of Microcystis aeruginosa,including the composition and functional groups of soluble EPS(Sl-EPS),loosely bound EPS(lB-EPS),and tightly bound EPS(tB-EPS),were detected to elucidate the toxicity and detoxification mechanisms of Cd(Ⅱ)for *** and physiological assays on *** showed that the 0.25-mg/l Cd(Ⅱ)resulted in a larger inhibition on growth and f_(v)/f_(m).Nevertheless,Cd(Ⅱ)significantly induced much higher contents of superoxide dismutase(SOD),intracellular microcystin lR(MC-lR),extracellular MC-lR,and *** electron microscopy with energy dispersive X-ray spectroscopy confirmed that Cd(Ⅱ)was absorbed into the EPS *** transform infrared spectrum analysis revealed that the functional groups bound with Cd(Ⅱ)of algae biomass,Sl-EPS,lB-EPS,and tB-EPS were somewhat *** C=O/C=N groups ofδ-lactam or protein were their prominent functional groups,suggesting that amide or proteins in the EPS played a key role in the adsorption in Cd(Ⅱ).the concentration of 0.25 mg/l of Cd(Ⅱ)may change the chemical structure of EPS by altering the production of protein-like substances containing *** study indicated that *** could detoxify Cd(Ⅱ)stress via induction of antioxidant capacity(higher SOD activity and MC synthesis),EPS production,and modification in chemical structure of EPS.

关键词： Microcystis aeruginosa cadmium extracellular polymeric substances(EPS) microcystin detoxification

Numerical study of novel OME_(1-6) combustion mechanism and spray combustion at changed ambient environments

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frontiers in Energy 2024年第4期18卷 483-505页

作者： frederik WIESMANN Zeyan QIU Dong han lukas StRAUβ Sebastian RIEβ Michael WENSING thomas lAUER Institute of Powertrains and Automotive technology TU Wien1060 ViennaAustria key laboratory for Power Machinery and Engineering of Ministry of Education Shanghai Jiao Tong UniversityShanghai 200240China Professorship for fluid Systems technology Friedrich-AlexanderUniversität Erlangen-Nürnberg91058 ErlangenGermany

for a climate-neutral future mobility,the socalled e-fuels can play an essential ***,oxygenated e-fuels containing oxygen in their chemical formula have the additional potential to burn with significantly lower soot *** particular,polyoxymethylene dimethyl ethers or oxymethylene ethers(PODEs or OMEs)do not contain carbon-carbon bonds,prohibiting the production of soot precursors like acetylene(C_(2)H_(2)).these properties make OMEs a highly interesting candidate for future climate-neutral compression-ignition ***,to fully leverage their potential,the auto-ignition process,flame propagation,and mixing regimes of the combustion need to be *** achieve this,efficient oxidation mechanisms suitable for computational fluid dynamics(CfD)calculations must be developed and *** present work aims to highlight the improvements made by developing an adapted oxidation mechanism for OME1-6 and introducing it into a validated spray combustion CfD model for *** simulations were conducted for single-and multi-injection patterns,changing ambient temperatures,and oxygen *** results were validated against high-pressure and high-temperature constantpressure chamber ****-chemiluminescence measurements accomplished the characterization of the auto-ignition *** experiments and simulations were conducted for two different *** improvements concerning the prediction of the ignition delay time were accomplished while also retaining an excellent agreement for the flame lift-off *** spatial zones of high-temperature reaction activity were also affected by the adaption of the reaction *** showed a greater tendency to form OH^(*) radicals within the center of the spray in accordance with the experiments.

关键词： oxygenated fuels reaction kinetics oxidation mechanisms computational fluid dynamics(CfD) oxymethylene ethers(OME) e-fuels multiinjection spray-combustion

Stepping forward:t-cell redirecting bispecific antibodies in cancer therapy

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2361-2377页

作者： Xiaojing Qin Wenjing Ning han liu Xue liu Wenxin luo Ningshao Xia State key laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen 361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsNational Innovation Platform for IndustryeEducation Integration in Vaccine Researchthe Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical SciencesXiamen UniversityXiamen 361102China

t cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the t cell *** linkage between tumor cells and t cells actively triggers t cell activation and initiates targeted killing of the identified tumor *** antibodies have emerged as one of the most promising avenues within tumor ***,despite success in treating hematological malignancies,significant advancements in solid tumors have yet to be *** this review,we aim to address the critical challenges associated with t cellredirecting bispecific antibodies and explore novel strategies to overcome these obstacles,with the ultimate goal of expanding the application of this therapy to include solid tumors.

关键词： Bispecific antibody(BsAbs) t-cell redirecting BsAbs tumor-associated antigens toxicity Cytokine release syndrome tumor microenvironment Cancer immunotherapy Combination therapy strategies

Masses of the conjectured H-dibaryon at different temperatures

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Chinese Physics C 2024年第8期48卷 83-93页

作者： liang-kai Wu han tang Ning li Xin-Yang Wang school of Physics and Electronic Engineering Jiangsu UniversityZhenjiang 212013China Center for fundamental Physics School of Mechanics and PhysicsAnhui University of Science and TechnologyHuainan 232001China

We present a lattice QCD determination of masses of the conjectured H-dibaryon,denoted as mH,at nine different temperatures:t/t_(c)=0.24,0.63,0.76,0.84,0.95,1.09,1.27,1.52,and *** masses of baryons N,Σ,Ξ,andΛat different temperatures were also *** simulations were performed on an anisotropic lattice with N_(f)=2+1 flavours of clover fermion at a quark mass corresponding to mπ=384(4)*** thermal ensembles were provided by the fAStSUM collaboration,whereas the zero temperature ensembles were provided by the Hadspec *** also calculated the spectral density of the correlation function of those *** spectral density distributions show a rich peak structure at the lowest temperature;at intermediate temperatures,the mass values of those particles obtained by the extrapolation method reflect a two-peak *** the spectral density for the octet baryon becomes smooth at t/t_(c)=1.27,1.52,and 1.90,the spectral density for the H-dibaryon becomes smooth at t/t_(c)=*** t/t_(c)=0.24,the mass difference of the H-dibaryon andΛpair,expressed asΔm=m_(H)−2m_(Λ),was estimated to beΔm=−14.6(6.2)MeV,which suggests the existence of a bound H-dibaryon state.

关键词： lattice QCD H-dibaryon spectral function clover fermion finite temperature

Immune checkpoint inhibitors:breakthroughs in cancer treatment

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Cancer Biology & Medicine 2024年第6期21卷 451-472页

作者： Xueqing kong Jinyi Zhang Shuwei Chen Xianyang Wang Qing Xi han Shen Rongxin Zhang laboratory of Immunology and Inflammation School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China Department of Biology School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China

Over the past two decades,immunotherapies have increasingly been considered as first-line treatments for most *** such treatment is immune checkpoint blockade(ICB),which has demonstrated promising results against various solid tumors in clinical *** antibodies(mAbs)are currently available as immune checkpoint inhibitors(ICIs).these ICIs target specific immune checkpoints,including cytotoxic t-lymphocyte-associated antigen-4(CtlA-4)and programmed cell death protein 1(PD-1).Clinical trial results strongly support the feasibility of this immunotherapeutic ***,a substantial proportion of patients with cancer develop resistance or tolerance to treatment,owing to tumor immune evasion mechanisms that counteract the host immune ***,substantial research focus has been aimed at identifying additional ICIs or synergistic inhibitory receptors to enhance the effectiveness of anti-PD-1,anti-programmed cell death ligand 1(anti-PD-l1),and anti-CtlA-4 ***,several immune checkpoint molecular targets have been identified,such as t cell immunoreceptor with Ig and ItIM domains(tIGIt),mucin domain containing-3(tIM-3),lymphocyte activation gene-3(lAG-3),V-domain immunoglobulin suppressor of t cell activation(VIStA),B and t lymphocyte attenuator(BtlA),and signal-regulatory proteinα(SIRPα).functional m Abs targeting these molecules are under ***-4,PD-1/PD-l1,and other recently discovered immune checkpoint proteins with distinct structures are at the forefront of *** review discusses these structures,as well as clinical progress in m Abs targeting these immune checkpoint molecules and their potential applications.

关键词： Immunotherapy cancer ICIs PD-1 CtlA-4